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個人詳細資料

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˹ʹϤ
姓名 林文偉
Office_Hour  
實驗室電話 (02) 77346200
辦公室電話 (02) 77346131
傳真 (02) 2932 4249
聯絡地址 (11677)台北市文山區汀州路四段88號
E-mail wenweilin@ntnu.edu.tw
實驗室網頁 http://www.chem.ntnu.edu.tw/~wwlin/index.htm
類別 專任師資
職稱 教授兼系主任
研究領域 不對稱有機催化,新穎反應的開發和雜環化學
學術專長 不對稱有機催化、有機合成。
指導學生 博士後研究員:Dr. Ganapuram Madhusudhan Reddy, Dr. Praneeth Karanam。 博士班:陳奕儒, 楊淑媚, Pankaj Khairnar, Sandip Vagh, 柳彥成。 碩士班:王敏, 林意蓉, 簡涵薇, 古貫君, 柯有軒, 廖證傑, 龍婇蕙, 曾秉曜, 陳禹亨。
實驗室 有機實驗室 / 有機不對稱催化和雜環化學研究實驗室 /

學術著作

  1. 期刊論文
    1. Yang, S.-M.; Tsai, Yi-Ling; Reddy, G. M.; Moehlmann, L.; Lin, W.* "Chemo- and diastereoselective Michael-Michael-acetalization cascade for the synthesis of 1,3-indandione-fused spiro[4.5]decan scanffolds" J. Org. Chem. 201782, 9182-9190.
      參考連結參考連結
    2. Yang, S.-M.; Reddy, G. M.; Wang, T.-P.; Yeh, Y.-S.; Wang, M.; Lin, W.* "An Enantioselective Cascade for Simultaneous Generation of Five Quartenary Stereocenters from Fully Substituted Enones" Chem. Commun. 2017, 53, 7649-7652. 參考連結參考連結
    3. Chen, Y.-R.; Reddy, G. M.; Hong, S.-H.; Wang, Y.-Z.; Yu, J.-K.; Lin, W.* "Four-component synthesis of phosphonium salts: application toward an alternative approach to cross-coupling for the synthesis of bis-heteroarenes" Angew. Chem. Int. Ed. 2017, 56, 5106-5110; Angew. Chem. 2017129, 5188-5192.  參考連結參考連結
    4. Yang, S.-M.; Reddy, G. M.; Liu, M.-H.; Wang, T.-P.; Yu, J.-K.; Lin, W.* "Diastereoselective Synthesis of Rauhut-Currier-Type Adducts via An Unexpected alpha,beta-Unsaturated gamma-Butyrolactams to Coumarin Derivatives" J. Org. Chem. 2017, 82, 781-789. 參考連結參考連結
    5. Chang, G.-H.; Wang, C.-Y.; Reddy, G. M.; Tsai, Y.-L.; Lin, W.* "Enantioselective synthesis of polysubstituted benzopyrano[3,4-c]pyrrolidine frameworks via [3+2] cycloaddition of azomethine ylides and coumarin derivatives" J. Org. Chem. 2016, 81, 10071-10080. 參考連結參考連結
    6. Lee, C.-J.; Chang, T.-H.; Yu, J.-K.; Reddy, G. M.; Hsiao, M.-Y.; Lin, W.* "Synthesis of functionalized furans via chemoselective reduction/Wittig reaction using catalytic triethylamine and phosphine" Org. Lett. 2016, 18, 3758-3761. 參考連結參考連結
    7. Reddy, G. M.; Ko, C.-T.; Hsieh, K.-H.; Lee, C.-J.; Das, U.; Lin, W.* "Expanding the scope of primary amine catalysis: Highly stereoselective synthesis of indanedione-fused 2,6-disubstituted trans-spirocyclohexanones" J. Org. Chem. 201681, 2420-2431. 參考連結參考連結
    8. Moehlmann, L.; Chang, G.-H.; Reddy, G. M.; Lee, C.-J.; Lin, W.* "Organocatalytic enantioselective synthesis of tetrahydro-fluoren-9-ones via vinylogous Michael addition/Henry reaction cascade of 1,3-indandione-derived pronucleophiles" Org. Lett. 201618, 688-691. 參考連結參考連結
    9. Lee, C.-J.; Tsai, C.-C.; Hong, S.-H.; Chang, G.-H.; Yang, M.-C.; Moehlmann, L.; Lin, W.* "Preparation of Furo[3,2-c]coumarins from 3-Cinnamoyl-4-hydroxy-2H-chromen-2-ones and Acyl Chlorides: A Bu3P-Mediated C-Acylation/Cyclization Sequence" Angew. Chem. Int. Ed. 201554, 8502-8505; Angew. Chem. 2015, 127, 8622-8625. 參考連結參考連結
    10. Tsai, Y.-L.;  Lin, W.* "Synthesis of multi-functional alkenes from substituted acrylates and aldehydes via phosphine-catalyzed Wittig reaction" Asian J. Org. Chem. 2015, 4, 1040-1043. 參考連結參考連結
    11. Chen, C.-H.; Ko, C.-T.; Reddy, G. M.; Lee, C.-J.; Lin, W.* "An enantioselective synthesis ofsubstituted cyclohexane derivatives bearing an all-carbon quaternary stereocenter via organocatalytic asymmetric domino double Michael reaction" Eur. J. Org. Chem. 2015, 5254-5265. 參考連結參考連結
    12. Jang, Y.-J.; Chen, Y.-S.; Lee, C.-J.; Chen, C.-H.; Reddy G. M.; Ko, C.-T.; Lin, W.* "Asymmetric organocatalytic synthesis of highly substituted cyclohexenols via domino double Michael reactions of 1-hydroxy-1,4-dien-3-ones and 2-alkylidene malononitirles" Eur. J. Org. Chem. 2015, 2066-2074.
      參考連結參考連結
    13. Chen, Y.-U.; Das, U.; Liu, M.-S.; Lin, W.* "Organocatalytic Enantioselective Direct Vinylogous Michael Addition of alpha,belta-Unsaturated gamma-Butyrolactam to belta-Acyl Acrylates and 1,2-Diacylethylenes” J. Org. Chem. 2015, 80, 1985-1992. 參考連結參考連結
    14. Jang, Y.-J.; Chen, Y.-S.; Lee, C.-J.; Chen, C.-H.; Lin, W.* "Base-Catalyzed Domino Double Michael Reactions of 1-Hydroxy-1,4-dien-3-ones and 2-Alkylidene Malononitirles: A Diastereoselective Route to Polysubstituted 4-Hydroxy-3-keto-cyclohex-3-ene” Synthesis 2015, 47, 95-107.

      參考連結參考連結
    15. Fan, Y.-S.; Das, U.; Hsiao, M.-Y.; Liu, M.-S.; Lin, W.* "Chemoselective Intramolecular Wittig Reactions for the Synthesis of Oxazoles and BenzofuransJ. Org. Chem. 2014, 79, 11567-11582. 參考連結參考連結
    16. Das, U.; Tsai, Y.-L.; Lin, W.* "Preparation of functionalized heteroaromatics using intramolecular Wittig reaction” Org. Biomol. Chem. 201412, 4044-4050. (Perspective) (This article is part of the themed collection: 2014 Hot Articles in Organic and Biomolecular Chemistry) 參考連結參考連結
    17. Tsai, Y.-L.; Syu, S.; Yang, S.-M.; Das, U.; Fan, Y.-S.; Lee, C.-J.; Lin, W.* "Synthesis of Multi-Functional Alkenes via Wittig Reaction with a New-Type of Phosphorus Ylides” Tetrahedron 2014, 70, 5038-5045.

      參考連結參考連結
    18. Lee, C.-J.; Sheu, C.-N.; Tsai, C.-C.; Wu, Z.-Z.; Lin, W.* "Direct  β-Acylation of 2-Arylidene-1,3-indandiones with Acyl Chlorides Catalyzed by Organophosphanes” Chem. Commun. 2014, 50, 5304-5306.(Featured in “Emerging investigators” issue 2014) 參考連結參考連結
    19. “Contributors to the Emerging Investigators Issue 2014”, Chem. Commun. 2014, 50, 5100-5114. 參考連結參考連結
    20. Lee, Y.-T.; Das, U.; Chen, Y.-R.; Lee, C.-J.; Chen, C.-H.; Yang, M.-C.; Lin, W.* "Enantioselective Synthesis of Coumarin Derivatives Catalyzed by Primary Amine” Adv. Synth. Catal. 2013355, 3154-3160. 參考連結參考連結
    21. Tsai, Y.-L.; Fan, Y.-S.; Lee, C.-J.; Huang, C.-H.; Das, U.; Lin, W.* "An Efficient Synthesis of Trisubstituted Oxazoles via Chemoselective O-Acylations and Intramolecular Wittig Reactions” Chem. Commun. 2013, 49, 10266-10268. 參考連結參考連結
    22. Lee, Y.-T.; Lee, Y.-T.; Lee, C.-J.; Sheu, C.-N.; Lin, B.-Y.; Wang, J.-H.*; Lin, W.* "Chemoselective Synthesis of Tetrasubstituted Furans via Intramolecular Wittig Reactions: Mechanism and Theoretical Analysis” Org. Biomol. Chem. 2013, 11, 5156-5161. 參考連結參考連結
    23. Tsai, Y.-L.; Das, U.; Syu, S.; Lee, C.-J.; Lin, W.* “Facile synthesis of functional tricyclic fused furans via intramolecular Wittig reactions” Eur. J. Org. Chem. 2013, 4634-4641.
      參考連結參考連結
    24. Das, U.; Chen, Y.-R.; Tsai, Y.-L.; Lin, W.* “Organocatalytic enantioselective direct vinylogous Michael addition of r-substituted butenolides to 3-aroyl acrylates and 1,2-diaroylethylenes” Chem. Eur. J. 201319, 7713-7717. 參考連結參考連結
    25. Wu, Z.-Z.; Jang, Y.-J.; Lee, C.-J.; Lee, Y.-T.; Lin, W.* “A Versatile and Practical Method for Regioselective Synthesis of Polysubstituted Furanonaphthoquinones” Org. Biomol. Chem. 201311, 828-834. (HOT article) 參考連結參考連結
    26. Das, U.; Tsai, Y.-L.; Lin, W.* “An efficient organocatalytic enantioselective synthesis of spironitrocyclopropanes” Org. Biomol. Chem. 201311, 44-47. (HOT communication) 參考連結參考連結
    27. Lee, Y.-T.; Jang, Y.-J.; Syu, S.; Chou, S.-C.; Lee, C.-J.; Lin, W.* “Preparation of Functional Benzofurans and Indoles via Chemoselective Intramolecular Wittig Reactions” Chem. Commun. 201248, 8135-8137. 參考連結參考連結
    28. Das, U.; Huang, C.-H.; Lin, W.* "Enantioselective synthesis of substituted pyrans via amine-catalyzed Michael addition and subsequent enolization/cyclisation" Chem. Commun. 201248, 5590-5592. (Featured in “Organocatalysis” Web-themed issue) 參考連結參考連結
    29. Lee, C.-J.; Jang, Y.-J.; Wu, Z.-Z. ; Lin, W.* “Preparation of Functional Phosphorus Zwitterions from Activated Alkanes, Aldehydes, and Tributylphosphine: Synthesis of Polysubstituted Furo[3,2-c]coumarins” Org. Lett. 201214, 1906-1909. 參考連結參考連結
    30. Jang, Y.-J.; Syu, S.; Jhang, Y.-W.; Lee, Y.-T.; Lee, C.-J.; Chen, K.-W.; Das, U.; Lin, W.* “Tandem three-component reactions of aldehyde, alkyl acrylate, and dialkylmalonate catalyzed by ethyl diphenylphosphine” Molecules 2012, 17, 2529-2541.
      參考連結參考連結
    31. Syu, S.; Huang, C.-H.; Chen, K.-W.; Lee, C.-J.; Das, U.; Jang, Y.-J.; Lin, W.* “Enantioselective organocatalytic Michael addition of ketones to alkylidene malonates” Chirality 2012, 24, 600-605.
      參考連結參考連結
    32. Jang, Y.-J.; Syu, S.; Chen, Y.-J.; Yang, M.-C.; Lin, W.* “Syntheses of Furo[3,4-c]coumarins and Related Furyl Coumarin Derivatives via Intramolecular Wittig Reactions” Org. Biomol. Chem. 2012, 10, 843-847.
      參考連結參考連結
    33. Syu, S.; Lee, Y.-T.; Jang, Y.-J.; Lin, W.* “Preparation of Functional Benzofurans, Benzothiophenes, and Indoles Using Ester, Thioester, and Amide via Intramolecular Wittig Reactions” Org. Lett. 2011, 13, 2970-2973.
      參考連結參考連結
    34. Syu, S.; Lee, Y.-T.; Jang, Y.-J.; Lin, W.* “Organocatalytic tandem three-component reaction of imine, alkyl vinyl ketone, and imide via aza-Baylis-Hillman reaction” J. Org. Chem. 2011, 76, 2888-2891.
      參考連結參考連結
    35. Chen, K.-W.; Syu, S.; Jang, Y.-J.; Lin, W.* “A facile approach to highly functional trisubstituted furans via intramolecular Wittig reactions” Org. Biomol. Chem. 2011, 9, 2098-2106.
      參考連結參考連結
    36. Wang, D.-W.; Syu, S.; Hung, Y.-T.; Chen, P.; Lee, C. J.; Chen, K.-W.; Chen, Y.-J.; Lin, W.* “Organocatalytic Tandem Three-Component Reaction of Aldehyde, Alkyl Vinyl Ketone, and Amide: One-Pot Syntheses of Highly Functional Alkenes” Org. Biomol. Chem. 2011, 9, 363-366.
      參考連結參考連結
    37. Syu, S.; Wang, D.-W.; Chen, P.; Hung, Y.-T.; Jhang, Y.-W.; Kao, T.-T.; Lee, Y.-T.; Lin, W.*  “Tandem Three-Component Reaction of Aldehyde, Alkyl Acrylate and Amide Using Ethyl Diphenylphosphine as Organocatalyst” Tetrahedron Lett. 2010, 51, 5943-5946.
      參考連結參考連結
    38. Kao, T.-T.; Syu, S.; Jhang, Y.-W.; Lin, W.* "Preparation of Tetrasubstituted Furans via Intramolecular Wittig Reactions with Phosphorus Ylides as Intermediates", Org. Lett. 201012, 3066-3069. 參考連結參考連結
    39. Syu, S.; Kao, T.-T.; Lin, W.* "A New Type of Organocatalyst for Highly Stereoselective Michael Addition of Ketones to Nitroolefins on Water", Tetrahedron 2010, 66, 891–897. 參考連結參考連結
    40. Lin, W.; Chen, L.; Knochel, P.* “Preparation of Functionalized 3,4-Pyridynes via 2-Magnesiated Diaryl Sulfonates”, Tetrahedron 2007, 63, 2787-2797.
    41. Lin, W.; Ilgen, F.; Knochel, P.* “Preparation of Highly Functionalized Arylmagnesium Reagents by the Addition of Magnesium Phenylselenide to Arynes”, Tetrahedron Lett. 2006, 47, 1941-1944.
    42. Lin, W.; Baron, O.; Knochel, P.* “Highly Functionalized Benzene Syntheses by Directed Mono or Multiple Magnesiations with TMPMgCl‧LiCl”, Org. Lett. 2006, 8, 5673-5676.
    43. Sapountzis, I.; Lin, W.; Kofink, C. C.; Despotopoulou, C.; Knochel, P.* “Iron-Catalyzed Aryl-Aryl Cross-Couplings with Magnesium-Derived Copper Reagents”, Angew. Chem. Int. Ed. 2005, 44, 1654-1657. Angew. Chem. 2005, 117, 1682-1685.
    44. Lin, W.; Sapountzis, I.; Knochel, P.* “Preparation of Functionalized Aryl Magnesium Reagents by the Addition of Magnesium Aryl Thiolates and Amides to Arynes”, Angew. Chem. Int. Ed. 2005, 44, 4258-4261. Angew. Chem. 2005, 117, 4330-4333.
    45. Sapountzis, I.; Lin, W.; Fischer, M.; Knochel, P.* “Preparation of Polyfunctional Arynes via 2-Magnesiated Diaryl sulfonates”, Angew. Chem. Int. Ed. 2004, 43, 4364-4366. Angew. Chem. 2004, 116, 4464-4466.
    46. Jang, Y.-J.; Lin, W.-W.; Shih, Y.-K.; Liu, J.-T.; Hwang, M.-H.; Yao, C.-F.* “An Easy One-Pot Method for the Synthesis of 2,2-Disubstituted 1-Nitroalkenes”, Tetrahedron 2003, 59, 4979-4992.
    47. Lin, W.-W.; Jang, Y.-J.; Wang, Y.; Liu, J.-T.; Hu, S.-R.; Wang, L.-Y.; Yao, C.-F.* “An Improved and Easy Method for the Preparation of 2,2-Disubstituted 1-Nitroalkenes”, J. Org. Chem. 2001, 66, 1984-1991.
    48. Liu, J.-T; Lin, W.-W.; Jang, J.-J.; Liu, J.-Y.; Yan, M.-C.; Hung, C.; Kao, K.-H.; Wang, Y.; Yao, C.-F.* “One-pot synthesis of six- or five-membered carbocycles through intramolecular cycloadditions by the use of ethyl chloroformate”, Tetrahedron 1999, 55, 7115-7128.
    49. Yan, M.-C.; Liu, J.-Y.; Lin, W.-W.; Kao, K.-H.; Liu, J.-T; Jang, J.-J.; Yao, C.-F.* “One-Pot Synthesis of Five-Membered Cyclic Thioethers or Ethers via Intramolecular Nitrile Oxide-Olefin Cycloaddition (INOC) or Intramolecular Alkoxycarbonyl Nitronate-Olefin Cycloaddition (IAOC) by the use of Methyl Chloroformate”, Tetrahedron 1999, 55, 12493-12514.
  2. 專利
    1. Knochel, P.; Sapountzis, I; Korn, T.; Lin, W.; Kofink, C. C. 2010,“Iron or Cobalt-Catalyzed Carbon-Carbon Coupling Reaction of Aryls, Alkenes and Alkines with Copper Reagents” European Patent EP1799627 (Publication Number:  WO/2006/040131; International Application No.:  PCT/EP2005/010936; Publication Date: 05.05.2010; International Filing Date: 11.10.2005).
      附件檔案附件檔案 Adobe PDF
    2. Knochel, P.; Sapountzis, I; Korn, T.; Lin, W.; Kofink, C. C. 2008,“Iron or Cobalt-Catalyzed Carbon-Carbon Coupling Reaction of Aryls, Alkenes and Alkines with Copper Reagents” United States Patent US20080269514 (Publication Number:  WO/2006/040131; International Application No.:  PCT/EP2005/010936; Publication Date: 30.10.2008; International Filing Date: 11.10.2005).
      附件檔案附件檔案 Adobe PDF
  3. 其他
    1. "師大化學系林文偉-有機不對稱催化和雜環實驗室", 科學月刊, 第549期 (民國104年九月), 第715頁至第717頁 參考連結參考連結
    2. "踏上充滿挑戰的化學之路  師大化學系教授林文偉專訪", 科學月刊, 第549期 (民國104年九月), 第712頁至第714頁 參考連結參考連結
    3. 科技部 2014 學術研究獎項 獲獎人專輯 (Ministry of Science and Technology, Academic Research award) 參考連結參考連結 附件檔案附件檔案 Adobe PDF
    4. 蔡乙鈴,范宇琇,林文偉,"發展新穎的分子內Wittig反應來合成芳香族的雜環化合物",自然科學簡訊,第二十五卷,第四期,第162頁至第168頁 參考連結參考連結 附件檔案附件檔案 Adobe PDF
經歷一覽
服務機關 職稱 部門/系所 擔任職務 起迄年月
國立臺灣師範大學主任化學系系主任2017年08月 ~
國立臺灣師範大學主任貴重儀器中心中心主任2014年08月 ~ 2017年07月
國立臺灣師範大學特聘教授化學系 2014年02月 ~ 2016年07月
國立臺灣師範大學教授化學系 2014年02月 ~
國立臺灣師範大學副教授化學系 2011年02月 ~ 2014年01月
國立臺灣師範大學助理教授化學系 2008年02月 ~ 2011年01月
德國柏林科技大學博士後研究化學所研究員2007年01月 ~ 2007年12月
德國慕尼黑大學博士後研究化學所研究員2006年11月 ~ 2006年12月
國立臺灣師範大學助教化學系助教2002年03月 ~ 2003年07月
陸軍(義務役軍官)少尉排長  2000年07月 ~ 2002年03月
學歷一覽
學校名稱 國別 系所 學位 起迄年月
德國慕尼黑大學德國化學所博士2003年08月 ~ 2006年11月
國立臺灣師範大學臺灣化學系碩士1998年09月 ~ 2000年06月
國立臺灣師範大學臺灣化學系理學士1994年09月 ~ 1998年06月
台北市立建國高級中學臺灣 高中1991年09月 ~ 1994年06月
台北縣立海山國中臺灣  1988年09月 ~ 1991年06月
校內榮譽一覽
得獎年度 獎項名稱 頒獎單位
2014102年度研究績優獎國立臺灣師範大學
校外榮譽一覽
得獎年度 獎項名稱 頒獎單位
20142014 Emerging Investigators英國皇家化學學會
2013吳大猷先生紀念獎行政院國家科學委員會
2013傑出青年化學獎章中國化學會
2013Asian Core Program Lectureship AwardThailand
2011Asian Core Program Lectureship AwardJapan Society for Promotion of Sciences, JSPS
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  1. 期刊論文
  2. 研討會論文
  3. 學術研究計畫
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