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系所成員

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˹ʹϤ
姓名 孫英傑
Office_Hour  
實驗室電話 (02)77346216
辦公室電話 (02)77346215
傳真 (02)29324249
聯絡地址 (11677)台北市文山區汀州路四段88號
E-mail sun@ntnu.edu.tw
實驗室網頁 http://web.ntnu.edu.tw/%7Esun/
類別 專任師資
職稱 教授
研究領域 生物物理化學、藥物設計
學術專長 癌症藥物、神經退化性疾病藥物研發。
電腦輔助藥物設計:蛋白質模擬、分子動力學模擬、Docking、系統生物學方法、QSAR方法。
藥物研究實驗:激酶抑制劑抑制效果測量。


指導學生 施惠真;許文綺;許嘉仁;劉安倫
實驗室 計算模擬、實驗研究室 - 生物物理化學、藥物設計 /

學術著作

  1. 期刊論文
    1. Chia-Jen Hsu, Wen-Chi Hsu, Der-Jay Lee,An-Lun Liu, Chia-Ming Chang, Huei-Jhen Shih, Wun-Han Huang, Guey-Jen Lee-Chen,Hsiu Mei Hsieh-Li, Guan-Chiun Lee, and Ying-Chieh Sun "Investigation of the Bindings of a Class of Inhibitors with GSK3b Kinase Using Thermodynamic Integration MD Simulation and Kinase Assay" Chem. Biol. Drug Des. 90, 272-281 (2017). 參考連結參考連結
    2. Hei-Jen Huang, Shu‐Ling Chen, Hsin-Yu Huang, Ying-Chieh Sun, Guan-Chiun Lee, Guey-Jen Lee-Chen, Hsiu Mei Hsieh-Li*, Ming-Tsan Su* “AM404, a newly identified GSK3β-inhibitor analog, ameliorates the cognitive impairment and pathological features of fly and mouse models of Alzheimer's disease” (submitted)
    3. Chih-Hsin Lin, Yu-Shao Hsieh, Yih-Ru Wu, Chia-Jen Hsu, Hsuan-Chiang Chen, Hsiu Mei Hsieh-Li, Ming-Tsan Su, Ying-Chieh Sun*, Guan-Chiun Lee*, Guey-Jen Lee-Chen*, "Identifying GSK-3<beta> kinase inhibitors of Alzheimer's disease: Virtual screening, enzyme, and cell assays", Eur. J. Pharm. Sci., 89, 11-19  (2016) 參考連結參考連結
    4. Ying-Chieh Sun, Wen-Chi Hsu, Chia-Jen Hsu, Chia-Ming Chang, Kai-Hsiang Cheng, "Investigation of differences in the Binding Affinity Differences in Ligands with un-Tagged and Tagged p38 Kinase Using Thermodynamic Integration MD Simulation" J. Mol. Model., 21, 283 (2015).
      參考連結參考連結
    5. Hsing-Chou Lee, Wen-Chi Hsu, An-Lun Liu, Chia-Jen Hsu, Ying-Chieh Sun, “Using Thermodynamic Integration MD Simulation to Compute Relative Protein-Ligand Binding Free Energy of a GSK3ß Kinase Inhibitor and its Analogs”, J. Mol. Graphics & Model. 51, 37-49 (2014). 參考連結參考連結
    6. Kuan-Wei Wu, Po-Chin Chen, Jun Wang, Ying-Chieh Sun, "Computation of Relative Binding Free Energy for an Inhibitor and its Analogs Binding with Erk Kinase Using Thermodynamic Integration MD Simulation", J. Comput. Aided Mol. Des. 26, 1159-1169 (2012). DOI 10.1007/s10822-012-9606-6
    7. Xu-Nan Tang, Cheng-Wei Lo, Yu-Chung Chuang, Chao-Tung Chen, Ying-Chieh Sun, Yi-Ren Hong, and Chia-Ning Yang, Prediction of the binding mode between GSK3b and a peptide derived from GSKIP using molecular dynamics simulation”, Biopolymers, (2011).
    8. Jia-Yang Chen, Sin-Ming Huang, Yen-An Tang, Hsueh-Fen Juan, Li-Wha Wu, Ying-Chieh Sun, Szu-Chi Wang, Kuan-Wei Wu, Gopula Balraj, Tzu-Tin Chang, Wen-Shan Li, Hung-Chi Cheng, and Yi-Ching Wang, "A novel sialyltransferase inhibitor suppresses FAK/paxillin and angiogenesis signaling and cancer metastasis”, Cancer Research, 71, 473-483 (2011).
    9. Cheng-Chang Hsu, Shih-Hong Wang, Hsing-Pang Hsieh, and Ying-Chieh Sun “Comparative Molecular Field Analysis of Anti-tubulin Agents with Indole Ring Binding at the Colchicine Binding Site”, J. Theore. Comput. Chem. 9, 279-291 (2010)
      參考連結參考連結
    10. Shu-Ping Lin, Kun-Chang Tseng, Ming-Chou Lin, Chii-Dong Chen, Chia-Chang Tsai, Shu-Han Yu, Ying-Chieh Sun, Tsung-Wu Lin, Chien-Yuan Pan, and Yit-Tsong Chen, “A Reversible Surface Functionalized Nanowire Transistor to Study Protein-Protein Interactions" Nano Today, 4, 235-243 (2009).
    11. Wen-Hung Wang, Yi-Ching Wang, and Ying-Chieh Sun, ‘A 3D-QSAR study of Celebrex-based PDK1 Inhibitors Using CoMFA Method’ J. Chin. Chem. Soc. 56, 59-64 (2009).
    12. Yi-Hung Tan, Kung-Hsueh Lee, Topp Lin , Ying-Chieh Sun , Hsueh-Fen Juan, Yi-Ching Wang , Cytotoxicity and Proteomics Analyses of OSU03013 in Lung Cancer'', Clinical Cancer Research, 14, 1823-1830 (2008).
    13. C.C. Chen, Chung-Cheng Wei , Ying-chieh Sun and Chi-Ming Chen , ''Packing of Transmembrane Helices in Bacteriorhodopsin Folding: Structure and Thermodynamics’, Journal of Structural Biology, 162, 237-247 (2008).
    14. Wei-Zhou Wang, Topp Lin , and Ying-Chieh Sun ,‘Examination of the Folding of a Short Alanine-Based Helical Peptide with Salt Bridges Using Molecular Dynamics Simulation’ J. Phys. Chem. B, 111, 3508-3514, (2007).
    15. Jeng-Han Wang, M. C. Lin, Ying-Chieh Sun,‘Reactions of Hydrazoic Acid on TiO2 Nanoparticles: An Experimental and Computational Study’ J. Phys. Chem. B, 109, 5133-5142 (2005).
    16. Chung-Cheng Wei, Ming-Hsun Ho, Wen-Hung Wang, and Ying-Chieh Sun ‘Molecular Dynamics Simulation of Folding of a Short Helical Peptide with Many Charged Residues’, J. Phys. Chem. B, 109, 19980-19986, (2005). SCI.
    17. Ying-Chieh Sun, I-Ting Wang, Thanh Lam Nguyen, Hsiu-Feng Lu, Xueming Yang, and Alexander M. Mebel‘A Combined Quantum Chemistry and RRKM Calculation Predicts the O(1D) + C2H6 Reaction Can Produce Water Molecule in Collision-free Crossed Molecular Beam Environment’ J. Phys. Chem. A 107, 6986-6994 (2003). SCI.
    18. Chai Ling Fan, Wei-Der Lee, Nai-Wei Teng, Ying-Chieh Sun and Kwunmin Chen,‘Asymmetric Epoxidation of Camphor N-Enoylpyrazolidinones with Methyl(trifluoromethyl)dioxirane and Urea Hydrogen Peroxide Complex: Reversal of Stereoselectivity’ J. Org. Chem. 68, 9816, (2003). SCI.
    19. Ming-Hsun Ho and Ying-Chieh Sun, ‘Molecular Dynamics Simulation of Hydrogen-covered Si(100):H-2x1 surface: Calculation of Vibrational Energy Relaxation Rates of Hydrogen Stretching Modes’ Surf. Sci., 516, L540-L546 (2002). SCI.
    20. Man-kit Leung, Ashis B. Mandal, Chih-Chieh Wang, Gene-Hsiang Lee, Shie-Ming Peng, Hsing-Ling Cheng, Guor-Rong Her, Ito Chao, Hsiu-feng Lu, Ying-Chieh Sun, Mei-Ying Shiao, and Pi-Tai Chou,‘Self-complementarity of oligo-aminopyridines: a new class of hydrogen-bonded ladders’ J. Am. Chem. Soc., 124, 4287 (2002) . SCI.
    21. Hsiu-Feng Lu and Ying-Chieh Sun, ‘Calculated Energies of Adsorption of Non-hydrocarbon Species on Diamond H/C(111) Surface and the Abstraction Energies of these Species Abstracted by Hydrogen Atoms Using ab initio Calculation’Diamond and Related Materials, 11, 1560 (2002) . SCI.
    22. Hsiu-Feng Lu and Ying-Chieh Sun, ‘Calculation of Hydrogen Abstraction Reaction on Hydrogen-covered H/C(111) Diamond Surface Abstracted by Non-Hydrocarbon Species’ Surf. Sci. 494 L787-L792 (2001). SCI.
    23. Ying-Chieh Sun, Hsiu-Feng Lu, and Ming-Shun Ho, 2000,`Molecular dynamics simulation of hydrogen isotope-terminated silicon (111) and (110) surfaces: calculation of vibrational energy relaxation rates of hydrogen isotope stretching modes’Chem. Phys. Lett. , 318, 7-14. SCI.
    24. Ying-Chieh Sun, Shu-Fen Yang, I-Lun Hwang,and Tzu-Hsien Wu, 1999 `A 500 ps Molecular dynamics simulation trajectory of cardiotoxin II from Taiwan cobra venom in solution: correlation with NMR and X-ray crystallography data‘ J. Comput. Chem. , 20, 546-562. SCI.
    25. Hsiu-Feng Lu, Ming-Shun Ho, Sho-Ching Hong, Ai-Hsin Liu, Pei-Fang Wu, and Ying-Chieh Sun, 1998,‘Determination of vibrational energy relaxation rates of C-H,D,T stretching modes on hydrogen, deuterium, and tritium-terminated H,D,T/C(111) and H,D,T/C(110) surfaces using molecular dynamics simulation: thermal effect’ J. Chem. Phys., 109,6898-6904. SCI.
    26. Ying-Chieh Sun and Jiunn-Ming Chen,1997,‘ Calculations of vibrational energy relaxation rates of C-H,D,T stretching modes on hydrogen, deuterium, and tritium-terminated H,D,T/C(111)lxl surface’ J. Phys. Chem., 101, 7082-7086. SCI.
  2. 專利
    1. 喹啉衍生化合物用於製備Tau蛋白病變類疾病之醫藥組成物上之用途 (台灣專利/Taiwan patent  2017)
    2. Method For Treating Tau-Associated Diseases (美國專利/US patent 2017)
經歷一覽
服務機關 職稱 部門/系所 擔任職務 起迄年月
國立臺灣師範大學教授化學系 2000年 ~
國立臺灣師範大學副教授化學系 1996年 ~ 2000年
美國加州大學舊金山分校博士後研究員藥理化學系研究員1994年 ~ 1996年
學歷一覽
學校名稱 國別 系所 學位 起迄年月
賓夕法尼亞大學美國化學研究所博士1989年09月 ~ 1994年06月
國立臺灣大學臺灣化學系理學士1983年09月 ~ 1987年06月
註:底下資料可能僅顯示網頁所有人一個人的名字。
  1. 期刊論文
  2. 學術研究計畫
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