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Academic

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Academic Researches
Catergory Writings Author
Journal ArticlesChen, Y.-R.; Reddy, G. M.; Hsieh, K.-H.; Chen, K.-H.; Karanam, P.; Vagh, S. S.; Liou, Y.-C.; Lin, W.* "3-Homoacyl Coumarins as a Class of All-Carbon 1,3-Dipole Precursors: An Enantioselective Concerted (3+2) Cycloaddition towards Coumarin/Indandione-Fused Spirocyclopentanes" Chem. Commun. 2018accepted.Wenwei Lin
Journal Articles "Identification of Stabilizing High-valent Active Sites by Operando High-energy Resolution Fluorescence-detected X-ray Absorption Spectroscopy for High Efficient Water Oxidation", 
 
Sung-Fu Hung,+ Yu-Te Chan (詹佑得),+ Chun-Chih Chang (張鈞智), Ming-Kang Tsai,* Yen-Fa Liao, Nozomu 
Hiraoka, Chia-Shuo Hsu, Hao Ming Chen,* 2018 (submitted).
 [+ denotes equal contribution]
Ming-Kang (Brad) Tsai
Journal Articles  

1.     Ling-Hsien Tu, Ning-Hsuan Tseng, Ya-Ru Tsai, Tien-Wei Lin, Yi-Wei Lo, Jien-Lin Charng, Hua-Ting Hsu, Yu-Sheng Chen, Rong-Jie Chen, Ying-Ta Wu, Yi-Tsu Chan, Chang-Shi Chen, Jim-Min Fang,* and Yun-Ru Chen* (2018, Oct). Rationally designed divalent caffeic amides inhibit amyloid-β fibrillization, induce fibril dissociation, and ameliorate cytotoxicity. European Journal of Medicinal Chemistry, 158, 393-404

 

2.    Arnaldo Serrano, Justin Lomont, Ling-Hsien Tu, Daniel Raleigh,and Martin Zanni* (2017, Oct). A free energy barrier caused by the refolding of an oligomeric intermediate controls the lag time of amyloid formation by hIAPP. Journal of the American Chemical Society, 139(46), pp 16748–16758. 
 

3.    Lydia M. Young, Ling-Hsien Tu, Daniel P. Raleigh, Alison E. Ashcroft and Sheena E. Radford* (2017, May). Understanding co-polymerization in amyloid formation by direct observation of mixed oligomers. Chemical Science, 8(7), 5030-5040.
 

4.     Andisheh Abedini*, Annette Plesner, Ping Cao, Zachary Ridgway,Jinghua Zhang, Ling-Hsien Tu, Chris T Middleton, Brian Chao,Daniel J Sartori, Fanling Meng, Hui Wang, Amy G Wong, Martin T Zanni,C Bruce Verchere, Daniel P Raleigh*, Ann Marie Schmidt* (2016, May). Time-resolved studies define the nature of toxic IAPP intermediates, providing nsight for anti-amyloidosis therapeutics. eLIFE, 5:e12977. 
 

5.      Rehana Akter, Ping Cao, Harris Noor, Zachary Ridgway, Ling-Hsien Tu, HuiWang, Amy G.Wong, Xiaoxue Zhang, Andisheh Abedini, AnnMarie Schmidt, and Daniel P. Raleigh* (2016). Islet Amyloid Polypeptide: Structure, Function, and Pathophysiology. Journal of Diabetes Research, Article ID 2798269. 
 

6.    Daniel T. Meier, Ling-Hsien Tu, Sakeneh Zraika, Meghan F. Hogan, Andrew T. Templin, Rebecca L. Hull, Daniel P. Raleigh, and Steven E. Kahn* (2015, Dec). Matrix Metalloproteinase-9 Protects Islets from Amyloid induced Toxicity. Journal of Biological Chemistry, 290(51), 30475–30485. co-first author

7.      Lydia M. Young, Rachel A. Mahood, Janet C. Saunders, Ling-Hsien Tu, Daniel P. Raleigh, Sheena E. Radford* and Alison E. Ashcroft* (2015, Oct). Insights into the consequences of co-polymerisation in the early stages of IAPP and Aβ peptide assembly from mass spectrometry. Analyst, 140, 6990–6999. 
 

8.    Ling-Hsien Tu, Lydia M. Young, Amy G. Wong, Alison E. Ashcroft, Sheena E. Radford, and Daniel P. Raleigh* (2015, Jan). Mutational Analysis of the Ability of Resveratrol To Inhibit Amyloid Formation by Islet Amyloid Polypeptide: Critical Evaluation of the Importance of Aromatic−Inhibitor and Histidine−Inhibitor Interactions. Biochemistry, 54, 666-676. 
 

9.      Lydia M. Young, Janet C. Saunders, Rachel A. Mahood, Charlotte H. Revill1,Richard J. Foster, Ling-Hsien Tu, Daniel P. Raleigh, Sheena E. Radford* and Alison E. Ashcroft* (2015, Jan). Screening and classifying small-molecule inhibitors of amyloid formation using ion mobility spectrometry–mass spectrometry. Nature Chemistry, 7, 73-81. 

10.  Ling-Hsien Tu, Harris Noor, Ping Cao, and Daniel P. Raleigh* (2014, May). Aspirin, Diabetes, and Amyloid: Re-examination of the Inhibition of Amyloid Formation by Aspirin and Ketoprofen. ACS Chemical Biology, 9, 1632-1637.
 

11.  Ling-Hsien Tu, Arnaldo L. Serrano, Martin T. Zanni, and Daniel P. Raleigh* (2014, Apr). Mutational Analysis of Preamyloid Intermediates: The Role of His-Tyr Interactions in Islet Amyloid Formation. Biophysical Journal , 106, 1520-1527.  
 

12.  Ping Cao, Andisheh Abedini, Hui Wang, Ling-Hsien Tu, Xiaoxue Zhang, Ann Marie Schmidt,and Daniel P. Raleigh* (2013, Nov). Islet amyloid polypeptide toxicity and membrane interactions. Proceedings of the National Academy of Sciences, 110(48), 19279–19284. 
 

13.  Ping Cao, Peter Marek, Harris Noor, Vadim Patsalo, Ling-Hsien Tu, Hui Wang, Andisheh Abedini,Daniel P. Raleigh* (2013, Apr). Islet amyloid: From fundamental biophysics to mechanisms of cytotoxicity. FEBS Letter, 587, 1106–1118. 
 

14.  Ling-Hsien Tu and Daniel P. Raleigh* (2013, Jan). Role of Aromatic Interactions in Amyloid Formation by Islet Amyloid Polypeptide. Biochemistry, 52, 333-342. 
 

15.  Ping Cao, Ling-Hsien Tu, Andisheh Abedini, Olesya Levsh, Rehana Akter, Vadim Patsalo, Ann Marie Schmidt and Daniel P. Raleigh* (2012, Aug). Sensitivity of Amyloid Formation by Human Islet Amyloid Polypeptide to Mutations at Residue 20. Journal of Molecular Biology, 421, 282–295. 
 

16.  Ming-Chang P. Yeh,* Wei-Jou Yeh, Ling-Hsien Tu and Jia-Ru Wu (2006, Jun). CeCl3.7H2O–NaI catalyzed intramolecular addition reactions of 7-hydroxy-1,3-dienes: a facile approach to hexahydrobenzofurans and tetrahydrofurans. Tetrahedron, 62, 7466–7470. 
 

17.  Ming-Chang P. Yeh,* Wen-Cheng Tsao, and Ling-Hsien Tu (2005, Oct). Palladium-Catalyzed Reaction of Aryl Bromides with 7-Hydroxy-1,3-Dienes. Organometallics, 24, 5909-5915. 
 

18.  Ming-Chang P. Yeh,* Wen-Cheng Tsao, Jin-Shen Ho, Chih-Chuan Tai,Dai-Yu Chiou, and Ling-Hsien Tu (2004, Jan). Rhodium(I)-Catalyzed Intramolecular Cyclohexadienyl Pauson-Khand Reaction: Facile Approach to Tricarbocycles. Organometallics, 23, 792-799. 

 

Ling-Hsien Tu
Journal Articles Ling-Hsien Tu
Journal ArticlesLee, S.-Y.; Chiu, Y.-J.; Yang, S.-M.; Chen, C.-M.; Huang, C.-C.; Lee-Chen, G.-J.*; Lin, W.*; Chang, K.-H.* "Novel Synthetic Chalcone–coumarin Hybrid for Aβ Aggregation Reduction, Antioxidation, and Neuroprotection" CNS Neurosci. Ther. 2018accepted.Wenwei Lin
Journal Articles
Sung-Fang Chen
Journal Articles
Sung-Fang Chen
Journal Articles
Sung-Fang Chen
Journal Articles
Sung-Fang Chen
Journal Articles
Sung-Fang Chen
Journal Articles
Sung-Fang Chen
Journal Articles
Sung-Fang Chen
Journal Articles
Sung-Fang Chen
Journal Articles
Sung-Fang Chen
Journal Articles
Sung-Fang Chen
Journal Articles
Sung-Fang Chen
Journal Articles
Sung-Fang Chen
Journal Articles
Sung-Fang Chen
Journal Articles
Sung-Fang Chen
Journal Articles
Sung-Fang Chen
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