杜玲嫻
姓名 杜玲嫻
電子郵件
聯絡電話 02-7749-6157
實驗室電話 02-7749-6178
職稱 教授
研究領域 有機化學,生物化學, 蛋白質錯誤摺疊與疾病研究
指導學生 碩二: 黃景鴻、李亭慧、單珮雅
碩一:  黃慈瑄、張家綺、潘沛君
1. Ling-Hsien Tu, Ning-Hsuan Tseng, Ya-Ru Tsai, Tien-Wei Lin, Yi-Wei Lo, Jien-Lin Charng, Hua-Ting Hsu, Yu-Sheng Chen, Rong-Jie Chen, Ying-Ta Wu, Yi-Tsu Chan, Chang-Shi Chen, Jim-Min Fang,* and Yun-Ru Chen* (2018, Oct). Rationally designed divalent caffeic amides inhibit amyloid-β fibrillization, induce fibril dissociation, and ameliorate cytotoxicity. European Journal of Medicinal Chemistry, 158, 393-404 
2. Arnaldo Serrano, Justin Lomont, Ling-Hsien Tu, Daniel Raleigh, and Martin Zanni* (2017, Oct). A free energy barrier caused by the refolding of an oligomeric intermediate controls the lag time of amyloid formation by hIAPP. Journal of the American Chemical Society, 139(46), pp 16748–16758. 
3. Lydia M. Young, Ling-Hsien Tu, Daniel P. Raleigh, Alison E. Ashcroft, and Sheena E. Radford* (2017, May). Understanding co-polymerization in amyloid formation by direct observation of mixed oligomers. Chemical Science, 8(7), 5030-5040.
4. Andisheh Abedini*, Annette Plesner, Ping Cao, Zachary Ridgway, Jinghua Zhang, Ling-Hsien Tu, Chris T Middleton, Brian Chao, Daniel J Sartori, Fanling Meng, Hui Wang, Amy G Wong, Martin T Zanni,C Bruce Verchere, Daniel P Raleigh*, Ann Marie Schmidt* (2016, May). Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics. eLIFE, 5:e12977. 
5. Rehana Akter, Ping Cao, Harris Noor, Zachary Ridgway, Ling-Hsien Tu, HuiWang, Amy G.Wong, Xiaoxue Zhang, Andisheh Abedini, AnnMarie Schmidt, and Daniel P. Raleigh* (2016). Islet Amyloid Polypeptide: Structure, Function, and Pathophysiology. Journal of Diabetes Research, Article ID 2798269. 
6. Daniel T. Meier, Ling-Hsien Tu, Sakeneh Zraika, Meghan F. Hogan, Andrew T. Templin, Rebecca L. Hull, Daniel P. Raleigh, and Steven E. Kahn* (2015, Dec). Matrix Metalloproteinase-9 Protects Islets from Amyloid induced Toxicity. Journal of Biological Chemistry, 290(51), 30475–30485. co-first author
7. Lydia M. Young, Rachel A. Mahood, Janet C. Saunders, Ling-Hsien Tu, Daniel P. Raleigh, Sheena E. Radford* and Alison E. Ashcroft* (2015, Oct). Insights into the consequences of co-polymerisation in the early stages of IAPP and Aβ peptide assembly from mass spectrometry. Analyst, 140, 6990–6999. 
8. Ling-Hsien Tu, Lydia M. Young, Amy G. Wong, Alison E. Ashcroft, Sheena E. Radford, and Daniel P. Raleigh* (2015, Jan). Mutational Analysis of the Ability of Resveratrol To Inhibit Amyloid Formation by Islet Amyloid Polypeptide: Critical Evaluation of the Importance of Aromatic−Inhibitor and Histidine−Inhibitor Interactions. Biochemistry, 54, 666-676. 
9. Lydia M. Young, Janet C. Saunders, Rachel A. Mahood, Charlotte H. Revill1, Richard J. Foster, Ling-Hsien Tu, Daniel P. Raleigh, Sheena E. Radford* and Alison E. Ashcroft* (2015, Jan). Screening and classifying small-molecule inhibitors of amyloid formation using ion mobility spectrometry–mass spectrometry. Nature Chemistry, 7, 73-81. 
10. Ling-Hsien Tu, Harris Noor, Ping Cao, and Daniel P. Raleigh* (2014, May). Aspirin, Diabetes, and Amyloid: Re-examination of the Inhibition of Amyloid Formation by Aspirin and Ketoprofen. ACS Chemical Biology, 9, 1632-1637.
11. Ling-Hsien Tu, Arnaldo L. Serrano, Martin T. Zanni, and Daniel P. Raleigh* (2014, Apr). Mutational Analysis of Preamyloid Intermediates: The Role of His-Tyr Interactions in Islet Amyloid Formation. Biophysical Journal, 106, 1520-1527.  
12. Ping Cao, Andisheh Abedini, Hui Wang, Ling-Hsien Tu, Xiaoxue Zhang, Ann Marie Schmidt, and Daniel P. Raleigh* (2013, Nov). Islet amyloid polypeptide toxicity and membrane interactions. Proceedings of the National Academy of Sciences, 110(48), 19279–19284. 
13. Ping Cao, Peter Marek, Harris Noor, Vadim Patsalo, Ling-Hsien Tu, Hui Wang, Andisheh Abedini, Daniel P. Raleigh* (2013, Apr). Islet amyloid: From fundamental biophysics to mechanisms of cytotoxicity. FEBS Letter, 587, 1106–1118. 
14. Ling-Hsien Tu and Daniel P. Raleigh* (2013, Jan). Role of Aromatic Interactions in Amyloid Formation by Islet Amyloid Polypeptide. Biochemistry, 52, 333-342. 
15. Ping Cao, Ling-Hsien Tu, Andisheh Abedini, Olesya Levsh, Rehana Akter, Vadim Patsalo, Ann Marie Schmidt, and Daniel P. Raleigh* (2012, Aug). Sensitivity of Amyloid Formation by Human Islet Amyloid Polypeptide to Mutations at Residue 20. Journal of Molecular Biology, 421, 282–295. 
16. Ming-Chang P. Yeh,* Wei-Jou Yeh, Ling-Hsien Tu, and Jia-Ru Wu (2006, Jun). CeCl3.7H2O–NaI catalyzed intramolecular addition reactions of 7-hydroxy-1,3-dienes: a facile approach to hexahydrobenzofurans and tetrahydrofurans. Tetrahedron, 62, 7466–7470. 
17. Ming-Chang P. Yeh,* Wen-Cheng Tsao, and Ling-Hsien Tu (2005, Oct). Palladium-Catalyzed Reaction of Aryl Bromides with 7-Hydroxy-1,3-Dienes. Organometallics, 24, 5909-5915. 
18.  Ming-Chang P. Yeh,* Wen-Cheng Tsao, Jin-Shen Ho, Chih-Chuan Tai, Dai-Yu Chiou, and Ling-Hsien Tu (2004, Jan). Rhodium(I)-Catalyzed Intramolecular Cyclohexadienyl Pauson-Khand Reaction: Facile Approach to Tricarbocycles. Organometallics, 23, 792-799. 
年度 論文名稱
2024 Unraveling the Underlying Mechanisms of Reduced Amyloidogenic Properties in Human Calcitonin via Double Mutations, Protein Science, Apr. 2024
2024 TPE conjugated islet amyloid polypeptide probe for detection of peptide oligomers, Biophysical Chemistry, Jan. 2024
2023 Beta amyloid oligomers with higher cytotoxicity have higher sidechain dynamics, Chemistry – A European Journal, Oct. 2023
2023 Piperic acid derivative as a molecular modulator to accelerate the IAPP aggregation process and alter its antimicrobial activity, Chemical Communications, Aug. 2023
2023 Synthesis of Fe3O4-Chlorophyllin Nanoparticles for Preventing Amyloid Formation by Human Calcitonin, ACS Applied Nano Materials, Jul. 2023
2023 Investigating the inhibitory property of DM hCT on hCT fibrillization via its relevant peptide fragments, Protein Science, Jun. 2023
2023 An environmentally sensitive molecular rotor as a NIR fluorescent probe for the detection of islet amyloid polypeptide, Talanta, vol. 254, Mar. 2023
2022 Aβ42 oligomers can seed the fibrillization of Aβ40 peptides, Journal of the Chinese Chemical Society, Aug. 2022
2022 Dihydrocaffeic acid decorated iron oxide nanomaterials effectively inhibit human calcitonin aggregation, ACS Omega, vol. 7, Aug. 2022
2022 Site specific NMR characterization of abeta-40 oligomers cross seeded by abeta-42 oligomers, Chemical Science, vol. 13, Jun. 2022
2022 Tyrosine 12 of human calcitonin modulates its amyloid formation, membrane binding, and bioactivity, Biochimie, vol. 197, Jun. 2022
2022 The Role of Aldehyde-Functionalized Crosslinkers on the Property of Chitosan Hydrogels, Macromolecular Bioscience, Feb. 2022
2021 Dopamine-Conjugated Carbon Dots Inhibit Human Calcitonin Fibrillation, nanomaterials, vol. 11, Aug. 2021
2021 Exploring the impact of glyoxal glycation on β-amyloid peptide (Aβ) aggregation in Alzheimer's disease, J. Phys. Chem. B, May. 2021
2020 TDP-43 interacts with amyloid-β, inhibits fibrillization, and worsens pathology in a model of Alzheimer’s disease, Nature Communications, vol. 11, Dec. 2020
2020 Role of Lysine Residue of Islet Amyloid Polypeptide in Fibril Formation, Membrane Binding, and Inhibitor Binding, Biochimie, vol. 177, Aug. 2020
2020 A Fluorogenic Molecule for Probing Islet Amyloid Using Flavonoid as a Scaffold Design, Biochemistry, vol. 59, Apr. 2020
2019 Inhibiting Human Calcitonin Fibril Formation with Its Most Relevant Aggregation-Resistant Analog, J. Phys. Chem. B, vol. 123, Nov. 2019
2019 Protein Glycation by Glyoxal Promotes Amyloid Formation by Islet Amyloid Polypeptide, Biophysical Journal, vol. 116, Jun. 2019
2018 Rationally designed divalent caffeic amides inhibit amyloid-β fibrillization, induce fibril dissociation, and ameliorate cytotoxicity, European Journal of Medicinal Chemistry, vol. 158, Oct. 2018
2017 A Free Energy Barrier Caused by the Refolding of an Oligomeric Intermediate Controls the Lag Time of Amyloid Formation by hIAPP, Journal of the American Chemical Society, vol. 139, Nov. 2017
年度 論文名稱
2019 Minimum Acquisition of Double Mutation in Human Calcitonin Enhances its Resistance to Fibrillization and its Use as Therapeutic Polypeptides, 26th American peptide symposium, Jun. 22-27, 2019, Monterey, USA
年度 計畫名稱 參與人 職稱/擔任之工作 計畫期間 補助/委託或合作機構
2021 以第二型糖尿病中有毒蛋白質寡聚體為目標，發展其偵測方式及策略計 畫以調控其生成(1/3) 主持人 2020.08 ~ 2021.07 科技部(原國科會)
2019 光敏性抗菌奈米纖維不織布於傷口敷料上之應用 國立臺灣師範大學 協同/共同主持人 2019.03 ~ 2019.12 其他
2020 探討與氧化壓力相關的異常鍵結修飾對阿茲海默病症β-類澱粉蛋白質聚集的影響 主持人 2018.08 ~ 2020.07 科技部(原國科會)
2018 研究醣化過程造成類澱粉蛋白產生的機制 主持人 2016.12 ~ 2018.07 科技部(原國科會)
國家 學校名稱 系所 學位 期間
美國 紐約州立大學石溪分校 化學所 博士 2008.08 ~ 2014.08
台灣 國立台灣師範大學 化學系 碩士 2003.09 ~ 2005.07
台灣 國立台灣師範大學 化學系 學士 1999.09 ~ 2003.06
服務機關名稱 單位 職務 期間
副教授 2021.02 ~ 迄今
國立台灣師範大學 化學系 助理教授 2016.08 ~ 2021.01
中央研究院 基因體中心 博士後研究學者 2014.09 ~ 2016.07