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個人詳細資料

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˹ʹϤ
姓名 張煥正
Office_Hour  
實驗室電話 +886-2-2366-8226, +886-2-2366-8249
辦公室電話 +886-2-2366-8260
傳真  
聯絡地址 10617 台北市羅斯福路四段一號 或 台北郵政 23-166號信箱
E-mail hchang@ntnu.edu.tw
實驗室網頁 http://www.iams.sinica.edu.tw/tw/?link=member&id=24
個人著作參考網址 請點我
個人研究計畫參考網址 請點我
類別 合聘教師
職稱 教授
研究領域 生物物理化學、生物質譜學,著重於新型質譜技術的開發與應用、奈米光子學,著重於高亮度螢光奈米鑽石的開發及其在生物成像方面的應用、奈米生物技術,著重於開發奈米鑽石成為生物分子萃取、濃縮、檢測、與結晶的基質
學術專長  
指導學生  
實驗室  

學術著作

  1. 期刊論文
    1.  
      1. W. W.-W. Hsiao, Y. Y. Hui, P.-C. Tsai, and H.-C. Chang*, “Fluorescent nanodiamond: A versatile tool for long-term cell tracking, super-resolution imaging, and nanoscale temperature sensing,” Acc. Chem. Res. 49, 400–407 (2016).
      2. Y.-K. Tzeng, P.-C. Tsai, H.-Y. Liu, O. Y. Chen, H. Hsu, F.-G. Yee, M.-S. Chang*, and H.-C. Chang*, “Time-resolved luminescence nanothermometry with nitrogen-vacancy centers in nanodiamonds,” Nano Lett. 15, 3945–3952 (2015).
      3. T.-J. Wu, Y.-K. Tzeng, W.-W. Chang, C.-A. Cheng, Y. Kuo, C.-H. Chien, H.-C. Chang*, and J. Yu*, “Tracking the engraftment and regenerative capabilities of transplanted lung stem cells using fluorescent nanodiamonds,” Nature Nanotech.8, 682–689 (2013).
      4. V. Vaijayanthimala, P.-Y. Cheng, S.-H. Yeh, K.-K. Liu, C.-H. Hsiao*, J.-I. Chao*, and H.-C. Chang*, “The long-term stability and biocompatibility of fluorescent nanodiamond as an in vivo contrast agent,” Biomaterials 33, 7794–7802 (2012). 
      5. Y.-K. Tzeng, O. Faklaris, B.-M. Chang, Y. Kuo, J.-H. Hsu, and H.-C. Chang*, “Superresolution imaging of albumin-conjugated fluorescent nanodiamonds in cells by stimulated emission depletion,” Angew. Chem. Int. Ed. 50, 2262–2265 (2011).
      6. N. Mohan, C.-S. Chen, H.-H. Hsieh, Y.-C. Wu*, and H.-C. Chang*, “In vivo imaging and toxicity assessments of fluorescent nanodiamonds in Caenorhabditis elegans,” Nano Lett. 10, 3692–3699 (2010).
      7. H.-C. Chang*, “Ultrahigh-mass mass spectrometry of single biomolecules and bioparticles,” Annu. Rev. Anal. Chem. 2, 169–185 (2009).
      8. Y.-R. Chang, H.-Y. Lee, K. Chen, C.-C. Chang, D.-S. Tsai, C.-C. Fu, T.-S. Lim, Y.-K. Tzeng, C.-Y. Fang, C.-C. Han, H.-C. Chang*, and W. Fann*, “Mass production and dynamic imaging of fluorescent nanodiamonds,” Nature Nanotech. 3, 284–288 (2008).
      9. C.-C. Fu, H.-Y. Lee, K. Chen, T.-S. Lim, H.-Y. Wu, P.-K. Lin, P.-K. Wei, P.-H. Tsao, H.-C. Chang*, and W. Fann*, “Characterization and application of single fluorescent nanodiamonds as cellular biomarkers,” Proc. Natl. Acad. Sci. USA104, 727–732 (2007).
      10. Z. X. Nie, Y.-K. Tzeng, H.-C. Chang*, C.-C. Chiu, C.-Y. Chang, C.-M. Chang, and M.-H. Tao, “Microscopy-based mass measurement of a single whole virus in a cylindrical ion trap,” Angew. Chem. Int. Ed. 45, 8131–8134 (2006).
      11. S.-J. Yu, M.-W. Kang, H.-C. Chang*, K.-M. Chen, and Y.-C. Yu, “Bright fluorescent nanodiamonds: No photobleaching and low cytotoxicity,” J. Am. Chem. Soc. 127, 17604–17605 (2005).
      12. X. L. Kong, L. C. L. Huang, C.-M. Hsu, W.-H. Chen, C.-C. Han, and H.-C. Chang*, “High-affinity capture of proteins by diamond nanoparticles for mass spectrometric analysis,” Anal. Chem. 77, 259–265 (2005).
      13. H.-C. Chang*, C.-C. Wu, and J.-L. Kuo*, “Recent advances in understanding the structures of medium-sized protonated water clusters,” Int. Rev. Phys. Chem. 24, 553–578 (2005).
      14. L. C. L. Huang and H.-C. Chang*, “Adsorption and immobilization of cytochrome on nanodiamonds,” Langmuir 20, 5879–5884 (2004).
      15. J. C. Jiang, H.-C. Chang, Y.-S. Wang, S. H. Lin, Y. T. Lee, G. Niedner-Schatteburg, and H.-C. Chang*, “Infrared spectra of H+(H2O)5-8 clusters: Evidence for symmetric proton hydration,” J. Am. Chem. Soc. 122, 1398–1410 (2000).
      16. C.-L. Cheng, H.-C. Chang*, J.-C. Lin*, K.-J. Song, and J.-K. Wang, “Direct observation of hydrogen etching anisotropy on diamond single crystal surfaces,” Phys. Rev. Lett. 78, 3712−3716 (1997).
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