Yi-Chun Yeh
Name Yi-Chun Yeh
Email yichuny@ntnu.edu.tw
Office Tel No. 02-77496117
Title Distinguished Professor
Research Biochemistry、Synthetic Biology、Bioenergy、Biosensor

Academic Researches

  1. Shih CI, Chou YC, Chen HY, Chen KH, Wang IH, and Yeh YC* (2020). A colorimetric and fluorometric paper-based assay for Cu2+ detection based on green synthesis of 2-aminoterephthalic acid-derived pigments. ACS Applied Bio Materials, DOI:10.1021/acsabm.0c00212.
  2. Chou YC, Shih CI, Chiang CC, Hsu CH, and Yeh YC* (2019). Reagent-free DOPA-dioxygenase Colorimetric Biosensor for Selective Detection of L-DOPA. Sensors and Actuators B: Chemical, 297,126717.
  3. Lin C, Zhang QX, and Yeh YC* (2019). Development of a Whole-cell Biosensor for the Determination of Tyrosine in Urine for Point-of-care Diagnostics. Analytical methods, 11, 1400-1404.
  4. Lu KH, Lin JH, Lin CY, Chen CF*, and Yeh YC* (2019). A fluorometric paper test for chromium(VI) based on the use of N-doped carbon dots. Microchimica Acta, 10.1007/s00604-019-3337-5.
  5. Lou CY, Chou YC , Tsai JH, Huang TM, Chen JZ*, and Yeh YC* (2019). Screen-printed electrochemical biosensor based on tyrosinase/chitosan/reduced graphene oxide biocomposites for the sensitive and interference-free detection of dopamine. Applied Sciences, 9(4), 622.
  6. Kuo KH, Lu KH, and Yeh YC* (2018). Cell-Based Biosensor with Dual Signal Outputs for Simultaneous Quantification of Phenylacetic Acid and Phenylethylamine. ACS synthetic biology, 7, 12, 2790-2795.
  7. Lin C, Jair YC, Chou YC, Chen PS, and Yeh YC* (2018). Transcription Factor-Based Biosensor for Detection of Phenylalanine and Tyrosine in Urine for Diagnosis of Phenylketonuria. Analytica Chimica Acta, 1041, 108-113. 
  8. Kuo KH, Chen PH, Lin C, Chen CF, Lee IR, and Yeh YC* (2018). Determination of Gold Ions in Human Urine Using Genetically Engineered Microorganisms on a Paper Device. ACS Sensors, 3, 4, 744-748. 
  9. Lin C, Guo KH, Liu CY, and Yeh YC* (2017). Using Fluorescence Resonance Energy Transfer for Bioimaging Applications. CHEMISTRY (The Chinese Chemical Society, Taipei), 75(3), 259-266.
  10. Chen YJ, Liu CY, Tsai DY, and Yeh YC* (2017). A portable fluorescence resonance energy transfer biosensor for rapid detection of silver ions. Sensors & Actuators: B. Chemical, 258: 784-788.
  11. Lin YK and Yeh YC* (2017). Dual-Signal Microbial Biosensor for the Detection of Dopamine without Inference from Other Catecholamine Neurotransmitters. Analytical Chemistry, 89(21):11178-11182.  
  12. Yang CH, Chen CW, Lin YK, Yeh YC, Hsu CC, Fan YJ, Yu IS, and Chen JZ (2017).Atmospheric-Pressure Plasma Jet Processed Carbon-Based Electrochemical Sensor Integrated with a 3D-Printed Microfluidic Channel. Journal of The Electrochemical Society, 164(12): B534-B541. 
  13. Chen PH, Lin C, Guo KH, and Yeh YC* (2017).Development of a pigment-based whole-cell biosensor for the analysis of environmental copper. RSC Advances, 7, 29302-29305. 
  14. Ouyang CY, Lin YK, Tsai DY, and Yeh YC* (2016).Secretion of metal-binding proteins by a newly discovered OsmY homolog in Cupriavidus metallidurans for the biogenic synthesis of metal nanoparticles. RSC Advances, 6, 16798-16801.
  15. Tsai DY, Tsai YJ, Yen CH, Ouyang CY, and Yeh YC * (2015).Bacterial surface display of metal binding peptides as whole-cell biocatalysts for 4-nitroaniline reduction. RSC Advances, 5, 87998 - 88001
  16. Ma SY and YC Yeh * (2015). One-step synthesis of water-soluble fluorescent copper nanoparticles for label-free detection of manganese ion. Analytical methods,7, 6475 - 6478.
  17. Tsai YJ, Ouyang CY, Ma SY, Tsai DY, Tseng HW, and Yeh YC * (2014).Biosynthesis and display of diverse metal nanoparticles by recombinant Escherichia coliRSC Advances, 4(102), 58717 - 58719 
  18. Tseng HW, Tsai YJ, Yen JH, Chen PH, Yeh YC* (2014).Fluorescence-based microbial sensor for the selective detection of gold. Chem. Commun. 50 (14), 1735 -7
  19. Müller J, Maceachran D, Burd H, Sathitsuksanoh N, Bi C, Yeh YC, Lee TS, Hillson NJ, Chhabra SR, Singer SW and Beller HR*(2013).  Engineering of Ralstonia eutropha H16 for Autotrophic and Heterotrophic Production of Methyl Ketones. Appl Environ Microbiol. ,79(14):4433-9.
  20. Yeh YC*, Müller J , Bi C, Hillson NJ, Beller HR, Chhabra SR and Singer SW* (2013). Functionalizing bacterial cell surfaces with a phage protein. Chem. Commun., 49, 910-912.  
  21. Bi C, Su P, Müller J, Yeh YC, Chhabra SR, Beller HR, Singer SW and Hillson NJ (2013). Development of a broad-host synthetic biology toolbox for ralstonia eutropha and its application to engineering hydrocarbon biofuel production. Microb Cell Fact., 12(1):107.
  22. Goley ED†*, Yeh YC†, Hong SH, Fero MJ, Abeliuk E, McAdams HH, and Shapiro L. (2011) Assembly of the Caulobacter cell division machine. Mol. Microbiol.80(6): 1680-98. (†Contributed equally)
  23. Yeh YC, Comolli LR, Downing KH, Shapiro L, and McAdams HH. (2010) The Caulobacter Tol-Pal complex is essential for outer membrane integrity and is required for the completion of cell division and polar protein localization. J. Bacteriol.;(192):4847–58.
  24. Lin CC, Yeh YC, Yang CY, Chen GF, Chen YC, Wu YC, and Chen CC. (2003) Quantitative analysis of multivalent interactions of carbohydrate-encapsulate gold nanoparticle with concanavalin A. Chem. Commun.; (23):2920-1. 
  25. Lin CC, Yeh YC, Yang CY, Chen CL, Chen GF, Chen CC, and Wu YC. (2002) Selective binding of mannose-encapsulated gold nanoparticles to type 1 pili in Escherichia coliJ. Am. Chem. Soc.; 124(14):3508-9.
Year Paper Title
2022 Engineering a monolithic 3D paper-based analytical device (μPAD) by stereolithography 3D printing and sequential digital masks for efficient 3D mixing and dopamine detection, Sensors and Actuators A: Physical, vol. 347, Nov. 2022
2022 Cu-PyC MOF with oxidoreductase-like catalytic activity boosting colorimetric detection of Cr(VI) on paper, Analytica Chimica Acta, vol. 1227, Aug. 2022
2022 Sequential Detection of Dopamine and L-DOPA by a 2,3-dopa-dioxygenase from Streptomyces sclerotialus, Analytica Chimica Acta, Feb. 2022
2021 Bi-metallic MOF-919 (Fe-Cu) nanozyme capable of bifunctional enzyme-mimicking catalytic activity, Chemical Communications, vol. DOI: 10.1039/D1CC05908D, Dec. 2021
2021 Gold-specific biosensor for monitoring wastewater using genetically engineered Cupriavidus metallidurans CH34, ACS Synthetic Biology, Dec. 2021
2021 Rapidly and Simultaneously Quantifying Multiple Biomarkers of L-tyrosine Hydroxylase Deficiency by Using Paper Microfluidic Devices and Smartphone-Based Analysis System., Sensors and Actuators: B. Chemical, vol. 349, Sep. 2021
2021 Rapid synthesis of microwave-assisted zinc oxide nanorods on a paper-based analytical device for fluorometric detection of L-dopa., Colloids and Surfaces B: Biointerfaces, vol. 207, Jul. 2021
2020 Simultaneous Determination of L-phenylalanine, Phenylethylamine, and Phenylacetic Acid Using Three-Color Whole-Cell Biosensors within a Microchannel Device, ACS Applied Bio Materials, vol. 3, Jul. 2020
2020 Detection of tyrosine and monitoring tyrosinase activity using an enzyme cascade-triggered colorimetric reaction, RSC Advances, vol. 10, Jul. 2020
2020 Simultaneous Determination of L-phenylalanine, Phenylethylamine, and Phenylacetic Acid Using Three-Color Whole-Cell Biosensors within a Microchannel Device, ACS Applied Bio Materials, vol. 3, Jul. 2020
2020 Colorimetric and Fluorometric Paper-Based Assay for Cu2+ Detection Based on Green Synthesis of 2-Aminoterephthalic Acid-Derived Pigments, ACS Appl. Bio Mater., vol. 3, Apr. 2020
2019 Reagent-free DOPA-dioxygenase Colorimetric Biosensor for Selective Detection of L-DOPA, Sensors & Actuators: B. Chemical, vol. 297, Jun. 2019
2019 Tyrosinase/Chitosan/Reduced Graphene Oxide Modified Screen-Printed Carbon Electrode for Sensitive and Interference-Free Detection of Dopamine, Applied Sciences, vol. 9, Feb. 2019
2019 Development of a Whole-cell Biosensor for the Determination of Tyrosine in Urine for Point-of-care Diagnostics, Analytical methods, vol. 10, Feb. 2019
2019 A fluorometric paper test for chromium(VI) based on the use of N-doped carbon dots, Microchimica Acta, vol. 186, Jan. 2019
2018 Cell-based biosensor with dual signal outputs for simultaneous quantification of phenylacetic acid and phenylethylamine, ACS Synthetic Biology, vol. 7, Nov. 2018
2018 Transcription Factor-Based Biosensor for Detection of Phenylalanine and Tyrosine in Urine for Diagnosis of Phenylketonuria., Analytica Chimica Acta, vol. 1041, Aug. 2018
2018 A portable fluorescence resonance energy transfer biosensor for rapid detection of silver ions, Sensors and Actuators, B: Chemical, vol. 259, Apr. 2018
2018 A portable fluorescence resonance energy transfer biosensor for rapid detection of silver ions, Sensors and Actuators, B: Chemical, vol. 259, Apr. 2018
2018 Determination of Gold Ions in Human Urine Using Genetically Engineered Microorganisms on a Paper Device, ACS sensors, vol. 3, Feb. 2018
2017 Dual-Signal Microbial Biosensor for the Detection of Dopamine without Inference from Other Catecholamine Neurotransmitters., Analytical chemistry, vol. 89, Oct. 2017
2017 Using Fluorescence Resonance Energy Transfer for Bioimaging Applications, CHEMISTRY (The Chinese Chemical Society, Taipei), vol. 75, Aug. 2017
2017 Atmospheric-Pressure Plasma Jet Processed Carbon-Based Electrochemical Sensor Integrated with a 3D-Printed Microfluidic Channel, Journal of The Electrochemical Society, vol. 164, Aug. 2017
2017 Development of a pigment-based whole-cell biosensor for the analysis of environmental copper, RSC advances, vol. 7, May. 2017
2017 Development of a pigment-based whole-cell biosensor for the analysis of environmental copper, RSC Advances, vol. 7, Jan. 2017
2016 Secretion of metal-binding proteins by a newly discovered OsmY homolog in Cupriavidus metallidurans for the biogenic synthesis of metal nanoparticles, RSC Advances, vol. 6, Feb. 2016
2016 Secretion of metal-binding proteins by a newly discovered OsmY homolog in Cupriavidus metallidurans for the biogenic synthesis of metal nanoparticles, RSC Advances, vol. 6, Jan. 2016
2015 Bacterial surface display of metal binding peptides as whole-cell biocatalysts for 4-nitroaniline reduction, RSC advances, vol. 5, Oct. 2015
2015 One-step synthesis of water-soluble fluorescent copper nanoparticles for label-free detection of manganese ions, Analytical Methods, vol. 7, Aug. 2015
2015 One-step synthesis of water-soluble fluorescent copper nanoparticles for label-free detection of manganese ion, Analytical methods, vol. 7, Aug. 2015
2015 Bacterial surface display of metal binding peptides as whole-cell biocatalysts for 4-nitroaniline reduction, RSC Advances, vol. 5, Jan. 2015
2014 Biosynthesis and display of diverse metal nanoparticles by recombinant Escherichia coli, RSC Advances, vol. 4, Nov. 2014
2014 Biosynthesis and display of diverse metal nanoparticles by recombinant Escherichia coli, RSC Advances, vol. 4, Oct. 2014
2014 Engineering of Ralstonia eutropha H16 for Autotrophic and Heterotrophic Production of Methyl Ketones, Applied and Environmental Microbiology, vol. 79, Jul. 2014
2014 A fluorescence-based microbial sensor for the selective detection of gold, Chemical Communications, vol. 50, Feb. 2014
2014 A fluorescence-based microbial sensor for the selective detection of gold, Chem. commun., vol. 50, Jan. 2014
2013 Development of a broad-host synthetic biology toolbox for ralstonia eutropha and its application to engineering hydrocarbon biofuel production, Microbial Cell Factories, vol. 12, Nov. 2013
2013 Development of a broad-host synthetic biology toolbox for ralstonia eutropha and its application to engineering hydrocarbon biofuel production, Microbial Cell Factories, vol. 12, Nov. 2013
2013 Engineering of Ralstonia eutropha H16 for autotrophic and heterotrophic production of methyl ketones, Applied and Environmental Microbiology, vol. 79, Jul. 2013
2013 Functionalizing bacterial cell surfaces with a phage protein, Chemical Communications, vol. 49, Jan. 2013
2013 Functionalizing Bacterial Cell Surfaces with a Phage Protein, Chemical Communications, vol. 49, Jan. 2013
2011 Assembly of the Caulobacter cell division machine, Molecular Microbiology, vol. 80, Jun. 2011
2011 Assembly of the Caulobacter cell division machine., Mol. Microbiol., vol. 80, May. 2011
2010 The Caulobacter Tol-Pal complex is essential for outer membrane integrity and the positioning of a polar localization factor, Journal of Bacteriology, vol. 192, Oct. 2010
2010 The Caulobacter Tol-Pal complex is essential for outer membrane integrity and is required for the completion of cell division and polar protein localization., J. Bacteriol, vol. 192, Aug. 2010
2003 Quantitative analysis of multivalent interactions of carbohydrate- encapsulated gold nanoparticles with concanavalin A, Chemical Communications, vol. 9, Dec. 2003
2003 Quantitative analysis of multivalent interactions of carbohydrate-encapsulate gold nanoparticle with concanavalin A, Chem. Commun., vol. 23, Jan. 2003
2002 Selective binding of mannose-encapsulated gold nanoparticles to type 1 pili in Escherichia coli, Journal of the American Chemical Society, vol. 124, Apr. 2002
2002 Selective binding of mannose-encapsulated gold nanoparticles to type 1 pili in Escherichia coli., J. Am. Chem. Soc., vol. 124, Jan. 2002
Year Project Title Job Title Period Unit
2019 以全細胞試紙呈色發展苯酮尿症偵測工具 主持人 2018.08 ~ 2019.07 科技部(原國科會)
2018 生物色素感測器於金屬檢測之開發與研究 主持人 2017.10 ~ 2018.07 科技部(原國科會)
2017 生物色素感測器於金屬檢測之開發與研究 主持人 2016.08 ~ 2017.07 科技部(原國科會)
2016 奈米材料之生物合成與回收 主持人 2015.08 ~ 2016.07 國科會
2015 奈米材料之生物合成與回收 主持人 2014.08 ~ 2015.07 國科會
2014 以細菌之信息傳遞設計新一代生物感測器與細胞表面展示技術 主持人 2013.08 ~ 2014.07 國科會
2013 以細菌之信息傳遞設計新一代生物感測器與細胞表面展示技術 主持人 2012.11 ~ 2013.07 國科會
Country School Name Department Degree Duration
U.S.A. Stanford University Chemistry PhD 2004.09 ~ 2010.12
Taiwan National Taiwan Normal University Chemistry MS 2001.09 ~ 2003.06
Taiwan National Taiwan Normal University Chemistry BS 1997.09 ~ 2001.06
Organization Title Department Job Title Duration
National Taiwan Normal University Department of Chemistry Associate Professor 2019.08 ~ 0000.01
2016.02 ~ 2019.07
National Taiwan Normal University Chemistry Assistant Professor 2012.08 ~ 2016.01
Lawrence Berkeley National Lab Physical biosciences division Postdoc 2011.01 ~ 2012.07