吳學亮
姓名 吳學亮
電子郵件 hlw@ntnu.edu.tw
聯絡電話 (02)77496142
實驗室電話 (02)77496155
職稱 優聘教授
研究領域 有機化學 不對稱合成 天然物合成 藥物合成
學術專長 有機合成化學 有機金屬化學
指導學生 博士後:李韋賢。
博士班: 曾昊葳,程友毅, 楊玉珠
碩士班:蕭萱霈,林羽宣,邱奕文,張景智,陳承威,郭瑀潔,蔡宇軒,黃俊傑 
實驗室 不對稱合成實驗室

學術著作

  1. Wei-Sian Li, Ting-Shen Kuo, Meng-Chi Hsieh, Ming-Kang Tsai, Ping-Yu Yu, Hsyueh-Liang Wu* "Enantioselective Rhodium-Catalyzed Allylation of Aliphatic Imines: Synthesis of Chiral C-Aliphatic Homoallylic Amines" Org. Lett. 2020, 22, 5675-5679.
  2. Hao-Wei Zeng, Ping-Yu Wu, Hsyueh-Liang Wu* "Progress in recent development of stereoselective synthesis of beta2-amino acid derivatives from beta-nitroacrylate derivatives" Org. Biomol. Chem. 2020, 18, 2991-3006.
  3. Jia-Hong Jian, Hao-Wei Zeng, Ting-Shen Kuo, Ping-Yu Wu, Hsyueh-Liang Wu* "Asymmetric Synthesis of Functionalized Phenylalanine Derivatives via Rh-Catalyzed Conjugate Addition and Enantioselective Protonation Cascade" Org. Lett. 2019, 21, 9468-9472.
  4. Jin-Fong Syu, Balraj, Gopula, Jia-Hong Jian, Wei-Sian Li, Ting-Shen Kuo, Ping-Yu Wu, Julian P. Henschke, Meng-Chi Hsieh, Ming-Kang Tsai, Hsyueh-Liang Wu* "Asymmetric Synthesis of beta-Aryl beta-Imido Sulfones Using Rhodium Catalysts with Chiral Diene Ligands: Synthesis of Apremilast" Org. Lett. 2019, 21, 4614-4618.
  5. Jia-Hong Jian, Chih-Lung Hsu, Jin-Fong Syu, Ting-Shen Kuo, Ming-Kang Tsai, Ping-Yu Wu, Hsyuh-Liang Wu* "Access to ß2-Amino Acids via Enantioselective 1,4-Arylation of ß-Nitroacrylates Catalyzed by Chiral Rhodium Catalysts" J. Org. Chem. 201883, 12184–12191.
  6. Chiung-An Chang, Tsung-Ying Uang, Jia-Hong Jian, Meng-Yi Zhou, Ming-Liang Chen, Ting-Shen Kuo, Ping-Yu Wu, and Hsyueh-Liang Wu* "Efficient and Enantioselective Rhodium(I)-Catalyzed Arylation of alpha-Ketoesters: Synthesis of (S)-Flutriafol"  Adv. Syn. Cat. 2018360, 3381-3390.
    參考連結參考連結
  7. Chiang, Pei-Feng; Li, Wei-Sian; Jian, Jia-Hong ; Kuo, Ting-Shen; Wu, Ping-Yu; Wu, Hsyueh-Liang  "Rh-catalyzed Enantioselective Allylation of N-Ts and N-Ns Aldimines: Total Synthesis of (–)-Crispine A" Org. Lett. 201820, 158–161.
    參考連結參考連結
  8. Jin-Fong Syu, Huang-Ying Lin, Yu-Yi Cheng, Yao-Chu Tsai, Yi-Ching Ting, Ting-Shen Kuo, Damodar Janmanchi, Ping-Yu Wu, Julian P. Henschke and Hsyueh-Liang Wu* "Design and Synthesis of Chiral Diene Ligands for Rh(I)-Catalyzed Enantioselective Arylation of N-DPP-protected Aldimines: Synthesis of the Antifungal Agent Bifonazole" Chem. Eur. J. 201723, 14515–14522.
    參考連結參考連結
  9. Hsyueh-Liang Wu,* Chiung-An Chang, Ping-Yu Wu, Biing-Jiun Uang.* "Recent developents in Zn-catalyzed asymmetric addition reaction to ketones: Syntheses of chiral tertiary alcohols" Tetrahedron Lett 201758, 706–710.  參考連結參考連結
  10. Jin-Fong Syu, Yun-Ting Wang, Kung-Cheng Liu, Ping-Yu Wu, Julian P. Henschke,*, and Hsyueh-Liang Wu*, "Rh(I)-Catalyzed 1,4-Conjugate Addition of Alkenylboronic Acids to a Cyclopentenone Useful for the Synthesis of Prostaglandins" J. Org. Chem. 201681, 10832–10844. 參考連結參考連結
  11. Jo-Hsuan Fang, Jia-Hong Jian, Hao-Ching Chang,Ting-Shen Kuo, Way-Zen Lee, Hsyueh-Liang Wu.* "Synthesis of Quaternary Carbon-containing β2,2-Amino Acids via Rh(I)-Catalyzed Enantioselective Arylation of α-Substituted β-Nitroacrylates" Chem. Eur.–J. 2017, 23, 1830–1838. 參考連結參考連結
  12.  Hsyueh-Liang Wu, Ping-Yu Wu, Ying-Ni Cheng, Biing-Jiun Uang,* "Enantioselective addition of organozinc reagents to carbonyl compounds catalyzed by a camphor derived chiral gamma-amino thiol ligand" Tetrahedron 2016, 72, 2656–2665 參考連結參考連結
  13. Jo-Hsuan Fang, Chiung-An Chang, Balraj Gopula,Ting-Shen Kuo, Ping-Yu Wu, Julian P. Henschke, and Hsyueh-Liang Wu* "Rhodium-Catalyzed Enantioselective Arylation of N-Substituted alpha,beta-Unsaturated gamma-Lactams: Preparation of Chiral 4-Aryl-2- Pyrrolidones" Asian J. Org. Chem. 20165, 481 – 485  參考連結參考連結
  14. Balraj Gopula, Shu-Han Yang, Ting-Shen Kuo, Jen-Chieh Hsieh,* Ping-Yu Wu, Julian P. Henschke,* and Hsyueh-Liang Wu* "Direct Synthesis of Chiral 3-Arylsuccinimides by Rhodium- Catalyzed Enantioselective Conjugate Addition of Arylboronic Acids to Maleimides" Chem. Eur. J. 201521, 11050 – 11055. (Hot paper and highlighted on back cover)  參考連結參考連結
  15. Balraj Gopula, Yun-Fan Tsai, Ting-Shen Kuo, Ping-Yu Wu, Julian, P. Henschke, and Hsyueh-Liang Wu " Rhodium/Chiral Diene Complexes in the Catalytic Asymmetric Arylation of beta-Pyrazole-1-yl Acrylates"
    Org. Lett. 2015, 17, 1142–1145. 參考連結參考連結
  16. Balraj Gopula, Chien-Wei Chiang, Way-Zen Lee, Ting-Shen Kuo, Ping-Yu Wu, Julian P. Henschke and Hsyueh-Liang Wu* " Highly Enantioselective Rh-Catalyzed Asymmetric Alkenylation of Imines: Synthesis of Chiral Allylic Amines via Asymmetric Addition of Potassium Alkenyltrifluoroborates fo N-Tosyl Imines " Org. Lett. 201416, 632-635.
  17. Chun-Chih Chen, Balraj Gopula, Jin-Fong Syu, Jhih-Han Pan, Ting-Shen Kuo, Ping-Yu Wu, Julian P. Henschke and Hsyueh-Liang Wu* " Enantioselective and Rapid Rh-Catalyzed Arylation of N-Tosyl and N-Nosylaldimines in Methanol" J. Org. Chem. 201479, 8077-8085.
  18. Yedukondalu Meesala, Hsyueh-Liang Wu, Bommisetti Koteswararao, Ting-Shen Kuo, and Way-Zen Lee* "Aerobic Oxidative Coupling of 2‐Naphthol Derivatives Catalyzed by a Hexanuclear Bis(μ-hydroxo)copper(II) Catalyst" Organometallics, 2014, 33, 4385–4393
    參考連結參考連結
  19. Kung-Chih Huang, Balraj Gopula, Ting-Shen Kuo, Chien-Wei Chiang, Ping-Yu Wu, Julian P. Henschke and Hsyueh-Liang Wu* " Rhodium-Catalyzed Asymmetric Addition of Arylboronic Acids to β-Nitroolefins: Formal Synthesis of (S)-SKF 38393 " Org. Lett. 201315, 5730-5733.
  20. Toshiyuki Moriuchi ,  Lisheng Mao ,  Hsyueh-Liang Wu ,  Satoshi D. Ohmura ,  Masami Watanabe and Toshikazu Hirao*"Synthesis of facial cyclometalated iridium(III) complexes triggered by tripodal ligands" DALTON TRANSACTIONS , 201241, 9519-9525.
  21. Balraj Gopula, Way-Zen Lee, and Hsyueh-Liang Wu* "Preparation of Chiral alpha-Substituted Alaninates through an Efficient Diastereoselective Synthesis of Trisubstituted Allylic Alcohols" Chem. Asian J. 20138, 80-83. -Most Accessed from Jan/2013-Sep/2013
  22.  Ying-Ni Cheng, Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang* “Enantioselective Addition of Dialkylzincs to Aldehydes Catalyzed by (-)-MITH“ Chem. Asian. J. 20127, 2921-2924.
  23. Yu-Chiang, Chung, Damodar Janmanchi and Hsyueh-Liang Wu* " Preparation of Chiral 3-Aryl Pyrrolidines via the Enantioselective 1,4-Addition of Arylboronic Acids to Fumaric Esters Catalyzed by Rh(I)/Chiral Diene Complexes." Org. Lett. 2012, 14, 2766-2769. 
  24. Chia-Chen Liu, Damodar Janmanchi, Chun-Chih Chen, Hsyueh-Liang Wu* “Expanding C1-Symmetric Bicyclo[2.2.1]heptadiene Ligand Family: Highly Enantioselective Synthesis of Cyclic b-Aryl Substituted Carbonyl Compounds.” Eur. J. Org. Chem. 2012, 2503-2507. 
  25. Wei-Ting Wei, Jiann-Yih Yeh, Ting-Shen Kuo, Hsyueh-Liang Wu* "Highly Enantioselective Rhodium-Catalyzed Asymmetric 1,4-Addition Reactions of Arylboronic Acids to Acyclic a,b-Unsaturated Compounds: The Formal Synthesis of (-)-Indatraline" Chem. Eur. J. 2011, 17, 11405-11409. 
  26. Ping-Yu Wu, Hsyueh-Liang Wu, Ying-Ying Shen, Biing-Jiun Uang “Asymmetric Synthesis of Propargylic Alcohols Catalyzed by (-)-MITH” Tetrahedron: Asymmetry 2009, 20, 1837-1841. 
  27. Zhi-Long Wu, Hsyueh-Liang Wu, Ping-Yu Wu, Biing-Jiun Uang “Asymmetric Addition of Diethylzinc to Aldehydes Catalyzed by a Camphor-Derived β-Amino Alcohol” Tetrahedron: Asymmetry 2009, 20, 1556-1560.
  28. Hsyueh-Liang Wu, Ping-Yu Wu, Biing-Jiun Uang “ Asymmetric Addition of Dimethylzinc to α-Ketoesters Catalyzed by (-)-MITH.” J. Org. Chem. 2008, 73, 6445-6447.
  29. Mei-Chi Chang, Hsyueh-Liang Wu, Chiu-Po Chan, Biing-Jiun Uang, Chia-Shan Lee, Bor-Dong Chen, Bor-Ru Lin, Hsiao-Hwa Chang, Chen-Jie Kao, Jiiang-Huei Jeng “Antithrombotic Effect of Hydroxychavicol, a Novel Betel Leaf Component: Role of Cyclooxygenase, Reactive Oxygen Species and Calcium Mobilization” British Journal of Pharmacology 2007, 152, 73-82. 
  30. Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang “ Highly enantioselective synthesis of (E)-allylic alcohols” J. Org. Chem. 2007, 72, 5935-5937 
  31. Toru Amaya, Koichi Mori, Hsyueh-Liang Wu, Satoshi Ishida, Jun-ichi Narkamura, Kazuhiko Murata, Toshikazu Hirao. “Synthesis and Characterization of π-extended Bowl-shaped π-Conjugated Molecules.” Chem. Commun. 2007, 1902-1904. 
  32. Ping-Yu Wu, Hsyueh-Liang Wu, and Biing-Jiun Uang, “Asymmetric Synthesis of Functionalized Diarylmethanols Catalyzed by a New γ-Amino Thiol.” J. Org. Chem. 2006, 71, 833-835.
  33. Post-Conference of 1st International Conference on Cutting Edge Organic Chemistry in Asia, Oct 21-24, 2006, National Tsing Hua University, Hsinchu, Taiwan, Presentation Titles: (a) Asymmetric Synthesis of Functionalized Diarylmethanols Catalyzed by a New γ−Amino Thiol (Best Poster Award) Ping-Yu Wu, Hsyueh-Liang Wu and Biing-Jiun Uang (b) The Effects of Sulfur and Oxygen Atoms of the Ligands in the Addition Reaction of Dialkylzinc to Aldehydes Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang 
  34. J. H. Jeng,Y. J. Wang, W. H. Chang, H. L. Wu, C. H. Li, B. J. Uang, J. J. Kang, J. J. Lee, L. J. Hahn, B. R. Lin, and M. C. Chang "Reactive Oxygen Species are Crucial for Hydroxychavicol Toxicity Toward KB Epithelial Cells" Cellular and Molecular Life Sciences2004, 61, 83-96.
  35. Hsyueh-Liang Wu and Biing-Jiun Uang “Asymmetric Epoxidation of Allylic Alcohols Catalyzed by New Chiral Vanadium (V) Complexes”. Tetrahedron: Asymmetry 2002, 13, 2625.
  36. M. C. Chang, B. J. Uang. H. L. Wu, J. J. Lee, L. J. Hahn, J. H. Jeng. “Inducing the cell cycle arrest and apoptosis of oral KB carcinoma cells by hydroxychavicol : roles of glutathione and reactive oxygen species” British Journal of Pharmacology 2002, 135, 619.
年度 論文名稱
2021 Application of Rh(I)/Bicyclo[2.2.1] heptadiene Catalysts to the Enantioselective Synthesis of Chiral Amines, The Chemical Record, vol. 21, Oct. 2021
2021 Cross-Dimerization of 2,5-Dihydrofuran with Conjugated Dienes Catalyzed by (Chiral Diene)ruthenium(0) Complexes and Origins of the Enantioselectivity, Organometallics, vol. 2021, Aug. 2021
2021 Enantioselective Synthesis of 1‑Aryl Tetrahydroisoquinolines by the Rhodium-Catalyzed Reaction of 3,4-Dihydroisoquinolinium Tetraarylborates, Organic Letter, vol. 23, Jan. 2021
2020 Enantioselective Rhodium-Catalyzed Allylation of Aliphatic Imines: Synthesis of Chiral C‐Aliphatic Homoallylic Amines, Organic Letters, vol. 2020, Jul. 2020
2020 Progress in recent development of stereoselective synthesis of β2-amino acid derivatives from β-nitroacrylate derivatives, Organic & Biomolecular Chemistry, vol. 2020, Mar. 2020
2019 Stimulation of MMP-9 of oral epithelial cells by areca nut extract is related to TGF-β/Smad2-dependent and –independent pathways and prevented by betel leaf extract, hydroxychavicol and melatonin, Aging, vol. 11, Dec. 2019
2019 Asymmetric Synthesis of Functionalized Phenylalanine Derivatives via Rh-Catalyzed Conjugate Addition and Enantioselective Protonation Cascade, Organic Letters, vol. 21, Dec. 2019
2019 Asymmetric Synthesis of β-Aryl β-Imido Sulfones Using Rhodium Catalysts with Chiral Diene Ligands: Synthesis of Apremilast, Organic Letters, vol. 21, Jun. 2019
2018 Access to β2‐Amino Acids via Enantioselective 1,4-Arylation of β‐Nitroacrylates Catalyzed by Chiral Rhodium Catalysts, The Journal of Organic Chemistry, vol. 83, Aug. 2018
2018 Efficient and Enantioselective Rhodium(I)-Catalyzed Arylation of a-Ketoesters: Synthesis of (S)-Flutriafol, Advanced Synthesis & Catalysis, vol. 360, Jul. 2018
2018 A Rapid Synthesis of Chiral Allylic Amines via Microwave-assisted Asymmetric Alkenylation of N-Tosyl Aldimines Catalyzed by Rhodium/Chiral Diene Complexes, JOURNAL OF THE CHINESE CHEMICAL SOCIETY, vol. 65, Mar. 2018
2018 Rh-catalyzed Enantioselective Allylation of N-Ts and N-Ns Aldimines: Total Synthesis of (–)-Crispine A, Organic Letters, vol. 20, Jan. 2018
2017 Design and Synthesis of Chiral Diene Ligands for RhI-Catalyzed Enantioselective Arylation of N-DPP-protected Aldimines: Synthesis of the Antifungal Agent Bifonazole, Chemistry-An European Journal, vol. 2017, Sep. 2017
2017 Recent developments in Zn-catalyzed asymmetric addition reaction to ketones: Syntheses of chiral tertiary alcohols, Tetrahedron Letters, vol. 58, Jan. 2017
2017 Synthesis of Quaternary-Carbon-Containing b2,2-Amino Acids by the RhI-Catalyzed Enantioselective Arylation of a-Substituted b-Nitroacrylates, Chemistry-A European Jounal, vol. 23, Jan. 2017
2016 Rh(I)-Catalyzed 1,4-Conjugate Addition of Alkenylboronic Acids to a Cyclopentenone Useful for the Synthesis of Prostaglandins, The Journal of Organic Chemistry, vol. 81, Oct. 2016
2016 Enantioselective addition of organozinc reagents to carbonyl compounds catalyzed by a camphor derived chiral g-amino thiol ligand, Tetrahedron, vol. 72, May. 2016
2016 Rhodium-Catalyzed Enantioselective Arylation of N-Substituted a,b-Unsaturated g-Lactams: Preparation of Chiral 4-Aryl-2- Pyrrolidones, Asian Journal of Organic Chemsitry, vol. 2016, Apr. 2016
2015 Direct Synthesis of Chiral 3-Arylsuccinimides by Rhodium- Catalyzed Enantioselective Conjugate Addition of Arylboronic Acids to Maleimides, Chemistry A European Journal, vol. 21, Jul. 2015
2015 Rhodium/Chiral Diene Complexes in the Catalytic Asymmetric Arylation of β‐Pyrazol-1-yl Acrylates, Organic Letters, vol. 17, Feb. 2015
2014 Aerobic Oxidative Coupling of 2‐Naphthol Derivatives Catalyzed by a Hexanuclear Bis(μ-hydroxo)copper(II) Catalyst, Organometallics, vol. 33, Aug. 2014
2014 Enantioselective and Rapid Rh-Catalyzed Arylation of N‐Tosyl- and N‐Nosylaldimines in Methanol, Journal of Organic Chemistry, vol. 79, Aug. 2014
2014 Highly Enantioselective Rh-Catalyzed Alkenylation of Imines: Synthesis of Chiral Allylic Amines via Asymmetric Addition of Potassium Alkenyltrifluoroborates to N‐Tosyl Imines, Organic Letters, vol. 15, Jan. 2014
2013 Rhodium-Catalyzed Asymmetric Addition of Arylboronic Acids to β‐Nitroolefins: Formal Synthesis of (S)‐SKF 38393, Organic Letters, vol. 15, Dec. 2013
2013 Preparation of Chiral alpha-Substituted Alaninates through an Efficient Diastereoselective Synthesis of Trisubstituted Allylic Alcohols, Chemistry An Asian Journal, vol. 2013, Jan. 2013
2012 Enantioselective Addition of Dialkylzincs to Aldehydes Catalyzed by (-)-MITH, Chemistry An Asian Journal, vol. 2012, Dec. 2012
2012 Synthesis of facial cyclometalated iridium(III) complexes triggered by tripodal ligands, Dalton Transactions, vol. 41, Jun. 2012
2012 Preparation of Chiral 3-Arylpyrrolidines via the Enantioselective 1,4-Addition of Arylboronic Acids to Fumaric Esters Catalyzed by Rh(I)/Chiral Diene Complexes, Organic Letter, vol. 14, Jun. 2012
2012 Expanding the C1-Symmetric Bicyclo[2.2.1]heptadiene Ligand Family: Highly Enantioselective Synthesis of Cyclic β-Aryl-Substituted Carbonyl Compounds, European Journal of Organic Chemistry, vol. 2012, Mar. 2012
2011 Highly Enantioselective Rhodium-Catalyzed Asymmetric 1,4-Addition Reactions of Arylboronic Acids to Acyclic alpha, beta-Unsaturated Compounds: The Formal Synthesis of (-)-Indatraline, Chemistry A European Journal, vol. 17, Oct. 2011
2009 Asymmetric synthesis of propargylic alcohols catalyzed by (-)-MITH, Tetrahedron: Asymmetry, vol. 20, Sep. 2009
2009 Asymmetric addition of diethylzinc to aldehydes catalyzed by a camphor-derived β-amino alcohol, Tetrahedron: Asymmetry, vol. 20, Jul. 2009
2008 Asymmetric Addition of Dimethylzinc to α-Ketoesters Catalyzed by (-)-MITH, J. Org. Chem., vol. 73, Jul. 2008
2007 Antithrombotic Effect of Hydroxychavicol, a Novel Betel Leaf Component: Role of Cyclooxygenase, Reactive Oxygen Species and Calcium Mobilization, British Journal of Pharmacology, vol. 152, Jul. 2007
2007 Highly enantioselective synthesis of (E)-allylic alcohols, J. Org. Chem., vol. 72, Jun. 2007
2007 Synthesis and characterization of π-extended bowl-shaped π-conjugated molecules, Chem. Commun., Apr. 2007
2006 Asymmetric Synthesis of Functionalized Diarylmethanols Catalyzed by a New γ-Amino Thiol, J. Org. Chem., vol. 71, Jan. 2006
  1. Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang. A review article regarding “(-)-2-exo-Morpholinoisobornane-10-thiol” in e-EROS Encyclopedia of Reagents for Organic Synthesis. 
  2. Hsyueh-Liang Wu and Toshikazu Hirao. First update on “Vanadyl Bis(acetyl acetonate)” in e-EROS Encyclopedia of Reagents for Organic Synthesis.
年度 論文名稱
2019 A Practical Synthesis of Apremilast, 第21届中国科协年会——海峡两岸暨港澳绿色发展青年论坛, Jun. 28-Jul. 01, 2019, 哈爾濱
2019 Asymmetric Synthesis of b-Imido-b-Aryl Sulfones through Rhodium Catalysts with Chiral Diene Ligands: Synthesis of Apremilast, 2019 Workshop on Organic Chemistry for Junior Chemists (WOCJC-11), Jun. 14-17, 2019, Daejeon, Korea
2019 Rh(I)-catalyzed enantioselective allylation of N -Ts and N -Ns aldimines: Total synthesis of (–)-crispine A, 台師大-九州大學研討會議, May. 27-28, 2019, 台灣、台北
2019 Enantioselective Rh-Catalyzed Syntheses of Chiral Nitrogen Containing Compounds, 10th OCARINA International Symposium, Mar. 05-06, 2019, Osaka
2018 Rh(I)-catalyzed enantioselective allylation of N -Ts and N -Ns aldimines: Total synthesis of (–)-crispine A, PERCH-CIC Congress X: 2018 International Congress for Innovation in Chemistry, Jul. 04-07, 2018, Jomtien Palm Beach Hotel & Resort, Pattaya, Chonburi, Thailand
2017 Rh(I)-Cataltzed Two-Component Synthesis of Prostaglandins: Gram Scale Synthesis of Dinoprost and Tafluprost, the 5th NRCT-IFS-MU-PERCH-CIC Workshops: NRCT-IFS-MU-PERCH-CIC: Current Trends in Chemical and Pharmaceutical Sciences, and Related Disciplines, Mar. 01-07, 2017, Wangchan Riverview, Phitsanulok Province, Thailand
2016 Preparation of Chiral 4-Aryl-2-Pyrrolidones via Enantioselective Rh- Catalyzed Arylation of N-Substituted α,β-Unsaturated-γ-lactams, The 12th International Symposium on Organic Reactions, Apr. 22-24, 2016, Kyoto
2016 Rhodium/Chiral Diene Complexes in the Catalytic Asymmetric Acylation and alkenylation of β-Pyrazole-1-yl Acrylates, Joint Workshop on Chirality in Chiba University (WCCU) and on Soft-Molecule Activation, Mar. 07, 2016, Chiba
2020 Asymmetric Synthesis of Functional Phenylalanines via Rh-Catalyzed Conjugate Addition and Enantioselective Protonation Cascade, The 14th International Symposium on Organic Reactions, Apr. 24-26, 2020, Yokohama
2020 Asymmetric Synthesis of Functional Phenylalanines via Rh-Catalyzed Conjugate Addition and Enantioselective Protonation Cascade, The 14th International Symposium on Organic Reactions, Apr. 24-26, 2020, Yokohama
2012 必填欄位, Taiwan-Japan Symposium of Frontier Research on Design and Application of Fine Chemicals, Jan. 06, 2012, Taipei
2011 Bicyclo[2.2.1] Chiral Dienes in the Rh-Catalyzed 1,4-Addition Reactions, 10th International Symposium Organic Reactions (ISOR-10), Nov. 21-24, 2011, Yokohama
2011 Bicyclo[2.2.1] Chiral Dienes in the Rh-Catalyzed 1,4-Addition Reactions, Workshop on Organic Chemistry for Junior Chemists Special Symposium at Tokyo Tech, Nov. 21, 2011, Yokohama
  1. Chiral diene ligands, a fabrication method thereof and applications thereof (US 8,586,810 B2) 
  2.  METAL-CATALYZED ASYMMETRIC 1,4-CONJUGATE ADDITION OF VINYLBORON COMPOUNDS TO 2-SUBSTITUTED-4-OXY-CYCLOPENT-2-EN-1-ONES YIELDING PROSTAGLANDINS AND PROSTAGLANDIN ANALOGS (U.S. Pat. Appl. 2016/0009740 A1, 2016)
  3. 掌性雙烯配體及其製備方法與應用-中華民國專利
I.  ORAL PRESENTATION
1. 2nd Workshop on Organic Chemistry for Junior Chemists (TIT-NTHU) 2002 Hsyueh-Liang Wu and Biing-Jiun Uang “Asymmetric epoxidation of allylic alcohols catalyzed by camphor derived chiral hydroxamic acids.”
2. 1st Workshop on Organic Chemistry for Junior Chemists 2003 (NTHU-Nagaoka Institute of Technology) Hsyueh-Liang Wu and Biing-Jiun Uang “Enantioselective addition of Et2Zn to aldehydes catalyzed by camphor derived chiral ligands.”
3. 4th Workshop on Organic Chemistry for Junior Chemists (2004), Tokyo Institute of Technology, Yokohama, Japan. Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang, Enantioselective Addition of Diethylzinc Reagent to Aldehydes with Camphor-Derived Ligands.
4. NTHU-KAIST 2005 Junior Chemists Workshop (2005), National Tsing Hua University, Hsinchu, Taiwan. Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang, (+)-Nonlinear Effect in Asymmetric Addition of the Diethylzinc to Aldehydes
5. 86th spring meeting. Toru Amaya, Hsyueh-Liang Wu, Koichi Mori, Toshikazu Hirao. Synthesis of p-conjugated Sumanenes.
6. 86th spring meeting. Toru Amaya, Hsyueh-Liang Wu, Satoshi Ishida, Jun-ichi Nakamura, Kazuhiko Murata, Hidehiro Sakurai, Toshikazu Hirao, Study on π- Conjugation of Bowl-shaped π-Conjugated Sumanene.
7.International Symposium on Organic Reaction 2006. Toru Amaya, Hsyueh-Liang Wu, Koichi Mori, Toshikazu Hirao. Synthesis of p-conjugated Sumanenes
8. Invited speaker in COEIEC 8 Symposium. Title: Camphor derived chiral ligands in organozincs addition to aldehydes.
9. Invited speaker in WOCJC-7 Symposium. Title: Chiral [2.2.1] Diene Ligands for Asymmetric Catalysis
II. POSTER:
1. 5th International Conference on Cutting Edge Organic Chemistry in Asia, Nov 7-11, 2010, National Tsing Hua University, Hsinchu, Taiwan, Presentation Titles: Chiral [2.2.1] Diene Ligands for Asymmetric Catalysis
2. 5th Workshop on Organic Chemistry for Junior Chemists. Nov 23-26, 2006, National Tsing Hua University, Hsinchu, Taiwan Presentation Titles: Asymmetric Catalytic Organozinc Addition Reactions Based on Camphor Derived Ligand. Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang.
3. Post-Conference of 1st International Conference on Cutting Edge Organic Chemistry in Asia, Oct 21-24, 2006, National Tsing Hua University, Hsinchu, Taiwan, Presentation Titles: (a) Asymmetric Synthesis of Functionalized Diarylmethanols Catalyzed by a New γ−Amino Thiol (Best Poster Award) Ping-Yu Wu, Hsyueh-Liang Wu and Biing-Jiun Uang
(b) The Effects of Sulfur and Oxygen Atoms of the Ligands in the Addition Reaction of Dialkylzinc to Aldehydes Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang
4. The 8th International 21st Century COE Symposium on Integrated EcoChemistry, Aug 28-29, 2006, Osaka University, Japan Presentation Title: Asymmetric Synthesis of Functionalized Diarylmethanols Catalyzed by a New γ-Amino Thiol
Ping-Yu Wu, Hsyueh-Liang Wu and Biing-Jiun Uang
5. The 8th International Symposium on Organic Reactions, Apr 23-26, 2006, Kobe,Japan. Presentation Titles: Highly Enantioselective Addition of Alkenylzinc to Aldehydes Catalyzed by γ-Amino Thiol Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang
6. The 10th International Chemical Conference, Taipei, Oct 28-30, 2005, National Tsing Hua University, Hsinchu, Taiwan. Presentation Titles: (a) Highly Enantioselective Addition of Alkenylzinc to Aldehydes Catalyzed by (-)- MITH
Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang
(b) Asymmetric Synthesis of Functionalized Diarylmethanols Catalyzed by a New γ- Amino Thiol Ping-Yu Wu, Hsyueh-Liang Wu and Biing-Jiun Uang
7. Tokyo Summer School on Frontier Chemistry 2005, Aug 25-27, 2005, The University of Tokyo, Tokyo, Japan Presentation Title: Asymmetric Synthesis of Functionalized Diarylmethanols Catalyzed by γ-Amino Thiol
Ping-Yu Wu, Hsyueh-Liang Wu and Biing-Jiun Uang
8. NTHU-KAIST 2005 Junior Chemists Workshop, Feb 25-27, 2005, National Tsing Hua University, Hsinchu, Taiwan Presentation Title: (+)-Nonlinear Effect in Asymmetric Addition of the Diethylzinc to Aldehydes Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang
9. Annual Meeting of Chinese Chemical Society, Taipei, Nov 19-20, 2005, National Sun Yat-Sen University, Kaohsiung, Taiwan Presentation Titles:
(a) Camphor-Derived Oxazolines in Asymmetic Addition of Et2Zn to Aldehydes Ming-Shau Yang, Hsyueh-Liang Wu, Ping-Yu Wu, Che-Chia Chen and Biing-Jiun Uang
(b) Asymmetric Synthesis of Functionalized Diarylmethanols Catalyzed by a New γ- Amino Thiol Ping-Yu Wu, Hsyueh-Liang Wu and Biing-Jiun Uang
(c) Highly Enantioselective Addition of Alkenylzinc to Aldehydes Catalyzed by (-)- MITH Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang
10. 4th Workshop on Organic Chemistry for Junior Chemists, Sep 24-27, 2004, Tokyo Institute of Technology, Japan Presentation Title: Enantioselective Addition of Diethylzinc Reagent to Aldehydes with Camphor Derived Ligands
Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang
11. Annual Symposium of Chinese Chemical Society 2004 a) Chih-Lung Wu, Hsyueh-Liang Wu and Biing-Jiun Uang “Enantioselective Addition of Et2Zn to Aldehydes Catalyzed by b-Amino Alcohols”.....ORS-B-089
b) Hsyueh-Liang Wu, Ping-Yu Wu and Biing Jiun Uang “ (+)-Nonlinear Effect in Asymmetric Addition of the Et2Zn to Aldehydes.” ........ ORS-B-090.
12. 3rd Workshop on Organic Chemistry for Junior Chemists (TIT-NTHU) 2004 Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang “Enantioselective addition of Et2Zn to aldehydes with camphor derived chiral ligands.”
13. Annual Symposium of Chinese Chemical Society 2003 Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang “Enantioselective addition of Et2Zn to aldehydes “..............................OR-PA-061.
14.The 7th International Symposium for Chinese Organic Chemists 2002 Hsyueh- Liang Wu and Biing-Jiun Uang “Chiral camphor based hydroxamic acid catalyzed asymmetric epoxidation of allylic alcohols”........P-058.
15. Annual Symposium of Chinese Chemical Society 2002 Hsyueh-Liang Wu and Biing-Jiun Uang “Chiral camphor based hydroxamic acid catalyzed asymmetric epoxidation of allylic alcohols”........P-OR-072.
16. 2nd Workshop on Organic Chemistry for Junior Chemists (TIT-NTHU) 2002 Hsyueh-Liang Wu and Biing-Jiun Uang “Asymmetric epoxidation of allylic alcohols catalyzed by camphor derived chiral hydroxamic acids.”
17. 1st Workshop on Organic Chemistry for Junior Chemists 2002 (NTHU-Shanghai Institute of Organic Chemistry) Hsyueh-Liang Wu and Biing-Jiun Uang “Asymmetric epoxidation of allylic alcohols catalyzed by camphor derived chiral hydroxamic acids.”
18. 3rd International Symposium on Chemistry and Chemical Biology of Vanadium at Osaka Japan 2001 Hsyueh-Liang Wu and Biing-Jiun Uang “Asymmetric epoxidation of allylic alcohols catalyzed by camphor derived chiral hydroxamic acids.
年度 計畫名稱 職稱/擔任之工作 計畫期間 補助/委託或合作機構
2023 設計與發展新穎性金屬催化不對稱反應及其合成應用研究(2/3) 2022.08 ~ 2023.07 科技部(原國科會)
2022 設計與發展新穎性金屬催化不對稱反應及其合成應用研究(1/3) 主持人 2021.08 ~ 2022.07 科技部(原國科會)
2021 新型過渡金屬催化不對稱反應之研究發展及其應用於合成天然物與藥物分子 主持人 2020.08 ~ 2021.07 科技部(原國科會)
2020 新型過渡金屬催化不對稱反應之研究發展及其應用於合成天然物與藥物分子 主持人 2019.08 ~ 2020.07 科技部(原國科會)
2019 新型過渡金屬催化不對稱反應之研究發展及其應用於合成天然物與藥物分子 主持人 2018.08 ~ 2019.07 科技部(原國科會)
2018 開發新穎金屬催化反應:具生物活性之天然物與藥物的合成 主持人 2017.08 ~ 2018.07 科技部(原國科會)
2017 開發新穎金屬催化反應:具生物活性之天然物與藥物的合成 主持人 2016.08 ~ 2017.07 科技部(原國科會)
2016 開發新穎金屬催化反應:具生物活性之天然物與藥物的合成 (中型儀器補助計畫) 主持人 2015.08 ~ 2016.07 科技部(原國科會)
2016 開發新穎金屬催化反應:具生物活性之天然物與藥物的合成 主持人 2015.08 ~ 2016.07 科技部(原國科會)
2015 發展高效能過渡金屬催化不對稱反應並應用於合成具生理活性與藥性的分子 主持人 2014.08 ~ 2015.07 國科會
2014 發展高效能過渡金屬催化不對稱反應並應用於合成具生理活性與藥性的分子 主持人 2013.08 ~ 2014.07 國科會
2013 掌性雙環「2.2.1」雙烯配體在一價銠金屬催化之不對稱合成上的應用 主持人 2012.08 ~ 2013.07 國科會
2012 掌性雙環「2.2.1」雙烯配體在一價銠金屬催化之不對稱合成上的應用 主持人 2011.08 ~ 2012.07 國科會
2012 重點二子題1:具掌性四級碳之生理活性分子的合成:Sphingofungin F 的全合成 主持人 2011.08 ~ 2012.07 國科會
2011 重點二子題1:具掌性四級碳之生理活性分子的合成:Sphingofungin F 的全合成 主持人 2010.08 ~ 2011.07 國科會
2011 新型掌性雙烯配體的開發及其在不對稱合成上的應用 主持人 2010.08 ~ 2011.07 國科會
2010 新型掌性雙烯配體的開發及其在不對稱合成上的應用 主持人 2009.12 ~ 2010.07 國科會
2010 1.金,銀,鎳,銠-催化環形雙烯分子內雙烯與官能基的偶合反應; 2.以環己二烯為共軛連接體的染料敏性太陽能電池材料的合成(創新啟動補助方案) 協同/共同主持人 2009.12 ~ 2010.11 國科會
國家 學校名稱 系所 學位 期間
臺灣 國立清華大學 化學所 博士 1998.09 ~ 2004.06
服務機關名稱 單位 職務 期間
國立臺灣師範大學 化學系 教授 2017.08 ~ 迄今
大阪大學 visiting professor supported by MEXT 2013.02 ~ 2013.02
國立臺灣師範大學 化學系 副教授 2013.02 ~ 迄今
大阪府立大學 化學系 訪問教授 2011.07 ~ 2011.07
國立臺灣師範大學 化學系 助理教授 2009.08 ~ 2013.01
美國麻省理工學院 博士後研究 2008.07 ~ 2009.06
國立清華大學 博士後研究 2007.04 ~ 2008.06
大阪大學 博士後研究 2005.04 ~ 2007.03
國立清華大學 博士後研究 2004.08 ~ 2005.03
類別 年度 獎項名稱 頒獎單位
校內榮譽 2017 優聘教授
校內榮譽 2016 績優產學合作獎
校內榮譽 2015 優聘教授
校內榮譽 2015 績優產學合作獎
校外榮譽 2015 年輕學者研究計畫 科技部自然司
校外榮譽 2015 Asian Core Program Lectureship Award to China
校外榮譽 2015 Asian Core Program Lectureship Award to Korea
校內榮譽 2014 績優產學合作獎
校外榮譽 2014 Asian Core Program Lectureship Award to Thailand
校外榮譽 2013 Asian Core Program Lectureship Award to Singapore
校外榮譽 2013 Asian Core Program Lectureship Award to Korea
校外榮譽 2012 Asian Core Program Lectureship Award to Japan