孙英杰
姓名 孙英杰
电子邮件 sun@ntnu.edu.tw
联络电话 (02)77496215
网站 http://web.ntnu.edu.tw/~sun/
实验室电话 (02)77496216
职称 教授
研究领域 生物物理化学、药物设计
学术专长 癌症药物、神经退化性疾病药物研发。 电脑辅助药物设计:蛋白质模拟、分子动力学模拟、Docking、系统生物学方法、QSAR方法。 药物研究实验:激酶抑制剂抑制效果测量。
指导学生 施惠真;许文绮;许嘉仁;刘安伦
实验室 计算模拟、实验研究室 - 生物物理化学、药物设计 / 物化/分析实验室

学术着作

    1. Chia-Jen Hsu, Wen-Chi Hsu, Der-Jay Lee,An-Lun Liu, Chia-Ming Chang, Huei-Jhen Shih, Wun-Han Huang, Guey-Jen Lee-Chen,Hsiu Mei Hsieh-Li, Guan-Chiun Lee, and Ying-Chieh Sun "Investigation of the Bindings of a Class of Inhibitors with GSK3b Kinase Using Thermodynamic Integration MD Simulation and Kinase Assay" Chem. Biol. Drug Des. 90, 272-281 (2017). 参考连结参考连结
    2. Hei-Jen Huang, Shu‐Ling Chen, Hsin-Yu Huang, Ying-Chieh Sun, Guan-Chiun Lee, Guey-Jen Lee-Chen, Hsiu Mei Hsieh-Li*, Ming-Tsan Su* “AM404, a newly identified GSK3β-inhibitor analog, ameliorates the cognitive impairment and pathological features of fly and mouse models of Alzheimer's disease” (submitted)
    3. Chih-Hsin Lin, Yu-Shao Hsieh, Yih-Ru Wu, Chia-Jen Hsu, Hsuan-Chiang Chen, Hsiu Mei Hsieh-Li, Ming-Tsan Su, Ying-Chieh Sun*, Guan-Chiun Lee*, Guey-Jen Lee-Chen*, "Identifying GSK-3<beta> kinase inhibitors of Alzheimer's disease: Virtual screening, enzyme, and cell assays", Eur. J. Pharm. Sci., 89, 11-19  (2016) 参考连结参考连结
    4. Ying-Chieh Sun, Wen-Chi Hsu, Chia-Jen Hsu, Chia-Ming Chang, Kai-Hsiang Cheng, "Investigation of differences in the Binding Affinity Differences in Ligands with un-Tagged and Tagged p38 Kinase Using Thermodynamic Integration MD Simulation" J. Mol. Model., 21, 283 (2015).
      参考连结参考连结
    5. Hsing-Chou Lee, Wen-Chi Hsu, An-Lun Liu, Chia-Jen Hsu, Ying-Chieh Sun, “Using Thermodynamic Integration MD Simulation to Compute Relative Protein-Ligand Binding Free Energy of a GSK3ß Kinase Inhibitor and its Analogs”, J. Mol. Graphics & Model. 51, 37-49 (2014). 参考连结参考连结
    6. Kuan-Wei Wu, Po-Chin Chen, Jun Wang, Ying-Chieh Sun, "Computation of Relative Binding Free Energy for an Inhibitor and its Analogs Binding with Erk Kinase Using Thermodynamic Integration MD Simulation", J. Comput. Aided Mol. Des. 26, 1159-1169 (2012). DOI 10.1007/s10822-012-9606-6
    7. Xu-Nan Tang, Cheng-Wei Lo, Yu-Chung Chuang, Chao-Tung Chen, Ying-Chieh Sun, Yi-Ren Hong, and Chia-Ning YangPrediction of the binding mode between GSK3b and a peptide derived from GSKIP using molecular dynamics simulation”, Biopolymers, (2011).
    8. Jia-Yang Chen, Sin-Ming Huang, Yen-An Tang, Hsueh-Fen Juan, Li-Wha Wu, Ying-Chieh Sun, Szu-Chi Wang, Kuan-Wei Wu, Gopula Balraj, Tzu-Tin Chang, Wen-Shan Li, Hung-Chi Cheng, and Yi-Ching Wang, "A novel sialyltransferase inhibitor suppresses FAK/paxillin and angiogenesis signaling and cancer metastasis”, Cancer Research, 71, 473-483 (2011).
    9. Cheng-Chang Hsu, Shih-Hong Wang, Hsing-Pang Hsieh, and Ying-Chieh Sun “Comparative Molecular Field Analysis of Anti-tubulin Agents with Indole Ring Binding at the Colchicine Binding Site”, J. Theore. Comput. Chem. 9, 279-291 (2010)
      参考连结参考连结
    10.  
    11. Shu-Ping Lin, Kun-Chang Tseng, Ming-Chou Lin, Chii-Dong Chen, Chia-Chang Tsai, Shu-Han Yu, Ying-Chieh Sun, Tsung-Wu Lin, Chien-Yuan Pan, and Yit-Tsong Chen“A Reversible Surface Functionalized Nanowire Transistor to Study Protein-Protein Interactions" Nano Today, 4, 235-243 (2009).
    12. Wen-Hung Wang, Yi-Ching Wang, and Ying-Chieh Sun, ‘A 3D-QSAR study of Celebrex-based PDK1 Inhibitors Using CoMFA Method’ J. Chin. Chem. Soc. 56, 59-64 (2009).
    13. Yi-Hung Tan, Kung-Hsueh Lee, Topp Lin , Ying-Chieh Sun , Hsueh-Fen Juan, Yi-Ching Wang , Cytotoxicity and Proteomics Analyses of OSU03013 in Lung Cancer'', Clinical Cancer Research, 14, 1823-1830 (2008).
    14. C.C. Chen, Chung-Cheng Wei , Ying-chieh Sun and Chi-Ming Chen , ''Packing of Transmembrane Helices in Bacteriorhodopsin Folding: Structure and Thermodynamics’, Journal of Structural Biology, 162, 237-247 (2008).
    15. Wei-Zhou Wang, Topp Lin , and Ying-Chieh Sun ,‘Examination of the Folding of a Short Alanine-Based Helical Peptide with Salt Bridges Using Molecular Dynamics Simulation’ J. Phys. Chem. B, 111, 3508-3514, (2007).
    16. Jeng-Han Wang, M. C. Lin, Ying-Chieh Sun,‘Reactions of Hydrazoic Acid on TiO2 Nanoparticles: An Experimental and Computational Study’ J. Phys. Chem. B, 109, 5133-5142 (2005).
    17. Chung-Cheng Wei, Ming-Hsun Ho, Wen-Hung Wang, and Ying-Chieh Sun ‘Molecular Dynamics Simulation of Folding of a Short Helical Peptide with Many Charged Residues’, J. Phys. Chem. B, 109, 19980-19986, (2005). SCI.
    18. Ying-Chieh Sun, I-Ting Wang, Thanh Lam Nguyen, Hsiu-Feng Lu, Xueming Yang, and Alexander M. Mebel‘A Combined Quantum Chemistry and RRKM Calculation Predicts the O(1D) + C2H6 Reaction Can Produce Water Molecule in Collision-free Crossed Molecular Beam Environment’ J. Phys. Chem. A 107, 6986-6994 (2003). SCI.
    19. Chai Ling Fan, Wei-Der Lee, Nai-Wei Teng, Ying-Chieh Sun and Kwunmin Chen,‘Asymmetric Epoxidation of Camphor N-Enoylpyrazolidinones with Methyl(trifluoromethyl)dioxirane and Urea Hydrogen Peroxide Complex: Reversal of Stereoselectivity’ J. Org. Chem. 68, 9816, (2003). SCI.
    20. Ming-Hsun Ho and Ying-Chieh Sun, ‘Molecular Dynamics Simulation of Hydrogen-covered Si(100):H-2x1 surface: Calculation of Vibrational Energy Relaxation Rates of Hydrogen Stretching Modes’ Surf. Sci., 516, L540-L546 (2002). SCI.
    21. Man-kit Leung, Ashis B. Mandal, Chih-Chieh Wang, Gene-Hsiang Lee, Shie-Ming Peng, Hsing-Ling Cheng, Guor-Rong Her, Ito Chao, Hsiu-feng Lu, Ying-Chieh Sun, Mei-Ying Shiao, and Pi-Tai Chou,‘Self-complementarity of oligo-aminopyridines: a new class of hydrogen-bonded ladders’ J. Am. Chem. Soc., 124, 4287 (2002) . SCI.
    22. Hsiu-Feng Lu and Ying-Chieh Sun, ‘Calculated Energies of Adsorption of Non-hydrocarbon Species on Diamond H/C(111) Surface and the Abstraction Energies of these Species Abstracted by Hydrogen Atoms Using ab initio Calculation’Diamond and Related Materials, 11, 1560 (2002) . SCI.
    23. Hsiu-Feng Lu and Ying-Chieh Sun, ‘Calculation of Hydrogen Abstraction Reaction on Hydrogen-covered H/C(111) Diamond Surface Abstracted by Non-Hydrocarbon Species’ Surf. Sci. 494 L787-L792 (2001). SCI.
    24. Ying-Chieh Sun, Hsiu-Feng Lu, and Ming-Shun Ho, 2000,`Molecular dynamics simulation of hydrogen isotope-terminated silicon (111) and (110) surfaces: calculation of vibrational energy relaxation rates of hydrogen isotope stretching modes’Chem. Phys. Lett. , 318, 7-14. SCI.
    25. Ying-Chieh Sun, Shu-Fen Yang, I-Lun Hwang,and Tzu-Hsien Wu, 1999 `A 500 ps Molecular dynamics simulation trajectory of cardiotoxin II from Taiwan cobra venom in solution: correlation with NMR and X-ray crystallography data‘ J. Comput. Chem. , 20, 546-562. SCI.
    26. Hsiu-Feng Lu, Ming-Shun Ho, Sho-Ching Hong, Ai-Hsin Liu, Pei-Fang Wu, and Ying-Chieh Sun, 1998,‘Determination of vibrational energy relaxation rates of C-H,D,T stretching modes on hydrogen, deuterium, and tritium-terminated H,D,T/C(111) and H,D,T/C(110) surfaces using molecular dynamics simulation: thermal effect’ J. Chem. Phys., 109,6898-6904. SCI.
    27. Ying-Chieh Sun and Jiunn-Ming Chen,1997,‘ Calculations of vibrational energy relaxation rates of C-H,D,T stretching modes on hydrogen, deuterium, and tritium-terminated H,D,T/C(111)lxl surface’ J. Phys. Chem., 101, 7082-7086. SCI.
    1. 喹啉衍生化合物用于制备Tau蛋白病变类疾病之医药组成物上之用途 (台湾专利/Taiwan patent  2017)
    2. Method For Treating Tau-Associated Diseases (美国专利/US patent 2017)
年度 论文名称
2022 Virtual Screening and Testing of GSK-3 Kinase Inhibitors Us-ing Human SH-SY5Y Neuronal Cells Expressing Tau Folding Reporter and Mouse Hippocampal Primary Neuron Culture Under Tau Cytotoxicity, Biomol Ther, Jul. 2022
2021 Flavones 7,8-DHF, Quercetin, and Apigenin Against Tau Toxicity via Activation of TRKB Signaling in ΔK280 TauRD-DsRed SH-SY5Y Cells, Frontiers in Aging Neuroscience, Dec. 2021
2021 Multi-Target Effects of Novel Synthetic Coumarin Derivatives Protecting Aβ-GFP SH-SY5Y Cells against Aβ Toxicity, Cells, Nov. 2021
2021 Novel Synthetic Coumarin-Chalcone Derivative (E)-3-(3-(4-(Dimethylamino)Phenyl)Acryloyl)-4-Hydroxy-2H-Chromen-2-One Activates CREB-Mediated Neuroprotection in Aβ and Tau Cell Models of Alzheimer’s Disease, Oxidative Medicine and Cellular Longevity, Nov. 2021
2020 LMDS-1, a potential TrkB receptor agonist provides a safe and neurotrophic effect for early-phase Alzheimer’s disease, Psychopharmacology, vol. 237, Oct. 2020
2020 Targeting Inflammation, PHA-767491 Shows a Broad Spectrum in Protein Aggregation Diseases, J. Mol. NeuroSci., vol. 70, Mar. 2020
2020 Effective methane conversion to methanol on bi-functional graphene-oxide-supported platinum nanoclusters (Pt5) – a DFT study, Phys. Chem. Chem. Phys., vol. 22, Feb. 2020
2019 Novel compound VB-037 inhibits Aβ aggregation and promotes neurite outgrowth through enhancement of HSP27 and reduction of P38 and JNK-mediated inflammation in cell models for Alzheimer's disease, Neurochemistry International, vol. 125, May. 2019
2019 Chronic low dose of AM404 ameliorates the cognitive impairment and pathological features in hyperglycemic 3xTg-AD mice., Psychopharmacology, vol. 236, Jan. 2019
2018 Synthesis of (3S,4S,5S)-trihydroxylpiperidine derivatives as enzyme stabilizers to improve therapeutic enzyme activity in Fabry patient cell lines, European Journal of Medicinal Chemistry, vol. 144, Jan. 2018
2017 Investigation of the Bindings of a Class of Inhibitors with GSK3 Kinase Using Thermodynamic Integration MD Simulation and Kinase Assay, Chem. Biol. Drug Des., vol. 90, Jan. 2017
2016 Identifying GSK-3 kinase inhibitors of Alzheimer's disease: Virtual screening, enzyme, and cell assays, European Journal of Pharmaceutical Sciences, vol. 89, Jun. 2016
2015 Investigation into the Binding Affinity Differences in Ligands with un-Tagged and Tagged p38 Kinase Using Thermodynamic Integration MD Simulation, Journal of Molecular Modeling, vol. 21, Nov. 2015
2014 Using thermodynamic integration MD simulation to compute relativeprotein–ligand binding free energy of a GSK3 kinase inhibitorand its analogs, Journal of Molecular Graphics and Modelling, vol. 51, Jun. 2014
2012 Computation of relative binding free energy for an inhibitor and its analogs binding with Erk kinase using thermodynamic integration MD simulation, J. Comput. Aided Mol. Des., vol. 26, Oct. 2012
2011 Prediction of the binding mode between GSK3b and a peptide derived from GSKIP using molecular dynamics simulation, Biopolymers, vol. 95, Jul. 2011
2011 A novel sialyltransferase inhibitor suppresses FAK/paxillin and angiogenesis signaling and cancer metastasis, cancer research, vol. 71, Jan. 2011
2010 Comparative Molecular Field Analysis of Anti-tubulin Agents with Indole Ring Binding at the Colchicine Binding Site, Journal of Theoretical and Computational Chemistry, vol. 9, Jan. 2010
2009 Examination of effects of GSK3β phosphorylation, β-catenin phosphorylation, and β-catenin degradation on kinetics of Wnt signaling pathway using computational method, Theoretical biology and medical modelling, vol. 6, Jul. 2009
2009 A 3D-QSAR study of Celebrex-based PDK1 Inhibitors Using CoMFA Method, Journal of the Chinese Chemical Society, vol. 56, Feb. 2009
2009 A Reversible Surface Functionalized Nanowire Transistor to Study Protein-Protein Interactions, Nano Today, vol. 4, Jan. 2009
2008 Cytotoxicity and Proteomics Analyses of OSU03013 in Lung Cance, Clinical Cancer Research, vol. 14, Mar. 2008
2008 Journal of Structural Biology, Packing of transmembrane helices in bacteriorhodopsin folding: Structure and thermodynamics, vol. 162, Jan. 2008
2007 Molecular Dynamics Simulation of Folding of a Short Helical Toxin Peptide, J. Theore. Comput. Chem., vol. 6, Jun. 2007
2007 Examination of the Folding of a Short Alanine-Based Helical Peptide with Salt Bridges Using Molecular Dynamics Simulation, Journal of Physical Chemistry B, vol. 111, Feb. 2007
年度 计画名称 参与人 职称/担任之工作 计画期间 补助/委讬或合作机构
2023 TrkB受体讯息传递路径动力学及其双稳态行为之计算研究 主持人 2022.08 ~ 2023.07 科技部(原国科会)
2018 新颖酵素蛋白质抑制剂的开发与设计:以分子动态模拟与酵素实验研究蛋白质-配体结合自由能与结合构形 主持人 2017.08 ~ 2018.07 科技部(原国科会)
2018 以理论计算方法探讨高活性金属奈米团簇与石墨烯在催化反应上的应用 主持人 2016.08 ~ 2018.07 科技部(原国科会)
2017 以热力学积分分子动态模拟方法研究激酶与配体复合体-结合嵌合计算及酵素实验 主持人 2015.08 ~ 2017.07 科技部(原国科会)
2015 配体与蛋白质的结合自由能研究:分子动态模拟和嵌合计算 主持人 2014.08 ~ 2015.07 科技部(原国科会)
2015 阿兹海默氏症的治疗策略—从基因到行为,--以阿兹海默氏症小鼠模式评估GSK3抑制剂之治疗潜力—奠基于电脑辅助药物设计及激酶生化检测(2/2) 化学系 协同/共同主持人 2014.08 ~ 2015.07 科技部(原国科会)
2014 阿兹海默氏症的治疗策略—从基因到行为-以阿兹海默氏症小鼠模式评 估GSK3抑制剂之治疗潜力—奠基于电脑辅助药物设计及激酶生化检测(1/2) 化学系 协同/共同主持人 2013.08 ~ 2014.07 国科会
2013 抑制剂化合物与蛋白质结合自由能和生化反应网络动力学之计算研究 主持人 2013.02 ~ 2013.05 科技部(原国科会)
2013 抑制剂化合物与蛋白质结合自由能和生化反应网络动力学之计算研究 主持人 2012.08 ~ 2013.07 国科会
2012 生化分子作用及动力学之计算化学研究: Kinase之抑制及在细胞讯息传递路径的角色 主持人 2011.08 ~ 2012.07 国科会
2011 生化分子作用及动力学之计算化学研究: Kinase之抑制及在细胞讯息传递路径的角色 主持人 2010.08 ~ 2011.07 国科会
2010 生化分子作用及动力学之计算化学研究: Kinase之抑制及在细胞讯息传递路径的角色 主持人 2009.08 ~ 2010.07 国科会
2009 生化分子之计算化学研究:(1)胜肽链折叠/展开(2)分子结合 主持人 2008.08 ~ 2009.07 国科会
2008 生化分子之计算化学研究:(1)胜肽链折叠/展开(2)分子结合 主持人 2007.08 ~ 2008.07 国科会
2007 生化分子之计算化学研究:(1)胜肽链折叠/展开(2)分子结合 主持人 2006.08 ~ 2007.07 国科会
国家 学校名称 系所 学位 期间
美国 宾夕法尼亚大学 化学研究所 博士 1989.09 ~ 1994.06
台湾 国立台湾大学 化学系 理学士 1983.09 ~ 1987.06
服务机关名称 单位 职务 期间
国立台湾师范大学 化学系 教授 2000.01 ~ 迄今
国立台湾师范大学 化学系 副教授 1996.01 ~ 2000.01
美国加州大学旧金山分校 药理化学系 博士后研究员 1994.01 ~ 1996.01