孙英杰
姓名 孙英杰
电子邮件
联络电话 (02)77496215
网站 http://web.ntnu.edu.tw/~sun/
实验室电话 (02)77496216
职称 教授
研究领域 生物物理化学、药物设计
学术专长 癌症药物、神经退化性疾病药物研发。 电脑辅助药物设计：蛋白质模拟、分子动力学模拟、Docking、系统生物学方法、QSAR方法。 药物研究实验:激酶抑制剂抑制效果测量。
指导学生 施惠真;许文绮;许嘉仁;刘安伦
实验室 计算模拟、实验研究室 - 生物物理化学、药物设计 / 物化/分析实验室

 

年度 论文名称
2023 Using ΔK280 TauRD Folding Reporter Cells to Screen TRKB Agonists as Alzheimer’s Disease Treatment Strategy, Biomolecules, Jan. 2023
2022 Neuroprotective Action of Coumarin Derivatives through Activation of TRKB-CREB-BDNF Pathway and Reduction of Caspase Activity in Neuronal Cells Expressing Pro-Aggregated Tau Protein, International Journal of Molecular Sciences, Oct. 2022
2022 Novel TRKB agonists activate TRKB and downstream ERK and AKT signaling to protect Aβ-GFP SH-SY5Y cells against Aβ toxicity, Aging, Sep. 2022
2022 Virtual Screening and Testing of GSK-3 Kinase Inhibitors Us-ing Human SH-SY5Y Neuronal Cells Expressing Tau Folding Reporter and Mouse Hippocampal Primary Neuron Culture Under Tau Cytotoxicity, Biomol Ther, Jul. 2022
2021 Flavones 7,8-DHF, Quercetin, and Apigenin Against Tau Toxicity via Activation of TRKB Signaling in ΔK280 TauRD-DsRed SH-SY5Y Cells, Frontiers in Aging Neuroscience, Dec. 2021
2021 Multi-Target Effects of Novel Synthetic Coumarin Derivatives Protecting Aβ-GFP SH-SY5Y Cells against Aβ Toxicity, Cells, Nov. 2021
2021 Novel Synthetic Coumarin-Chalcone Derivative (E)-3-(3-(4-(Dimethylamino)Phenyl)Acryloyl)-4-Hydroxy-2H-Chromen-2-One Activates CREB-Mediated Neuroprotection in Aβ and Tau Cell Models of Alzheimer’s Disease, Oxidative Medicine and Cellular Longevity, Nov. 2021
2020 LMDS-1, a potential TrkB receptor agonist provides a safe and neurotrophic effect for early-phase Alzheimer’s disease, Psychopharmacology, vol. 237, Oct. 2020
2020 Targeting Inflammation, PHA-767491 Shows a Broad Spectrum in Protein Aggregation Diseases, J. Mol. NeuroSci., vol. 70, Mar. 2020
2020 Effective methane conversion to methanol on bi-functional graphene-oxide-supported platinum nanoclusters (Pt5) – a DFT study, Phys. Chem. Chem. Phys., vol. 22, Feb. 2020
2019 Novel compound VB-037 inhibits Aβ aggregation and promotes neurite outgrowth through enhancement of HSP27 and reduction of P38 and JNK-mediated inflammation in cell models for Alzheimer's disease, Neurochemistry International, vol. 125, May. 2019
2019 Chronic low dose of AM404 ameliorates the cognitive impairment and pathological features in hyperglycemic 3xTg-AD mice., Psychopharmacology, vol. 236, Jan. 2019
2018 Synthesis of (3S,4S,5S)-trihydroxylpiperidine derivatives as enzyme stabilizers to improve therapeutic enzyme activity in Fabry patient cell lines, European Journal of Medicinal Chemistry, vol. 144, Jan. 2018
2017 Investigation of the Bindings of a Class of Inhibitors with GSK3 Kinase Using Thermodynamic Integration MD Simulation and Kinase Assay, Chem. Biol. Drug Des., vol. 90, Jan. 2017
2016 Identifying GSK-3 kinase inhibitors of Alzheimer's disease: Virtual screening, enzyme, and cell assays, European Journal of Pharmaceutical Sciences, vol. 89, Jun. 2016
2015 Investigation into the Binding Affinity Differences in Ligands with un-Tagged and Tagged p38 Kinase Using Thermodynamic Integration MD Simulation, Journal of Molecular Modeling, vol. 21, Nov. 2015
2014 Using thermodynamic integration MD simulation to compute relativeprotein–ligand binding free energy of a GSK3 kinase inhibitorand its analogs, Journal of Molecular Graphics and Modelling, vol. 51, Jun. 2014
2012 Computation of relative binding free energy for an inhibitor and its analogs binding with Erk kinase using thermodynamic integration MD simulation, J. Comput. Aided Mol. Des., vol. 26, Oct. 2012
2011 Prediction of the binding mode between GSK3b and a peptide derived from GSKIP using molecular dynamics simulation, Biopolymers, vol. 95, Jul. 2011
2011 A novel sialyltransferase inhibitor suppresses FAK/paxillin and angiogenesis signaling and cancer metastasis, cancer research, vol. 71, Jan. 2011
2010 Comparative Molecular Field Analysis of Anti-tubulin Agents with Indole Ring Binding at the Colchicine Binding Site, Journal of Theoretical and Computational Chemistry, vol. 9, Jan. 2010
2009 Examination of effects of GSK3β phosphorylation, β-catenin phosphorylation, and β-catenin degradation on kinetics of Wnt signaling pathway using computational method, Theoretical biology and medical modelling, vol. 6, Jul. 2009
2009 A 3D-QSAR study of Celebrex-based PDK1 Inhibitors Using CoMFA Method, Journal of the Chinese Chemical Society, vol. 56, Feb. 2009
2009 A Reversible Surface Functionalized Nanowire Transistor to Study Protein-Protein Interactions, Nano Today, vol. 4, Jan. 2009
2008 Cytotoxicity and Proteomics Analyses of OSU03013 in Lung Cance, Clinical Cancer Research, vol. 14, Mar. 2008
2008 Journal of Structural Biology, Packing of transmembrane helices in bacteriorhodopsin folding: Structure and thermodynamics, vol. 162, Jan. 2008
2007 Molecular Dynamics Simulation of Folding of a Short Helical Toxin Peptide, J. Theore. Comput. Chem., vol. 6, Jun. 2007
2007 Examination of the Folding of a Short Alanine-Based Helical Peptide with Salt Bridges Using Molecular Dynamics Simulation, Journal of Physical Chemistry B, vol. 111, Feb. 2007
年度 计画名称 参与人 职称/担任之工作 计画期间 补助/委讬或合作机构
2023 TrkB受体讯息传递路径动力学及其双稳态行为之计算研究 主持人 2022.08 ~ 2023.07 科技部(原国科会)
2018 新颖酵素蛋白质抑制剂的开发与设计:以分子动态模拟与酵素实验研究蛋白质-配体结合自由能与结合构形 主持人 2017.08 ~ 2018.07 科技部(原国科会)
2018 以理论计算方法探讨高活性金属奈米团簇与石墨烯在催化反应上的应用 主持人 2016.08 ~ 2018.07 科技部(原国科会)
2017 以热力学积分分子动态模拟方法研究激酶与配体复合体-结合嵌合计算及酵素实验 主持人 2015.08 ~ 2017.07 科技部(原国科会)
2015 配体与蛋白质的结合自由能研究:分子动态模拟和嵌合计算 主持人 2014.08 ~ 2015.07 科技部(原国科会)
2015 阿兹海默氏症的治疗策略—从基因到行为,--以阿兹海默氏症小鼠模式评估GSK3抑制剂之治疗潜力—奠基于电脑辅助药物设计及激酶生化检测(2/2) 化学系 协同/共同主持人 2014.08 ~ 2015.07 科技部(原国科会)
2014 阿兹海默氏症的治疗策略—从基因到行为－以阿兹海默氏症小鼠模式评 估GSK3抑制剂之治疗潜力—奠基于电脑辅助药物设计及激酶生化检测(1/2) 化学系 协同/共同主持人 2013.08 ~ 2014.07 国科会
2013 抑制剂化合物与蛋白质结合自由能和生化反应网络动力学之计算研究 主持人 2013.02 ~ 2013.05 科技部(原国科会)
2013 抑制剂化合物与蛋白质结合自由能和生化反应网络动力学之计算研究 主持人 2012.08 ~ 2013.07 国科会
2012 生化分子作用及动力学之计算化学研究: Kinase之抑制及在细胞讯息传递路径的角色 主持人 2011.08 ~ 2012.07 国科会
2011 生化分子作用及动力学之计算化学研究: Kinase之抑制及在细胞讯息传递路径的角色 主持人 2010.08 ~ 2011.07 国科会
2010 生化分子作用及动力学之计算化学研究: Kinase之抑制及在细胞讯息传递路径的角色 主持人 2009.08 ~ 2010.07 国科会
2009 生化分子之计算化学研究:(1)胜肽链折叠/展开(2)分子结合 主持人 2008.08 ~ 2009.07 国科会
2008 生化分子之计算化学研究:(1)胜肽链折叠/展开(2)分子结合 主持人 2007.08 ~ 2008.07 国科会
2007 生化分子之计算化学研究:(1)胜肽链折叠/展开(2)分子结合 主持人 2006.08 ~ 2007.07 国科会
专利名称 专利编号 专利国别 着作人
Method For Treating Tau-Associated Diseases 美国
喹啉衍生化合物用于制备Ｔａｕ蛋白病变类疾病之医药组成物上之用途 台湾
国家 学校名称 系所 学位 期间
美国 宾夕法尼亚大学 化学研究所 博士 1989.09 ~ 1994.06
台湾 国立台湾大学 化学系 理学士 1983.09 ~ 1987.06
服务机关名称 单位 职务 期间
国立台湾师范大学 化学系 教授 2000.01 ~ 迄今
国立台湾师范大学 化学系 副教授 1996.01 ~ 2000.01
美国加州大学旧金山分校 药理化学系 博士后研究员 1994.01 ~ 1996.01