简敦诚
姓名 简敦诚
电子邮件
联络电话 +886-2-77496126
实验室电话 +886-2-77496201
职称 教授
研究领域 有机化学, 有机合成, 生物有机化学, 药物化学
学术专长 研究兴趣:
  1. 有机合成: 研究发展碳-碳键、碳-氮键、及氮-氮键的建构反应,制备多样性含氮有机化合物,并应用于生物分子、天然物、及其衍生物/类似物的合成。
  2. 生物有机及药物化学: 利用设计合成的受质分子及其类似物研究生物巨分子与受质分子间的作用与反应,并对合成的有机分子进行生物活性评估。
  1. Tang, H.; Wu, M.-H.; Lin, H.-Y.; Han, M.-R.; Tu, Y.-H.; Yang, Z.-J.; Chien, T.-C.;* Chan, N.-L.;* Chang, W.-c.* Mechanistic Analysis of Carbon–carbon Bond Formation by Deoxypodophyllotoxin Synthase. Proc. Natl. Acad. Sci. U. S. A. 2022, 119, e2113770119.
  2. Chen, T.-Y.; Xue, S.; Tsai, W.-C.; Chien, T.-C.;* Guo, Y.;* Chang, W.-c.* Deciphering Pyrrolidine and Olefin Formation Mechanism in Kainic Acid Biosynthesis. ACS Catal. 2021, 11, 278-282.
  3. Yu, C.-P.; Chang, H.-Y.; Chien, T.-C.* Total Synthesis of Pseudouridine via Heck-type C-Glycosylation. New J. Chem. 201943, 8796-8803.
  4. Chang, W.-c.;* Yang, Z.-J.; Tu, Y.-H.; Chien, T.-C.* Reaction Mechanism of a Non-heme Iron Enzyme Catalyzed Oxidative Cyclization via C-C Bond Formation. Org. Lett. 201921, 228-232.
  5. Liao, Z.-Y.; Yeh, W.-H.; Liao, P.-Y.; Liu, Y.-T.; Chen, Y.-C.; Chen, Y.-H.; Hsieh, T.-H.; Lin, C.-C.; Lu, M.-H.; Chen, Y.-S.; Hsu, M.-C.; Li, T.-K.;* Chien, T.-C.* Regioselective Synthesis and Biological Evaluation of N-Substituted 2-Aminoquinazolin-4-ones. Org. Biomol. Chem. 201816, 4482-4494.
  6. Tsai, C.-H.; Tang, Y.-H.; Chen, H.-T.; Yao, Y.-W.; Chien, T.-C.;* Kao, C.-L.* A Selective Glucose Sensor: Cooperative Effect by Monoboronic Acid-modified Poly(amidoamine) Dendrimers. Chem. Commun. 201854, 4577-4580.
  7. Hsieh, T.-H.; Liao, P.-Y.; Liu, Y.-T.; Wang, C.-H.; Lin, C.-C.; Chien, T.-C.* Investigation of O-Sulfonylation-promoted Heterolytic N-O Bond Cleavage of Amidoximes and Ketoximes. J. Chin. Chem. Soc. (Taipei) 201865, 325-330. (special issue: International Symposium in Catalysis and Fine Chemicals 2016)
  8. Wang, Y.-R.; Chen, S.-F.; Wu, C.-C.; Liao, Y.-W.; Lin, T.-S.; Liu, K.-T.; Chen, Y.-S.; Li, T.-K.;* Chien, T.-C.;* Chan, N.-L.* Producing Irreversible Topoisomerase II-Mediated DNA Breaks by Site-Specific Pt(II)-Methionine Coordination Chemistry. Nucleic Acids Res. 201745, 10861-10871.
  9. Liao, Z.-Y.; Liao, P.-Y.; Chien, T.-C.* CuI-catalyzed Intramolecular Aminocyanation of Terminal Alkynes in N-(2-Ethynylphenyl)-N-sulfonylcyanamides via Cu-vinylidene Intermediates. Chem. Commun. 201652, 14404-14407.
  10. Shih, Y.-C.; Wang, J.-S.; Hsu, C.-C.; Tsai, P.-H.; Chien, T.-C.* Identification of Reactive Intermediates for the Decarbonylative Reaction of 1-Alkylprolines. Synlett201627, 2841-2845.
  11. Wu, N.-L.; Lee, T.-A.; Wang, S.-F.; Li, H.-J.; Chen, H.-T.; Chien, T.-C.; Huang, C.-C.;* Hung, C.-F.* Green Fluorescent Protein Chromophore Derivative Suppresses Ultraviolet A-induced JNK-signalling and Apoptosis in Keratinocytes and Adverse Effects in Zebrafish Embryos. Exp. Dermatol. 201625, 983-990.
  12. Wang, C.-H.; Hsieh, T.-H.; Lin, C.-C.; Yeh, W.-H.; Lin, C.-A.; Chien, T.-C.* One-Pot Synthesis of N-Monosubstituted Ureas from Nitriles via Tiemann Rearrangement. Synlett201526, 1823-1826.
  13. Shih, Y.-C.; Tsai, P.-H.; Hsu, C.-C.; Chang, C.-W.; Jhong, Y.; Chen, Y.-C.; Chien, T.-C.* Biomimetic Approach toward the Total Synthesis of rac-2-(Acylmethylene)pyrrolidine Alkaloids. J. Org. Chem. 201580, 6669–6678.
  14. Zeng, C.-J.; Chen, C.-J.; Chang, C.-W.; Chen, H.-T.;* Chien, T.-C.* Copper(I) Iodide-Catalyzed Synthesis of N,N’-Disubstituted Guanidines from N-Substituted Cyanamides. Aust. J. Chem. 201467, 1134–1137. (invited manuscript in the special issue - Research Front on ‘The Chemistry of Guanidine, Guanidinium and Guanidinate Compounds’
  15. Lin, C.-C.; Hsieh, T.-H.; Liao, P.-Y.; Liao, Z.-Y.; Chang, C.-W.; Shih, Y.-C.; Yeh, W.-H.; Chien, T.-C.* Practical Synthesis of N-Substituted Cyanamides via Tiemann Rearrangement of Amidoximes. Org. Lett. 201416, 892−895.
  16. Chang, C.-W.; Wu, C.-C.; Chang, Y.-Y.; Lin, C.-C.; Chien, T.-C.* Synthesis and Unexpected Oxidization of the Tricyclic Core of Ugibohlin, Isophakellin and Styloguanidine. J. Org. Chem. 201378, 10459-10468.
  17. Shih, Y.-C.; Yang, Y.-Y.; Lin, C.-C.; Chien, T.-C.* Synthesis of 6-Alkyluridines from 6-Cyanouridine via Zinc(II) Chloride-Catalyzed Nucleophilic Substitution with Alkyl Grignard Reagents. J. Org. Chem. 201378, 4027-4036.
  18. Cheng, C.; Shih, Y.-C.; Chen, H.-T.;* Chien, T.-C.* Regioselective Arylation of Uracil and 4-Pyridone Derivatives via Copper(I) Bromide Mediated C-H Bond Activation. Tetrahedron201369, 1387-1396.
  19. Choi, S.-h.; Mansoorabadi, S. O.; Liu, Y.-n.; Chien, T.-C.; Liu, H.-w.* Analysis of UDP-D-Apiose/UDP-D-Xylose Synthase-Catalyzed Conversion of UDP-D-Apiose Phosphonate to UDP-D-Xylose Phosphonate: Implications for a Retroaldol-Aldol Mechanism. J. Am. Chem. Soc. 2012134, 13946-13949.
  20. Lee, C.-Y.; Chen, Y.-C.; Lin, H.-C.; Jhong, Y.; Chang, C.-W.; Tsai, C.-H.; Kao, C.-L.;* Chien, T.-C.* Facile Synthesis of 4-Arylidene-5-imidazolinones as Synthetic Analogs of Fluorescent Protein Chromophore. Tetrahedron201268, 5898-5907.
  21. Lin, J.-B.; He, J.-L.; Shih, Y.-C.; Chien, T.-C.* Study on the Synthesis of 6-Alkylaminouridines via the Nucleophilic Aromatic Substitution Reaction of 6-Cyanouridine Derivatives. Tetrahedron Lett. 201152, 3969-3972.
  22. Shih, Y.-C.; Chien, T.-C.* Practical Synthesis of 6-Aryluridines via Palladium(II) Acetate Catalyzed Suzuki-Miyaura Cross-coupling Reaction. Tetrahedron201167, 3915-3923.
  23. Wu, Y.-J.; Liao, C.-C.; Jen, C.-H.; Shih, Y.-C.; Chien, T.-C.* Chemical Models and Their Mechanistic Implications for the Transformation of 6-Cyanouridine 5'-Monophosphate Catalyzed by Orotidine 5'-Monophosphate Decarboxylase. Chem. Commun. 201046, 4821-4823.
  24. Jen, C.-H.; Chien, T.-C.* Reinvestigation of the Synthesis of 1-Deazauridine. Nucleosides Nucleotides Nucleic Acids201029, 523-534.
  25. Chien, T.-C.; Chen, C.-S.; Chern, J.-W.* Nucleosides XIII. Facile Synthesis of 4-Amino-1-(2-deoxy-beta-D-ribofuranosyl)quinazolin-2-one as a 2'-Deoxycytidine Analog for Oligonucleotide Synthesis. J. Chin. Chem. Soc. (Taipei) 200552, 1237-1244.
  26. Chien, T.-C.; Berry, D. A.; Drach, J. C.; Townsend, L. B.* Synthesis of 3-Aminoimidazo[4,5-c]pyrazole Nucleoside via the N-N Bond Formation Strategy as a [5:5] Fused Analog of Adenosine. Nucleosides Nucleotides Nucleic Acids200524, 1971-1996.
  27. Chien, T.-C.; Kuo, C.-C.; Chen, C.-S.; Chern, J.-W.* Nucleoside XII. Synthesis of 5'-Modified Isoguanosines and Reinvestigation of 5'-Deoxy-N3,5'-cycloisoguanosine. J. Chin. Chem. Soc. (Taipei) 2004, 51, 1401-1406.
  28. Chien, T.-C.; Chen, C.-S.; Yu, F.-H.; Chern, J.-W.* Nucleosides XI. Synthesis and Antiviral Evaluation of 5'-Alkylthio-5'-deoxy Quinazolinone Nucleoside Derivatives as S-Adenosyl-L-homocysteine Analogs. Chem. Pharm. Bull. 200452,1422-1426.
  29. Berry, D. A.; Chien, T.-C.; Townsend, L. B.* Mononuclear Heterocyclic Rearrangement: Synthesis of [5:5] Bicyclic [c]-Fused 3-Aminopyrazoles via the N-N Bond Formation Strategy. Heterocycles200463, 2475-2494.
  30. Chien, T.-C.; Saluja, S. S.; Drach, J. C.; Townsend, L. B.* Synthesis and Antiviral Evaluation of Polyhalogenated Imidazole Nucleosides: Dimensional Analogs of 2,5,6-Trichloro-1-(beta-D-ribofuranosyl)benzimidazole. J. Med. Chem. 200447, 5743-5752.
  31. Chien, T.-C.; Meade, E. A.; Hinkley, J. M.; Townsend, L. B.* Facile Synthesis of 1-Substituted 2-Amino-3-cyanopyrroles: New Synthetic Precursors for 5,6-Unsubstituted Pyrrolo[2,3-d]pyrimidines. Org. Lett20046, 2857-2859.
  32. Chien, T.-C.; Smaldone, R. A.; Townsend, L. B.* Facile Synthesis of 1-Substituted 4,5-Diaminopyrazoles and Its Application Toward the Synthesis of Pyrazolo[3,4-b]pyrazines. Tetrahedron Lett. 200445, 4105-4108.
  33. Chien, T.-C.; Chern, J.-W.* A Convenient Preparation of 1,2,3-Tri-O-acetyl-beta-D-ribofuranose by Enzymatic Regioselective 5-O-Deacetylation of the Peracetylated Ribofuranose (Nucleosides X.). Carbohydr. Res. 2004, 339, 1215-1217.
  34. Chen, G. S.; Chen, C.-S.; Chien, T.-C.; Yeh, J.-Y.; Kuo, C.-C.; Talekar, R. S.; Chern, J.-W.* Nucleosides IX. Synthesis of Purine N3,5'-Cyclonucleosides and N3,5'-Cyclo-2',3'-seconucleosides via Mitsunobu Reaction as TIBO-like Derivatives. Nucleosides Nucleotides Nucleic Acids2004, 23, 347-359.
  35. Chien, T.-C.; Chen, C.-S.; Yeh, J.-Y.; Wang, K.-C.; Chern, J.-W.* Nucleosides VII. Synthesis of N-Triphenylphosphoranylidene Nucleosides by Mitsunobu Reaction. A Novel Protecting Group for Primary Amines of Nucleosides. Tetrahedron Lett. 1995, 36, 7881-7884.
  1. Shih, Y.-C.; Liao, Y.-S.; Lin, C.-C.; Yang, Y.-Y.; Lin, J.-B.; Cheng, C.; He, J.-L.; Liao, Z.-Y.; Jen, C.-H.; Wu, Y.-J.; Chien, T.-C.* Synthesis of 6-Substituted Uracil and Uridine Derivatives. Collect. Symp. Ser. 201414, 129-132.
  2. Chien, T.-C.;* Jen, C.-H.; Wu, Y.-J.; Liao, C.-C. Chemical Models and Their Mechanistic Implications for the Transformation of 6-Cyanouridine 5'-Monophosphate Catalyzed by Orotidine 5'-Monophosphate Decarboxylase. Nucleic Acids Symp. Ser. 200852, 297-298.
  3. Chien, T.-C.;* Drach, J. C.; Townsend, L. B. Design and Synthesis of 1-(beta-D-Ribofuranosyl)imidazo[4,5-c]pyrazoles as 5:5 Bicyclic Analogs of Purine Nucleosides. Nucleic Acids Symp. Ser. 200852, 593-594.
国家 学校名称 系所 学位
台湾 国立台湾大学 化学系 学士
台湾 国防医学院 药学系 硕士
美国 密西根大学 化学系 博士
服务机关名称 单位 职务 期间
中原大学 化学系 兼任教授 2021.02 ~ 迄今
高雄医学大学 医药暨应用化学系 合聘教授 2020.08 ~ 迄今
国际纯粹化学与应用化学联盟 (IUPAC) 化学与人类健康领域 国家代表 2020.01 ~ 迄今
国立阳明大学 药学系 兼任教授 2019.02 ~ 迄今
国立台湾师范大学 化学系 教授 2017.08 ~ 迄今
国立台湾师范大学 化学系 副教授 2012.02 ~ 2017.07
国立台湾师范大学 化学系 助理教授 2006.08 ~ 2012.01
美国德州大学 药学院 博士后研究 2005.01 ~ 2006.01