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個人詳細資料

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˹ʹϤ
姓名 陳焜銘
Office_Hour  
實驗室電話 (02)77346150
辦公室電話 (02)77346124
傳真 (02) 2932-4249
聯絡地址 (11677)台北市文山區汀州路4段88號
E-mail kchen@ntnu.edu.tw
實驗室網頁  
類別 專任師資
職稱 教授兼理學院院長
研究領域 有機不對稱合成
學術專長 1.設計合成以樟腦架構為主之對掌輔助劑/對掌螯
合劑並探討其在有機不對稱合成上的應用。
2.新藥物分子設計合成。
3.結構新穎之有機催化劑設計合成及應用探討。
指導學生 陳蓉萱,馬達南,管軒浩,張惠茹,李佩勳,何青胤,葉倫輔,陳致皓,劉積瑞,黃琬澐,柯羿均,呂依旻,陳奕杰,陳彥銘
實驗室 對掌催化合成研究室 /

學術著作

  1. 期刊論文
    1. 2013
      Hsuan-Hao Kuan, Chung-Han Chien,and Kwunmin Chen* “Synthesis of Fully Substituted Dispirocyclohexanes by Organocatalytic [2+2+2] Annulation Strategy Between 2-Arylideneindane-1,3-diones and Aldehydes” Org. Lett. 2013, 15, 2880-2883.
    2. Dhananjay R. Magar, Yi-Jiun Ke and Kwunmin Chen* ”Three Component Synthesis  of Functionalized N-Protected Tetrasubstituted Pyrroles via Addition-Elimination-Aromatization Process” Asia J. Org. Chem. 2013,  2, 330-335. (inside cover)
    3. Shaik Anwar, Wan-Yun Huang,Chih-Hao Chen, You-Song Cheng and Kwunmin   Chen* ”An Efficient Friedel-Crafts/Oxa-Michael/Aromatic Annulation: Rapid Access    to Substituted Naphtho[2,1-b]-, [1,2-b]furan and Benzofuran Derivatives” Chem. Eur. J. 2013, 19, 4344-4351.
    4.  Yan ming Chen, Pei-Hsun Lin, Jun Lin, and Kwunmin Chen* “Desymmetrization and switching of stereoselectivity in direct organocatalytic Michael addition of ketones to 1,1-bis(phenylsulfonyl)ethylene ”Eur. J. Org. Chem. 2013 , 2699-92707.


       
    5. 2012
      Lun Fu Yeh,Shaik Anwar and Kwunmin Chen* “ The Combination of Domino Process and Kinetic Resolution: Organocatalytic Synthesis of Functionalised Cyclopentenes by Sequential SN2'-Michael Reaction“ Tetrahedron 2012, 68, 7317-7321. (13/57; IF: 3.219)
    6. Raju Jannapu Reddy, Pei-Hsun Lee, Dhananjay R. Magar, Jung-Hsuan Chen and Kwunmin Chen*Kinetic resolution of activated nitroallylic acetates with aldehydes and ketones via conjugate addition-elimination SN2’ process” Eur. J. Org. Chem. 2012, 353-363. (15/57; IF:3.016)
    7. Wan-Yun Huang, Yi-Chieh Chen and Kwunmin Chen* “Efficient synthesis of tetrasubstituted furans from nitroallylic acetates and 1,3-dicarbonyl/a-activating ketones by Feist-Bénary addition-elimination” Chem. Asian J. 2012, 7, 688-691. (19/140; IF:4.287)
    8. Suparna Roy and Kwunmin Chen* “Three-Component Organocascade Kinetic Resolution of Racemic Nitroallylic Acetates via Sequentia l Iminium/Enamine Asymmetric Catalysis” Org. Lett. 2012, 14, 2496-2499. (5/57 IF:5.420)


       
    9. 2011
      Jung-Hsuan Chen, Chihliang Chang, Hui-Ju Chang and Kwunmin Chen* “Efficient Synthesis of 2,3,5,6-Tetrahydro-1-Alkyl/Aryl-1H-Benzo[f]Chromen-3-Ol Derivatives from b-Tetralones and a,b-Unsaturated Aldehydes“Organic & Biomolecular Chemistry 2011, 9, 7510-7516. (12/56; IF: 3.451)
    10. Shaik Anwar, Pei-Hsun Lee, Tsai-Yung Chou, Chihliang Chang, and Kwunmin Chen* Pyrrolidine-linker-camphor assembly: bifunctional organocatalysts for efficient Michael addition of cyclohexanone to nitroolefins under neat conditions” Tetrahedron 2011, 67, 1171-1177. (13/57; IF: 3.219)
    11. Raju Jannapu Reddy and Kwunmin Chen* “Highly Efficient Organocatalytic Kinetic Resolution of Activated Nitroallylic Acetates with Aldehydes via Conjugate Addition-Elimination” Org. Lett. 2011, 13, 1458-1461. (4/57; IF: 5.420)
    12. Shaik Anwar, Hui-Ju Chang and Kwunmin Chen* “Organocatalytic Synthesis of Multiple Substituted Bicyclo[4.4.0]Decalin System” Org. Lett. 2011, 13, 2200-2203. (4/57; IF: 5.420)
    13. Shaik Anwar, Hui-Ju Chang, and Kwunmin Chen*, "Organocatalytic Synthesis of Multiple Substituted Bicyclo[4.4.0]Decalin System" Org. Lett. 2011, ASAP. 附件檔案附件檔案 Adobe PDF
    14. Raju Jannapu Reddy and Kwunmin Chen " Highly Efficient Organocatalytic Kinetic Resolution of Activated Nitroallylic Acetates with Aldehydes via Conjugate Addition-Elimination" Org. Lett. 2011, 13, 1458-1461. 附件檔案附件檔案 Adobe PDF
    15. Shaik Anwar, Pei-Hsun Lee, Tsai-Yung Chou, Chihliang Chang, Kwunmin Chen " Pyrrolidine-linker-camphor assembly: bifunctional organocatalysts for efficient Michael addition of cyclohexanone to nitroolefins under neat conditions" Tetrahedron 2011, 67, 1171-1177. 附件檔案附件檔案 Adobe PDF
    16. 2010
      Hsuan-Hao Kuan, Raju Jannapu Reddy, Kwunmin Chen " An efficient MoritaeBayliseHillman reaction for the synthesis of multifunctional 2-hydroxy-3-nitrobut-3-enoate derivatives" Tetrahedron 2010, 66, 9875-9879. 附件檔案附件檔案 Adobe PDF
    17. Jung-Hsuan Chen, Shuan-Ru Liu, and Kwunmin Chen* “An Efficient and Convenient Synthesis of Ethyl 1-(4-methoxyphenyl)-5-Phenyl-1H-1,2,3-Triazole-4-Carboxylates” Chem. Asian J. 2010, 5, 328-333. (19/140; IF:4.197).
    18. Hsuan-Hao Kuan,Raju Jannapu Reddy and Kwunmin Chen* “An efficient Morita-Baylis-Hillman reaction for the synthesis of multifunctional 2-hydroxy-3-nitro-but-3-enoate derivatives” Tetrahedron 2010, 66, 9875-9879 (13/57; IF: 3.219)
    19. Ying-Fang Ting, Chihliang Chang, Raju Jannapu Reddy, Dhananjay R. Magar and Kwunmin Chen* “Pyrrolidine-Camphor Derivatives as a New Class of Organocatalysts for Direct Asymmetric Michael Addition of Aldehydes and Ketones to β-Nitroalkenes” Chem. Eur. J. 2010, 16, 7030-7038. (17/140; IF: 5.454)
    20. Pang-Min Liu, Dhananjay R. Magar, and Kwunmin Chen " Highly Efficient and Practical Pyrrolidine–Camphor-Derived Organocatalysts for the Direct α-Amination of Aldehydes" Eur. J. Org. Chem. 2010, 5705-5713. 附件檔案附件檔案 Adobe PDF
    21. Ying-Fang Ting, Chihliang Chang, Raju Jannapu Reddy, Dhananjay R. Magar, and Kwunmin Chen* " Pyrrolidinyl–Camphor Derivatives as a New Class of Organocatalyst for Direct Asymmetric Michael Addition of Aldehydes and Ketones to beta-Nitroalkenes" Chem. Eur. J. 2010, 16, 7030-7038. 附件檔案附件檔案 Adobe PDF
    22. Dhananjay R. Magar, Chihliang Chang, Ying-Fang Ting, Kwunmin Chen "Highly Enantioselective Conjugate Addition of Ketones to Alkylidene Malonates Catalyzed by a Pyrrolidinyl-Camphor-Derived Organocatalyst " Eur. J. Org. Chem. 2010, 2062-2066. 附件檔案附件檔案 Adobe PDF
    23. Jung-Hsuan Chen, Shuan-Ru Liu, and Kwunmin Chen* “An Efficient and Convenient Synthesis of Ethyl 1-(4-methoxyphenyl)-5-Phenyl-1H-1,2,3-Triazole-4-Carboxylates” Chem. Asian J. 2010 , 5, 2, 328 附件檔案附件檔案 Adobe PDF
    24. 2009
      Raju Jannapu Reddy, Hsuan-Hao Kuan, Tsai-Yung Chou and Kwunmin Chen* “Novel Prolinamide-Camphor Containing Organocatalysts for Direct Asymmetric Michael Addition of Unmodified Aldehydes to Nitroalkenes” Chem. Eur. J. 2009, 15, 9294-9298. (17/140; IF: 5.454)
    25. Chin-Sheng Chao, Chung-Kai Cheng, Ssu-Hsien Li and  Kwunmin Chen* “Diastereoselective electrophilic a-amination of camphor  N1-acyl N2-phenylpyrazolidinones: the metal enolate-dependent synthesis of two possible hydrazide diastereomers” Tetrahedron Lett.  2009, 50, 333-336. (21/57; IF: 2.538)
    26. Chin-Sheng Chao, Chung-Kai Cheng, Ssu-Hsien Li and  Kwunmin Chen* “Diastereoselective electrophilic a-amination of camphor  N1-acyl N2-phenylpyrazolidinones: the metal enolate-dependent synthesis of two possible hydrazide diastereomers” Tetrahedron Lett.  2009, 50, 333-336. 附件檔案附件檔案 Adobe PDF
    27. Zheng-Hao Tzeng, Hung-Yao Chen, Raju Jannapu Reddy, Ching-Ting Huang and Kwunmin Chen*Highlydiastereo- and enantioselective direct aldol reactions promoted by water-compatible organocatalysts bearing a pyrrolidinyl camphor structural scaffold” Tetrahedron 2009, 65, 2879-2888. 附件檔案附件檔案 Adobe PDF
    28. Chihliang Chang, Ssu-Hsien Li, Raju Jannapu Reddy and Kwunmin Chen* “Pyrrolidine-camphor derivative as an organocatalyst for asymmetic Michael addition of a,a-disubstituted aldehydes to β-nitroalkenes: construction of quaternary carbon bearing aldehydes under solvent-free conditionsAdv. Synth. Catal. 2009, 351, 1273-1278. 附件檔案附件檔案 Adobe PDF
    29. Raju Jannapu Reddy, Hsuan-Hao Kuan, Tsai-Yung Chouand Kwunmin Chen* “Novel Prolinamide-Camphor Containing Organocatalysts for Direct Asymmetric Michael Addition of Unmodified Aldehydes to Nitroalkenes” Chem. Eur. J. 2009, 15, 9294-9298. 附件檔案附件檔案 Adobe PDF
    30. Pang-Min Liu, Chihliang Chang, Raju Jannapu Reddy, Ying-Fang Ting, Hsuan-Hao Kuan and Kwunmin Chen* “Remarkable Reaction Rate and Excellent Enantioselective Direct a-Amination of Aldehydes with Azodicarboxylates Catalyzed by Pyrrolidinyl-Camphor Derived Organocatalysts” Eur. J. Org. Chem. 2010, 42-46 附件檔案附件檔案 Adobe PDF
    31. Shy-Guey Wang, Chia-Wen Wu, Kwunmin Chen and Victor S,-Y. Lin* “Fine-Tuning Mesochannel Orientation of Organically Functionalized Mesoporous Silica Nanoparticles” Chem. Asian J. 2009, 4, 658-661.
    32. 2008
      Zheng-Hao Tzeng, Hung-Yao Chen, Ching-Ting Huang and Kwunmin Chen* “
      Camphor containing organocatalysts in asymmetric aldol reaction on water” Tetrahedron Lett. 2008, 49, 4134-4137. 附件檔案附件檔案 Adobe PDF
    33. Pei-Wen Duan,Ching-Chen Chiu, Wei-Der Lee, Li Shiue Pan, Uppala Venkatesham, Zheng-Hao Tzeng  and Kwunmin Chen*On the scope of diastereoselective aziridination of various chiral auxiliaries derived N- and O-enones with N-aminophthalimide in the presence of lead tetraacetate” Tetrahedron: Asymmetry 2008, 18, 682-690. 附件檔案附件檔案 Adobe PDF
    34. Zheng-Hao Tzeng , Shuen-Wen Yang, Pang-Min Liu and Kwunmin Chen* “Optical Resolution of 5-Oxo-1-Phenyl-Pyrazolidine-3-Carboxylic Acid as a New Organocatalyst for Organic Reactions J. Chin. Chem. Soc. 2008, 55, 626-631. 附件檔案附件檔案 Adobe PDF
    35. Chihliang Chang and Kwunmin Chen* “Diastereoselective three component reaction of N-glyoxyloyl camphorpyrazolidinone, amine and allyltributylstannane: facile synthesis of homoallylic amines” J. Chin. Chem. Soc. 2007, 54, 1591-1594. 附件檔案附件檔案 Adobe PDF
    36. Chuen-Ming Shih, Kwunmin Chen, Yu-Chieh Wang, Pei-Jung Lee and Yi-Ching Wang* “Elevated p53 and p21waf1 mRNA expression in blood lymphocytes from lung cancer patients with chemoresistance” Cancer Detection and Preventation 2007, 31, 366-370.
    37. Jung-Hsuan Chen, Uppala Venkatesham, Li-Chen    Lee and Kwunmin Chen* “Diastereoselective Allylation of a-Ketoamides Bearing Camphor N-Tosylpyrazolidinone Auxiliary: Efficient Synthesis of  Highly Optically Active Two Stereoisomers” Tetrahedron 2006, 62, 887. 附件檔案附件檔案 Adobe PDF
    38. Neelesh A. Kulkarni and Kwunmin Chen* “Excellent    diastereoselective allylation of camphor derived glyoxylic oxime ethers mediated by a Lewis acid” Tetrahedron Lett. 2006, 47, 611. 附件檔案附件檔案 Adobe PDF
    39. Neelesh A. Kulkarni, Ching-Fa Yao and Kwunmin    Chen “On the scope of diastereoselective allylation of various chiral glyoxylic oxime ethers with allyltributylstannane in the presence of a Lewis acid and triallylaluminum” Tetrahedron 2007, 63, 7816. 附件檔案附件檔案 Adobe PDF
    40. Jia-Fu Pan and Kwunmin Chen “Diastereoselective Baylis-Hillman Reaction Using N-Glyoxyloyl Camphorpyrazolidinone as an Electrophile: Synthesis of Optically Pure 2- Hydroxy-3-Methylene Succinic Acid Derivative” Tetrahedron Lett. 2004, 45, 2541. 附件檔案附件檔案 Adobe PDF
    41. Wei-Der Lee, Ching-Chen Chiu, Hua-Lin Hsu and Kwunmin Chen “On the Scope of Diastereoselective Epoxidation of Various Chiral Auxiliaries Derived Enones: The Conformational Analysis of Camphor Derived N- and O-Enones” Tetrahedron 2004, 60, 6657. 附件檔案附件檔案 Adobe PDF
    42. Shy-Guey Wang, Huei Ru Tsai and Kwunmin Chen “Lewis Acid-Mediated Diastereoselective Allylation of Camphorpyrazolidinone Derived a-Ketoamides” Tetrahedron Lett. 2004, 45, 6183. 附件檔案附件檔案 Adobe PDF
    43. Chai Ling Fang, Wei-Der Lee, Nai-Wei Teng, Ying-Chieh Sun* and Kwunmin Chen “Epoxidation of Chiral Camphor N-Enoyl- pyrazolidinones with Methyl(trifluoromethyl)-dioxirane and Urea Hydrogen Peroxide/Acid Anhydride: Reversal of Stereoselectivity” J. Org. Chem. 2003, 68, 9816. 附件檔案附件檔案 Adobe PDF
    44. Chai Ling Fan, Gondi Sudershan Reddy and Kwunmin Chen ‘Diastereoselective Epoxidation of Camphor N-Enoylpyrazolidinones’ J. Chin. Chem. Soc. 2003, 50, 1047.
    45. Kung-Shou Yang, Wei-Der Lee, Jia-Fu Pan and Kwunmin Chen* ‘Chiral Lewis Acid-Catalyzed Asymmetric Baylis-Hillman Reactions’ J. Org. Chem. 2003, 68, 915. 附件檔案附件檔案 Adobe PDF
    46. Kung-Shou Yang and Kwunmin Chen* ‘Enantioselective Aziridination of Alkenes with N-Aminophthalimide in the Presence of Lead Tetraacetate-Mediated Chiral Ligand” Org. Lett. 2002, 4, 1107. 附件檔案附件檔案 Adobe PDF
    47. Jia-Fu Pan and Kwunmin Chen “A Facile Catalytic Oxidation of Activated Hydrocarbons to the Carbonyl Functionality Mediated by Mn(II) Complexes” J. Molecular Catalysis A; Chemical 2001, 176, 19.
    48. Wei-Der Lee, Kung-Shuo Yang and Kwunmin Chen* ‘A Remarkable Rate Acceleration of Baylis-Hillman Reaction’ Chem. Commun.,2001, 1612.
      附件檔案附件檔案 Adobe PDF
經歷一覽
服務機關 職稱 部門/系所 擔任職務 起迄年月
國立臺灣師範大學教授化學系 2001年08月 ~
國立臺灣師範大學副教授化學系 1998年08月 ~ 2001年07月
朝陽科技大學副教授應用化學系 1995年08月 ~ 1998年07月
美國雅立雅德製藥公司資深研究員 研究員1992年 ~ 1995年
學歷一覽
學校名稱 國別 系所 學位 起迄年月
賓州大學美國 博士 ~ 1992年
國立臺灣師範大學臺灣化學系理學士1978年09月 ~ 1982年06月
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  1. 期刊論文
  2. 研討會論文
  3. 學術研究計畫
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