Ching-Fa Yao
Name Ching-Fa Yao
Email
Office Tel No. (02)77496128
Personal Website http://140.122.142.231/~cheyaocf/Yao/
Title Distinguished Professor
Research Physical Organic Chemistry, Organic Synthesis

Academic Researches

  1.  
  2. 135. Chang, K.-H.; Lin, C.-H.; Chen, H.-C.; Huang, H.-Y.; Chen, S.-L.; Lin, T.-H.; Ramesh, C.; Huang, C.-C.; Fung, H.-C.; Wu, Y.-R.; Huang, H.-J.; Lee-Chen, G. J.*; Hsieh-Li, H. M.*; Yao, C.-F.* CNS Neuroscience & Therapeutics 2016, 22(x), xxxx-xxxx. (x月) (Pharmacology & Pharmacy: 42/253 or Neuroscience: 65/256, 2015 IF: 4.018; 5 year impact factor: 4.089) Online ISSN: 1755-5930
    The Potential of Indole/Indolylquinoline Compounds in Tau Misfolding Reduction by Enhancement of HSPB1          
    計畫編號: NSC-100-2113-M-003-008-MY3
     
    134. Liu, C.-Y.; Hsieh, C.-H.; Kim, S.-H.; Wang, J.-P.; Ni, Y.-L.; Su, C.-L.; Yao, C.-F.; Fang, K.* International Journal of Oncology 2016, 49 (xx), 2031-2041. (x月) (Oncology: 100/213, 2015 IF: 3.018; 5 year impact factor: 2.990) Online ISSN: 1791-2423
    An indolylquinoline derivatives activates DNA damage resoponse and apotosis in human hepatocellular carcinoma cells
    計畫編號: NSC-100-2113-M-003-008-MY3
     
    133. Huang, C.-Y.; Kuo, C.-W.; Konala, A.; Yang, T.-H.; Lin, L.; Chen, Y.-.; Kavala, V.; Yao, C.-F.* RSC Adv. 2016, 6 (98), 96049-96056. (10月) (Chemistry, Multidisciplinary: 49/163, 2015 IF: 3.289; 5 year impact factor: 3.485) Online ISSN: 2046-2069
    Synthesis of 3-arylindole derivatives from nitroalkane precursors
    計畫編號: NSC-100-2113-M-003-008-MY3
     
    132. Chang, H. H.; Lee, L.-H.; Leong, W.-Y.; Yang, T.-C.; Yao, C.-F.; Fang, K.* Drug Design, Development and Therapy 2016, 10, 2947-2957. (9月) (Pharmacology & Pharmacy 84/255, 2014 IF: 2.881; 5 year impact factor: 2.962) Online ISSN: 1177-8881
    A triazole derivative elicits autophagic clearance of polyglutamine aggregation in neuronal cells
    計畫編號: NSC-100-2113-M-003-008-MY3
     
    131. Villuri, B. K.; Kotipalli, T.; Kavala, V.; Ichake, S. S.; Bandi, V. ; Kuo, C.-W.; Yao, C.-F.* RSC Adv. 2016, 6 (78), 74845-74858. (8月) (Chemistry, Multidisciplinary: 49/163, 2015 IF: 3.289; 5 year impact factor: 3.485) Online ISSN: 2046-2069
    Synthesis of Spiro Isoindolinone-indolines and 1,2-Disubstituted Indoles from 2-Iodobenzamide Derivatives 
    計畫編號: NSC-100-2113-M-003-008-MY3
     
    130. Kotipalli, T.;  Kavala, V.; Ashok konala, A.;  Janreddy, D.; Kuo, C.-W.; Yao, C.-F.* Adv. Synth. Catal. 2016, 358(16), 2652-2660. (8月) (Applied Chemistry: 1/72 or Organic Chemistry: 5/59, 2015 IF: 6.453; 5 year impact factor: 5.852) Online ISSN: 1615-4169 (Times Cited: 1)
    Reagent/Substituent Switching Approach for the Synthesis of Substituted 1,3,4-Oxadiazole/1,3,4-Oxadiazoline and 1,2,4-Triazole Derivatives from N-Substituted Hydrazides
    計畫編號: NSC-100-2113-M-003-008-MY3
     
    129. Kuo, C.-W.; Konala, A.; Lin, L.; Chiang, T.-T.; Huang, C-Y.; Yang, T-H .; Kavala, V.; Yao, C.-F* Chem. Commun. 2016, 52(50), 7870-7873. (6月) (Chemistry, Multidisciplinary: 21/163, 2015 IF: 6.567; 5 year impact factor:6.628) Online ISSN: 1359-7345
    Synthesis of Benzo[a]carbazole derivatives from 3-Ethylindoles by Exploiting the Dual Character of Benzoquinone as an oxidizing agent and Dienophile
    計畫編號: NSC-100-2113-M-003-008-MY3
     
    128. Huang, C.-Y.; Kuo, C.-W.; Kavala, V.; Yao, C.-F* Eur. J. Org. Chem. 2016, (15), 2720-2734. (5月) (Organic Chemistry: 17/59, 2015 IF: 3.068; 5 year impact factor:2.971) Online ISSN: 1099-0690
    Syntheses of 2-benzylbenzofuran derivatives and 2-arylnitrochroman derivatives from nitroalkene precursors
    計畫編號: NSC-100-2113-M-003-008-MY3
     
    127. Kotipalli, T.; Kavala, V.; Janreddy, D.; Bandi, V.; Kuo, C.-W.; Yao, C.-F*
    Eur. J. Org. Chem. 2016, (6), 1182-1193. (2月) (Organic Chemistry: 17/59, 2015 IF: 3.068; 5 year impact factor: 2.971) Online ISSN: 1099-0690 (Times Cited:2)
    Synthesis of 2,3-Disubstituted Quinazolinone Derivatives Through Copper Catalyzed C–H Amidation Reactions
    計畫編號: NSC-100-2113-M-003-008-MY3
     
    126. Ichake, S. S.; Rajawinslin, R. R.; Kavala, V.; Villuri, B. K.; Yang, H.-T.; Kuo, C.-W.; Yao, C.-F.* Asian J. Org. Chem. 2016, 5(3), 343-352. (3月) (Organic Chemistry: 16/59, 2015 IF: 3.275; 5 year impact factor: 3.296) Online ISSN: 2193-5815 (Times Cited: 0)
    NBS Mediated Thiocyanation of Cyclohexene Fused Isoxazoline N-Oxides
    計畫編號: NSC-100-2113-M-003-008-MY3
     
    125. Chang, K. H.; Chiu, Y. J.; Chen, S. L.; Huang, C. H.; Lin, C. H.; Lin, T. H.; Lee, C. M.; Ramesh, C.; Wu, C. H., Huang, C. C.; Fung, H. C.; Chen, Y. C.; Lin, J. Y.; Yao, C. F.; Huang, H. J.; Lee-Chen, G. J.*; Lee, M. C.*; Hsieh-Li, H. M.* Neuropharmacology 2016, 101, 309-319. (2月) (Field of Pharmacology & Pharmacy: 19/253, 2015 IF:4.936; 5 year impact factor: 4.709) Online ISSN 0028-3908 (Times Cited: 1)
    The potential of synthetic indolylquinoline derivatives for Aβ aggregation reduction by chemical chaperone activity
    計畫編號: NSC-100-2113-M-003-008-MY3
     
    124. Liu,C.-Y.; Wu, P.-T.; Wang, J.-P.; Fan, P.-W.; Hsieh, C.-H.; Su, C.; Chiu, C.-C.; Yao, C.-F.; Fang, K.* Apoptosis 2015, 20(11), 1471-1482. (12月) (Field of Biochemistry & Molecular Biology: 93/289 or Cell Biology: 80/180, 2014 IF:3.592; 5 year impact factor: 3.617) ISSN: 1360-8185 (Print) 1573-675X (Online) (Times Cited: 3)
    An indolylquinoline derivative promotes apoptosis in human lung cancer cells by impairing mitochondrial functions
    計畫編號: NSC-100-2113-M-003-008-MY3
     
    123. Chen, W.-C.: Lin, C.-C.; Kavala, V.; Kuo, C.-W.; Huang, C.-Y.; Yao, C.-F.* Molecules 2015, 20(12), 22419-22519. (12月) (Organic Chemistry: 24/59, 2015 IF: 2.465; 5 year impact factor: 2.749) Online ISSN 1420-3049 (Times Cited: 0)
    Syntheses of 4-Indolylquinoline Derivatives via Reductive Cyclization of Indolylnitrochalcone Derivatives by Fe/HCl
    計畫編號: NSC-100-2113-M-003-008-MY3
     
    122. Rajawinslin, R. R.; Gawande, S. D.; Kavala, V.; Huang, Y.-H. ; Kuo, C.-W.; Kuo, T.-S.; Chen, M.-L.; He, C.-H.; Yao, C.-F.* RSC Adv., 2015, 5 (64), 52141-52153. (7月) (Chemistry, Multidisciplinary: 48/163, 2015 IF: 3.289; 5 year impact factor: 3.485) Online ISSN: 2046-2069 (Times Cited: 2)
    Iron/acetic acid mediated synthesis of 6,7-dihydrodibenzo [b,j] [1,7] phenanthroline derivatives via intramolecular reductive cylization
    計畫編號: NSC-100-2113-M-003-008-MY3
     
    121. Chen, W.-C.: Kavala, V.; Shih, Y.-H.; Wang, Y.-H.; Kuo, C.-W.; Yang, T.-H.; Huang, C.-Y.; Chiu, H,-H.; Yao, C.-F.* Molecules 2015, 20(6), 10910-10927. (6月) (Organic Chemistry: 24/59, 2015 IF: 2.465; 5 year impact factor: 2.749) Online ISSN 1420-3049 (Times Cited: 1)
    Synthesis of Bicyclic Isoxazoles and Isoxazolines via Intramolecular Nitrile Oxide Cycloaddition
    計畫編號: NSC-100-2113-M-003-008-MY3
     
    120. Gawande, S. D.; Zanwar, M. R.; Kavala, V.; Kuo, C.-W.; Yao, C.-F.* Adv. Synth. Catal. 2015, 375(1), 168-175. (1月) (Applied Chemistry: 1/71 or Organic Chemistry: 5/59, 2015 IF: 6.453; 5 year impact factor: 5.852) Online ISSN: 1615-4169 (Times Cited: 2)
    One Pot Synthesis of 2-Arylquinaloine and Tetracyclic-Isoindolo[1,2-a]quinazoline Derivatives via Cyanation Followed by the Rearrangement of o-Substituted 2-Halo-N-Arylbenzamides
    計畫編號: NSC-100-2113-M-003-008-MY3
     
    119. Meesala, Y.; Kavala, V.; Chang , H.-C.; Kuo, T.-S.; Yao, C.-F.*; Lee, W.-Z.* Dalton Trans. 2015, 44(3), 1120-1129. (1月) (Inorganic & Nuclear Chemistry: 6/45, 2015 IF: 4.177; 5 year impact factor: 4.003) Online ISSN: 1477-9226 (Times Cited: 6)
    Synthesis, structures and electrochemical and photophysical properties of anilido-benzoxazole boron difluoride (ABB) complexes
    計畫編號: NSC-100-2113-M-003-008-MY3
     
    118. Zanwar, M. R.; Gawande, S. D.; Kavala, V.; Kuo, C.-W.; Yao, C.-F.* Adv. Synth. Catal. 2014, 356(18), 3849-3860. (12月) (Applied Chemistry: 2/71 or Organic Chemistry: 5/58, 2013 IF: 5.542) Online ISSN: 1615-4169 (Times Cited: 3)
    Iron(III)chloride Catalyzed Synthesis of Highly Substituted Indolyl-Tetrahydroquinoline Derivatives by Using Electron Deficient Dienophiles and Its Application to the Synthesis of Indolo-Benzonaphthyridine Derivatives
    計畫編號: NSC-100-2113-M-003-008-MY3
     
    117. Lin, C.-H.; Wu, Y.-R.; Kung, P.-J.; Chen, W.-L.; Lee, L.-C.; Lin, T.-H.; Chao, C.-Y.; Chen, C.-M.; Chang, K.-H.; Janreddy, D.; Lee-Chen, G.-J.*; Yao, C.-F.* ACS Chem. Neurosci., 2014, 5(10), 1063-1074. (10月)  ISSN: 1948-7193 (Times Cited: 2) (Neuroscience: 65/251, 2013 IF: 4.210) published online September 8, 2014
    The Potential of Indole and a Synthetic Derivative for PolyQ Aggregation Reduction by Enhancement of the Chaperone and Autophagy Systems
    計畫編號: NSC-100-2113-M-003-008-MY3
     
    116. Kung, P.-J.; Tao, Y.-C.; Hsu, H.-C.; Chen, W.-L.; Lin, T.-H.; Janreddy, D.; Yao, C.-F.; Cahng, K.-H.; Lin, J.-Y.; Su, M.-T.; Wu, C.-H.; Lee-Chen, G.-J.*; Hsieh-Li, H.-M.* Drug Design, Development and Therapy 2014, 8, 1929-1939. (10月) (Pharmacology & Pharmacy 76/254, 2014 IF: 3.03) Online ISSN: 1177-8881 (Times Cited: 2)
    Indole and synthetic derivative activate chaperone expression to reduce polyQ aggregation in SCA17 neuronal cell and slice culture models
    計畫編號: NSC-100-2113-M-003-008-MY3
     
    115. Kotipalli, T.; Janreddy, D.; Kavala, V.; Kuo, C.-W.; Kuo, T.-S.; Chen, M.-L.; He, C.-H.; Yao, C.-F.* RSC Adv., 2014, 4(88), 47833-47840. (10月) (Chemistry, Multidisciplinary: 35/148, 2013 IF:  3.840; 5 year impact factor: 3.907) Online ISSN: 2046-2069 (Times Cited: 0)
    BF3•OEt2-mediated one pot synthesis of 10-indolyldibenzo[b,f]azepine derivatives via tandem ring expansion and C-C bond formation
    計畫編號: NSC-100-2113-M-003-008-MY3
     
    114. Janreddy, D.; Kavala, V.; Kotipalli, T.; Kuo, C.-W.; Kuo, T.-S.; Chen, M.-L.; He, C.-H.; Yao, C.-F.* Adv. Synth. Catal. 2014, 356(14-15), 3083-3091. (10月) (Applied Chemistry: 2/71 or Organic Chemistry: 5/58, 2013 IF: 5.542) Online ISSN: 1615-4169  (Times Cited: 0)
    Palladium(II)Chloride Catalyzed Aerobic Oxidative Intermolecular [4+2] Cycloaddition Reaction of 2-Alkynyl Benzaldehydes and Electron-Deficient Terminal Alkenes: An Efficient Synthesis of Naphthyl ketones
    計畫編號: NSC-100-2113-M-003-008-MY3
Year Paper Title
2023 Iodine-Catalyzed Regioselective Synthesis of Diphenyl-Substituted Carbazoles via [4+2] Annulation of β-Formyl ketones with Indoles (Cover Page), Journal of Organic Chemistry, vol. 88, Sep. 2023
2023 Pd-Catalyzed regioselective (Markovnikov) Addition of aryl boronic acids to terminal alkynes of 1,3-dicarbonyl compounds and cyclization/debenzoylation of olefinic dicarbonyl: Access to arylated Pyran and (E)-4-methylene-1,6-diphenylhex-5-en-1-one (Cover Page), Organic Letters, vol. 25, Sep. 2023
2023 Synthesis of Isoindolo [1,2-b]quinazolin-12(10H)-one by Double Ullman reaction of 2-Iodobenzamides with Copper Cyanide under Microwave Irradiation, ChemistrySelect, vol. 8, Aug. 2023
2023 Coumarin-chalcone hybrid LM-021 and indole derivative NC009-1 targeting inflammation and oxidative stress to protect BE (2)-M17 cells against α-synuclein toxicity, Aging (US), vol. 15, Aug. 2023
2023 One-Pot Knoevenagel/Imination/6π Azaelectrocyclization Sequence for the Synthesis of Disubstituted Nicotinonitriles, Journal of Organic Chemistry, vol. 88, Jul. 2023
2023 Iodine-Catalyzed Annulation Reaction of Ortho-Formylarylketones with Indoles: A General Strategy for the Synthesis of Indolylbenzo[b]carbazoles 科技部計畫編號: MOST 111-2113-M-003-016, Journal of Organic Chemistry, vol. 88, Mar. 2023
2023 Investigating Therapeutic Effects of Indole Derivatives Targeting Inflammation and Oxidative Stress in Neurotoxin-Induced Cell and Mouse Models of Parkinson’s Disease, Int. J. Mol. Sci. 2023, 24, 2642-2660, vol. 24, Jan. 2023
2022 Synthesis of Unsymmetrical Urea Derivatives via Cu-Catalyzed Reaction of Acylazide and Secondary Amine, Chem. & Biodiversity 2022, 19, e202200346, vol. 19, Aug. 2022
2022 Copper Catalyzed Oxidative Cascade Inter-Molecular Double Cyclisation of 2-Iodobenzamide Derivatives and Propargyl Dicarbonyl Compounds for Accessing 3-Hydroxy-3-furylisoindolinone Derivatives, Advanced Synthesis & Catalysis 2022, 364(16), 2801-2814. (8月), vol. 364, Aug. 2022
2021 A Study of the Reactions of 3-Bromopropenals with Anilines for the Synthesis of α-Bromo Enaminones, Advanced Synthesis & Catalysis, vol. 363, Oct. 2021
2021 Water-Soluble Rhenium (I)-Catalyst for Regio- and Stereoselective C(sp2)-H Alkenylation of N-Pyridyl/N-Pyrimidyl Indole and N-H Alkenylation of N-Pyrimidylaniline derivatives with Ynamides (Cover pgae), Organic Letters, vol. 23, Mar. 2021
2021 Synthesis of Perinaphthenones via BF3·Et2O Mediated One-Pot Cascade Dearomative 4,5-annulation reactions of 1-Naphthols and Ynones, Advanced Synthesis & Catalysis, vol. 363, Mar. 2021
2020 Pathomechanism characterization and potential therapeutics identification for SCA3 targeting neuroinflammation, Aging, 2020, 12(23), 23619-23646., vol. 12, Dec. 2020
2020 Synthesis of pyrido[2,3-b]indoles via Bronsted acid promoted decarboxylative annulation of 3-bromopropenals and ethyl 2-amino-1H-indole-3-carboxylates (Cover page), Asian Journal of Organic Chemistry, vol. 9, Jul. 2020
2020 Copper-catalysed synthesis of 3-hydroxyisoindolin1-ones from benzylcyanide 2-iodobenzamides, Org. Biomol. Chem. 2020, 18(5), 988. (1月), vol. 18, Jan. 2020
2019 Microwave‐Assisted Ruthenium(II)‐Catalyzed C−H/N−O Activation of N‐Methoxybenzamides with Alkynylsulfane (Cover page), Asian Journal of Organic Chemistry, vol. 8, Oct. 2019
2019 Neuroprotection of indole-derivative compound NC001-8 by regulation of NRF2 pathway in Parkinson's disease cell models, Oxidative Medicine and Cellular Longevity, vol. 2019, Oct. 2019
2019 Modeling Alzheimer’s Disease by Induced Pluripotent Stem Cells Carrying APP D678H Mutation, Molecular Neurobiology 2019, 56(6), 3972-3983., vol. 56, Jun. 2019
2019 A Synthetic Strategy for the Construction of Functionalized Triphenylene Frameworks via Palladium Catalyzed Intramolecular Annulation/Decyanogenative C–H Bond Alkenylation, Organic Letters, vol. 21, Mar. 2019
2019 Synthesis of Polysubstituted Cyclopentene and Cyclopenta[b]carbazole Analogues from Unsymmetrical 4-Arylidene-3,6-diarylylhex-2-en-5-ynal and Indole Derivatives via an Iodine Mediated Electrocyclization Reaction (Cover page), Journal of Organic Chemistry, vol. 84, Feb. 2019
2019 Indole Compound NC009-1 Augments APOE and TRKA in Alzheimer’s Disease Cell and Mouse Models for Neuroprotection and Cognitive Improvement, Journal of Alzheimer's Disease, vol. 67, Feb. 2019
2018 Copper-Catalyzed Cascade Synthesis of 2-Aryl-3-cyanobenzofuran and Dibenzo[b,f]oxepine-10-carbonitrile Derivatives, Journal of Organic Chemistry, vol. 83, Sep. 2018
2018 The indole compound NC009-1 inhibits aggregation and promotes neurite outgrowth through enhancement of HSPB1 in SCA17 cells and ameliorates the behavioral deficits in SCA17 mice, NeuroToxicology, vol. 67, Jul. 2018
2018 Synthesis of 1,2,3-fused indole polyheterocycles by copper catalyzed cascade reaction, Eur. J. Org. Chem., vol. 10, Mar. 2018
2018 A triazole-conjugated benzoxazone induces reactive oxygen species and promotes autophagic apoptosis in human lung cancer cells, Apoptosis, vol. 23, Jan. 2018
2017 Synthesis of functionalized unsymmetrical 1,3-butadiene-3-yne derivatives from β-halo styrene derivatives and its application for the synthesis of trisubstituted pyridines, RSC Advances, vol. 7, Oct. 2017
2017 A potent indolylquinoline alleviates growth of human lung cancer cell tumorspheres, Apoptosis, vol. 22, Oct. 2017
2017 Copper Catalyzed Cascade Approach for the Synthesis of Dibenzo1,8-naphthyridine Derivatives, Advanced Synthesis & Catalysis, vol. 359, Sep. 2017
2017 Synthesis of benzofusedpyridoindolone derivatives via one-pot copper catalyzed tandem reaction of 2-iodobenzamide derivatives and 2-iodobenzylcyanides, Journal of Organic Chemistry, vol. 82, Jul. 2017
2017 Using gene expression database to uncover biology functions of 1,4-disubstituted 1,2,3-triazole analogues synthesized via a copper (I)-catalyzed reaction, European Journal of Medicinal Chemistry, vol. 132, Mar. 2017
2017 Concise Synthesis of Biologically Active Indenoisoquinoline Derivatives via A One-Pot Copper(II)-Catalyzed Tandem Reaction, Journal of Organic Chemistry, vol. 82, Feb. 2017
2017 Regioselective Switching Approach for the Synthesis of α and δ Carboline Derivatives, Chemical Communications, vol. 53, Feb. 2017
2017 Palladium-Catalyzed Tandem CH Functionalization/Cyclization Strategy for the Synthesis of 5-Hydroxybenzofuran Derivatives, Organic Letters, vol. 19, Jan. 2017
2017 The Potential of Indole/Indolylquinoline Compounds in Tau Misfolding Reduction by Enhancement of HSPB1, CNS Neuroscience & Therapeutics, vol. 23, Jan. 2017
2016 An indolylquinoline derivatives activates DNA damage resoponse and apotosis in human hepatocellular carcinoma cells, International Journal of Oncology, vol. 49, Dec. 2016
2016 Atriazoile derivatve elicits autophagic clearance of polyglutamine aggregation in neuronal cells, Drug Design, Development and Therapy, vol. 10, Oct. 2016
2016 Synthesis of 3-arylindole derivatives from nitroalkane precursors, RSC Adv, vol. 6, Oct. 2016
2016 Synthesis of Spiro Isoindolinone-indolines and 1,2-Disubstituted Indoles from 2-Iodobenzamide Derivatives, RSC Adv, vol. 6, Aug. 2016
2016 Reagent/Substituent Switching Approach for the Synthesis of Substituted 1,3,4-Oxadiazole/1,3,4-Oxadiazoline and 1,2,4-Triazole Derivatives from N-Substituted Hydrazides, Adv. Synth. Catal., vol. 358, Aug. 2016
2016 Synthesis of Benzo[a]carbazole derivatives from 3-Ethylindoles by Exploiting the Dual Character of Benzoquinone as an oxidizing agent and Dienophile, Chem. Commun., vol. 52, Jun. 2016
2016 Syntheses of 2-benzylbenzofuran derivatives and 2-arylnitrochroman derivatives from nitroalkene precursors, Eur. J. Org. Chem., vol. 2016, May. 2016
2016 NBS Mediated Thiocyanation of Cyclohexene Fused Isoxazoline N-Oxides, Asian J. Org. Chem., vol. 5, Mar. 2016
2016 Synthesis of 2,3-Disubstituted Quinazolinone Derivatives Through Copper Catalyzed C–H Amidation Reactions, Eur. J. Org. Chem., vol. 2016, Feb. 2016
2016 The potential of synthetic indolylquinoline derivatives for Aβ aggregation reduction by chemical chaperone activity, Neuropharmacology 2016, 101, 309-319., vol. 101, Feb. 2016
2015 Syntheses of 4-Indolylquinoline Derivatives via Reductive Cyclization of Indolylnitrochalcone Derivatives by Fe/HCl, Molecules, vol. 20, Dec. 2015
2015 An indolylquinoline derivative promotes apoptosis in human lung cancer cells by impairing mitochondrial functions, Apotosis, vol. 375, Dec. 2015
2015 Iron/acetic acid mediated synthesis of 6,7-dihydrodibenzo [b,j] [1,7] phenanthroline derivatives via intramolecular reductive cylization, RSC Adv, vol. 5, Jul. 2015
2015 Synthesis of Bicyclic Isoxazoles and Isoxazolines via Intramolecular Nitrile Oxide Cycloaddition, Molecules, vol. 20, Jun. 2015
2015 One-Pot Synthesis of 2-Arylquinaloine and Tetracyclic-Isoindolo[1,2-a]quinazoline Derivatives via Cyanation Followed by the Rearrangement of o-Substituted 2-Halo-N-Arylbenzamides, Adv. Synth. Catal., vol. 357, Jan. 2015
2015 Synthesis, structures and electrochemical and photophysical properties of anilido-benzoxazole boron difluoride (ABB) complexes, Dalton Trans. 2015, 44(3), 1120-1129. (1月), vol. 44, Jan. 2015
2014 Indolyl-Tetrahydroquinoline Derivatives by Using Electron Deficient Dienophiles and Its Application to the Synthesis of Indolo-Benzonaphthyridine Derivatives, Adv. Synth. Catal., vol. 356, Dec. 2014
2014 Molecular Iodine-Mediated Reaction of 2-(2-phenylethynyl)-Morita-Baylis-Hillman Adducts: An Easy Access to Naphthyl ketones and Iodo-Substituted Isochromenes, Organic & Biomolecular Chemistry, vol. 12, Nov. 2014
2014 Indole and synthetic derivative activate chaperone expression to reduce polyQ aggregation in SCA17 neuronal cell and slice culture models, Drug Design, Development and Therapy, vol. 8, Oct. 2014
2014 Palladium(II)Chloride Catalyzed Aerobic Oxidative Intermolecular [4+2] Cycloaddition Reaction of 2-Alkynyl Benzaldehydes and Electron-Deficient Terminal Alkenes: An Efficient Synthesis of Naphthyl ketones, Adv. Synth. Catal., vol. 356, Oct. 2014
2014 The Potential of Indole and a Synthetic Derivative for PolyQ Aggregation Reduction by Enhancement of the Chaperone and Autophagy Systems, ACS Chem. Neurosci., vol. 5, Oct. 2014
2014 Regioselective synthesis of thiophene fused sultam derivatives via iodocyclization approach and their application towards triazole linker, Tetrahedron, vol. 70, Oct. 2014
2014 Selectfluor mediated one pot synthesis of cyclohexanone ring fused isoxazole derivatives, Tetrahedron, vol. 70, Oct. 2014
2014 BF3•OEt2-mediated one pot synthesis of 10-indolyldibenzo[b,f]azepine derivatives via tandem ring expansion and C-C bond formation, RSC Adv., 2014, 4(88), 47833-47840, vol. 4, Oct. 2014
2014 Iron/Acetic acid Mediated Intermolecular Tandem C-C and C-N Bond Formation: An Easy Access to Acridinone and Quinoline Derivatives, RSC Adv., 2014, 4(71), 37806-37811, vol. 4, Sep. 2014
2014 Synthesis of Fused Isoquinolinone Derivatives and Iminoisoindolinone Derivatives via Copper-Catalyzed Regioselective Switching Process, Adv. Synth. Catal., vol. 356, Aug. 2014
2014 Synthesis of Dibenzodiazepinones via Tandem Copper (I) Catalyzed C-N Bond Formation, Adv. Synth. Catal., vol. 356, Aug. 2014
2014 Syntheses of indolo[1,2-a]quinazolinone derivatives via palladium catalyzed intramolecular C–H amidation, RSC Adv., vol. 4, Mar. 2014
2014 FeCl3 Catalyzed Regioselective C-Alkylation of Indolylnitroalkenes with Amino Group Substituted Arenes, J. Org. Chem., vol. 79, Feb. 2014
2013 Synthesis of 2-Amino-3-Substituted Naphtho[2,3-b]Furan-4,9-Dione from 2-Hydroxy-1,4-Naphthoquinone and Nitroalkenes, Eur. J. Org. Chem., vol. xx, Nov. 2013
2013 Molecular Iodine Mediated Cascade Reaction of 2-Alkynylbenzaldehyde and Indole: An Easy Access to Tetracyclic Indoloazulene Derivatives, Adv. Synth. Catal., vol. 355, Oct. 2013
2013 Cu (I) Catalyzed Aerobic Oxidative Azide-Alkene Cycloaddition: An Efficient Synthesis of Substituted 1,2,3-Triazoles, Adv. Synth. Catal., vol. 355, Oct. 2013
2013 New Dual Donor–Acceptor (2D-p-2A) Porphyrin Sensitizers for Stable and Cost-Effective Dye-Sensitized Solar Cells, Chem. Asian. J., vol. 8, Sep. 2013
2013 The Halonium Ion Mediated Synthesis of 2-Halomethylene-3-oxo-ketoxime Derivatives from Isoxazoline N-Oxides, J. Org. Chem., vol. 78, Sep. 2013
2013 Selectfluor-Mediated Fluorination and C–C Bond Cleavage of Cyclohexene-Fused Isoxazoline N-Oxides, Eur. J. Org. Chem., vol. 2013, Sep. 2013
2013 The Study of Cascade PdCl2-Catalyzed Sequential Heterocyclization/Michael Addition for the Synthesis of 2,3-Disubstituted Indoles, Tetrahedron, vol. 69, Apr. 2013
2013 Catalyst free and Cu catalyzed reactions of cyanochromenes and sodium azide: Synthesis of benzofurans and chromenotetrazoles, Tetrahedron, vol. 69, Feb. 2013
2012 Beckmann rearrangement of ketoximes induced by phenyl dichlorophosphate at ambient temperature, Molecules, vol. 17, Nov. 2012
2012 Synthesis of Indolyl-quinolines, Indolyl-acridines and Indolyl-cyclopenta[b]quinolines from the Baylis-Hillman Adducts: An in situ [1,3] Sgmatropic Rearrangement of an Indole Nucleus to access Indolyl-acridines and Indolyl-cyclopenta[b]quinolines, J. Org. Chem., vol. 77, Oct. 2012
2012 The Halonium Ion Mediated C-C Bond Cleavage of Cyclohexene Fused Isoxazoline N-Oxides, Adv. Synth. Catal., vol. 354, Aug. 2012
2012 One-pot tandem synthesis of 2-arylbenzoxazole derivatives via copper catalyzed C-N and C-O bond formation, Adv. Synth. Catal., vol. 354, Aug. 2012
2012 Alcohol Mediated Synthesis of 4-oxo-2-aryl-4H-chromene-3-carboxylate Derivatives from 4-Hydroxycoumarins, J. Org. Chem, vol. 77, Jul. 2012
2012 Synthesis of Isocoumarin Derivatives via the Copper-Catalyzed Tandem Sequential Cyclization of 2- Halo-N-phenyl Benzamides and Acyclic 1,3-Diketones, J. Org. Chem., vol. 77, Jun. 2012
2012 Effects of Porphyrinic meso-Substituents on the Photovoltaic Performance of Dye-Sensitized Solar Cells: Number and Position of p-Carboxyphenyl and Thienyl Groups on Zinc Porphyrins, J. Phys. Chem. C, vol. 116, Jun. 2012
2012 A Convenient One-Pot Preparation of 2-Methyl-3-(phenylthio-methyl)quinolines from Morita-Baylis-Hillman Adducts and Their Oxidation to the Corresponding Sulfones, Molecules, vol. 17, May. 2012
2012 Naphthyl and Thienyl Units as Bridges for Metal-Free Dye-Sensitized Solar Cells, Chem. Asian. J., vol. 7, May. 2012
2012 Thieno[3,4-b]thiophene-Based Organic Dyes for Dye-Sensitized Solar Cells, Chem. Eur. J., vol. 18, Apr. 2012
2012 Synthesis and Evaluation of the Cytotoxicities of Tetraindoles: Observation that the 5-Hydroxy Tetraindole (SK228) Induces G2 Arrest and Apoptosis in Human Breast Cancer Cells, J. Med. Chem., vol. 55, Feb. 2012
2012 Iodine catalyzed one-pot synthesis of flavanone and tetrahydropyrimidine derivatives via Mannich type reaction, Tetrahedron, vol. 68, Jan. 2012
2011 Toward Carboxylate Group Functionalized A4, A2B2, A3B Oxaporphyrins and Zinc Complex of Oxaporphyrins, Tetrahedron, vol. 67, Jun. 2011
2011 Synthesis of C3-nitroalkylated-4-hydroxycoumarin and hydroxyiminodihydrofuroquinolinone derivatives via Michael addition of cyclic 1,3-dicarbonyl compounds to b-nitrostyrenes, Tetrahedron, vol. 67, Apr. 2011
2011 An Easy Access to Carbazolones and 2,3-Substituted Indoles via Iron/Acetic Acid Mediated Reductive Cyclization, Euro. J. Org. Chem., vol. 2011, Apr. 2011
2011 A simple and facile route for the synthesis of 2H-1,4-benzoxazin-3-(4H)-ones via reductive cyclization of 2-(2-nitrophenoxy)acetonitrile adducts in the presence of Fe/acetic acid, Tetrahedron, vol. 67, Feb. 2011
2011 Synthesis of Isoxazoline-N-oxides via [Hydroxy (tosyloxy)iodo]benzene (HTIB) Mediated Oxidative N-O Coupling, J. Org. Chem., vol. 76, Jan. 2011
2011 One-pot Synthesis of Triazolothiadiazepine-1,1-dioxide Derivatives via Copper Catalyzed Tandem [3+2] Cycloaddition/N-Arylation, Adv. Synth. Catal., vol. 353, (18), 41-48., Jan. 2011
2010 On Water Synthesis of Chromeno Isoxazoles Mediated by [hydroxy(tosyloxy)iodo]benzene (HTIB), Green Chem., vol. 12, Dec. 2010
2010 Iron/Acetic acid mediated carbon degradation: a facile route for the synthesis of quinoline derivatives, Tetrahedron Lett., vol. 51, Oct. 2010
2010 Catalyst free conjugative addition of indoles and pyrrole to nitro alkenes under solvent free condition (SFC): an effective greener route to acess 3-(2-nitro-1-phenylethyl)-1H-indole and 2-(2-nitro-1-phenylethyl)-1H-pyrrole derivatives, Tetrahedron, vol. 66, Aug. 2010
2010 An unprecedented route for the synthesis of 3,3'-biindoles via reductive cyclization of 3-(2-nitro-1-(2-nitrophenyl)ethyl)-1H-indoles mediated by Iron/Acetic acid, Eur. J. Org. Chem., vol. 2010, Jun. 2010
2010 A Mild And Convenient One-Pot Two-Step Synthesis Of Hydroxyiminodihydrobenzofurans Mediated By Silica Gel Under Microwave Activation Condition, Tetrahedron, vol. 66, May. 2010
2010 Synthesis and Structure-activity Relationships of Novel Furazan-3,4-diamide Analogs as Potent Anti-cancer Agents, Bioorganic & Medicinal Chemistry Letters, vol. 20, Jan. 2010
2009 Triethylborane-induced free radical reactions with benzylidene Meldrum’s acids. Simple and efficient synthesis of benzyl Meldrum’s acids, Arkivoc., vol. 2009, Dec. 2009
2009 Based-Catalyzed Conjugate Addition of Thiols to Indolyl Acrylic Acids and in situ Decarboxylation: An Expedient Synthesis of Functionalized 3-(1-Thio)ethyl-1H-indoles, Synlett., vol. 2009, Nov. 2009
2009 An Efficient Method for the N-Bromosuccinimide Catalyzed Synthesis of Indolyl-nitroalkanes, Molecules, vol. 14, Oct. 2009
2009 ‘On water’ promoted C-alkylation of indoles with 2-aryl-3-nitro-2H-chromenes under catalyst free conditions, Eur. J. Org. Chem., vol. 2009, Sep. 2009
2009 Facile and highly efficient method for the C-alkylation of 2-hydroxy-1,4-naphthoquinones to nitroalkenes under catalyst free 'on water' conditions, Tetrahedron Lett., vol. 50, Sep. 2009
2009 Novel synthesis of indolylquinoline derivatives via C-alkylation of Baylis-Hillman adducts, Tetrahedron Lett., vol. 50, Jul. 2009
2009 Catalyst-free 1,3-dipolar cycloaddition of 3-nitrochromen with sodium azide: A facile method for the synthesis of 4-aryl-1,4-dihydrochromeno[4,3-d][1,2,3]triazole derivatives, Tetrahedron, vol. 65, Jul. 2009
2009 Straightforward and Highly Efficient Catalyst-Free Regioselective Reaction of Thiol to b-Nitrostyrene: A Concise Synthesis of Vinyl Sulfide and Nitro Sulfide, Tetrahedron, vol. 65, May. 2009
2009 A simple and green approach for the synthesis of tetrahydrobenzo[a]xanthen-11-one derivatives using tetrabutyl ammonium fluoride in water, Synlett., vol. 2009, Apr. 2009
2009 An efficient method for the synthesis of -Arylated nitroalkanes and -Arylated hydroximoyl chlorides mediated by AlCl3, Tetrahedron, vol. 65, Mar. 2009
2008 Catalyst free aqueous mediated conjugative addition of indoles to β-nitrostyrenes, Tetrahedron Lett., vol. 49, Dec. 2008
2008 Efficient TCT-catalyzed Synthesis of 1,5-Benzodiazepine Derivatives under Mild Conditions, Molecules, vol. 13, Sep. 2008
2008 Novel 2-Step Synthetic Indole Compound 1,1,3-tri(3-indolyl)Cyclohexane Inhibits Cancer Cell Growth in Lung Cancer Cells and Xenograft Models, Cancer, vol. 113, Aug. 2008
2008 Fluoride ion catalyzed multicomponent reactions for efficient synthesis of 4H-chromene and N-arylquinoline derivatives in aqueous media, Tetrahedron, vol. 64, Aug. 2008
2008 Fluoride ion catalyzed conjugate addition for easy synthesis of 3-sulfanylpropionic acid from thiol and a,b-unsaturated carboxylic acid, Tetrahedron, vol. 64, Feb. 2008
2007 Conjugate Addition of Triallylaluminum to α,β-Unsaturated Nitroalkenes to Produce 4,5-Unsaturated Nitroalkenes, Synth. Commun., vol. 37, Oct. 2007
2007 Highly Efficient Iodine-Catalyzed Hydroarylation of Arenes with Styrenes, Tetrahedron Letters, vol. 48, Sep. 2007
2007 An Efficient of Grignard-type Procedure for the Preparation of Gem-Diallylated Compound, Tetrahedron Lett., vol. 48, Sep. 2007
2007 On the scope of diastereoselective allylation of various chiral glyoxylic oxime ethers with allyltributylstannane in the presence of a Lewis acid and triallylaluminum, Tetrahedron, vol. 63, Aug. 2007
2007 Ceric Ammonia Nitrate (CAN) as a convenient and highly efficient promoter for 1,4-addition of thiols and benzeneselenol to α,β-unsaturated ketones under solvent-free condition, Tetrahedron, vol. 63, Feb. 2007
2007 A convenient new procedure for converting primary amides into nitriles, Chem. Commun, vol. 2007, Jan. 2007
2006 Heterogeneous Catalyst: Amberlyst-15 Catalyzed the Synthesis of 14-Substituted-14H-dibenzo[a, j]xanthenes under Solvent-free Condition, Tetrahedron Lett., vol. 47, Dec. 2006
2006 NBS-Catalyzed mild, efficient and solvent free reaction for the synthesis of 1,5-benzodiazepine derivatives, Tetrahedron Lett., vol. 47, Nov. 2006
2006 Iron(III) chloride-mediated the 1,4-addition of mercaptans to α,β-unsaturated ketones and esters under solvent free condition, Tetrahedron Lett., vol. 47, Oct. 2006
2006 Efficient conversion of the nitronate into nitrile oxide using TCT. One-Pot synthesis of bicyclic isoxazolines and isoxazoles from nitroalkenes, Organic & Biomolecular Chemistry, vol. 4, Aug. 2006
2006 One-pot Synthesis of Malononitriles from Free Radical Reactions of Ylidenemalononitrile with Triethylborane and Organoiodo in the Biphase of Ether and Aqueous Solution, Tetrahedron Lett., vol. 47, Aug. 2006
2006 Stereoselective of Three-component Synthesis of trans-endo-decahydroquinolin-4-one Derivatives from Aldehydes, Aniline and Acetylcyclohexene, J. Org. Chem., vol. 71, Aug. 2006
2006 Polyhydroquinoline via Hantzch Reaction, Tetrahedron, vol. 62, Jul. 2006
2006 TMSCl Catalyzed Aza-Diels-Alder Reaction: A Simple and Efficient Synthesis of Pyrano- and Furanoquinoline, Synlett., vol. 2006, Jun. 2006
2006 A Novel and Efficient Method for the Allylation of Carbonyl Compounds and Imines using Triallylaluminum, J. Org. Chem., vol. 71, May. 2006
2006 Iodine Catalyzed Conjugate Addition of Mercaptans to α,β-Unsaturated Carboxylic Acids under Solvent–free condition, Tetrahedron Lett., vol. 47, Mar. 2006
2006 Cerium (IV) ammonium nitrate (CAN) as a catalyst in tap water : A simple, proficient and green approach for the synthesis of quinoxalines, Green Chem., vol. 8, Jan. 2006
2006 Cerium (IV) ammonium nitrate (CAN) as a catalyst in tap water : A simple, proficient and green approach for the synthesis of quinoxalines, Green Chem., vol. 8, Jan. 2006
2006 CAN and iodine-catalyzed reaction of indole or 1-methylindole with a,b-unsaturated ketone or aldehyde, Tetrahedron Lett., vol. 47, Jan. 2006
2005 I2-catalyzed Michael addition of indole and pyrrole to nitroolefins, Tetrahedron, vol. 61, Dec. 2005
2005 The study of reaction mechanism for the transformation of nitronate into nitrile by phosphorus trichloride, Tetrahedron, vol. 61, Oct. 2005
2005 Molecular iodine: A powerful catalyst for the easy and efficient synthesis of quinoxalines, Tetrahedron Lett., vol. 46, Jun. 2005
2005 Molecular iodine-catalyzed one-pot synthesis of 4-substituted-1,4-dihydropyridine derivatives via Hantzsch reaction, Tetrahedron Lett., vol. 46, Jun. 2005
2005 Iodine-catalyzed Michael addition of mercaptans to a,b-unsaturated ketones under solvent-free conditions, Tetrahedron Lett., vol. 46, May. 2005
2004 A Highly Diastereoselective Tandem Radical Reaction. Facile Three-Component Routes to Protected (E)-Polysubstituted Homoallylic Alcohols, Tetrahedron, vol. 60, Jun. 2004
2004 A Simple Radical Addition-Elimination Route to Geometrically Pure (E)-Alkene and Chromanone Derivatives via b-Nitrostyrene, J. Org. Chem., vol. 69, May. 2004
2004 Radical Reactions in Esters with Alkoxy Functionality Chemistry: An Unusual Alcohol Moiety Hydrogen-Abstraction, Tetrahedron Lett., vol. 45, Apr. 2004
2004 An Investigation of the Reaction of 2-Aminobenzaldehyde Derivatives with Conjugated Nitro-olefins: An Easy and Efficient Synthesis of 3-Nitro-1,2-dihydroquinolines and 3-Nitroquinolines, J. Org. Chem., vol. 69, Mar. 2004
2003 A one-pot, two step synthesis 1,1-disubstituted 2-nitroalkens, Tetrahedron, vol. 59, Jun. 2003
2003 Improved One-Pot Synthesis of Styryl Tetrahedrofurans and Cyclohexanes by Radical Addition to -Nitrostyrenes in the Presence of Benzoyl Peroxide, Chem. Eur. J., vol. 9, May. 2003
2003 A Theoretical Study of Face Selectivity in the Michael Addition of a Grignard Reagent with 5-Substituted-2-dicyanomethyleneadamantanes, J. Chin. Chem. Soc., vol. 50, May. 2003
2003 An Easy and Efficient Synthesis of 3-Nitrochromans, Tetrahedron Lett., vol. 44, May. 2003
2003 Triethylaluminum or Triethylborane-Induced Free-Radical Reaction of Alkyl Iodides and α,β-Unsaturated Compounds, J. Org. Chem., vol. 68, May. 2003
2002 An easy and efficient method for the synthesis of hydroximoyl chloride form nitro olefin and silyl enol ether, Tetrahedron Lett., vol. 43, Oct. 2002
2002 The Synthesis of 2,2-Disubstituted 3-Nitrochromenes from Salicylaldehyde and 2,2-Disubstituted 1-Nitroalkenes, Heterocycles, vol. 57, Jun. 2002
2001 Novel Synthesis of Alkenes via Triethylborane-Induced Free-Radcial Reactions of Alkyl iodides and -Nitrostyrenes, J. Org. Chem., vol. 66, Sep. 2001
2001 One-Pot synthesis of trans-b-alkylstyrenes, Tetrahedron Lett., vol. 42, Aug. 2001
2001 Novel Synthesis of Alkenes via Triethylaluminum–Induced Free-Radical Reactions of Alkyl Iodides and b-Nitrostyrenes, Tetrahedron Lett., vol. 42, May. 2001
2001 An Improved and Easy Method for the Preparation of 2,2-Disubstituted 1-Nitroalkenes, J. Org. Chem., vol. 66, Apr. 2001
2001 An Improved, Easy, and Efficient Method for the Synthesis of 3-Nitro-2-phenyl-2H-chromene, Tetrahedron Lett., vol. 42, Apr. 2001
1999 One-Pot Synthesisof Five-Membered Cyclic Thioethers or Ethers via Intramolecular Nitrile Oxide-Olefin Cycloaddition (INOC) or Intramolecular Alkoxycarbonyl Nitronate-Olefin Cycloaddition (IAOC) by the use of Methyl Chloroformate, Tetrahedron, vol. 55, Nov. 1999
1999 Face selectivity in the reactions of Grignard reagents with 5-substituted-2-dicyanomethyleneadamantanes, J. Chem. Soc. Perkin Trans. 1, vol. 1999, Aug. 1999
1999 One-pot synthesis of six- or five-membered carbocycles through intramolecular cycloadditions by the use of ethyl chloroformate, Tetrahedron, vol. 55, Jun. 1999
1999 An improved, easy and efficient method for the generation of nitrile oxides from nitronates for in situ 1,3-dipolar cycloaddition, J. Chem. Soc. Perkin Trans. 1, vol. 1999, May. 1999
1999 Free radical reactions to generate alkenes and/or ionic reactions to generate hydroximoyl halides when -nitrostyrenes react with triethylaluminium or diethylaluminium chloride, J. Chem. Soc. Perkin Trans. 1, vol. 1999, Jan. 1999
1998 One-Pot Synthesis of the Hydroximoyl Chlorides and [3.3.0]Bicyclic Compounds from the Reactions of  -Nitrostyrenes with Stabilized Nucleophiles, Tetrahedron, vol. 54, Nov. 1998
1998 Free Radical Reactions of Trialkylboranes with b-Nitrostyrenes to Generate Alkenes, J. Org. Chem., vol. 63, Sep. 1998
1998 Generation of Nitroalkanes, Hydroximoyl Halides and Nitrile Oxides from the Reactions of b-Nitrostyrenes with Grignard or Organolithium Reagents., Tetrahedron, vol. 54, Jan. 1998
1997 Reactions of b -Nitrostyrenes with Stabilized Nucleophiles, Tetrahedron Letters, vol. 38, Sep. 1997
1997 1,3-Diphenyl-2-tricyclo[3,3,1,1]dec-2-ylideneproapane-1,3-diimine, and, Acta Cryst, vol. 53, Jul. 1997
1996 Reactions of b-Nitrostyrenes with Grignard Reagents, Tetrahedron Letters, vol. 37, Aug. 1996
Year Project Title Participator Job Title Period Unit
2024 應用氧化腈進行1,3-偶極加成反應或使用碘分子或錸化物為催化劑來合成有機化合物(2/3) 主持人 2023.08 ~ 2024.07 國科會
2023 112年提升國民中小 學自然科學領域實驗操作能力計畫 主持人 2023.01 ~ 2023.12 教育部
2023 新興影響精神活性物質標準品合成及圖譜建立 主持人 2023.01 ~ 2023.12 其他政府部門
2023 應用氧化腈進行1,3-偶極加成反應或使用碘分子或錸化物為催化劑來合成有機化合物 主持人 2022.08 ~ 2023.07 科技部(原國科會)
2023 111學年度國民中 小學課程推動工作「課程與教學輔導組─自然科學領域 輔導群」業務計畫 主持人 2022.08 ~ 2023.07 教育部
2022 111年提升國民中小 學自然科學領域實驗操作能力計畫 主持人 2022.01 ~ 2022.12 教育部
2022 新興影響精神活性物質標準品合成及圖譜建立 主持人 2022.01 ~ 2022.12 其他政府部門
2022 USR Hub 計畫 4：落實偏鄉科學教育及加強科學基礎實驗操作課程計畫 USR Hub 計畫 4：落實偏鄉科學教育及加強科學基礎實驗操作課程計畫 分項計畫主持人 2022.01 ~ 2022.12 教育部
2022 110學年度國民中 小學課程推動工作「課程與教學輔導組─自然科學領域 輔導群」業務計畫 主持人 2021.08 ~ 2022.07 教育部
2022 由異-納札羅夫環化反應來合成環戊烯類化合物及過渡金屬催化碳-氫鍵的活化反應 主持人 2021.08 ~ 2022.07 科技部(原國科會)
2021 110年度提升國中小學生自然科學實驗操作能力計畫 主持人 2021.01 ~ 2021.12 教育部
2021 110年度加強中小學操作自然科課本實驗計畫 主持人 2021.01 ~ 2021.12 教育部
2021 USR Hub 計畫 4：落實偏鄉科學教育及加強科學基礎實驗操作課程計畫 USR Hub 計畫 4：落實偏鄉科學教育及加強科學基礎實驗操作課程計畫 分項計畫主持人 2021.01 ~ 2021.12 教育部
2021 109學年度國民中小學課程推動工作「課程與教學輔導組－自然科學學習輔導群」業務實施計畫 主持人 2020.08 ~ 2021.07 教育部
2021 由異-納札羅夫環化反應來合成環戊烯類化合物及過渡金屬催化碳-氫鍵的活化反應 主持人 2020.08 ~ 2021.07 科技部(原國科會)
2020 109年度提升國中小學生自然科學實驗操作能力計畫 主持人 2020.01 ~ 2020.12 教育部
2020 新興濫用藥物流行趨勢分析、標準品合成及圖譜建立 主持人 2020.01 ~ 2020.12 其他政府部門
2020 USR Hub 計畫 4：落實偏鄉科學教育及加強科學基礎實驗操作課程計畫 USR Hub 計畫 4：落實偏鄉科學教育及加強科學基礎實驗操作課程計畫 分項計畫主持人 2020.01 ~ 2020.12 教育部
2020 108學年度國民中小學課程推動工作「課程與教學輔導組－自然科學學習輔導群」業務實施計畫 主持人 2019.08 ~ 2020.07 教育部
2020 金屬催化串聯環化反應(3/3) 主持人 2019.08 ~ 2020.07 科技部(原國科會)
2020 108及109年度加強中小學操作自然科課本實驗計畫 主持人 2019.05 ~ 2020.12 教育部
2019 108年度提升國中小學生自然科學實驗操作能力計畫 主持人 2019.01 ~ 2019.12 教育部
2019 新興濫用藥物流行趨勢分析、標準品合成及圖譜建立 主持人 2019.01 ~ 2019.12 其他政府部門
2019 107學年度國民中小學課程推動工作「課程與教學輔導組－自然科學學習輔導群」業務實施計畫 主持人 2018.08 ~ 2019.07 教育部
2019 金屬催化串聯環化反應(2/3) 主持人 2018.08 ~ 2019.07 科技部(原國科會)
2019 107年度加強中小學操作自然科課本實驗計畫 主持人 2018.05 ~ 2019.04 教育部
2018 107年度提升國中小學生自然科學實驗操作能力計畫 主持人 2018.01 ~ 2018.12 教育部
2018 新興濫用藥物流行趨勢分析、標準品合成及圖譜建立 主持人 2018.01 ~ 2018.12 其他政府部門
2018 106學年度國民中小學九年一貫課程推動工作「課程與教學輔導組－自然科學學習輔導群」業務實施計畫 主持人 2017.08 ~ 2018.07 教育部
2018 金屬催化串聯環化反應(1/3) 主持人 2017.08 ~ 2018.07 科技部(原國科會)
2018 106年度落實中小學基處實驗教育計畫 主持人 2017.05 ~ 2018.04 教育部
2017 以過渡金屬催化一鍋化之多元雜環化合物的合成(3/3) 主持人 2016.08 ~ 2017.07 科技部(原國科會)
2016 以過渡金屬催化一鍋化之多元雜環化合物的合成(2/3) 主持人 2015.08 ~ 2016.07 科技部(原國科會)
2015 以過渡金屬催化一鍋化之多元雜環化合物的合成 (1/3) 主持人 2014.08 ~ 2015.07 科技部(原國科會)
2016 中學教師科學素養評量能力之培育及推廣(1/2) 主持人 2014.05 ~ 2016.04 科技部(原國科會)
2014 探討以新穎方法合成含氮雜環化合物與應用之研究(3/3) 主持人 2013.08 ~ 2014.07 科技部(原國科會)
2014 中學教師科學素養評量能力之培育及推廣(2/2) 主持人 2013.05 ~ 2014.04 科技部(原國科會)
2013 探討以新穎方法合成含氮雜環化合物與應用之研究(2/3) 主持人 2012.08 ~ 2013.07 科技部(原國科會)
2012 具新穎性的有機催化劑應用於硫醇化物加至硝基烯化合物之不對稱反應及不對稱性質的1,3-偶極加成反應之研究(2/2) 主持人 2011.08 ~ 2012.07 科技部(原國科會)
2012 探討以新穎方法合成含氮雜環化合物與應用之研究(1/3) 主持人 2011.08 ~ 2012.07 科技部(原國科會)
2011 具不對稱性質的1,3-雙偶極加成反應及(在微波條件下)使用水來促發的反應之研究以及雜環化合物的合成之探討(2/3) 主持人 2010.08 ~ 2011.07 科技部(原國科會)
2011 具新穎性的有機催化劑應用於硫醇化物加至硝基烯化合物之不對稱反應及不對稱性質的1,3-偶極加成反應之研究(2/2) 主持人 2010.08 ~ 2011.07 科技部(原國科會)
2010 99年度國立台灣師範大學貴重儀器共同使用服務計畫經費核定清單 生命科學系 主持人 2010.01 ~ 2010.12 科技部(原國科會)
2010 具不對稱性質的1,3-雙偶極加成反應及(在微波條件下)使用水來促發的反應之研究以及雜環化合物的合成之探討(2/3) 主持人 2009.08 ~ 2010.07 科技部(原國科會)
2009 具不對稱性質的1,3-雙偶極加成反應及(在微波條件下)使用水來促發的反應之研究以及雜環化合物的合成之探討(1/3) 主持人 2008.08 ~ 2009.07 科技部(原國科會)
2008 β-硝基苯乙烯和各種試劑進行離子性或自由基類型反應之探討(3/3) 主持人 2007.08 ~ 2008.07 科技部(原國科會)
2007 β-硝基苯乙烯和各種試劑進行離子性或自由基類型反應之探討(2/3) 主持人 2006.08 ~ 2007.07 科技部(原國科會)
2006 β-硝基苯乙烯和各種試劑進行離子性或自由基類型反應之探討(1/3) 主持人 2005.08 ~ 2006.07 科技部(原國科會)
2005 β-硝基苯乙烯與離子性或自由基試劑反應之探討及利用三烷基鋁作為自由基之誘發試劑(3/3) 主持人 2004.08 ~ 2005.07 科技部(原國科會)
2004 β-硝基苯乙烯與離子性或自由基試劑反應之探討及利用三烷基鋁作為自由基之誘發試劑(2/3) 主持人 2003.08 ~ 2004.07 科技部(原國科會)
2003 β-硝基苯乙烯與離子性或自由基試劑反應之探討及利用三烷基鋁作為自由基之誘發試劑(1/3) 主持人 2002.08 ~ 2003.07 科技部(原國科會)
2002 2002兒童資訊月-兒童反毒教育電腦遊戲軟體製作之研究 主持人 2001.08 ~ 2002.08 科技部(原國科會)
2002 1,1-雙取代-2-硝基烯(II)和2,2-雙取代-3-硝基色烯之製備及b-硝基苯乙烯和有機金屬之自由基反應 主持人 2001.08 ~ 2002.07 科技部(原國科會)
2001 1,1-雙取代-2-硝基烯之製備以及和親核性試劑反應時位向選擇之探討 主持人 2000.08 ~ 2001.07 科技部(原國科會)
2000 固相合成法製備含氮之雜環化合物 主持人 1999.08 ~ 2000.07 科技部(原國科會)
1999 芳基的合環反應 主持人 1998.08 ~ 1999.07 科技部(原國科會)
1998 從硝基烯和有機鋰或有機鋰銅試劑的反應來合成氧化晴 主持人 1997.08 ~ 1998.07 科技部(原國科會)
1997 1,1-二取代-2-乙烯基環丙烷和自由基的反應 主持人 1996.08 ~ 1997.07 科技部(原國科會)
1996 高活性鎂之應用(I) 主持人 1995.08 ~ 1996.07 科技部(原國科會)
1995 有機鋅化物,有機汞化物及格里納劑和β- 硝基苯乙烯及硝基烯烴之反應 主持人 1994.03 ~ 1995.07 科技部(原國科會)
Country School Name Department Degree Duration
U.S. Iowa State University Ph.D. 1986.08 ~ 1991.05
Taiwan National Taiwan Normal University Chemistry B.S. 1978.09 ~ 1983.06
Organization Title Department Job Title Duration
2014.01 ~ 2019.12
2013.01 ~ 2013.12
2012.08 ~ Up to today
2010.08 ~ 2012.07
2006.08 ~ 2007.07
1999.08 ~ Up to today
National Taiwan Normal University Department of Chemistry Associate Professor 1993.08 ~ 1999.07
1993.06 ~ 1993.07
Georgia Institute of Technology Postdoctoral Research Associate 1992.09 ~ 1993.05
Iowa State University Postdoctoral Research Associate 1991.05 ~ 1992.08
1986.07 ~ 1991.05
National Taiwan Normal University Department of Chemistry Teaching Assistant 1985.08 ~ 1986.07
1983.07 ~ 1985.05
1982.08 ~ 1983.07