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Name Ying-Chieh Sun
Lab TEL (02)77496216
Office TEL (02)77496215
FAX No. (02)29324249
Address. (11677)No. 88, Sec. 4, Ting-Chow Rd, Taipei, Taiwan, 11677, R.O.C.
E-mail sun@ntnu.edu.tw
Lab. Website http://web.ntnu.edu.tw/%7Esun/
Classification Full-Time
Title Professor
Research Computational biophysical chemistry,
Computer - aided drug design
Research Specialization  
Laboratory Molecular dynamics & Simulation Research Lab /

Academic Researches

  1. Journal Articles
    1.  Chia-Jen Hsu, Wen-Chi Hsu,Der-Jay Lee, An-Lun Liu, Chia-Ming Chang, Huei-Jhen Shih, Wun-Han Huang, Guey-Jen Lee-Chen, Hsiu Mei Hsieh-Li, Guan-Chiun Lee, and Ying-Chieh Sun "Investigation of the Bindings of a Class of Inhibitors with GSK3b Kinase Using Thermodynamic Integration MD Simulation and Kinase Assay" Chem. Biol. Drug Des. (2017, accepted)


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    2. Chih-Hsin Lin, Yu-Shao Hsieh, Yih-Ru Wu, Chia-Jen Hsu, Hsuan-Chiang Chen, Hsiu Mei Hsieh-Li, Ming-Tsan Su, Ying-Chieh Sun*, Guan-Chiun Lee*, Guey-Jen Lee-Chen*, "Identifying GSK-3<beta> kinase inhibitors of Alzheimer's disease: Virtual screening, enzyme, and cell assays", European Journal of Pharmaceutical Sciences (accepted 2016) Reference LinkReference Link
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    6. Xu-Nan Tang, Cheng-Wei Lo, Yu-Chung Chuang, Chao-Tung Chen, Ying-Chieh Sun, Yi-Ren Hong, and Chia-Ning Yang, Prediction of the binding mode between GSK3b and a peptide derived from GSKIP using molecular dynamics simulation”, Biopolymers, (accepted).

    9. Jia-Yang Chen, Sin-Ming Huang, Yen-An Tang, Hsueh-Fen Juan, Li-Wha Wu, Ying-Chieh Sun, Szu-Chi Wang, Kuan-Wei Wu, Gopula Balraj, Tzu-Tin Chang, Wen-Shan Li, Hung-Chi Cheng, and Yi-Ching Wang, "A novel sialyltransferase inhibitor suppresses FAK/paxillin and angiogenesis signaling and cancer metastasis”, Cancer Research, 71, 473-483 (2011).
    10. InLin Chiu and Ying-Chieh Sun, “Calculation of Binding Affinity for Colchicine Analogues Binding with Tubulin Using MD/MM-PBSA Method” (in preparation)

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    12. Cheng-Chang Hsu, Shih-Hong Wang, Hsing-Pang Hsieh, and Ying-Chieh Sun Comparative Molecular Field Analysis of Anti-tubulin Agents with Indole Ring Binding at the Colchicine Binding Site”, J. Theore. Comput. Chem., 9, 279-291 (2010).

    13. Ying-Chieh Sun, “Examination of Effects of GSK3b Phosphorylation, b-catenin Phosphorylation, and b-catenin Degradation in Kinetics of Wnt Signaling Pathway Using Computational MethodTheore. Biol. Med. Modelling, 6: 13 (2009).
    14. Shu-Ping Lin, Kun-Chang Tseng, Ming-Chou Lin, Chii-Dong Chen, Chia-Chang Tsai, Shu-Han Yu, Ying-Chieh Sun, Tsung-Wu Lin, Chien-Yuan Pan, and Yit-Tsong Chen, “A Reversible Surface Functionalized Nanowire Transistor to Study Protein-Protein Interactions" Nano Today, 4, 235-243 (2009).
    15. Wen-Hung Wang, Yi-Ching Wang, and Ying-Chieh Sun, ‘A 3D-QSAR study of Celebrex-based PDK1 Inhibitors Using CoMFA Method’ J. Chin. Chem. Soc. 56, 59-64 (2009).
    16. Yi-Hung Tan, Kung-Hsueh Lee, Topp Lin , Ying-Chieh Sun , Hsueh-Fen Juan, Yi-Ching Wang , ‘Cytotoxicity and Proteomics Analyses of OSU03013 in Lung Cancer’, Clinical Cancer Research, 14, 1823-1830 (2008).
    17. C.C. Chen, Chung-Cheng Wei , Ying-chieh Sun and Chi-Ming Chen , ''Packing of Transmembrane Helices in Bacteriorhodopsin Folding: Structure and Thermodynamics’, Journal of Structural Biology, 162, 237-247 (2008)
    18. Wei-Zhou Wang, Topp Lin , and Ying-Chieh Sun ,‘Examination of the Folding of a Short Alanine-Based Helical Peptide with Salt Bridges Using Molecular Dynamics Simulation’ J. Phys. Chem. B, 111, 3508-3514, (2007).
    19. Jeng-Han Wang, M. C. Lin, Ying-Chieh Sun,‘Reactions of Hydrazoic Acid on TiO2 Nanoparticles: An Experimental and Computational Study’ J. Phys. Chem. B, 109, 5133-5142 (2005).
    20. Chung-Cheng Wei, Ming-Hsun Ho, Wen-Hung Wang, and Ying-Chieh Sun ‘Molecular Dynamics Simulation of Folding of a Short Helical Peptide with Many Charged Residues’, J. Phys. Chem. B, 109, 19980-19986, (2005). SCI.
    21. Ying-Chieh Sun, I-Ting Wang, Thanh Lam Nguyen, Hsiu-Feng Lu, Xueming Yang, and Alexander M. Mebel‘A Combined Quantum Chemistry and RRKM Calculation Predicts the O(1D) + C2H6 Reaction Can Produce Water Molecule in Collision-free Crossed Molecular Beam Environment’ J. Phys. Chem. A 107, 6986-6994 (2003). SCI.
    22. Chai Ling Fan, Wei-Der Lee, Nai-Wei Teng, Ying-Chieh Sun and Kwunmin Chen,‘Asymmetric Epoxidation of Camphor N-Enoylpyrazolidinones with Methyl(trifluoromethyl)dioxirane and Urea Hydrogen Peroxide Complex: Reversal of Stereoselectivity’ J. Org. Chem. 68, 9816, (2003). SCI.
    23. Ming-Hsun Ho and Ying-Chieh Sun, ‘Molecular Dynamics Simulation of Hydrogen-covered Si(100):H-2x1 surface: Calculation of Vibrational Energy Relaxation Rates of Hydrogen Stretching Modes’ Surf. Sci., 516, L540-L546 (2002). SCI.
    24. Man-kit Leung, Ashis B. Mandal, Chih-Chieh Wang, Gene-Hsiang Lee, Shie-Ming Peng, Hsing-Ling Cheng, Guor-Rong Her, Ito Chao, Hsiu-feng Lu, Ying-Chieh Sun, Mei-Ying Shiao, and Pi-Tai Chou,‘Self-complementarity of oligo-aminopyridines: a new class of hydrogen-bonded ladders’ J. Am. Chem. Soc., 124, 4287 (2002) . SCI.
    25. Hsiu-Feng Lu and Ying-Chieh Sun, ‘Calculated Energies of Adsorption of Non-hydrocarbon Species on Diamond H/C(111) Surface and the Abstraction Energies of these Species Abstracted by Hydrogen Atoms Using ab initio Calculation’Diamond and Related Materials, 11, 1560 (2002) . SCI.
    26. Hsiu-Feng Lu and Ying-Chieh Sun, ‘Calculation of Hydrogen Abstraction Reaction on Hydrogen-covered H/C(111) Diamond Surface Abstracted by Non-Hydrocarbon Species’ Surf. Sci. 494 L787-L792 (2001). SCI.
    27. Ying-Chieh Sun, Hsiu-Feng Lu, and Ming-Shun Ho,2000,`Molecular dynamics simulation of hydrogen isotope-terminated silicon (111) and (110) surfaces: calculation of vibrational energy relaxation rates of hydrogen isotope stretching modes’Chem. Phys. Lett. ,  318, 7-14. SCI.
    28. Ying-Chieh Sun, Shu-Fen Yang, I-Lun Hwang,and Tzu-Hsien Wu, 1999 `A 500 ps Molecular dynamics simulation trajectory of cardiotoxin II from Taiwan cobra venom in solution: correlation with NMR and X-ray crystallography data‘ J. Comput. Chem. , 20, 546-562. SCI.
    29. Hsiu-Feng Lu, Ming-Shun Ho, Sho-Ching Hong, Ai-Hsin Liu, Pei-Fang Wu, and Ying-Chieh Sun, 1998,‘Determination of vibrational energy relaxation rates of C-H,D,T stretching modes on hydrogen, deuterium, and tritium-terminated H,D,T/C(111) and H,D,T/C(110) surfaces using molecular dynamics simulation: thermal effect’ J. Chem. Phys.,  109,6898-6904. SCI.
    30. Ying-Chieh Sun and Jiunn-Ming Chen,1997,‘ Calculations of vibrational energy relaxation rates of C-H,D,T stretching modes on hydrogen, deuterium, and tritium-terminated H,D,T/C(111)lxl surface’ J. Phys. Chem., 101, 7082-7086. SCI.
  2. Patent
    Unit Title Department Position Date
    National Taiwan Normal UniversityProfessorDepartment of chemistry 2000 ~
    National Taiwan Normal UniversityAssociate ProfessorDepartment of Chemistry 1996 ~ 2000
    University of California, San FranciscoPostdoctoral ResearchDepartment of Pharmaceutical Chemistry 1994 ~ 1996
    Academic Degrees
    School Nation Department Degree Date
    University of PennsylvaniaU.S.Department of chemistryPh.D.1989-09 ~ 1994-06
    National Taiwan UniversityTaiwanDepartment of chemistryB.S.1983-09 ~ 1987-06
    Note: The following information may show the name of the Web page owner only.
    1. Journal papers
    2. Research projects