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個人詳細資料

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˹ʹϤ
姓名 杜玲嫻
Office_Hour  
實驗室電話 02-7734-6178
辦公室電話 02-7734-6157
傳真 02-2932-4249
聯絡地址 台北市文山區汀州路4段88號師大化學系
E-mail litu@ntnu.edu.tw
實驗室網頁  
類別 專任師資
職稱 助理教授
研究領域 有機化學,生物化學, 蛋白質錯誤摺疊與疾病研究
學術專長  
指導學生 碩二: 吳孟鑫 碩一: 陳昱傑 沈采玲 詹璦琪 謝宜靜
實驗室  

學術著作

  1. 期刊論文
    1.  Hsu, Y. H.; Chen, Y. W.; Wu, M. H.; Tu, L. H., Protein Glycation by Glyoxal Promotes Amyloid Formation by Islet Amyloid Polypeptide. Biophys J 2019, 116 (12), 2304-2313.
       
    2.   

      1.    Ling-Hsien Tu, Ning-Hsuan Tseng, Ya-Ru Tsai, Tien-Wei Lin, Yi-Wei Lo, Jien-Lin Charng, Hua-Ting Hsu, Yu-Sheng Chen, Rong-Jie Chen, Ying-Ta Wu, Yi-Tsu Chan, Chang-Shi Chen, Jim-Min Fang,* and Yun-Ru Chen* (2018, Oct). Rationally designed divalent caffeic amides inhibit amyloid-β fibrillization, induce fibril dissociation, and ameliorate cytotoxicity. European Journal of Medicinal Chemistry, 158, 393-404

       

      2.    Arnaldo Serrano, Justin Lomont, Ling-Hsien Tu, Daniel Raleigh,and Martin Zanni* (2017, Oct). A free energy barrier caused by the refolding of an oligomeric intermediate controls the lag time of amyloid formation by hIAPP. Journal of the American Chemical Society, 139(46), pp 16748–16758. 
       

      3.    Lydia M. Young, Ling-Hsien Tu, Daniel P. Raleigh, Alison E. Ashcroft and Sheena E. Radford* (2017, May). Understanding co-polymerization in amyloid formation by direct observation of mixed oligomers. Chemical Science, 8(7), 5030-5040.
       

      4.    Andisheh Abedini*, Annette Plesner, Ping Cao, Zachary Ridgway,Jinghua Zhang, Ling-Hsien Tu, Chris T Middleton, Brian Chao,Daniel J Sartori, Fanling Meng, Hui Wang, Amy G Wong, Martin T Zanni,C Bruce Verchere, Daniel P Raleigh*, Ann Marie Schmidt* (2016, May). Time-resolved studies define the nature of toxic IAPP intermediates, providing nsight for anti-amyloidosis therapeutics. eLIFE, 5:e12977. 
       

      5.    Rehana Akter, Ping Cao, Harris Noor, Zachary Ridgway, Ling-Hsien Tu, HuiWang, Amy G.Wong, Xiaoxue Zhang, Andisheh Abedini, AnnMarie Schmidt, and Daniel P. Raleigh* (2016). Islet Amyloid Polypeptide: Structure, Function, and Pathophysiology. Journal of Diabetes Research, Article ID 2798269. 
       

      6.    Daniel T. Meier, Ling-Hsien Tu, Sakeneh Zraika, Meghan F. Hogan, Andrew T. Templin, Rebecca L. Hull, Daniel P. Raleigh, and Steven E. Kahn* (2015, Dec). Matrix Metalloproteinase-9 Protects Islets from Amyloid induced Toxicity. Journal of Biological Chemistry, 290(51), 30475–30485. co-first author

      7.      Lydia M. Young, Rachel A. Mahood, Janet C. Saunders, Ling-Hsien Tu, Daniel P. Raleigh, Sheena E. Radford* and Alison E. Ashcroft* (2015, Oct). Insights into the consequences of co-polymerisation in the early stages of IAPP and Aβ peptide assembly from mass spectrometry. Analyst, 140, 6990–6999. 
       

      8.    Ling-Hsien Tu, Lydia M. Young, Amy G. Wong, Alison E. Ashcroft, Sheena E. Radford, and Daniel P. Raleigh* (2015, Jan). Mutational Analysis of the Ability of Resveratrol To Inhibit Amyloid Formation by Islet Amyloid Polypeptide: Critical Evaluation of the Importance of Aromatic−Inhibitor and Histidine−Inhibitor Interactions. Biochemistry, 54, 666-676. 
       

      9.    Lydia M. Young, Janet C. Saunders, Rachel A. Mahood, Charlotte H. Revill1,Richard J. Foster, Ling-Hsien Tu, Daniel P. Raleigh, Sheena E. Radford* and Alison E. Ashcroft* (2015, Jan). Screening and classifying small-molecule inhibitors of amyloid formation using ion mobility spectrometry–mass spectrometry. Nature Chemistry, 7, 73-81. 

      10.  Ling-Hsien Tu, Harris Noor, Ping Cao, and Daniel P. Raleigh* (2014, May). Aspirin, Diabetes, and Amyloid: Re-examination of the Inhibition of Amyloid Formation by Aspirin and Ketoprofen. ACS Chemical Biology, 9, 1632-1637.
       

      11.  Ling-Hsien Tu, Arnaldo L. Serrano, Martin T. Zanni, and Daniel P. Raleigh* (2014, Apr). Mutational Analysis of Preamyloid Intermediates: The Role of His-Tyr Interactions in Islet Amyloid Formation. Biophysical Journal , 106, 1520-1527.  
       

      12.  Ping Cao, Andisheh Abedini, Hui Wang, Ling-Hsien Tu, Xiaoxue Zhang, Ann Marie Schmidt,and Daniel P. Raleigh* (2013, Nov). Islet amyloid polypeptide toxicity and membrane interactions. Proceedings of the National Academy of Sciences, 110(48), 19279–19284. 
       

      13.  Ping Cao, Peter Marek, Harris Noor, Vadim Patsalo, Ling-Hsien Tu, Hui Wang, Andisheh Abedini,Daniel P. Raleigh* (2013, Apr). Islet amyloid: From fundamental biophysics to mechanisms of cytotoxicity. FEBS Letter, 587, 1106–1118. 
       

      14.  Ling-Hsien Tu and Daniel P. Raleigh* (2013, Jan). Role of Aromatic Interactions in Amyloid Formation by Islet Amyloid Polypeptide. Biochemistry, 52, 333-342. 
       

      15.  Ping Cao, Ling-Hsien Tu, Andisheh Abedini, Olesya Levsh, Rehana Akter, Vadim Patsalo, Ann Marie Schmidt and Daniel P. Raleigh* (2012, Aug). Sensitivity of Amyloid Formation by Human Islet Amyloid Polypeptide to Mutations at Residue 20. Journal of Molecular Biology, 421, 282–295. 
       

      16.  Ming-Chang P. Yeh,* Wei-Jou Yeh, Ling-Hsien Tu and Jia-Ru Wu (2006, Jun). CeCl3.7H2O–NaI catalyzed intramolecular addition reactions of 7-hydroxy-1,3-dienes: a facile approach to hexahydrobenzofurans and tetrahydrofurans. Tetrahedron, 62, 7466–7470. 
       

      17.  Ming-Chang P. Yeh,* Wen-Cheng Tsao, and Ling-Hsien Tu (2005, Oct). Palladium-Catalyzed Reaction of Aryl Bromides with 7-Hydroxy-1,3-Dienes. Organometallics, 24, 5909-5915. 
       

      18.  Ming-Chang P. Yeh,* Wen-Cheng Tsao, Jin-Shen Ho, Chih-Chuan Tai,Dai-Yu Chiou, and Ling-Hsien Tu (2004, Jan). Rhodium(I)-Catalyzed Intramolecular Cyclohexadienyl Pauson-Khand Reaction: Facile Approach to Tricarbocycles. Organometallics, 23, 792-799. 

       

經歷一覽
服務機關 職稱 部門/系所 擔任職務 起迄年月
國立台灣師範大學助理教授化學系 2016年08月 ~
中央研究院博士後研究學者基因體中心 2014年09月 ~ 2016年07月
學歷一覽
學校名稱 國別 系所 學位 起迄年月
紐約州立大學石溪分校美國化學所博士2008年08月 ~ 2014年08月
國立台灣師範大學台灣化學系碩士2003年09月 ~ 2005年07月
國立台灣師範大學台灣化學系學士1999年09月 ~ 2003年06月
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  1. 期刊論文
  2. 研討會論文
  3. 學術研究計畫
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