林文偉
姓名 林文偉
電子郵件 wenweilin@ntnu.edu.tw
聯絡電話 (02)77496131
網站 http://140.122.142.231/~wwlin/index.htm
實驗室電話 (02)77496200
職稱 特聘教授
研究領域
  • 不對稱有機催化反應的開發
  • 新穎合成反應的開發
  • 雜環化學合成、有機合成
學術專長 不對稱有機催化、有機磷誘導或催化反應、雜環化學合成、有機金屬。
指導學生 博士後研究員: Dr. 陳奕儒, Dr. Sandip Sambhaji Vagh, Dr. Balaji Dnyaneshwar Barve。
博士班: 柳彥成, 吳佩珊, Durga Prasad Gurram。
碩士班: 鄭蔚晴, 王品晴, 簡柏仲, 許瀞文, 張禎玲, 周宥成, 顏子峻, 薛智允, 黃炫瑞, 張晴棻。
 
實驗室 有機實驗室  / 有機不對稱催化和雜環化學研究實驗室
  1. Vagh, S.; Hou, B.-J.; Edukondalu, A.; Wang, P.-C.; Chen, Y.-R.; Lin, W.* "Phosphine-Mediated Rauhut-Currier-Type/Acyl Transfer/ Wittig Strategy for Synthesis of Spirocyclopenta[c]chromene-Indolinones" Adv. Synth. Catal. 2021, 363, 5429-5435.參考連結
  2. Khairnar, P.; Su, Y.-H.; Edukondalu, A.; Lin, W.* "Enantioselective Synthesis of Spiropyrazolone-Fused Cyclopenta[c]chromen-4-ones Bearing Five Contiguous Stereocenters via (3+2) Cycloaddition" J. Org. Chem. 2021, 86, 12326-12335參考連結
  3. Jeng, W.-C.; Chien, P.-C.; Vagh, S.; Edukondalu, A.; Lin, W.* "Organophosphane-Catalyzed Construction of Functionalized 2-Ylideneoxindoles via Direct β-Acylation" Synthesis 2021, 53, 4409-4418參考連結
  4. Liou, Y.-C.; Wang, H.-W.; Edukondalu, A.; Lin, W.* "Phosphine-Catalyzed Chemoselective Reduction/Elimination/Wittig Sequence for Synthesis of Functionalized 3-Alkenyl Benzofurans" Org. Lett. 2021, 23, 3064-3069.參考連結
     
  5. Edukondalu, A.; Vagh, S.; Lin, T.-H.; Lin, W.* "Construction of Indeno[1,2-b]pyrroles via Chemoselective N‒Acylation/Cyclization/Wittig Reaction Sequence" Chem. Commun. 2021, 57, 2045-2048.參考連結
  6. Vagh, S.; Hou, B.-J.; Edukondalu, A.; Wang, P.-C.; Lin, W.* "Phosphine-Mediated MBH-Type/Acyl Transfer/Wittig Sequence for Construction of Functionalized Furo[3,2-c]coumarins" Org. Lett. 2021, 23, 842-846.參考連結
  7. Khairnar, P.; Su, Y.-H.; Chen, Y.-C.; Edukondalu, A.; Chen, Y.-R.; Lin, W.* "Organophosphane-Catalyzed Direct β-Acylation of 4-Arylidene Pyrazolones and 5-Arylidene Thiazolones with Acyl Chlorides" Org. Lett. 2020, 22, 6868-6872.參考連結
  8. Wang, M.; Tseng, P.-Y.; Chi, W.-J.; Suresh, S.; Edukondalu, A.; Chen, Y.-R.; Lin, W.* "Diversity-Oriented Synthesis of Spirocyclohexene Indane-1,3-diones and Coumarin-Fused Cyclopentanes via an Organobase-Controlled Cascade Reaction" Adv. Synth. Catal. 2020362, 3407-3415. 參考連結
  9. Khairnar, P.; Wu, C.-Y.; Lin, Y.-F.; Edukondalu, A. Chen, Y.-R.; Lin, W.* "Diversity-Oriented Synthesis of Spiropentadiene Pyrazolones and 1-H-Oxepino[2,3-c]pyrazoles from Doubly Conjugated Pyrazolones via Intramolecular Wittig Reaction" Org. Lett. 202022, 4760-4765. 參考連結
  10. Vagh, S. S.; Karanam, P.; Liao, C.-C.; Lin, T.-H.; Liou, Y.-C.; Edukondalu, A.; Chen, Y.-R.; Lin, W.* "Enantioselective Construction of Spirooxindole-Fused Cyclopenta[c]chromen-4-ones Bearing Five Contiguous Stereocenters via a Stepwise (3+2) Cycloaddition" Adv. Synth. Catal. 2020362, 1679-1685. 
     
     參考連結
  11. Chiu, Y.-J.*; Lin, S.-A.*; Chen, W.-L.; Lin, T.-H.; Lin, C.-H.; Yao, C.-F.; Lin, W.; Wu, Y.-R.; Chang, K.-H.; Lee-Chen, G.-J.; Chen, C.-M. "Pathomechanism characterization and potential therapeutics identification for SCA3 targeting neuroinflammation " Aging 202012, 23619-23646. 參考連結
  12. Fan, C.-H.; Lin, C.-W.; Huang, H.-J.; Lee-Chen, G.-J.; Sun, Y.-C.; Lin, W.; Chen, C.-M.; Chang, K.-H.; Su, M.-T.*; Hsieh-Li, H. M.* "LMDS-1, a potential TrkB receptor agonist provides a safe and neurotrophic effect for early-phase Alzheimer's disease" Psychopharmacology 2020237, 3173–3190. 參考連結
  13. Lin, T.-H.; Chiu, Y.-J.; Lin, C.-Y.; Chao, C.-Y.; Chen, Y.-C.; Yang, S.-M.; Lin, W.; Hsieh-Li, H. M.; Wu, Y.-R.; Chang, K.-H.; Lee-Chen, G.-J.*; Chen, C. M.* "Exploration of multi-target effects of 3-benzoyl-5-hydroxychromen-2-one in Alzheimer's disease cell and mouse models" Aging Cell 202019, e13169. DOI: 10.1111/acel.13169 參考連結
  14. Chen, C. M.; Chen, W.-L.; Yang, S.-T.; Lin, T.-H.; Yang, S.-M.; Lin, W.; Chao, C.-Y.; Wu, Y.-R.; Chang, K.-H.; Lee-Chen, G.-J.* "New Synthetic 3-Benzoyl-5-Hydroxy-2H-Chromen-2-One (LM-031) Inhibits Polyglutamine Aggregation and Promotes Neurite Outgrowth through Enhancement of CREB, NRF2, and Reduction of AMPKα in SCA17 Cell Models" Oxid. Med. Cell. Longev. 2020 (1):1-17. 參考連結
  15. Liou, Y.-C.; Su, Y.-H.; Ku, K.-C.; Edukondalu, A.; Lin, C.-K.; Ke, Y.-S.; Karanam, P.; Lee, C.-J.; Lin, W.* "Organophosphane-Promoted Synthesis of Functionalized α,β-Unsaturated Alkenes and Furanones via Direct β-Acylation" Org. Lett. 201921, 8339-8343.
     
     參考連結
  16. Liou, Y.-C.; Karanam, P.; Jang, Y.-J.; Lin, W.* "Synthesis of Functionalized Benzofurans from para-Quinone Methides via Phospha-1,6-Addition/O-acylation/Wittig Pathway" Org. Lett. 201921, 8008-8012. 參考連結
  17. Khairnar, P.; Lung, T.-H.; Lin, Y.-J.; Wu, C.-Y.; Koppolu, S.; Edukondalu, A.; Karanam, P.; Lin, W.* "An Intramolecular Wittig Approach toward Heteroarenes: Synthesis of Pyrazoles, Isoxazoles, and Chromenone-oximes" Org. Lett. 201921, 4219-4223. 
     
     參考連結
  18. Yang, S.-M.; Karanam, P.; Wang, M.; Jang, Y.-J.; Yeh, Y.-S.; Tseng, P.-Y.; Reddy, G. M.; Liou, Y.-C.; Lin, W.* "A Vinylogous Michael Addition-Triggered Quadruple Cascade Reaction for the Enantioselective Generation of Multiple Quaternary Stereocenters" Chem. Commun. 201955, 1398-1401. 參考連結
  19. Karanam, P.; Reddy, G. M.; Lin, W.* "Strategic Exploitation of Wittig Reaction: Facile Synthesis of Heteroaromatics and Multifunctional Olefins" Synlett 201829, 2608-2622. 參考連結
  20. Lee, S.-Y.; Chiu, Y.-J.; Yang, S.-M.; Chen, C.-M.; Huang, C.-C.; Lee-Chen, G.-J.*; Lin, W.*; Chang, K.-H.* "Novel Synthetic Chalcone–coumarin Hybrid for Aβ Aggregation Reduction, Antioxidation, and NeuroprotectionCNS Neurosci. Ther. 201824, 1286-1298. 參考連結
  21. Chen, Y.-R.; Reddy, G. M.; Hsieh, K.-H.; Chen, K.-H.; Karanam, P.; Vagh, S. S.; Liou, Y.-C.; Lin, W.* "3-Homoacyl coumarin: an all carbon 1,3-dipole for enantioselective concerted (3+2) cycloaddition" Chem. Commun. 201854, 12702-12705. 參考連結
  22. Yu, J.-K.; Chien, H.-W.; Lin, Y.-J.; Karanam, P.; Chen, Y.-H.; Lin, W.* "Diversity-oriented synthesis of chromenopyrrolidines from azomethine ylides and 2-hydroxybenzylidene indandiones via base-controlled regiodivergent (3+2) cycloaddition" Chem. Commun. 201854, 9921-9924. 參考連結
  23. Yang, S.-M.; Wang, C.-Y.; Lin, C.-K.; Karanam, P.; Reddy, G. M.; Tsai, Y.-L.; Lin, W.* "Diversity-Oriented Synthesis of Furo[3,2-c]coumarins and Benzofuranyl Chromenones via Chemoselective Acylation/Wittig Reaction" AngewChemIntEd201857, 1668-1672; AngewChem2018130, 1684-1688. 參考連結
  24. Karanam, P.; Reddy, G. M.; Koppolu, S. R.; Lin, W.* "Recent topics of phosphine-mediated reactions" Tetrahedron Lett201859, 59-76. 參考連結
  25. Yang, S.-M.; Tsai, Y.-L.; Reddy, G. M.; Moehlmann, L.; Lin, W.* "Chemo- and diastereoselective Michael-Michael-acetalization cascade for the synthesis of 1,3-indandione-fused spiro[4.5]decan scaffolds" J. Org. Chem. 201782, 9182-9190. 參考連結
  26. Yang, S.-M.; Reddy, G. M.; Wang, T.-P.; Yeh, Y.-S.; Wang, M.; Lin, W.* "An Enantioselective Cascade for Simultaneous Generation of Five Quaternary Stereocenters from Fully Substituted Enones" Chem. Commun. 201753, 7649-7652. 參考連結
  27. Chen, Y.-R.; Reddy, G. M.; Hong, S.-H.; Wang, Y.-Z.; Yu, J.-K.; Lin, W.* "Four-component synthesis of phosphonium salts: application toward an alternative approach to cross-coupling for the synthesis of bis-heteroarenes" Angew. Chem. Int. Ed. 201756, 5106-5110; Angew. Chem. 2017129, 5188-5192.  參考連結
  28. Yang, S.-M.; Reddy, G. M.; Liu, M.-H.; Wang, T.-P.; Yu, J.-K.; Lin, W.* "Diastereoselective Synthesis of Rauhut-Currier-Type Adducts via An Unexpected α-Addition of α,β-Unsaturated r-Butyrolactams to Coumarin Derivatives" J. Org. Chem. 201782, 781-789. 參考連結
  29. Chang, G.-H.; Wang, C.-Y.; Reddy, G. M.; Tsai, Y.-L.; Lin, W.* "Enantioselective synthesis of polysubstituted benzopyrano[3,4-c]pyrrolidine frameworks via [3+2] cycloaddition of azomethine ylides and coumarin derivatives" J. Org. Chem. 201681, 10071-10080. 參考連結
  30. Lee, C.-J.; Chang, T.-H.; Yu, J.-K.; Reddy, G. M.; Hsiao, M.-Y.; Lin, W.* "Synthesis of functionalized furans via chemoselective reduction/Wittig reaction using catalytic triethylamine and phosphine" Org. Lett. 201618, 3758-3761. 參考連結
  31. Reddy, G. M.; Ko, C.-T.; Hsieh, K.-H.; Lee, C.-J.; Das, U.; Lin, W.* "Expanding the scope of primary amine catalysis: Highly stereoselective synthesis of indanedione-fused 2,6-disubstituted trans-spirocyclohexanones" J. Org. Chem. 201681, 2420-2431. 參考連結
  32. Moehlmann, L.; Chang, G.-H.; Reddy, G. M.; Lee, C.-J.; Lin, W.* "Organocatalytic enantioselective synthesis of tetrahydrofluoren-9-ones via vinylogous Michael addition/Henry reaction cascade of 1,3-indandione-derived pronucleophiles" Org. Lett. 201618, 688-691. 參考連結
  33. Lee, C.-J.; Tsai, C.-C.; Hong, S.-H.; Chang, G.-H.; Yang, M.-C.; Moehlmann, L.; Lin, W.* "Preparation of Furo[3,2-c]coumarins from 3-Cinnamoyl-4-hydroxy-2H-chromen-2-ones and Acyl Chlorides: A Bu3P-Mediated C-Acylation/Cyclization Sequence" Angew. Chem. Int. Ed. 201554, 8502-8505; Angew. Chem. 2015127, 8622-8625. 參考連結
  34. Tsai, Y.-L.;  Lin, W.* "Synthesis of multifunctional alkenes from substituted acrylates and aldehydes via phosphine-catalyzed Wittig reaction" Asian J. Org. Chem. 2015, 4, 1040-1043. 參考連結
  35. Chen, C.-H.; Ko, C.-T.; Reddy, G. M.; Lee, C.-J.; Lin, W.* "An enantioselective synthesis of substituted cyclohexanone derivatives with an all-carbon quaternary stereocenter by using an organocatalytic asymmetric domino double Michael addition" Eur. J. Org. Chem. 2015, 5254-5265. 參考連結
  36. Jang, Y.-J.; Chen, Y.-S.; Lee, C.-J.; Chen, C.-H.; Reddy G. M.; Ko, C.-T.; Lin, W.* "Asymmetric organocatalytic synthesis of highly substituted cyclohexenols via domino double Michael reactions of 1-hydroxy-1,4-dien-3-ones and 2-alkylidene malononitirles" Eur. J. Org. Chem. 2015, 2066-2074. 參考連結
  37. Chen, Y.-R.; Das, U.; Liu, M.-S.; Lin, W.* "Organocatalytic Enantioselective Direct Vinylogous Michael Addition of alpha,belta-Unsaturated gamma-Butyrolactam to belta-Acyl Acrylates and 1,2-Diacylethylenes” J. Org. Chem. 2015, 80, 1985-1992. 參考連結
  38. Jang, Y.-J.; Chen, Y.-S.; Lee, C.-J.; Chen, C.-H.; Lin, W.* "Base-Catalyzed Domino Double Michael Reactions of 1-Hydroxy-1,4-dien-3-ones and 2-Alkylidene Malononitirles: A Diastereoselective Route to Polysubstituted 4-Hydroxy-3-keto-cyclohex-3-ene” Synthesis 201547, 95-107. 參考連結
  39. Fan, Y.-S.; Das, U.; Hsiao, M.-Y.; Liu, M.-S.; Lin, W.* "Chemoselective Intramolecular Wittig Reactions for the Synthesis of Oxazoles and Benzofurans” J. Org. Chem. 201479, 11567-11582. 參考連結
  40. Das, U.; Tsai, Y.-L.; Lin, W.* "Preparation of functionalized heteroaromatics using intramolecular Wittig reaction" Org. Biomol. Chem. 201412, 4044-4050. (Perspective) (This article is part of the themed collection: 2014 Hot Articles in Organic and Biomolecular Chemistry參考連結
  41. Tsai, Y.-L.; Syu, S.; Yang, S.-M.; Das, U.; Fan, Y.-S.; Lee, C.-J.; Lin, W.* "Synthesis of Multi-Functional Alkenes via Wittig Reaction with a New-Type of Phosphorus Ylides” Tetrahedron 2014, 70, 5038-5045參考連結
  42. Lee, C.-J.; Sheu, C.-N.; Tsai, C.-C.; Wu, Z.-Z.; Lin, W.* "Direct  β-Acylation of 2-Arylidene-1,3-indandiones with Acyl Chlorides Catalyzed by Organophosphanes” Chem. Commun. 201450, 5304-5306.(Featured in "Emerging investigators" issue 2014) 參考連結
  43. "Contributors to the Emerging Investigators Issue 2014", Chem. Commun. 201450, 5100-5114. 參考連結
  44. Lee, Y.-T.; Das, U.; Chen, Y.-R.; Lee, C.-J.; Chen, C.-H.; Yang, M.-C.; Lin, W.* "Enantioselective Synthesis of Coumarin Derivatives Catalyzed by Primary Amine" Adv. Synth. Catal. 2013355, 3154-3160. 參考連結
  45. Tsai, Y.-L.; Fan, Y.-S.; Lee, C.-J.; Huang, C.-H.; Das, U.; Lin, W.* "An Efficient Synthesis of Trisubstituted Oxazoles via Chemoselective O-Acylations and Intramolecular Wittig Reactions" Chem. Commun. 201349, 10266-10268. 參考連結
  46. Lee, Y.-T.; Lee, Y.-T.; Lee, C.-J.; Sheu, C.-N.; Lin, B.-Y.; Wang, J.-H.*; Lin, W.* "Chemoselective Synthesis of Tetrasubstituted Furans via Intramolecular Wittig Reactions: Mechanism and Theoretical Analysis" Org. Biomol. Chem. 201311, 5156-5161. 參考連結
  47. Tsai, Y.-L.; Das, U.; Syu, S.; Lee, C.-J.; Lin, W.* "Facile synthesis of functional tricyclic fused furans via intramolecular Wittig reactions" Eur. J. Org. Chem. 2013, 4634-4641參考連結
  48. Das, U.; Chen, Y.-R.; Tsai, Y.-L.; Lin, W.* "Organocatalytic enantioselective direct vinylogous Michael addition of r-substituted butenolides to 3-aroyl acrylates and 1,2-diaroylethylenes"Chem. Eur. J. 201319, 7713-7717. 參考連結
  49. Wu, Z.-Z.; Jang, Y.-J.; Lee, C.-J.; Lee, Y.-T.; Lin, W.* "A Versatile and Practical Method for Regioselective Synthesis of Polysubstituted Furanonaphthoquinones" Org. Biomol. Chem. 201311, 828-834. (HOT article) 參考連結
  50. Das, U.; Tsai, Y.-L.; Lin, W.* "An efficient organocatalytic enantioselective synthesis of spironitrocyclopropanes" Org. Biomol. Chem. 201311, 44-47. (HOT communication) 參考連結
  51. Lee, Y.-T.; Jang, Y.-J.; Syu, S.; Chou, S.-C.; Lee, C.-J.; Lin, W.* “Preparation of Functional Benzofurans and Indoles via Chemoselective Intramolecular Wittig Reactions" Chem. Commun. 201248, 8135-8137. 參考連結
  52. Das, U.; Huang, C.-H.; Lin, W.* "Enantioselective synthesis of substituted pyrans via amine-catalyzed Michael addition and subsequent enolization/cyclisation" Chem. Commun. 201248, 5590-5592. (Featured in "Organocatalysis" Web-themed issue) 參考連結
  53. Lee, C.-J.; Jang, Y.-J.; Wu, Z.-Z. ; Lin, W.* "Preparation of Functional Phosphorus Zwitterions from Activated Alkanes, Aldehydes, and Tributylphosphine: Synthesis of Polysubstituted Furo[3,2-c]coumarins" Org. Lett. 201214, 1906-1909. 參考連結
  54. Jang, Y.-J.; Syu, S.; Jhang, Y.-W.; Lee, Y.-T.; Lee, C.-J.; Chen, K.-W.; Das, U.; Lin, W.* "Tandem three-component reactions of aldehyde, alkyl acrylate, and dialkylmalonate catalyzed by ethyl diphenylphosphine" Molecules 201217, 2529-2541. 參考連結
  55. Syu, S.; Huang, C.-H.; Chen, K.-W.; Lee, C.-J.; Das, U.; Jang, Y.-J.; Lin, W.* "Enantioselective organocatalytic Michael addition of ketones to alkylidene malonates"Chirality 201224, 600-605參考連結
  56. Jang, Y.-J.; Syu, S.; Chen, Y.-J.; Yang, M.-C.; Lin, W.* "Syntheses of Furo[3,4-c]coumarins and Related Furyl Coumarin Derivatives via Intramolecular Wittig Reactions" Org. Biomol. Chem. 201210, 843-847. 參考連結
  57. Syu, S.; Lee, Y.-T.; Jang, Y.-J.; Lin, W.* "Preparation of Functional Benzofurans, Benzothiophenes, and Indoles Using Ester, Thioester, and Amide via Intramolecular Wittig Reactions" Org. Lett. 201113, 2970-2973. 參考連結
  58. Syu, S.; Lee, Y.-T.; Jang, Y.-J.; Lin, W.* "Organocatalytic tandem three-component reaction of imine, alkyl vinyl ketone, and imide via aza-Baylis-Hillman reaction" J. Org. Chem. 201176, 2888-2891. 參考連結
  59. Chen, K.-W.; Syu, S.; Jang, Y.-J.; Lin, W.* "A facile approach to highly functional trisubstituted furans via intramolecular Wittig reactions"Org. Biomol. Chem. 20119, 2098-2106. 參考連結
  60. Wang, D.-W.; Syu, S.; Hung, Y.-T.; Chen, P.; Lee, C. J.; Chen, K.-W.; Chen, Y.-J.; Lin, W.* "Organocatalytic Tandem Three-Component Reaction of Aldehyde, Alkyl Vinyl Ketone, and Amide: One-Pot Syntheses of Highly Functional Alkenes"Org. Biomol. Chem. 20119, 363-366. 參考連結
  61. Syu, S.; Wang, D.-W.; Chen, P.; Hung, Y.-T.; Jhang, Y.-W.; Kao, T.-T.; Lee, Y.-T.; Lin, W.* "Tandem Three-Component Reaction of Aldehyde, Alkyl Acrylate and Amide Using Ethyl Diphenylphosphine as Organocatalyst" Tetrahedron Lett. 201051, 5943-5946.
    參考連結
  62. Kao, T.-T.; Syu, S.; Jhang, Y.-W.; Lin, W.* "Preparation of Tetrasubstituted Furans via Intramolecular Wittig Reactions with Phosphorus Ylides as Intermediates", Org. Lett. 201012, 3066-3069. 參考連結
  63. Syu, S.; Kao, T.-T.; Lin, W.* "A New Type of Organocatalyst for Highly Stereoselective Michael Addition of Ketones to Nitroolefins on Water", Tetrahedron 201066, 891–897. 參考連結
  64. Lin, W.; Chen, L.; Knochel, P.* "Preparation of Functionalized 3,4-Pyridynes via 2-Magnesiated Diaryl Sulfonates", Tetrahedron 200763, 2787-2797.
  65. Lin, W.; Ilgen, F.; Knochel, P.* "Preparation of Highly Functionalized Arylmagnesium Reagents by the Addition of Magnesium Phenylselenide to Arynes", Tetrahedron Lett2006, 47, 1941-1944.
  66. Lin, W.; Baron, O.; Knochel, P.* "Highly Functionalized Benzene Syntheses by Directed Mono or Multiple Magnesiations with TMPMgCl‧LiCl", Org. Lett. 20068, 5673-5676.
  67. Sapountzis, I.; Lin, W.; Kofink, C. C.; Despotopoulou, C.; Knochel, P.* "Iron-Catalyzed Aryl-Aryl Cross-Couplings with Magnesium-Derived Copper Reagents", Angew. Chem. Int. Ed. 200544, 1654-1657. Angew. Chem. 2005117, 1682-1685.
  68. Lin, W.; Sapountzis, I.; Knochel, P.* "Preparation of Functionalized Aryl Magnesium Reagents by the Addition of Magnesium Aryl Thiolates and Amides to Arynes", Angew. Chem. Int. Ed. 200544, 4258-4261. Angew. Chem. 2005117, 4330-4333.
  69. Sapountzis, I.; Lin, W.; Fischer, M.; Knochel, P.* "Preparation of Polyfunctional Arynes via 2-Magnesiated Diaryl sulfonates", Angew. Chem. Int. Ed. 200443, 4364-4366. Angew. Chem. 2004116, 4464-4466.
  70. Jang, Y.-J.; Lin, W.-W.; Shih, Y.-K.; Liu, J.-T.; Hwang, M.-H.; Yao, C.-F.* "An Easy One-Pot Method for the Synthesis of 2,2-Disubstituted 1-Nitroalkenes", Tetrahedron 200359, 4979-4992.
  71. Lin, W.-W.; Jang, Y.-J.; Wang, Y.; Liu, J.-T.; Hu, S.-R.; Wang, L.-Y.; Yao, C.-F.* "An Improved and Easy Method for the Preparation of 2,2-Disubstituted 1-Nitroalkenes", J. Org. Chem. 200166, 1984-1991.
  72. Liu, J.-T; Lin, W.-W.; Jang, J.-J.; Liu, J.-Y.; Yan, M.-C.; Hung, C.; Kao, K.-H.; Wang, Y.; Yao, C.-F.* "One-pot synthesis of six- or five-membered carbocycles through intramolecular cycloadditions by the use of ethyl chloroformate", Tetrahedron 199955, 7115-7128.
  73. Yan, M.-C.; Liu, J.-Y.; Lin, W.-W.; Kao, K.-H.; Liu, J.-T; Jang, J.-J.; Yao, C.-F.* "One-Pot Synthesis of Five-Membered Cyclic Thioethers or Ethers via Intramolecular Nitrile Oxide-Olefin Cycloaddition (INOC) or Intramolecular Alkoxycarbonyl Nitronate-Olefin Cycloaddition (IAOC) by the use of Methyl Chloroformate", Tetrahedron 199955, 12493-12514.
  74. Lee-Chen, G.-J.; Lin, W. "Method for Treating Abnormal B-Amyloid Aggregation Mediated Diseases" 2018, United States Patent (Publication Number:  US 2018/0042864A1).
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  75. 李桂楨、林文偉 2018 化合物用於製備治療不正常乙型-澱粉樣蛋白聚集類疾病之醫藥組成物之用途” 中華民國專利證書發明第I 633881  附件檔案 Adobe PDF
  76. Knochel, P.; Sapountzis, I; Korn, T.; Lin, W.; Kofink, C. C. 2010, “Iron or Cobalt-Catalyzed Carbon-Carbon Coupling Reaction of Aryls, Alkenes and Alkines with Copper Reagents” European Patent EP1799627 (Publication Number:  WO/2006/040131; International Application No.:  PCT/EP2005/010936; Publication Date: 05.05.2010; International Filing Date: 11.10.2005).
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  77. Knochel, P.; Sapountzis, I; Korn, T.; Lin, W.; Kofink, C. C. 2008, “Iron or Cobalt-Catalyzed Carbon-Carbon Coupling Reaction of Aryls, Alkenes and Alkines with Copper Reagents” United States Patent US20080269514 (Publication Number:  WO/2006/040131; International Application No.:  PCT/EP2005/010936; Publication Date: 30.10.2008; International Filing Date: 11.10.2005).
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  81. 蔡乙鈴,范宇琇,林文偉,"發展新穎的分子內Wittig反應來合成芳香族的雜環化合物",自然科學簡訊,第二十五卷,第四期,第162頁至第168頁 參考連結 附件檔案 Adobe PDF
年度 論文名稱
2021 Organophosphane-Catalyzed Construction of Functionalized 2-Ylideneoxindoles via Direct β-Acylation, Synthesis-Stuttgart, vol. 53, Dec. 2021
2021 Phosphine-Mediated Rauhut-Currier-Type/Acyl Transfer/Wittig Strategy for Synthesis of Spirocyclopenta[c]chromene-Indolinones, Advanced Synthesis & Catalysis, vol. 363, Dec. 2021
2021 Enantioselective Synthesis of Spiropyrazolone-Fused Cyclopenta[c]chromen-4-ones Bearing Five Contiguous Stereocenters via (3+2) Cycloaddition, The Journal of Organic Chemistry, vol. 86, Sep. 2021
2021 Phosphine-Catalyzed Chemoselective Reduction/Elimination/Wittig Sequence for Synthesis of Functionalized 3-Alkenyl Benzofurans, Organic Letters, vol. 23, Apr. 2021
2021 Phosphine-Mediated MBH-Type/Acyl Transfer/Wittig Sequence for Construction of Functionalized Furo[3,2-c]coumarins, Organic Letters, vol. 23, Feb. 2021
2021 Construction of Indeno[1,2-b]pyrroles via Chemoselective N‒Acylation/Cyclization/Wittig Reaction Sequence, Chemical Communications, vol. 57, Feb. 2021
2020 Organophosphane-Catalyzed Direct β-Acylation of 4-Arylidene Pyrazolones and 5-Arylidene Thiazolones with Acyl Chlorides, Organic Letters, vol. 22, Sep. 2020
2020 Diversity-Oriented Synthesis of Spirocyclohexene Indane-1,3-diones and Coumarin-Fused Cyclopentanes via an Organobase-Controlled Cascade Reaction, Advanced Synthesis & Catalysis, vol. 362, Aug. 2020
2020 Diversity-Oriented Synthesis of Spiropentadiene Pyrazolones and 1-H-Oxepino[2,3-c]pyrazoles from Doubly Conjugated Pyrazolones via Intramolecular Wittig Reaction, Organic Letters, vol. 22, Jun. 2020
2020 Enantioselective Construction of Spirooxindole-Fused Cyclopenta[c]chromen-4-ones Bearing Five Contiguous Stereocenters via a Stepwise (3+2) Cycloaddition, Advanced Synthesis & Catalysis, vol. 362, Apr. 2020
2019 Organophosphane-Promoted Synthesis of Functionalized α,β-Unsaturated Alkenes and Furanones via Direct β-Acylation, Organic Letters, vol. 21, Oct. 2019
2019 Synthesis of Functionalized Benzofurans from para-Quinone Methides via Phospha-1,6-Addition/O-acylation/Wittig Pathway, Organic Letters, vol. 21, Sep. 2019
2019 An Intramolecular Wittig Approach toward Heteroarenes: Synthesis of Pyrazoles, Isoxazoles, and Chromenone-oximes, Organic Letters, vol. 21, Jun. 2019
2019 A vinylogous Michael addition-triggered quadruple cascade reaction for the enantioselective generation of multiple quaternary stereocenters, Chemical Communications, vol. 55, Feb. 2019
2018 Strategic Exploitation of Wittig Reaction: Facile Synthesis of Heteroaromatics and Multifunctional Olefins, Synlett, vol. 29, Dec. 2018
2018 Novel Synthetic Chalcone–coumarin Hybrid for Aβ Aggregation Reduction, Antioxidation, and Neuroprotection, CNS Neuroscience & Therapeutics, vol. 24, Dec. 2018
2018 3-Homoacyl coumarin: an all carbon 1,3-dipole for enantioselective concerted (3+2) cycloaddition, Chemical Communications, vol. 54, Nov. 2018
2018 Diversity-oriented synthesis of chromenopyrrolidines from azomethine ylides and 2-hydroxybenzylidene indandiones via base-controlled regiodivergent (3+2) cycloaddition, Chemical Communications, vol. 54, Sep. 2018
2018 Diversity-Oriented Synthesis of Furo[3,2-c]coumarins and Benzofuranyl Chromenones via Chemoselective Acylation/Wittig Reaction, Angewandte Chemie International Edition, vol. 57, Feb. 2018
2018 Recent topics of phosphine-mediated reactions, Tetrahedron Letters, vol. 59, Jan. 2018
2017 Chemo- and diastereoselective Michael-Michael-acetalization cascade for the synthesis of 1,3-indandione-fused spiro[4.5]decan scanffolds, The Journal of Organic Chemistry, vol. 82, Sep. 2017
2017 An Enantioselective Cascade for Simultaneous Generation of Five Quartenary Stereocenters from Fully Substituted Enones, Chemical Communicatons, vol. 53, Jul. 2017
2017 Four-component synthesis of phosphonium salts: application toward an alternative approach to cross-coupling for the synthesis of bis-heteroarenes, Angewandte Chemie International Edition, vol. 56, Apr. 2017
2017 Diastereoselective Synthesis of Rauhut-Currier-Type Adducts via An Unexpected alpha,beta-Unsaturated gamma-Butyrolactams to Coumarin Derivatives, The Journal of Organic Chemistry, vol. 82, Jan. 2017
2016 Enantioselective synthesis of polysubstituted benzopyrano[3,4-c]pyrrolidine frameworks via [3+2] cycloaddition of azomethine ylides and coumarin derivatives, The Journal of Organic Chemistry, vol. 81, Oct. 2016
2016 Synthesis of functionalized furans via chemoselective reduction/Wittig reaction using catalytic triethylamine and phosphine, Organic Letters, vol. 18, Aug. 2016
2016 Expanding the Scope of Primary Amine Catalysis: Stereoselective Synthesis of Indanedione-Fused 2,6-Disubstituted trans-Spirocyclohexanones, The Journal of Organic Chemistry, vol. 81, Mar. 2016
2016 Organocatalytic Enantioselective Synthesis of Tetrahydrofluoren-9-ones via Vinylogous Michael Addition/Henry Reaction Cascade of 1,3-Indandione-Derived Pronucleophiles, Organic Letters, vol. 18, Feb. 2016
2015 Synthesis of multi-functional alkenes from substituted acrylates and aldehydes via phosphine-catalyzed Wittig reaction, Asian Journal Organic Chemistry, vol. 4, Sep. 2015
2015 An enantioselective synthesis ofsubstituted cyclohexane derivatives bearing an all-carbon quaternary stereocenter via organocatalytic asymmetric domino double Michael reaction, European Journal of Organic Chemistry, vol. 2015, Jul. 2015
2015 Preparation of Furo[3,2-c]coumarins from 3-Cinnamoyl-4-hydroxy-2H-chromen-2-ones and Acyl Chlorides: A Bu3P-Mediated C-Acylation/Cyclization Sequence, Angewandte Chemie International Edition, vol. 54, Jul. 2015
2015 Asymmetric organocatalytic synthesis of highly substituted cyclohexenols via domino double Michael reactions of 1-hydroxy-1,4-dien-3-ones and 2-alkylidene malononitirles, European Journal of Organic Chemistry, vol. 2015, Mar. 2015
2015 Organocatalytic Enantioselective Direct Vinylogous Michael Addition of alpha,belta-Unsaturated gamma-Butyrolactam to belta-Acyl Acrylates and 1,2-Dacylethylenes, The Journal of Organic Chemistry, vol. 80, Jan. 2015
2015 Base-Catalyzed Domino Double Michael Reactions of 1-Hydroxy-1,4-dien-3-ones and 2-Alkylidene Malononitirles: A Diastereoselective Route to Polysubstituted 4-Hydroxy-3-keto-cyclohex-3-enes, Synthesis-Stuttgart, vol. 47, Jan. 2015
2014 Chemoselective Intramolecular Wittig Reactions for the Synthesis of Oxazoles and Benzofurans, The Journal of Organic Chemistry, vol. 79, Dec. 2014
2014 Synthesis of Multi-Functional Alkenes via Wittig Reaction with a New-Type of Phosphorus Ylides, Tetrahedron, vol. 70, Aug. 2014
2014 Preparation of functionalized heteroaromatics using intramolecular Wittig reaction, Organic and Biomolecular Chemistry, vol. 12, Jun. 2014
2014 Direct β-Acylation of 2-Arylidene-1,3-indandiones with Acyl Chlorides Catalyzed by Organophosphanes, Chemical Communications, vol. 50, Apr. 2014
2013 Enantioselective Synthesis of Coumarin Derivatives Catalyzed by Primary Amine, Advanced Synthesis & Catalysis, vol. 355, Dec. 2013
2013 An Efficient Synthesis of Trisubstituted Oxazoles via Chemoselective O-acylations and Intramolecular Wittig Reactions, Chemical Communications, vol. 49, Nov. 2013
2013 Chemoselective Synthesis of Tetrasubstituted Furans via Intramolecular Wittig Reactions: Mechanism and Theoretical Analysis, Organic and Biomolecular Chemistry, vol. 11, Jul. 2013
2013 Facile synthesis of functional tricyclic fused furans via intramolecular Wittig reactions, European Journal of Organic Chemistry, vol. 2013, Jul. 2013
2013 Organocatalytic enantioselective direct vinylogous Michael addition of r-substituted butenolides to 3-aroyl acrylates and 1,2-diaroylethylenes, Chemistry - A European Journal, vol. 19, Jun. 2013
2013 A Versatile and Practical Method for Regioselective Synthesis of Polysubstituted Furanonaphthoquinones, Organic and Biomolecular Chemistry, vol. 11, Jan. 2013
2013 An efficient organocatalytic enantioselective synthesis of spironitrocyclopropanes, Organic and Biomolecular Chemistry, vol. 11, Jan. 2013
2012 Preparation of Functional Benzofurans and Indoles via Chemoselective Intramolecular Wittig Reactions, Chemical Communications, vol. 48, Aug. 2012
2012 Enantioselective organocatalytic Michael addition of ketones to alkylidene malonates, Chirality, vol. 24, Aug. 2012
2012 Enantioselective synthesis of substituted pyrans via amine-catalyzed Michael addition and subsequent enolization/cyclisation, Chemical Communications, vol. 48, Jun. 2012
2012 Preparation of Functional Phosphorus Zwitterions from Activated Alkanes, Aldehydes, and Tributylphosphine: Synthesis of Polysubstituted Furo[3,2-c]coumarins, Organic Letters, vol. 14, Apr. 2012
2012 Tandem Three-Component Reactions of Aldehyde, Alkyl Acrylate, and Dialkylmalonate Catalyzed by Ethyl Diphenylphosphine, Molecules, vol. 17, Mar. 2012
2012 Syntheses of furo[3,4-c]coumarins and related furyl coumarin derivatives via intramolecular Wittig reactions, Organic and Biomolecular Chemistry, vol. 10, Jan. 2012
2011 Preparation of Functional Benzofurans, Benzothiophenes, and Indoles Using Ester, Thioester, and Amide via Intramolecular Wittig Reactions, Organic Letters, vol. 13, Jun. 2011
2011 Organocatalytic tandem three-component reaction of imine, alkyl vinyl ketone, and imide via aza-Baylis-Hillman reaction, The Journal of Organic Chemistry, vol. 76, Apr. 2011
2011 A facile approach to highly functional trisubstituted furans via intramolecular Wittig reactions, Organic and Biomolecular Chemistry, vol. 9, Mar. 2011
2011 Organocatalytic Tandem Three-Component Reaction of Aldehyde, Alkyl Vinyl Ketone, and Amide: One-Pot Syntheses of Highly Functional Alkenes, Organic and Biomolecular Chemistry, vol. 9, Jan. 2011
2010 Tandem Three-Component Reaction of Aldehyde, Alkyl Acrylate and Amide Using Ethyl Diphenylphosphine as Organocatalyst, Tetrahedron Lett., vol. 51, Sep. 2010
2010 Preparation of Tetrasubstituted Furans via Intramolecular Wittig Reactions with Phosphorus Ylides as Intermediates, Organic Letters, vol. 12, Jul. 2010
2010 A New Type of Organocatalyst for Highly Stereoselective Michael Addition of Ketones to Nitroolefins on Water, Tetrahedron, vol. 66, Jan. 2010
年度 計畫名稱 參與人 職稱/擔任之工作 計畫期間 補助/委託或合作機構
2024 開發新穎的磷偶極體之合成方法及其應用在多官能基雜環分子之多樣性導向合成 主持人 2023.08 ~ 2024.07 科技部(原國科會)
2023 開發新穎的磷偶極體之合成方法及其應用在多官能基雜環分子之多樣性導向合成 主持人 2022.08 ~ 2023.07 科技部(原國科會)
2022 化學學門(有機組與無機組)研究發展推動計畫(2/2) 國立臺灣師範大學 協同/共同主持人 2022.01 ~ 2022.12 科技部(原國科會)
2022 開發新穎的磷偶極體之合成方法及其應用在多官能基雜環分子之多樣性導向合成 主持人 2021.08 ~ 2022.07 科技部(原國科會)
2021 新型的磷偶極體和有機磷鹽之製備及其應用在芳香雜環分子之合成 主持人 2020.08 ~ 2021.07 科技部(原國科會)
2020 新型的磷偶極體和有機磷鹽之製備及其應用在芳香雜環分子之合成 主持人 2019.08 ~ 2020.07 科技部(原國科會)
2019 新型的磷偶極體和有機磷鹽之製備及其應用在芳香雜環分子之合成 主持人 2018.08 ~ 2019.07 科技部(原國科會)
2018 發展新穎的有機磷誘導或催化反應:合成具官能基的雜環芳香族化合物 主持人 2017.08 ~ 2018.07 科技部(原國科會)
2017 有機催化Michael或連鎖反應的研究:合成具光學活性香豆素衍生物 主持人 2016.08 ~ 2017.07 科技部(原國科會)
2017 發展新穎的有機磷誘導或催化反應:合成具官能基的雜環芳香族化合物 主持人 2016.08 ~ 2017.07 科技部(原國科會)
2016 發展新穎的有機磷誘導或催化反應:合成具官能基的雜環芳香族化合物 主持人 2015.08 ~ 2016.07 科技部(原國科會)
2016 有機催化 Michael 或 連鎖反應的研究: 合成具光學活性香豆素衍生物 主持人 2015.08 ~ 2016.07 科技部(原國科會)
2015 有機催化 Michael 或 連鎖反應的研究: 合成具光學活性香豆素衍生物 主持人 2014.08 ~ 2015.07 科技部(原國科會)
2015 磷試劑對親電子性化合物進行Michael 加成或1,2-加成產生Wittig試劑 的研究及此類反應在有機合成上的應用 主持人 2014.08 ~ 2015.07 科技部(原國科會)
2015 多麩醯胺小腦萎縮症/阿茲海默氏症的藥物開發-(子計畫二)以粒線體新 生成及氧化壓力為目標的多麩醯胺小腦萎縮症及阿茲海默氏症治療策略(1/3) 化學系和醫學系 協同/共同主持人 2014.05 ~ 2015.04 國科會
2014 磷試劑對親電子性化合物進行Michael 加成或1,2-加成產生Wittig試劑 的研究及此類反應在有機合成上的應用 主持人 2013.08 ~ 2014.07
2013 磷試劑對親電子性化合物進行Michael 加成或1,2-加成產生Wittig試劑 的研究及此類反應在有機合成上的應用 主持人 2012.08 ~ 2013.07 國科會
2012 重點一子題1及2:不對稱有機催化Michael加成反應和三組分反應的研發 主持人 2011.08 ~ 2012.07 國科會
2012 新穎的醛(或亞胺)、高反應性的烯類及親核性試劑所進行的三組分反應的研發:具有光學活性的β2-氨基酸的合成 主持人 2011.08 ~ 2012.07 國科會
2011 重點一子題1及2:不對稱有機催化Michael加成反應和三組分反應的研發 主持人 2010.08 ~ 2011.07 國科會
2011 新穎的醛(或亞胺)、高反應性的烯類及親核性試劑所進行的三組分反應的研發:具有光學活性的β2-氨基酸的合成 主持人 2010.08 ~ 2011.07 國科會
2010 多功能化的不對稱有機催化劑的研發和其在有機合成上的應用 主持人 2009.08 ~ 2010.07 國科會
2009 多功能化的不對稱有機催化劑的研發和其在有機合成上的應用 主持人 2008.08 ~ 2009.07 國科會
年度 名稱 發表日期 全部作者
Phosphine-mediated Reactions 2015-08-08
Phosphine-catalyzed reactions 2014-09-01
Asymmetric organocatalysis 2014-08-01
國家 學校名稱 系所 學位 期間
德國 德國慕尼黑大學 化學所 博士 2003.08 ~ 2006.11
臺灣 國立臺灣師範大學 化學系 碩士 1998.09 ~ 2000.06
臺灣 國立臺灣師範大學 化學系 理學士 1994.09 ~ 1998.06
臺灣 台北市立建國高級中學 高中 1991.09 ~ 1994.06
臺灣 台北縣立海山國中 1988.09 ~ 1991.06
服務機關名稱 單位 職務 期間
國立臺灣師範大學 化學系 特聘教授 2020.01 ~ 2022.12
國立臺灣師範大學 化學系 主任 2017.08 ~ 2019.07
科技部 化學推動中心/自然司 審議委員 2016.01 ~ 2020.12
國立臺灣師範大學 貴重儀器中心 主任 2014.08 ~ 2017.07
國立臺灣師範大學 化學系 特聘教授 2014.02 ~ 2016.07
國立臺灣師範大學 化學系 教授 2014.02 ~ 迄今
國立臺灣師範大學 化學系 副教授 2011.02 ~ 2014.01
國立臺灣師範大學 化學系 助理教授 2008.02 ~ 2011.01
德國柏林科技大學 化學所 博士後研究 2007.01 ~ 2007.12
德國慕尼黑大學 化學所 博士後研究 2006.11 ~ 2006.12
國立臺灣師範大學 化學系 助教 2002.03 ~ 2003.07
陸軍(義務役軍官) 少尉排長 2000.07 ~ 2002.03
類別 年度 獎項名稱 頒獎單位
校外榮譽 2014 2014 Emerging Investigators 英國皇家化學學會
校內榮譽 2014 102年度研究績優獎 國立臺灣師範大學
校外榮譽 2013 Asian Core Program Lectureship Award Thailand
校外榮譽 2013 傑出青年化學獎章 中國化學會
校外榮譽 2013 吳大猷先生紀念獎 行政院國家科學委員會
校外榮譽 2011 Asian Core Program Lectureship Award Japan Society for Promotion of Sciences, JSPS