陳焜銘
姓名 陳焜銘
電子郵件 kchen@ntnu.edu.tw
聯絡電話 (02)77496124
實驗室電話 (02)77496150
職稱 優聘教授
研究領域 有機不對稱合成
學術專長
  1. 設計合成以樟腦架構為主之對掌輔助劑/對掌螯 合劑並探討其在有機不對稱合成上的應用。 
  2. 新藥物分子設計合成。
  3. 結構新穎之有機催化劑設計合成及應用探討。
指導學生 陳蓉萱,馬達南,管軒浩,張惠茹,李佩勳,何青胤,葉倫輔,陳致皓,劉積瑞,黃琬澐,柯羿均,呂依旻,陳奕杰,陳彥銘
實驗室 對掌催化合成研究室

學術著作

    1. 2013
      Hsuan-Hao Kuan, Chung-Han Chien,and Kwunmin Chen* “Synthesis of Fully Substituted Dispirocyclohexanes by Organocatalytic [2+2+2] Annulation Strategy Between 2-Arylideneindane-1,3-diones and Aldehydes” Org. Lett. 2013, 15, 2880-2883.
    2. Dhananjay R. Magar, Yi-Jiun Ke and Kwunmin Chen* ”Three Component Synthesis  of Functionalized N-Protected Tetrasubstituted Pyrroles via Addition-Elimination-Aromatization Process” Asia J. Org. Chem. 2013,  2, 330-335. (inside cover)
    3. Shaik Anwar, Wan-Yun Huang,Chih-Hao Chen, You-Song Cheng and Kwunmin   Chen* ”An Efficient Friedel-Crafts/Oxa-Michael/Aromatic Annulation: Rapid Access    to Substituted Naphtho[2,1-b]-, [1,2-b]furan and Benzofuran Derivatives” Chem. Eur. J. 2013, 19, 4344-4351.
    4.  Yan ming Chen, Pei-Hsun Lin, Jun Lin, and Kwunmin Chen* “Desymmetrization and switching of stereoselectivity in direct organocatalytic Michael addition of ketones to 1,1-bis(phenylsulfonyl)ethylene ”Eur. J. Org. Chem. 2013 , 2699-92707.
       
       
    5. 2012
      Lun Fu Yeh,Shaik Anwar and Kwunmin Chen* “ The Combination of Domino Process and Kinetic Resolution: Organocatalytic Synthesis of Functionalised Cyclopentenes by Sequential SN2'-Michael Reaction“ Tetrahedron 201268, 7317-7321. (13/57; IF: 3.219)
    6. Raju Jannapu Reddy, Pei-Hsun Lee, Dhananjay R. Magar, Jung-Hsuan Chen and Kwunmin Chen* “Kinetic resolution of activated nitroallylic acetates with aldehydes and ketones via conjugate addition-elimination SN2’ process” Eur. J. Org. Chem. 2012, 353-363. (15/57; IF:3.016)
    7. Wan-Yun Huang, Yi-Chieh Chen and Kwunmin Chen* “Efficient synthesis of tetrasubstituted furans from nitroallylic acetates and 1,3-dicarbonyl/a-activating ketones by Feist-Bénary addition-elimination” Chem. Asian J. 20127, 688-691. (19/140; IF:4.287)
    8. Suparna Roy and Kwunmin Chen* “Three-Component Organocascade Kinetic Resolution of Racemic Nitroallylic Acetates via Sequentia l Iminium/Enamine Asymmetric Catalysis” Org. Lett. 2012, 14, 2496-2499. (5/57 IF:5.420)
       
       
    9. 2011
      Jung-Hsuan Chen, Chihliang Chang, Hui-Ju Chang and Kwunmin Chen* “Efficient Synthesis of 2,3,5,6-Tetrahydro-1-Alkyl/Aryl-1H-Benzo[f]Chromen-3-Ol Derivatives from b-Tetralones and a,b-Unsaturated Aldehydes“Organic & Biomolecular Chemistry 2011, 9, 7510-7516. (12/56; IF: 3.451)
    10. Shaik Anwar, Pei-Hsun Lee, Tsai-Yung Chou, Chihliang Chang, and Kwunmin Chen* Pyrrolidine-linker-camphor assembly: bifunctional organocatalysts for efficient Michael addition of cyclohexanone to nitroolefins under neat conditions” Tetrahedron 2011, 67, 1171-1177. (13/57; IF: 3.219)
    11. Raju Jannapu Reddy and Kwunmin Chen* “Highly Efficient Organocatalytic Kinetic Resolution of Activated Nitroallylic Acetates with Aldehydes via Conjugate Addition-Elimination” Org. Lett. 2011, 13, 1458-1461. (4/57; IF: 5.420)
    12. Shaik Anwar, Hui-Ju Chang and Kwunmin Chen* “Organocatalytic Synthesis of Multiple Substituted Bicyclo[4.4.0]Decalin System” Org. Lett. 2011, 13, 2200-2203. (4/57; IF: 5.420)
    13. Shaik Anwar, Hui-Ju Chang, and Kwunmin Chen*, "Organocatalytic Synthesis of Multiple Substituted Bicyclo[4.4.0]Decalin System" Org. Lett. 2011, ASAP. 附件檔案附件檔案 Adobe PDF
    14. Raju Jannapu Reddy and Kwunmin Chen " Highly Efficient Organocatalytic Kinetic Resolution of Activated Nitroallylic Acetates with Aldehydes via Conjugate Addition-Elimination" Org. Lett. 201113, 1458-1461. 附件檔案附件檔案 Adobe PDF
    15. Shaik Anwar, Pei-Hsun Lee, Tsai-Yung Chou, Chihliang Chang, Kwunmin Chen " Pyrrolidine-linker-camphor assembly: bifunctional organocatalysts for efficient Michael addition of cyclohexanone to nitroolefins under neat conditions" Tetrahedron 201167, 1171-1177. 附件檔案附件檔案 Adobe PDF
    16. 2010
      Hsuan-Hao Kuan, Raju Jannapu Reddy, Kwunmin Chen " An efficient MoritaeBayliseHillman reaction for the synthesis of multifunctional 2-hydroxy-3-nitrobut-3-enoate derivatives" Tetrahedron 201066, 9875-9879. 附件檔案附件檔案 Adobe PDF
    17. Jung-Hsuan Chen, Shuan-Ru Liu, and Kwunmin Chen* “An Efficient and Convenient Synthesis of Ethyl 1-(4-methoxyphenyl)-5-Phenyl-1H-1,2,3-Triazole-4-Carboxylates” Chem. Asian J. 2010, 5, 328-333. (19/140; IF:4.197).
    18. Hsuan-Hao Kuan,Raju Jannapu Reddy and Kwunmin Chen* “An efficient Morita-Baylis-Hillman reaction for the synthesis of multifunctional 2-hydroxy-3-nitro-but-3-enoate derivatives” Tetrahedron 201066, 9875-9879 (13/57; IF: 3.219)
    19. Ying-Fang Ting, Chihliang Chang, Raju Jannapu Reddy, Dhananjay R. Magar and Kwunmin Chen* “Pyrrolidine-Camphor Derivatives as a New Class of Organocatalysts for Direct Asymmetric Michael Addition of Aldehydes and Ketones to β-Nitroalkenes” Chem. Eur. J. 201016, 7030-7038. (17/140; IF: 5.454)
    20. Pang-Min Liu, Dhananjay R. Magar, and Kwunmin Chen " Highly Efficient and Practical Pyrrolidine–Camphor-Derived Organocatalysts for the Direct α-Amination of Aldehydes" Eur. J. Org. Chem. 2010, 5705-5713. 附件檔案附件檔案 Adobe PDF
    21. Ying-Fang Ting, Chihliang Chang, Raju Jannapu Reddy, Dhananjay R. Magar, and Kwunmin Chen* " Pyrrolidinyl–Camphor Derivatives as a New Class of Organocatalyst for Direct Asymmetric Michael Addition of Aldehydes and Ketones to beta-Nitroalkenes" Chem. Eur. J. 2010, 16, 7030-7038. 附件檔案附件檔案 Adobe PDF
    22. Dhananjay R. Magar, Chihliang Chang, Ying-Fang Ting, Kwunmin Chen "Highly Enantioselective Conjugate Addition of Ketones to Alkylidene Malonates Catalyzed by a Pyrrolidinyl-Camphor-Derived Organocatalyst " Eur. J. Org. Chem. 2010, 2062-2066. 附件檔案附件檔案 Adobe PDF
    23. Jung-Hsuan Chen, Shuan-Ru Liu, and Kwunmin Chen* “An Efficient and Convenient Synthesis of Ethyl 1-(4-methoxyphenyl)-5-Phenyl-1H-1,2,3-Triazole-4-Carboxylates” Chem. Asian J. 2010 , 5, 2, 328 附件檔案附件檔案 Adobe PDF
    24. 2009
      Raju Jannapu Reddy, Hsuan-Hao Kuan, Tsai-Yung Chou and Kwunmin Chen* “Novel Prolinamide-Camphor Containing Organocatalysts for Direct Asymmetric Michael Addition of Unmodified Aldehydes to Nitroalkenes” Chem. Eur. J. 200915, 9294-9298. (17/140; IF: 5.454)
    25. Chin-Sheng Chao, Chung-Kai Cheng, Ssu-Hsien Li and  Kwunmin Chen* “Diastereoselective electrophilic a-amination of camphor  N1-acyl N2-phenylpyrazolidinones: the metal enolate-dependent synthesis of two possible hydrazide diastereomers” Tetrahedron Lett.  2009, 50, 333-336. (21/57; IF: 2.538)
    26. Chin-Sheng Chao, Chung-Kai Cheng, Ssu-Hsien Li and  Kwunmin Chen* “Diastereoselective electrophilic a-amination of camphor  N1-acyl N2-phenylpyrazolidinones: the metal enolate-dependent synthesis of two possible hydrazide diastereomers” Tetrahedron Lett.  2009, 50, 333-336. 附件檔案附件檔案 Adobe PDF
    27. Zheng-Hao Tzeng, Hung-Yao Chen, Raju Jannapu Reddy, Ching-Ting Huang and Kwunmin Chen* “Highlydiastereo- and enantioselective direct aldol reactions promoted by water-compatible organocatalysts bearing a pyrrolidinyl camphor structural scaffold” Tetrahedron 2009, 65, 2879-2888. 附件檔案附件檔案 Adobe PDF
    28. Chihliang Chang, Ssu-Hsien Li, Raju Jannapu Reddy and Kwunmin Chen* “Pyrrolidine-camphor derivative as an organocatalyst for asymmetic Michael addition of a,a-disubstituted aldehydes to β-nitroalkenes: construction of quaternary carbon bearing aldehydes under solvent-free conditions” Adv. Synth. Catal. 2009351, 1273-1278. 附件檔案附件檔案 Adobe PDF
    29. Raju Jannapu Reddy, Hsuan-Hao Kuan, Tsai-Yung Chouand Kwunmin Chen* “Novel Prolinamide-Camphor Containing Organocatalysts for Direct Asymmetric Michael Addition of Unmodified Aldehydes to Nitroalkenes” Chem. Eur. J. 200915, 9294-9298. 附件檔案附件檔案 Adobe PDF
    30. Pang-Min Liu, Chihliang Chang, Raju Jannapu Reddy, Ying-Fang Ting, Hsuan-Hao Kuan and Kwunmin Chen* “Remarkable Reaction Rate and Excellent Enantioselective Direct a-Amination of Aldehydes with Azodicarboxylates Catalyzed by Pyrrolidinyl-Camphor Derived Organocatalysts” Eur. J. Org. Chem. 2010, 42-46 附件檔案附件檔案 Adobe PDF
    31. Shy-Guey Wang, Chia-Wen Wu, Kwunmin Chen and Victor S,-Y. Lin* “Fine-Tuning Mesochannel Orientation of Organically Functionalized Mesoporous Silica Nanoparticles” Chem. Asian J. 20094, 658-661.
    32. 2008
      Zheng-Hao Tzeng, Hung-Yao Chen, Ching-Ting Huang and Kwunmin Chen* “
      Camphor containing organocatalysts in asymmetric aldol reaction on water” Tetrahedron Lett. 200849, 4134-4137. 附件檔案附件檔案 Adobe PDF
    33. Pei-Wen Duan,Ching-Chen Chiu, Wei-Der Lee, Li Shiue Pan, Uppala Venkatesham, Zheng-Hao Tzeng  and Kwunmin Chen* “On the scope of diastereoselective aziridination of various chiral auxiliaries derived N- and O-enones with N-aminophthalimide in the presence of lead tetraacetate” Tetrahedron: Asymmetry 200818, 682-690. 附件檔案附件檔案 Adobe PDF
    34. Zheng-Hao Tzeng , Shuen-Wen Yang, Pang-Min Liu and Kwunmin Chen* “Optical Resolution of 5-Oxo-1-Phenyl-Pyrazolidine-3-Carboxylic Acid as a New Organocatalyst for Organic Reactions J. Chin. Chem. Soc200855, 626-631. 附件檔案附件檔案 Adobe PDF
    35. Chihliang Chang and Kwunmin Chen* “Diastereoselective three component reaction of N-glyoxyloyl camphorpyrazolidinone, amine and allyltributylstannane: facile synthesis of homoallylic amines” J. Chin. Chem. Soc200754, 1591-1594. 附件檔案附件檔案 Adobe PDF
    36. Chuen-Ming Shih, Kwunmin Chen, Yu-Chieh Wang, Pei-Jung Lee and Yi-Ching Wang* “Elevated p53 and p21waf1 mRNA expression in blood lymphocytes from lung cancer patients with chemoresistance” Cancer Detection and Preventation 200731, 366-370.
    37. Jung-Hsuan Chen, Uppala Venkatesham, Li-Chen    Lee and Kwunmin Chen* “Diastereoselective Allylation of a-Ketoamides Bearing Camphor N-Tosylpyrazolidinone Auxiliary: Efficient Synthesis of  Highly Optically Active Two Stereoisomers” Tetrahedron 200662, 887. 附件檔案附件檔案 Adobe PDF
    38. Neelesh A. Kulkarni and Kwunmin Chen* “Excellent    diastereoselective allylation of camphor derived glyoxylic oxime ethers mediated by a Lewis acid” Tetrahedron Lett. 200647, 611. 附件檔案附件檔案 Adobe PDF
    39. Neelesh A. Kulkarni, Ching-Fa Yao and Kwunmin    Chen “On the scope of diastereoselective allylation of various chiral glyoxylic oxime ethers with allyltributylstannane in the presence of a Lewis acid and triallylaluminum” Tetrahedron 200763, 7816. 附件檔案附件檔案 Adobe PDF
    40. Jia-Fu Pan and Kwunmin Chen “Diastereoselective Baylis-Hillman Reaction Using N-Glyoxyloyl Camphorpyrazolidinone as an Electrophile: Synthesis of Optically Pure 2- Hydroxy-3-Methylene Succinic Acid Derivative” Tetrahedron Lett. 2004, 45, 2541. 附件檔案附件檔案 Adobe PDF
    41. Wei-Der Lee, Ching-Chen Chiu, Hua-Lin Hsu and Kwunmin Chen “On the Scope of Diastereoselective Epoxidation of Various Chiral Auxiliaries Derived Enones: The Conformational Analysis of Camphor Derived N- and O-Enones” Tetrahedron 2004, 60, 6657. 附件檔案附件檔案 Adobe PDF
    42. Shy-Guey Wang, Huei Ru Tsai and Kwunmin Chen “Lewis Acid-Mediated Diastereoselective Allylation of Camphorpyrazolidinone Derived a-Ketoamides” Tetrahedron Lett. 2004, 45, 6183. 附件檔案附件檔案 Adobe PDF
    43. Chai Ling Fang, Wei-Der Lee, Nai-Wei Teng, Ying-Chieh Sun* and Kwunmin Chen “Epoxidation of Chiral Camphor N-Enoyl- pyrazolidinones with Methyl(trifluoromethyl)-dioxirane and Urea Hydrogen Peroxide/Acid Anhydride: Reversal of Stereoselectivity” J. Org. Chem. 2003, 68, 9816. 附件檔案附件檔案 Adobe PDF
    44. Chai Ling Fan, Gondi Sudershan Reddy and Kwunmin Chen ‘Diastereoselective Epoxidation of Camphor N-Enoylpyrazolidinones’ J. Chin. Chem. Soc200350, 1047.
    45. Kung-Shou Yang, Wei-Der Lee, Jia-Fu Pan and Kwunmin Chen* ‘Chiral Lewis Acid-Catalyzed Asymmetric Baylis-Hillman Reactions’ J. Org. Chem. 2003, 68, 915. 附件檔案附件檔案 Adobe PDF
    46. Kung-Shou Yang and Kwunmin Chen* ‘Enantioselective Aziridination of Alkenes with N-Aminophthalimide in the Presence of Lead Tetraacetate-Mediated Chiral Ligand” Org. Lett. 20024, 1107. 附件檔案附件檔案 Adobe PDF
    47. Jia-Fu Pan and Kwunmin Chen “A Facile Catalytic Oxidation of Activated Hydrocarbons to the Carbonyl Functionality Mediated by Mn(II) Complexes” J. Molecular Catalysis A; Chemical 2001, 176, 19.
    48. Wei-Der Lee, Kung-Shuo Yang and Kwunmin Chen* ‘A Remarkable Rate Acceleration of Baylis-Hillman Reaction’ Chem. Commun.,2001, 1612.
      附件檔案附件檔案 Adobe PDF
 
 
年度 論文名稱
2020 Enantioselective Organocatalytic Synthesis of δ-Lactone-Fused 4-Chromanones, Advanced Synthesis & Catalysis, vol. 362, May. 2020
2020 Organocatalytic Diastereoselective Synthesis of Diazoarylbenzo[ b]azepine Derivatives, Journal of Organic Chemistry, vol. 85, May. 2020
2019 An Unprecedented Organocascade Synthesis of Functionalized Bicyclic Nitrones from 2-Aminomalonate Derived Nucleophiles and 1-Nitro-1,3-Enynes via Allenes Formation and Subsequent Rearrangement, Adv. synth. catal, vol. 361, Jan. 2019
2018 Organocatalytic synthesis of densely functionalized oxa-bridged 2,6- epoxybenzo[b][1,5]oxazocine heterocycles, Chem. Commun., Jan. 1970
2017 Organocascade Syntheis of Bicyclo[3.3.1]noane, Adv. Synth. Catal, vol. 359, Jan. 2017
2017 Diastereoselective Syntheis of functionalized angulary-fused, Adv. synth. catal, vol. 359, Jan. 2017
2017 Morita–Baylis–Hillman (MBH) Reaction Derived Nitroallylic Alcohols, Acetates and Amines as Synthons in Organocatalysis and Heterocycle Synthesis, Chemical Record, vol. 17, Jan. 1970
2016 Organocatalytic One-Pot Asymmetric Synthesis of Functionalized Spiropyrazolones via a Michael-Aldol Sequential Reaction, RSC advances, vol. 必填欄位, Sep. 2016
2016 Recent Advances in Organocatalytic Kinetic Resolution for the Synthesis of Functionalized Products, ChemCatChem, vol. 8, Jan. 2016
2016 Recent advances in organocatalytic kinetic resolution for the synthesis of functionalized products, ChemCatChem, vol. 8, Jan. 2016
2016 Organocascade Synthesis of Annulated (Z)-2-mehhylenepyrans, Org. Lett., vol. 18, Jan. 2016
2016 Dihydrooxazine N-Oxide Intermediates as Resting States in Organocatalytic Kinetic Resolution of Functionalized Nitroallylic Amines with Aldehydes, Org. Lett, vol. 18, Jan. 2016
2015 Organocatalytic synthesis of spirocyclohexane indane-1,3-diones via a chiral squaramide-catalyzed Michael/aldol cascade reaction of γ-nitro ketones and 2-arylideneindane-1, 3-diones, Tetrahedron, vol. 71, Aug. 2015
2015 Rauhut-Currier0Initiated Organocascade Reaction:Synthesis of Substituted..., Adv. Synth. Catal., vol. 357, Aug. 2015
2015 Enantioselective Synthesis of Functionalized Polycarbocycles via a three-component........, Org. Lett, vol. 17, May. 2015
2015 Control of five contiguous stereogenic centers in an organocatalytic kinetic resolution, Org. Lett., vol. 17, Jan. 2015
2014 Organocatalytic KInetic Resolution of Racemic Secondary Nitroallylic, J. Org. Chem., vol. 79, Nov. 2014
2014 Organocatalytic syntheis of sub stituted spirocyclohexane carbaldehydes via [4+2], Org. Lett., vol. 16, Oct. 2014
2014 Organocatalytic Desymmetrization of Cyclic meso-Anhydrides through Enantioselective Alcoholysis with Functionalized Primary Nitroallylic Alcohols, Tetrahedron, vol. 70, Jun. 2014
2013 Organocatalytic formal [5+1] annulation: Diastereoselective cascade synthesis of functionalized six-membered spirocyclic indane-1,3-diones/oxindoles via Michael-aldol reaction, Tetrahedron, vol. 69, Aug. 2013
2013 An efficient Friedel-Crafts/oxa-Michael/aromatic annulation:, Chemistry: a European Journal, vol. 19, May. 2013
2013 Synthesis of Fully Substituted Dispirocyclohexanes by Organocatalytic [2+2+2] Annulation Strategy Between 2-Arylideneindane-1,3-diones and Aldehydes”, Org. Lett., vol. 15, May. 2013
2013 An Efficient Friedel-Crafts/Oxa-Michael/Aromatic Annulation: Rapid Access to Substituted Naphtho[2,1-b]-, [1,2-b]furan and Benzofuran Derivatives, Chem. Eur. J., vol. 19, May. 2013
2013 Desymmetrization and switching of stereoselectivity in direct organocatalytic Michael addition of ketones to 1,1-bis(phenylsulfonyl)ethylene, Eur. J. Org. Chem., vol. 2013, Apr. 2013
2013 Three component synthesis of functionalized N-protected tetrasubstituted pyrroles, Asia J. Org. Chem, vol. 2, Jan. 2013
2012 The combination of domino process and kinetic resolution, Tetrahedron, vol. 68, Sep. 2012
2012 efficient synthesis of tetrasubstituted furans from nitroallylic acetates and 1,3-, chemistry an asia journal, vol. 7, Aug. 2012
2012 Silica gel-Mediated Friedel-Crafts Reaction of Indoles with Functionalized Nitroallylic Acetates via an SN1 Process, JCCS, vol. 59, Jun. 2012
2012 Three-component organocascade kinetic resolution of racemic nitroallylic acetates, organic letter, vol. 14, Jun. 2012
2012 synthesis of substituted chiral chromans via organocatalytic kinetic resolution of racemic, Tetrahderon, vol. 68, May. 2012
2012 kinetic resolution of activated nitroallylic acetates with aldehydes and ketones, eur.j.org. chem., vol. 5, Apr. 2012
2011 Efficient Synthesis of 2,3,5,6-Tetrahydro-1-Alkyl/Aryl-1H-Benzo[f]Chromen-3-Ol Derivatives from -Tetralones and ,-Unsaturated Aldehydes, Org. Biomol. Chem, vol. 9, Oct. 2011
2011 Organocatalytic Synthesis of Multiple Substituted Bicyclo[4.4.0]Decalin System, Org. Lett., vol. 13, Apr. 2011
2011 Highly Efficient Organocatalytic Kinetic Resolution of Activated Nitroallylic Acetates with Aldehydes via Conjugate Addition-Elimination, Org. Lett., vol. 13, Feb. 2011
2011 Pyrrolidine-linker-camphor assembly: bifunctional organocatalysts for efficient Michael addition of cyclohexanone to nitroolefins under neat conditions, Tetrahedron, vol. 67, Feb. 2011
2010 An efficient Morita-Baylis-Hillman reaction for the synthesis of multifunctional 2-hydroxy-3-nitro-but-3-enoate derivatives, Tetrahedron, vol. 66, Dec. 2010
2010 Highly efficient and practical pyrrolidinyl-camphor derived organocatalysts for the direct α-amination of aldehydes, Eur. J. Org. Chem, vol. 2010, Aug. 2010
2010 Pyrrolidine-Camphor Derivatives as a New Class of Organocatalysts for Direct Asymmetric Michael Addition of Aldehydes and Ketones to β-Nitroalkenes, Chem. Eur. J., vol. 16, May. 2010
2010 Highly enantioselective conjugate addition of ketones to alkylidene malonates catalyzed by pyrrolidinyl-camphor derived organocatalyst, Eur. J. Org. Chem., vol. 2010, Apr. 2010
2010 Remarkable Reaction Rate and Excellent Enantioselective Direct -Amination of Aldehydes with Azodicarboxylates Catalyzed by Pyrrolidinyl-Camphor Derived Organocatalysts, Eur. J. Org. Chem., vol. 2010, Jan. 2010
2010 An Efficient and Convenient Synthesis of Ethyl 1-(4-methoxyphenyl)-5-Phenyl-1H-1,2,3-Triazole-4-Carboxylates, Chem. Asian J., vol. 5, Jan. 2010
2009 Novel Prolinamide-Camphor Containing Organocatalysts for Direct Asymmetric Michael Addition of Unmodified Aldehydes to Nitroalkenes, Chem. Eur. J., vol. 15, Aug. 2009
2009 Pyrrolidine-camphor derivative as an organocatalyst for asymmetic Michael addition of ,-disubstituted aldehydes to β-nitroalkenes: construction of quaternary carbon bearing aldehydes under solvent-free conditions, Adv. Synth. Catal., vol. 351, May. 2009
2009 Fine-tuning mesochannel orientation of organically functionalized mesoporous silica nanoparticles, Chem. Asian J., vol. 4, Mar. 2009
2009 Highly diastereo- and enantioselective direct aldol reactions promoted by water-compatible organocatalysts bearing a pyrrolidinyl camphor structural scaffold, Tetrahedron, vol. 65, Feb. 2009
2009 Diastereoselective electrophilic alpha-amination of camphor N1-acyl N2-phenylpyrazolidinones: the metal enolate-dependent synthesis of two possible hydrazide diastereomers, Tetrahedron Lett., vol. 50, Jan. 2009
2008 Optical Resolution of 5-Oxo-1-Phenyl-Pyrazolidine-3-Carboxylic Acid as a New Organocatalyst for Organic Reactions, J. Chin. Chem. Soc., vol. 55, Jun. 2008
2008 On the scope of diastereoselective aziridination of various chiral auxiliaries derived N- and O-enones with N-aminophthalimide in the presence of lead tetraacetate, Tetrahedron: Asymmetry, vol. 19, Apr. 2008
2008 Camphor containing organocatalysts in asymmetric aldol reaction on water, Tetrahedron Lett., vol. 49, Apr. 2008
2007 Diastereoselective three component reaction of N-glyoxyloyl camphorpyrazolidinone, amine and allyltributylstannane: facile synthesis of homoallylic amines, J. Chin. Chem. Soc., vol. 54, Dec. 2007
2007 Elevated p53 and p21waf1 mRNA expression in blood lymphocytes from lung cancer patients with chemoresistance, Cancer Detection and Preventation, vol. 31, Oct. 2007
2007 On the scope of diastereoselective allylation of various chiral glyoxylic oxime ethers with allyltributylstannane in the presence of a Lewis acid and triallylaluminum, Tetrahedron, vol. 63, May. 2007
2006 Diastereoselective cyanation of -keto amides derived from N-phenyl camphorpyrazolidinone and camphorsultam, J. Chin. Chem. Soc., vol. 53, Apr. 2006
2006 立體化學中心反轉之不對稱有機合成, Chemistry (The Chin. Chem. Soc., Taipei), vol. 64, Mar. 2006
2006 Highly diastereoselective allylation and reduction of chiral camphor-derived -ketoamides, Tetrahedron: Aymmetry, vol. 17, Feb. 2006
2006 Diastereoselective Allylation of -Ketoamides Bearing Camphor N-Tosylpyrazolidinone Auxiliary: Efficient Synthesis of Highly Optically Active Two Stereoisomers, Tetrahedron, vol. 62, Jan. 2006
2006 Excellent diastereoselective allylation of camphor derived glyoxylic oxime ethers mediated by a Lewis acid, Tetrahedron Lett., vol. 47, Jan. 2006
年度 計畫名稱 參與人 職稱/擔任之工作 計畫期間 補助/委託或合作機構
2021 光化學與有機手性催化反應: 立體選擇性之串聯反應在多官能基手性 (2/3) 主持人 2020.08 ~ 2021.07 科技部(原國科會)
2020 光化學與有機手性催化反應: 立體選擇性之串聯反應在 主持人 2019.08 ~ 2020.07 科技部(原國科會)
2019 有機手性催化連鎖反應:具手性中心之多官能基碳/雜環狀化合物之合成(3/3) 主持人 2018.08 ~ 2019.07 科技部(原國科會)
2018 有機手性催化連鎖反應:具手性中心之多官能基碳/雜環化合物之合成 主持人 2017.08 ~ 2018.07 科技部(原國科會)
2017 有機手性催化連鎖反應:具手性中心之多官能基碳/雜環化合物之合成 主持人 2016.08 ~ 2017.07 科技部(原國科會)
2016 綠色催化合成-有機催化劑在多成份連鎖催化反應之探討(3/3) 主持人 2015.08 ~ 2016.07 科技部(原國科會)
2016 多麩醯胺小腦萎縮症/阿茲海默氏症的藥物開發.....(2/3) 化學系 協同/共同主持人 2015.05 ~ 2016.04 國科會
2015 綠色催化合成-有機催化劑在多成份連鎖催化反應之探討(2/3) N/A 主持人 2014.08 ~ 2015.07 科技部(原國科會)
2015 多麩醯胺小腦萎縮症/阿茲海默氏症的藥物開發.....(1/3) 化學系 協同/共同主持人 2014.05 ~ 2015.04 國科會
2014 綠色催化合成-有機催化劑在多成份連鎖催化反應之探討(1/3) N/A 主持人 2013.08 ~ 2014.07
2013 手性有機催化劑在不對稱合成上之開發研究(3/3) 國立臺灣師範大學 主持人 2012.08 ~ 2013.07 國科會
2012 手性有機催化劑在不對稱合成上之開發研究(2/3) 國立臺灣師範大學 主持人 2011.08 ~ 2012.07 國科會
2006 對掌輔助劑/對掌螯合劑在有機不對稱合成上的開發應用(2/3) 主持人 2005.08 ~ 2006.07 科技部(原國科會)
2005 對掌輔助劑/對掌螯合劑在有機不對稱合成上的開發應用(1/3) 主持人 2004.08 ~ 2005.07 科技部(原國科會)
2004 對掌催化劑之開發應用(3/3) 主持人 2003.08 ~ 2004.07 科技部(原國科會)
2003 對掌催化劑之開發應用(2/3) 主持人 2002.08 ~ 2003.07 科技部(原國科會)
2001 對掌催化劑之開發應用(1/3) 主持人 2001.08 ~ 2001.07 科技部(原國科會)
2001 對掌輔助劑 / 催化劑的設計合成及其在有機不對稱合成上的應用 主持人 2000.08 ~ 2001.07 科技部(原國科會)
2000 新立體輔助劑在有機不對稱合成上的應用 主持人 1999.08 ~ 2000.07 科技部(原國科會)
1999 新立體輔助劑在有機不對稱合成上的應用(III) 主持人 1998.08 ~ 1999.07 科技部(原國科會)
國家 學校名稱 系所 學位 期間
臺灣 國立臺灣師範大學 化學系 理學士 1978.09 ~ 1982.06
美國 賓州大學 博士
服務機關名稱 單位 職務 期間
國立臺灣師範大學 化學系 教授 2001.08 ~ 迄今
國立臺灣師範大學 化學系 副教授 1998.08 ~ 2001.07
朝陽科技大學 應用化學系 副教授 1995.08 ~ 1998.07
美國雅立雅德製藥公司 資深研究員 1992.01 ~ 1995.01