陈焜铭
姓名 陈焜铭
电子邮件 kchen@ntnu.edu.tw
联络电话 (02)77496124
实验室电话 (02)77496150
职称 优聘教授
研究领域 有机不对称合成
学术专长
  1. 设计合成以樟脑架构为主之对掌辅助剂/对掌螯 合剂并探讨其在有机不对称合成上的应用。 
  2. 新药物分子设计合成。
  3. 结构新颖之有机催化剂设计合成及应用探讨。
指导学生 陈蓉萱,马达南,管轩浩,张惠茹,李佩勳,何青胤,叶伦辅,陈致皓,刘积瑞,黄琬沄,柯羿均,吕依旻,陈奕杰,陈彦铭
实验室 对掌催化合成研究室

学术着作

    1. 2013
      Hsuan-Hao Kuan, Chung-Han Chien,and Kwunmin Chen* “Synthesis of Fully Substituted Dispirocyclohexanes by Organocatalytic [2+2+2] Annulation Strategy Between 2-Arylideneindane-1,3-diones and Aldehydes” Org. Lett. 2013, 15, 2880-2883.
    2. Dhananjay R. Magar, Yi-Jiun Ke and Kwunmin Chen* ”Three Component Synthesis  of Functionalized N-Protected Tetrasubstituted Pyrroles via Addition-Elimination-Aromatization Process” Asia J. Org. Chem. 2013,  2, 330-335. (inside cover)
    3. Shaik Anwar, Wan-Yun Huang,Chih-Hao Chen, You-Song Cheng and Kwunmin   Chen* ”An Efficient Friedel-Crafts/Oxa-Michael/Aromatic Annulation: Rapid Access    to Substituted Naphtho[2,1-b]-, [1,2-b]furan and Benzofuran Derivatives” Chem. Eur. J. 2013, 19, 4344-4351.
    4.  Yan ming Chen, Pei-Hsun Lin, Jun Lin, and Kwunmin Chen* “Desymmetrization and switching of stereoselectivity in direct organocatalytic Michael addition of ketones to 1,1-bis(phenylsulfonyl)ethylene ”Eur. J. Org. Chem. 2013 , 2699-92707.
       
       
    5. 2012
      Lun Fu Yeh,Shaik Anwar and Kwunmin Chen* “ The Combination of Domino Process and Kinetic Resolution: Organocatalytic Synthesis of Functionalised Cyclopentenes by Sequential SN2'-Michael Reaction“ Tetrahedron 201268, 7317-7321. (13/57; IF: 3.219)
    6. Raju Jannapu Reddy, Pei-Hsun Lee, Dhananjay R. Magar, Jung-Hsuan Chen and Kwunmin Chen* “Kinetic resolution of activated nitroallylic acetates with aldehydes and ketones via conjugate addition-elimination SN2’ process” Eur. J. Org. Chem. 2012, 353-363. (15/57; IF:3.016)
    7. Wan-Yun Huang, Yi-Chieh Chen and Kwunmin Chen* “Efficient synthesis of tetrasubstituted furans from nitroallylic acetates and 1,3-dicarbonyl/a-activating ketones by Feist-Bénary addition-elimination” Chem. Asian J. 20127, 688-691. (19/140; IF:4.287)
    8. Suparna Roy and Kwunmin Chen* “Three-Component Organocascade Kinetic Resolution of Racemic Nitroallylic Acetates via Sequentia l Iminium/Enamine Asymmetric Catalysis” Org. Lett. 2012, 14, 2496-2499. (5/57 IF:5.420)
       
       
    9. 2011
      Jung-Hsuan Chen, Chihliang Chang, Hui-Ju Chang and Kwunmin Chen* “Efficient Synthesis of 2,3,5,6-Tetrahydro-1-Alkyl/Aryl-1H-Benzo[f]Chromen-3-Ol Derivatives from b-Tetralones and a,b-Unsaturated Aldehydes“Organic & Biomolecular Chemistry 2011, 9, 7510-7516. (12/56; IF: 3.451)
    10. Shaik Anwar, Pei-Hsun Lee, Tsai-Yung Chou, Chihliang Chang, and Kwunmin Chen* Pyrrolidine-linker-camphor assembly: bifunctional organocatalysts for efficient Michael addition of cyclohexanone to nitroolefins under neat conditions” Tetrahedron 2011, 67, 1171-1177. (13/57; IF: 3.219)
    11. Raju Jannapu Reddy and Kwunmin Chen* “Highly Efficient Organocatalytic Kinetic Resolution of Activated Nitroallylic Acetates with Aldehydes via Conjugate Addition-Elimination” Org. Lett. 2011, 13, 1458-1461. (4/57; IF: 5.420)
    12. Shaik Anwar, Hui-Ju Chang and Kwunmin Chen* “Organocatalytic Synthesis of Multiple Substituted Bicyclo[4.4.0]Decalin System” Org. Lett. 2011, 13, 2200-2203. (4/57; IF: 5.420)
    13. Shaik Anwar, Hui-Ju Chang, and Kwunmin Chen*, "Organocatalytic Synthesis of Multiple Substituted Bicyclo[4.4.0]Decalin System" Org. Lett. 2011, ASAP. 附件档案附件档案 Adobe PDF
    14. Raju Jannapu Reddy and Kwunmin Chen " Highly Efficient Organocatalytic Kinetic Resolution of Activated Nitroallylic Acetates with Aldehydes via Conjugate Addition-Elimination" Org. Lett. 201113, 1458-1461. 附件档案附件档案 Adobe PDF
    15. Shaik Anwar, Pei-Hsun Lee, Tsai-Yung Chou, Chihliang Chang, Kwunmin Chen " Pyrrolidine-linker-camphor assembly: bifunctional organocatalysts for efficient Michael addition of cyclohexanone to nitroolefins under neat conditions" Tetrahedron 201167, 1171-1177. 附件档案附件档案 Adobe PDF
    16. 2010
      Hsuan-Hao Kuan, Raju Jannapu Reddy, Kwunmin Chen " An efficient MoritaeBayliseHillman reaction for the synthesis of multifunctional 2-hydroxy-3-nitrobut-3-enoate derivatives" Tetrahedron 201066, 9875-9879. 附件档案附件档案 Adobe PDF
    17. Jung-Hsuan Chen, Shuan-Ru Liu, and Kwunmin Chen* “An Efficient and Convenient Synthesis of Ethyl 1-(4-methoxyphenyl)-5-Phenyl-1H-1,2,3-Triazole-4-Carboxylates” Chem. Asian J. 2010, 5, 328-333. (19/140; IF:4.197).
    18. Hsuan-Hao Kuan,Raju Jannapu Reddy and Kwunmin Chen* “An efficient Morita-Baylis-Hillman reaction for the synthesis of multifunctional 2-hydroxy-3-nitro-but-3-enoate derivatives” Tetrahedron 201066, 9875-9879 (13/57; IF: 3.219)
    19. Ying-Fang Ting, Chihliang Chang, Raju Jannapu Reddy, Dhananjay R. Magar and Kwunmin Chen* “Pyrrolidine-Camphor Derivatives as a New Class of Organocatalysts for Direct Asymmetric Michael Addition of Aldehydes and Ketones to β-Nitroalkenes” Chem. Eur. J. 201016, 7030-7038. (17/140; IF: 5.454)
    20. Pang-Min Liu, Dhananjay R. Magar, and Kwunmin Chen " Highly Efficient and Practical Pyrrolidine–Camphor-Derived Organocatalysts for the Direct α-Amination of Aldehydes" Eur. J. Org. Chem. 2010, 5705-5713. 附件档案附件档案 Adobe PDF
    21. Ying-Fang Ting, Chihliang Chang, Raju Jannapu Reddy, Dhananjay R. Magar, and Kwunmin Chen* " Pyrrolidinyl–Camphor Derivatives as a New Class of Organocatalyst for Direct Asymmetric Michael Addition of Aldehydes and Ketones to beta-Nitroalkenes" Chem. Eur. J. 2010, 16, 7030-7038. 附件档案附件档案 Adobe PDF
    22. Dhananjay R. Magar, Chihliang Chang, Ying-Fang Ting, Kwunmin Chen "Highly Enantioselective Conjugate Addition of Ketones to Alkylidene Malonates Catalyzed by a Pyrrolidinyl-Camphor-Derived Organocatalyst " Eur. J. Org. Chem. 2010, 2062-2066. 附件档案附件档案 Adobe PDF
    23. Jung-Hsuan Chen, Shuan-Ru Liu, and Kwunmin Chen* “An Efficient and Convenient Synthesis of Ethyl 1-(4-methoxyphenyl)-5-Phenyl-1H-1,2,3-Triazole-4-Carboxylates” Chem. Asian J. 2010 , 5, 2, 328 附件档案附件档案 Adobe PDF
    24. 2009
      Raju Jannapu Reddy, Hsuan-Hao Kuan, Tsai-Yung Chou and Kwunmin Chen* “Novel Prolinamide-Camphor Containing Organocatalysts for Direct Asymmetric Michael Addition of Unmodified Aldehydes to Nitroalkenes” Chem. Eur. J. 200915, 9294-9298. (17/140; IF: 5.454)
    25. Chin-Sheng Chao, Chung-Kai Cheng, Ssu-Hsien Li and  Kwunmin Chen* “Diastereoselective electrophilic a-amination of camphor  N1-acyl N2-phenylpyrazolidinones: the metal enolate-dependent synthesis of two possible hydrazide diastereomers” Tetrahedron Lett.  2009, 50, 333-336. (21/57; IF: 2.538)
    26. Chin-Sheng Chao, Chung-Kai Cheng, Ssu-Hsien Li and  Kwunmin Chen* “Diastereoselective electrophilic a-amination of camphor  N1-acyl N2-phenylpyrazolidinones: the metal enolate-dependent synthesis of two possible hydrazide diastereomers” Tetrahedron Lett.  2009, 50, 333-336. 附件档案附件档案 Adobe PDF
    27. Zheng-Hao Tzeng, Hung-Yao Chen, Raju Jannapu Reddy, Ching-Ting Huang and Kwunmin Chen* “Highlydiastereo- and enantioselective direct aldol reactions promoted by water-compatible organocatalysts bearing a pyrrolidinyl camphor structural scaffold” Tetrahedron 2009, 65, 2879-2888. 附件档案附件档案 Adobe PDF
    28. Chihliang Chang, Ssu-Hsien Li, Raju Jannapu Reddy and Kwunmin Chen* “Pyrrolidine-camphor derivative as an organocatalyst for asymmetic Michael addition of a,a-disubstituted aldehydes to β-nitroalkenes: construction of quaternary carbon bearing aldehydes under solvent-free conditions” Adv. Synth. Catal. 2009351, 1273-1278. 附件档案附件档案 Adobe PDF
    29. Raju Jannapu Reddy, Hsuan-Hao Kuan, Tsai-Yung Chouand Kwunmin Chen* “Novel Prolinamide-Camphor Containing Organocatalysts for Direct Asymmetric Michael Addition of Unmodified Aldehydes to Nitroalkenes” Chem. Eur. J. 200915, 9294-9298. 附件档案附件档案 Adobe PDF
    30. Pang-Min Liu, Chihliang Chang, Raju Jannapu Reddy, Ying-Fang Ting, Hsuan-Hao Kuan and Kwunmin Chen* “Remarkable Reaction Rate and Excellent Enantioselective Direct a-Amination of Aldehydes with Azodicarboxylates Catalyzed by Pyrrolidinyl-Camphor Derived Organocatalysts” Eur. J. Org. Chem. 2010, 42-46 附件档案附件档案 Adobe PDF
    31. Shy-Guey Wang, Chia-Wen Wu, Kwunmin Chen and Victor S,-Y. Lin* “Fine-Tuning Mesochannel Orientation of Organically Functionalized Mesoporous Silica Nanoparticles” Chem. Asian J. 20094, 658-661.
    32. 2008
      Zheng-Hao Tzeng, Hung-Yao Chen, Ching-Ting Huang and Kwunmin Chen* “
      Camphor containing organocatalysts in asymmetric aldol reaction on water” Tetrahedron Lett. 200849, 4134-4137. 附件档案附件档案 Adobe PDF
    33. Pei-Wen Duan,Ching-Chen Chiu, Wei-Der Lee, Li Shiue Pan, Uppala Venkatesham, Zheng-Hao Tzeng  and Kwunmin Chen* “On the scope of diastereoselective aziridination of various chiral auxiliaries derived N- and O-enones with N-aminophthalimide in the presence of lead tetraacetate” Tetrahedron: Asymmetry 200818, 682-690. 附件档案附件档案 Adobe PDF
    34. Zheng-Hao Tzeng , Shuen-Wen Yang, Pang-Min Liu and Kwunmin Chen* “Optical Resolution of 5-Oxo-1-Phenyl-Pyrazolidine-3-Carboxylic Acid as a New Organocatalyst for Organic Reactions J. Chin. Chem. Soc200855, 626-631. 附件档案附件档案 Adobe PDF
    35. Chihliang Chang and Kwunmin Chen* “Diastereoselective three component reaction of N-glyoxyloyl camphorpyrazolidinone, amine and allyltributylstannane: facile synthesis of homoallylic amines” J. Chin. Chem. Soc200754, 1591-1594. 附件档案附件档案 Adobe PDF
    36. Chuen-Ming Shih, Kwunmin Chen, Yu-Chieh Wang, Pei-Jung Lee and Yi-Ching Wang* “Elevated p53 and p21waf1 mRNA expression in blood lymphocytes from lung cancer patients with chemoresistance” Cancer Detection and Preventation 200731, 366-370.
    37. Jung-Hsuan Chen, Uppala Venkatesham, Li-Chen    Lee and Kwunmin Chen* “Diastereoselective Allylation of a-Ketoamides Bearing Camphor N-Tosylpyrazolidinone Auxiliary: Efficient Synthesis of  Highly Optically Active Two Stereoisomers” Tetrahedron 200662, 887. 附件档案附件档案 Adobe PDF
    38. Neelesh A. Kulkarni and Kwunmin Chen* “Excellent    diastereoselective allylation of camphor derived glyoxylic oxime ethers mediated by a Lewis acid” Tetrahedron Lett. 200647, 611. 附件档案附件档案 Adobe PDF
    39. Neelesh A. Kulkarni, Ching-Fa Yao and Kwunmin    Chen “On the scope of diastereoselective allylation of various chiral glyoxylic oxime ethers with allyltributylstannane in the presence of a Lewis acid and triallylaluminum” Tetrahedron 200763, 7816. 附件档案附件档案 Adobe PDF
    40. Jia-Fu Pan and Kwunmin Chen “Diastereoselective Baylis-Hillman Reaction Using N-Glyoxyloyl Camphorpyrazolidinone as an Electrophile: Synthesis of Optically Pure 2- Hydroxy-3-Methylene Succinic Acid Derivative” Tetrahedron Lett. 2004, 45, 2541. 附件档案附件档案 Adobe PDF
    41. Wei-Der Lee, Ching-Chen Chiu, Hua-Lin Hsu and Kwunmin Chen “On the Scope of Diastereoselective Epoxidation of Various Chiral Auxiliaries Derived Enones: The Conformational Analysis of Camphor Derived N- and O-Enones” Tetrahedron 2004, 60, 6657. 附件档案附件档案 Adobe PDF
    42. Shy-Guey Wang, Huei Ru Tsai and Kwunmin Chen “Lewis Acid-Mediated Diastereoselective Allylation of Camphorpyrazolidinone Derived a-Ketoamides” Tetrahedron Lett. 2004, 45, 6183. 附件档案附件档案 Adobe PDF
    43. Chai Ling Fang, Wei-Der Lee, Nai-Wei Teng, Ying-Chieh Sun* and Kwunmin Chen “Epoxidation of Chiral Camphor N-Enoyl- pyrazolidinones with Methyl(trifluoromethyl)-dioxirane and Urea Hydrogen Peroxide/Acid Anhydride: Reversal of Stereoselectivity” J. Org. Chem. 2003, 68, 9816. 附件档案附件档案 Adobe PDF
    44. Chai Ling Fan, Gondi Sudershan Reddy and Kwunmin Chen ‘Diastereoselective Epoxidation of Camphor N-Enoylpyrazolidinones’ J. Chin. Chem. Soc200350, 1047.
    45. Kung-Shou Yang, Wei-Der Lee, Jia-Fu Pan and Kwunmin Chen* ‘Chiral Lewis Acid-Catalyzed Asymmetric Baylis-Hillman Reactions’ J. Org. Chem. 2003, 68, 915. 附件档案附件档案 Adobe PDF
    46. Kung-Shou Yang and Kwunmin Chen* ‘Enantioselective Aziridination of Alkenes with N-Aminophthalimide in the Presence of Lead Tetraacetate-Mediated Chiral Ligand” Org. Lett. 20024, 1107. 附件档案附件档案 Adobe PDF
    47. Jia-Fu Pan and Kwunmin Chen “A Facile Catalytic Oxidation of Activated Hydrocarbons to the Carbonyl Functionality Mediated by Mn(II) Complexes” J. Molecular Catalysis A; Chemical 2001, 176, 19.
    48. Wei-Der Lee, Kung-Shuo Yang and Kwunmin Chen* ‘A Remarkable Rate Acceleration of Baylis-Hillman Reaction’ Chem. Commun.,2001, 1612.
      附件档案附件档案 Adobe PDF
 
 
年度 论文名称
2021 [3+2] regioselective annulation reaction of 2- arylidene-1,3-indandiones towards synthesis of spirocyclopentenes: understanding the mechanism of g-attack vs. a-attack using DFT studies, RSC Advances, vol. 11, Jun. 2021
2021 Enantioselective Aza-Friedel-Crafts Reaction of Heteroarenes with in situ Generated Isoxazolium Ions via Chiral Phosphoric Acid Catalysis, Adv. Synth. Catal., vol. 363, Apr. 2021
2020 Enantioselective Organocatalytic Synthesis of δ-Lactone-Fused 4-Chromanones, Advanced Synthesis & Catalysis, vol. 362, May. 2020
2020 Organocatalytic Diastereoselective Synthesis of Diazoarylbenzo[ b]azepine Derivatives, Journal of Organic Chemistry, vol. 85, May. 2020
2019 An Unprecedented Organocascade Synthesis of Functionalized Bicyclic Nitrones from 2-Aminomalonate Derived Nucleophiles and 1-Nitro-1,3-Enynes via Allenes Formation and Subsequent Rearrangement, Adv. synth. catal, vol. 361, Jan. 2019
2018 Organocatalytic synthesis of densely functionalized oxa-bridged 2,6- epoxybenzo[b][1,5]oxazocine heterocycles, Chem. Commun., Jan. 1970
2017 Organocascade Syntheis of Bicyclo[3.3.1]noane, Adv. Synth. Catal, vol. 359, Jan. 2017
2017 Diastereoselective Syntheis of functionalized angulary-fused, Adv. synth. catal, vol. 359, Jan. 2017
2017 Morita–Baylis–Hillman (MBH) Reaction Derived Nitroallylic Alcohols, Acetates and Amines as Synthons in Organocatalysis and Heterocycle Synthesis, Chemical Record, vol. 17, Jan. 1970
2016 Organocatalytic One-Pot Asymmetric Synthesis of Functionalized Spiropyrazolones via a Michael-Aldol Sequential Reaction, RSC advances, vol. 必填字段, Sep. 2016
2016 Recent Advances in Organocatalytic Kinetic Resolution for the Synthesis of Functionalized Products, ChemCatChem, vol. 8, Jan. 2016
2016 Recent advances in organocatalytic kinetic resolution for the synthesis of functionalized products, ChemCatChem, vol. 8, Jan. 2016
2016 Organocascade Synthesis of Annulated (Z)-2-mehhylenepyrans, Org. Lett., vol. 18, Jan. 2016
2016 Dihydrooxazine N-Oxide Intermediates as Resting States in Organocatalytic Kinetic Resolution of Functionalized Nitroallylic Amines with Aldehydes, Org. Lett, vol. 18, Jan. 2016
2015 Organocatalytic synthesis of spirocyclohexane indane-1,3-diones via a chiral squaramide-catalyzed Michael/aldol cascade reaction of γ-nitro ketones and 2-arylideneindane-1, 3-diones, Tetrahedron, vol. 71, Aug. 2015
2015 Rauhut-Currier0Initiated Organocascade Reaction:Synthesis of Substituted..., Adv. Synth. Catal., vol. 357, Aug. 2015
2015 Enantioselective Synthesis of Functionalized Polycarbocycles via a three-component........, Org. Lett, vol. 17, May. 2015
2015 Control of five contiguous stereogenic centers in an organocatalytic kinetic resolution, Org. Lett., vol. 17, Jan. 2015
2014 Organocatalytic KInetic Resolution of Racemic Secondary Nitroallylic, J. Org. Chem., vol. 79, Nov. 2014
2014 Organocatalytic syntheis of sub stituted spirocyclohexane carbaldehydes via [4+2], Org. Lett., vol. 16, Oct. 2014
2014 Organocatalytic Desymmetrization of Cyclic meso-Anhydrides through Enantioselective Alcoholysis with Functionalized Primary Nitroallylic Alcohols, Tetrahedron, vol. 70, Jun. 2014
2013 Organocatalytic formal [5+1] annulation: Diastereoselective cascade synthesis of functionalized six-membered spirocyclic indane-1,3-diones/oxindoles via Michael-aldol reaction, Tetrahedron, vol. 69, Aug. 2013
2013 An efficient Friedel-Crafts/oxa-Michael/aromatic annulation:, Chemistry: a European Journal, vol. 19, May. 2013
2013 Synthesis of Fully Substituted Dispirocyclohexanes by Organocatalytic [2+2+2] Annulation Strategy Between 2-Arylideneindane-1,3-diones and Aldehydes”, Org. Lett., vol. 15, May. 2013
2013 An Efficient Friedel-Crafts/Oxa-Michael/Aromatic Annulation: Rapid Access to Substituted Naphtho[2,1-b]-, [1,2-b]furan and Benzofuran Derivatives, Chem. Eur. J., vol. 19, May. 2013
2013 Desymmetrization and switching of stereoselectivity in direct organocatalytic Michael addition of ketones to 1,1-bis(phenylsulfonyl)ethylene, Eur. J. Org. Chem., vol. 2013, Apr. 2013
2013 Three component synthesis of functionalized N-protected tetrasubstituted pyrroles, Asia J. Org. Chem, vol. 2, Jan. 2013
2012 The combination of domino process and kinetic resolution, Tetrahedron, vol. 68, Sep. 2012
2012 efficient synthesis of tetrasubstituted furans from nitroallylic acetates and 1,3-, chemistry an asia journal, vol. 7, Aug. 2012
2012 Silica gel-Mediated Friedel-Crafts Reaction of Indoles with Functionalized Nitroallylic Acetates via an SN1 Process, JCCS, vol. 59, Jun. 2012
2012 Three-component organocascade kinetic resolution of racemic nitroallylic acetates, organic letter, vol. 14, Jun. 2012
2012 synthesis of substituted chiral chromans via organocatalytic kinetic resolution of racemic, Tetrahderon, vol. 68, May. 2012
2012 kinetic resolution of activated nitroallylic acetates with aldehydes and ketones, eur.j.org. chem., vol. 5, Apr. 2012
2011 Efficient Synthesis of 2,3,5,6-Tetrahydro-1-Alkyl/Aryl-1H-Benzo[f]Chromen-3-Ol Derivatives from -Tetralones and ,-Unsaturated Aldehydes, Org. Biomol. Chem, vol. 9, Oct. 2011
2011 Organocatalytic Synthesis of Multiple Substituted Bicyclo[4.4.0]Decalin System, Org. Lett., vol. 13, Apr. 2011
2011 Highly Efficient Organocatalytic Kinetic Resolution of Activated Nitroallylic Acetates with Aldehydes via Conjugate Addition-Elimination, Org. Lett., vol. 13, Feb. 2011
2011 Pyrrolidine-linker-camphor assembly: bifunctional organocatalysts for efficient Michael addition of cyclohexanone to nitroolefins under neat conditions, Tetrahedron, vol. 67, Feb. 2011
2010 An efficient Morita-Baylis-Hillman reaction for the synthesis of multifunctional 2-hydroxy-3-nitro-but-3-enoate derivatives, Tetrahedron, vol. 66, Dec. 2010
2010 Highly efficient and practical pyrrolidinyl-camphor derived organocatalysts for the direct α-amination of aldehydes, Eur. J. Org. Chem, vol. 2010, Aug. 2010
2010 Pyrrolidine-Camphor Derivatives as a New Class of Organocatalysts for Direct Asymmetric Michael Addition of Aldehydes and Ketones to β-Nitroalkenes, Chem. Eur. J., vol. 16, May. 2010
2010 Highly enantioselective conjugate addition of ketones to alkylidene malonates catalyzed by pyrrolidinyl-camphor derived organocatalyst, Eur. J. Org. Chem., vol. 2010, Apr. 2010
2010 Remarkable Reaction Rate and Excellent Enantioselective Direct -Amination of Aldehydes with Azodicarboxylates Catalyzed by Pyrrolidinyl-Camphor Derived Organocatalysts, Eur. J. Org. Chem., vol. 2010, Jan. 2010
2010 An Efficient and Convenient Synthesis of Ethyl 1-(4-methoxyphenyl)-5-Phenyl-1H-1,2,3-Triazole-4-Carboxylates, Chem. Asian J., vol. 5, Jan. 2010
2009 Novel Prolinamide-Camphor Containing Organocatalysts for Direct Asymmetric Michael Addition of Unmodified Aldehydes to Nitroalkenes, Chem. Eur. J., vol. 15, Aug. 2009
2009 Pyrrolidine-camphor derivative as an organocatalyst for asymmetic Michael addition of ,-disubstituted aldehydes to β-nitroalkenes: construction of quaternary carbon bearing aldehydes under solvent-free conditions, Adv. Synth. Catal., vol. 351, May. 2009
2009 Fine-tuning mesochannel orientation of organically functionalized mesoporous silica nanoparticles, Chem. Asian J., vol. 4, Mar. 2009
2009 Highly diastereo- and enantioselective direct aldol reactions promoted by water-compatible organocatalysts bearing a pyrrolidinyl camphor structural scaffold, Tetrahedron, vol. 65, Feb. 2009
2009 Diastereoselective electrophilic alpha-amination of camphor N1-acyl N2-phenylpyrazolidinones: the metal enolate-dependent synthesis of two possible hydrazide diastereomers, Tetrahedron Lett., vol. 50, Jan. 2009
2008 Optical Resolution of 5-Oxo-1-Phenyl-Pyrazolidine-3-Carboxylic Acid as a New Organocatalyst for Organic Reactions, J. Chin. Chem. Soc., vol. 55, Jun. 2008
2008 On the scope of diastereoselective aziridination of various chiral auxiliaries derived N- and O-enones with N-aminophthalimide in the presence of lead tetraacetate, Tetrahedron: Asymmetry, vol. 19, Apr. 2008
2008 Camphor containing organocatalysts in asymmetric aldol reaction on water, Tetrahedron Lett., vol. 49, Apr. 2008
2007 Diastereoselective three component reaction of N-glyoxyloyl camphorpyrazolidinone, amine and allyltributylstannane: facile synthesis of homoallylic amines, J. Chin. Chem. Soc., vol. 54, Dec. 2007
2007 Elevated p53 and p21waf1 mRNA expression in blood lymphocytes from lung cancer patients with chemoresistance, Cancer Detection and Preventation, vol. 31, Oct. 2007
2007 On the scope of diastereoselective allylation of various chiral glyoxylic oxime ethers with allyltributylstannane in the presence of a Lewis acid and triallylaluminum, Tetrahedron, vol. 63, May. 2007
2006 Diastereoselective cyanation of -keto amides derived from N-phenyl camphorpyrazolidinone and camphorsultam, J. Chin. Chem. Soc., vol. 53, Apr. 2006
2006 立体化学中心反转之不对称有机合成, Chemistry (The Chin. Chem. Soc., Taipei), vol. 64, Mar. 2006
2006 Highly diastereoselective allylation and reduction of chiral camphor-derived -ketoamides, Tetrahedron: Aymmetry, vol. 17, Feb. 2006
2006 Diastereoselective Allylation of -Ketoamides Bearing Camphor N-Tosylpyrazolidinone Auxiliary: Efficient Synthesis of Highly Optically Active Two Stereoisomers, Tetrahedron, vol. 62, Jan. 2006
2006 Excellent diastereoselective allylation of camphor derived glyoxylic oxime ethers mediated by a Lewis acid, Tetrahedron Lett., vol. 47, Jan. 2006
年度 计画名称 参与人 职称/担任之工作 计画期间 补助/委讬或合作机构
2021 光化学与有机手性催化反应: 立体选择性之串联反应在多官能基手性 (2/3) 主持人 2020.08 ~ 2021.07 科技部(原国科会)
2020 光化学与有机手性催化反应: 立体选择性之串联反应在 主持人 2019.08 ~ 2020.07 科技部(原国科会)
2019 有机手性催化连锁反应:具手性中心之多官能基碳/杂环状化合物之合成(3/3) 主持人 2018.08 ~ 2019.07 科技部(原国科会)
2018 有机手性催化连锁反应:具手性中心之多官能基碳/杂环化合物之合成 主持人 2017.08 ~ 2018.07 科技部(原国科会)
2017 有机手性催化连锁反应:具手性中心之多官能基碳/杂环化合物之合成 主持人 2016.08 ~ 2017.07 科技部(原国科会)
2016 绿色催化合成-有机催化剂在多成份连锁催化反应之探讨(3/3) 主持人 2015.08 ~ 2016.07 科技部(原国科会)
2016 多麸醯胺小脑萎缩症/阿兹海默氏症的药物开发.....(2/3) 化学系 协同/共同主持人 2015.05 ~ 2016.04 国科会
2015 绿色催化合成-有机催化剂在多成份连锁催化反应之探讨(2/3) N/A 主持人 2014.08 ~ 2015.07 科技部(原国科会)
2015 多麸醯胺小脑萎缩症/阿兹海默氏症的药物开发.....(1/3) 化学系 协同/共同主持人 2014.05 ~ 2015.04 国科会
2014 绿色催化合成-有机催化剂在多成份连锁催化反应之探讨(1/3) N/A 主持人 2013.08 ~ 2014.07
2013 手性有机催化剂在不对称合成上之开发研究(3/3) 国立台湾师范大学 主持人 2012.08 ~ 2013.07 国科会
2012 手性有机催化剂在不对称合成上之开发研究(2/3) 国立台湾师范大学 主持人 2011.08 ~ 2012.07 国科会
2006 对掌辅助剂/对掌螯合剂在有机不对称合成上的开发应用(2/3) 主持人 2005.08 ~ 2006.07 科技部(原国科会)
2005 对掌辅助剂/对掌螯合剂在有机不对称合成上的开发应用(1/3) 主持人 2004.08 ~ 2005.07 科技部(原国科会)
2004 对掌催化剂之开发应用(3/3) 主持人 2003.08 ~ 2004.07 科技部(原国科会)
2003 对掌催化剂之开发应用(2/3) 主持人 2002.08 ~ 2003.07 科技部(原国科会)
2001 对掌催化剂之开发应用(1/3) 主持人 2001.08 ~ 2001.07 科技部(原国科会)
2001 对掌辅助剂 / 催化剂的设计合成及其在有机不对称合成上的应用 主持人 2000.08 ~ 2001.07 科技部(原国科会)
2000 新立体辅助剂在有机不对称合成上的应用 主持人 1999.08 ~ 2000.07 科技部(原国科会)
1999 新立体辅助剂在有机不对称合成上的应用(III) 主持人 1998.08 ~ 1999.07 科技部(原国科会)
国家 学校名称 系所 学位 期间
台湾 国立台湾师范大学 化学系 理学士 1978.09 ~ 1982.06
美国 宾州大学 博士
服务机关名称 单位 职务 期间
国立台湾师范大学 化学系 教授 2001.08 ~ 迄今
国立台湾师范大学 化学系 副教授 1998.08 ~ 2001.07
朝阳科技大学 应用化学系 副教授 1995.08 ~ 1998.07
美国雅立雅德制药公司 资深研究员 1992.01 ~ 1995.01