Hsyueh-Liang Wu
Name Hsyueh-Liang Wu
Email hlw@ntnu.edu.tw
Office Tel No. (02)77496142
Title Outstanding Professor
Research Organic Chemistry Asymmetric Synthesis Natural Product Synthesis
Research Specialization Organic Chemistry Asymmetric Synthesis Natural Product Synthesis

cademic Researches

    1. Jia-Hong Jian, Chih-Lung Hsu, Jin-Fong Syu, Ting-Shen Kuo, Ming-Kang Tsai, Ping-Yu Wu, Hsyuh-Liang Wu* "Access to ß2-Amino Acids via Enantioselective 1,4-Arylation of ß-Nitroacrylates Catalyzed by Chiral Rhodium Catalysts" J. Org. Chem. 201883, 12184–12191

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    5.  "Design and Synthesis of Chiral Diene Ligands for Rh(I)-Catalyzed Enantioselective Arylation of N-DPP-protected Aldimines: Synthesis of the Antifungal Agent Bifonazole"  

      Jin-Fong Syu, Huang-Ying Lin, Yu-Yi Cheng, Yao-Chu Tsai, Yi-Ching Ting, Ting-Shen Kuo, Damodar Janmanchi, Ping-Yu Wu, Julian P. Henschke and Hsyueh-Liang Wu*  Chem. Eur. J. 201723, 14515–14522. Reference LinkReference Link
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    12. Balraj Gopula, Yun-Fan Tsai, Ting-Shen Kuo, Ping-Yu Wu, Julian, P. Henschke, and Hsyueh-Liang Wu " Rhodium/Chiral Diene Complexes in the Catalytic Asymmetric Arylation of beta-Pyrazole-1-yl Acrylates"
      Organic Letter ASAP Reference LinkReference Link
    13. Balraj Gopula, Chien-Wei Chiang, Way-Zen Lee, Ting-Shen Kuo, Ping-Yu Wu, Julian P. Henschke and Hsyueh-Liang Wu* " Highly Enantioselective Rh-Catalyzed Asymmetric Alkenylation of Imines: Synthesis of Chiral Allylic Amines via Asymmetric Addition of Potassium Alkenyltrifluoroborates fo N-Tosyl Imines " Org. Lett. 201416, 632-635.
    14. Chun-Chih Chen, Balraj Gopula, Jin-Fong Syu, Jhih-Han Pan, Ting-Shen Kuo, Ping-Yu Wu, Julian P. Henschke and Hsyueh-Liang Wu* " Enantioselective and Rapid Rh-Catalyzed Arylation of N-Tosyl and N-Nosylaldimines in Methanol" J. Org. Chem. 201479, 8077-8085.
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    16. Kung-Chih Huang, Balraj Gopula, Ting-Shen Kuo, Chien-Wei Chiang, Ping-Yu Wu, Julian P. Henschke and Hsyueh-Liang Wu* " Rhodium-Catalyzed Asymmetric Addition of Arylboronic Acids to β-Nitroolefins: Formal Synthesis of (S)-SKF 38393 " Org. Lett. 201315, 5730-5733.
    17. Toshiyuki Moriuchi ,  Lisheng Mao ,  Hsyueh-Liang Wu ,  Satoshi D. Ohmura ,  Masami Watanabe and Toshikazu Hirao*"Synthesis of facial cyclometalated iridium(III) complexes triggered by tripodal ligands" DALTON TRANSACTIONS , 201241, 9519-9525.
    18. Balraj Gopula, Way-Zen Lee, and Hsyueh-Liang Wu* "Preparation of Chiral alpha-Substituted Alaninates through an Efficient Diastereoselective Synthesis of Trisubstituted Allylic Alcohols" Chem. Asian J. 20138, 80-83. -Most Accessed from Jan/2013-Sep/2013
    19.   Ying-Ni Cheng, Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang* “Enantioselective Addition of Dialkylzincs to Aldehydes Catalyzed by (-)-MITH“ Chem. Asian. J. 20127, 2921-2924.
    20.  Yu-Chiang, Chung, Damodar Janmanchi and Hsyueh-Liang Wu* " Preparation of Chiral 3-Aryl Pyrrolidines via the Enantioselective 1,4-Addition of Arylboronic Acids to Fumaric Esters Catalyzed by Rh(I)/Chiral Diene Complexes." Org. Lett. 2012, 14, 2766-2769.
    21.  Chia-Chen Liu, Damodar Janmanchi, Chun-Chih Chen, Hsyueh-Liang Wu* “Expanding C1-Symmetric Bicyclo[2.2.1]heptadiene Ligand Family: Highly Enantioselective Synthesis of Cyclic b-Aryl Substituted Carbonyl Compounds.” Eur. J. Org. Chem. 2012, 2503-2507.
    22.  Wei-Ting Wei, Jiann-Yih Yeh, Ting-Shen Kuo, Hsyueh-Liang Wu* "Highly Enantioselective Rhodium-Catalyzed Asymmetric 1,4-Addition Reactions of Arylboronic Acids to Acyclic a,b-Unsaturated Compounds: The Formal Synthesis of (-)-Indatraline" Chem. Eur. J. 2011, 17, 11405-11409.
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Year Paper Title
2021 Application of Rh(I)/Bicyclo[2.2.1] heptadiene Catalysts to the Enantioselective Synthesis of Chiral Amines, The Chemical Record, vol. 21, Oct. 2021
2021 Cross-Dimerization of 2,5-Dihydrofuran with Conjugated Dienes Catalyzed by (Chiral Diene)ruthenium(0) Complexes and Origins of the Enantioselectivity, Organometallics, vol. 2021, Aug. 2021
2021 Enantioselective Synthesis of 1‑Aryl Tetrahydroisoquinolines by the Rhodium-Catalyzed Reaction of 3,4-Dihydroisoquinolinium Tetraarylborates, Organic Letter, vol. 23, Jan. 2021
2020 Enantioselective Rhodium-Catalyzed Allylation of Aliphatic Imines: Synthesis of Chiral C‐Aliphatic Homoallylic Amines, Organic Letters, vol. 2020, Jul. 2020
2020 Progress in recent development of stereoselective synthesis of β2-amino acid derivatives from β-nitroacrylate derivatives, Organic & Biomolecular Chemistry, vol. 2020, Mar. 2020
2019 Stimulation of MMP-9 of oral epithelial cells by areca nut extract is related to TGF-β/Smad2-dependent and –independent pathways and prevented by betel leaf extract, hydroxychavicol and melatonin, Aging, vol. 11, Dec. 2019
2019 Asymmetric Synthesis of Functionalized Phenylalanine Derivatives via Rh-Catalyzed Conjugate Addition and Enantioselective Protonation Cascade, Organic Letters, vol. 21, Dec. 2019
2019 Asymmetric Synthesis of β-Aryl β-Imido Sulfones Using Rhodium Catalysts with Chiral Diene Ligands: Synthesis of Apremilast, Organic Letters, vol. 21, Jun. 2019
2018 Access to β2‐Amino Acids via Enantioselective 1,4-Arylation of β‐Nitroacrylates Catalyzed by Chiral Rhodium Catalysts, The Journal of Organic Chemistry, vol. 83, Aug. 2018
2018 Efficient and Enantioselective Rhodium(I)-Catalyzed Arylation of a-Ketoesters: Synthesis of (S)-Flutriafol, Advanced Synthesis & Catalysis, vol. 360, Jul. 2018
2018 A Rapid Synthesis of Chiral Allylic Amines via Microwave-assisted Asymmetric Alkenylation of N-Tosyl Aldimines Catalyzed by Rhodium/Chiral Diene Complexes, JOURNAL OF THE CHINESE CHEMICAL SOCIETY, vol. 65, Mar. 2018
2018 Rh-catalyzed Enantioselective Allylation of N-Ts and N-Ns Aldimines: Total Synthesis of (–)-Crispine A, Organic Letters, vol. 20, Jan. 2018
2017 Design and Synthesis of Chiral Diene Ligands for RhI-Catalyzed Enantioselective Arylation of N-DPP-protected Aldimines: Synthesis of the Antifungal Agent Bifonazole, Chemistry-An European Journal, vol. 2017, Sep. 2017
2017 Recent developments in Zn-catalyzed asymmetric addition reaction to ketones: Syntheses of chiral tertiary alcohols, Tetrahedron Letters, vol. 58, Jan. 2017
2017 Synthesis of Quaternary-Carbon-Containing b2,2-Amino Acids by the RhI-Catalyzed Enantioselective Arylation of a-Substituted b-Nitroacrylates, Chemistry-A European Jounal, vol. 23, Jan. 2017
2016 Rh(I)-Catalyzed 1,4-Conjugate Addition of Alkenylboronic Acids to a Cyclopentenone Useful for the Synthesis of Prostaglandins, The Journal of Organic Chemistry, vol. 81, Oct. 2016
2016 Enantioselective addition of organozinc reagents to carbonyl compounds catalyzed by a camphor derived chiral g-amino thiol ligand, Tetrahedron, vol. 72, May. 2016
2016 Rhodium-Catalyzed Enantioselective Arylation of N-Substituted a,b-Unsaturated g-Lactams: Preparation of Chiral 4-Aryl-2- Pyrrolidones, Asian Journal of Organic Chemsitry, vol. 2016, Apr. 2016
2015 Direct Synthesis of Chiral 3-Arylsuccinimides by Rhodium- Catalyzed Enantioselective Conjugate Addition of Arylboronic Acids to Maleimides, Chemistry A European Journal, vol. 21, Jul. 2015
2015 Rhodium/Chiral Diene Complexes in the Catalytic Asymmetric Arylation of β‐Pyrazol-1-yl Acrylates, Organic Letters, vol. 17, Feb. 2015
2014 Aerobic Oxidative Coupling of 2‐Naphthol Derivatives Catalyzed by a Hexanuclear Bis(μ-hydroxo)copper(II) Catalyst, Organometallics, vol. 33, Aug. 2014
2014 Enantioselective and Rapid Rh-Catalyzed Arylation of N‐Tosyl- and N‐Nosylaldimines in Methanol, Journal of Organic Chemistry, vol. 79, Aug. 2014
2014 Highly Enantioselective Rh-Catalyzed Alkenylation of Imines: Synthesis of Chiral Allylic Amines via Asymmetric Addition of Potassium Alkenyltrifluoroborates to N‐Tosyl Imines, Organic Letters, vol. 15, Jan. 2014
2013 Rhodium-Catalyzed Asymmetric Addition of Arylboronic Acids to β‐Nitroolefins: Formal Synthesis of (S)‐SKF 38393, Organic Letters, vol. 15, Dec. 2013
2013 Preparation of Chiral alpha-Substituted Alaninates through an Efficient Diastereoselective Synthesis of Trisubstituted Allylic Alcohols, Chemistry An Asian Journal, vol. 2013, Jan. 2013
2012 Enantioselective Addition of Dialkylzincs to Aldehydes Catalyzed by (-)-MITH, Chemistry An Asian Journal, vol. 2012, Dec. 2012
2012 Synthesis of facial cyclometalated iridium(III) complexes triggered by tripodal ligands, Dalton Transactions, vol. 41, Jun. 2012
2012 Preparation of Chiral 3-Arylpyrrolidines via the Enantioselective 1,4-Addition of Arylboronic Acids to Fumaric Esters Catalyzed by Rh(I)/Chiral Diene Complexes, Organic Letter, vol. 14, Jun. 2012
2012 Expanding the C1-Symmetric Bicyclo[2.2.1]heptadiene Ligand Family: Highly Enantioselective Synthesis of Cyclic β-Aryl-Substituted Carbonyl Compounds, European Journal of Organic Chemistry, vol. 2012, Mar. 2012
2011 Highly Enantioselective Rhodium-Catalyzed Asymmetric 1,4-Addition Reactions of Arylboronic Acids to Acyclic alpha, beta-Unsaturated Compounds: The Formal Synthesis of (-)-Indatraline, Chemistry A European Journal, vol. 17, Oct. 2011
2009 Asymmetric synthesis of propargylic alcohols catalyzed by (-)-MITH, Tetrahedron: Asymmetry, vol. 20, Sep. 2009
2009 Asymmetric addition of diethylzinc to aldehydes catalyzed by a camphor-derived β-amino alcohol, Tetrahedron: Asymmetry, vol. 20, Jul. 2009
2008 Asymmetric Addition of Dimethylzinc to α-Ketoesters Catalyzed by (-)-MITH, J. Org. Chem., vol. 73, Jul. 2008
2007 Antithrombotic Effect of Hydroxychavicol, a Novel Betel Leaf Component: Role of Cyclooxygenase, Reactive Oxygen Species and Calcium Mobilization, British Journal of Pharmacology, vol. 152, Jul. 2007
2007 Highly enantioselective synthesis of (E)-allylic alcohols, J. Org. Chem., vol. 72, Jun. 2007
2007 Synthesis and characterization of π-extended bowl-shaped π-conjugated molecules, Chem. Commun., Apr. 2007
2006 Asymmetric Synthesis of Functionalized Diarylmethanols Catalyzed by a New γ-Amino Thiol, J. Org. Chem., vol. 71, Jan. 2006
Year Paper Title
2019 A Practical Synthesis of Apremilast, 第21届中国科协年会——海峡两岸暨港澳绿色发展青年论坛, Jun. 28-Jul. 01, 2019, 哈爾濱
2019 Asymmetric Synthesis of b-Imido-b-Aryl Sulfones through Rhodium Catalysts with Chiral Diene Ligands: Synthesis of Apremilast, 2019 Workshop on Organic Chemistry for Junior Chemists (WOCJC-11), Jun. 14-17, 2019, Daejeon, Korea
2019 Rh(I)-catalyzed enantioselective allylation of N -Ts and N -Ns aldimines: Total synthesis of (–)-crispine A, 台師大-九州大學研討會議, May. 27-28, 2019, 台灣、台北
2019 Enantioselective Rh-Catalyzed Syntheses of Chiral Nitrogen Containing Compounds, 10th OCARINA International Symposium, Mar. 05-06, 2019, Osaka
2018 Rh(I)-catalyzed enantioselective allylation of N -Ts and N -Ns aldimines: Total synthesis of (–)-crispine A, PERCH-CIC Congress X: 2018 International Congress for Innovation in Chemistry, Jul. 04-07, 2018, Jomtien Palm Beach Hotel & Resort, Pattaya, Chonburi, Thailand
2017 Rh(I)-Cataltzed Two-Component Synthesis of Prostaglandins: Gram Scale Synthesis of Dinoprost and Tafluprost, the 5th NRCT-IFS-MU-PERCH-CIC Workshops: NRCT-IFS-MU-PERCH-CIC: Current Trends in Chemical and Pharmaceutical Sciences, and Related Disciplines, Mar. 01-07, 2017, Wangchan Riverview, Phitsanulok Province, Thailand
2016 Preparation of Chiral 4-Aryl-2-Pyrrolidones via Enantioselective Rh- Catalyzed Arylation of N-Substituted α,β-Unsaturated-γ-lactams, The 12th International Symposium on Organic Reactions, Apr. 22-24, 2016, Kyoto
2016 Rhodium/Chiral Diene Complexes in the Catalytic Asymmetric Acylation and alkenylation of β-Pyrazole-1-yl Acrylates, Joint Workshop on Chirality in Chiba University (WCCU) and on Soft-Molecule Activation, Mar. 07, 2016, Chiba
2020 Asymmetric Synthesis of Functional Phenylalanines via Rh-Catalyzed Conjugate Addition and Enantioselective Protonation Cascade, The 14th International Symposium on Organic Reactions, Apr. 24-26, 2020, Yokohama
2020 Asymmetric Synthesis of Functional Phenylalanines via Rh-Catalyzed Conjugate Addition and Enantioselective Protonation Cascade, The 14th International Symposium on Organic Reactions, Apr. 24-26, 2020, Yokohama
2012 必填欄位, Taiwan-Japan Symposium of Frontier Research on Design and Application of Fine Chemicals, Jan. 06, 2012, Taipei
2011 Bicyclo[2.2.1] Chiral Dienes in the Rh-Catalyzed 1,4-Addition Reactions, 10th International Symposium Organic Reactions (ISOR-10), Nov. 21-24, 2011, Yokohama
2011 Bicyclo[2.2.1] Chiral Dienes in the Rh-Catalyzed 1,4-Addition Reactions, Workshop on Organic Chemistry for Junior Chemists Special Symposium at Tokyo Tech, Nov. 21, 2011, Yokohama
Year Project Title Job Title Period Unit
2023 設計與發展新穎性金屬催化不對稱反應及其合成應用研究(2/3) 2022.08 ~ 2023.07 科技部(原國科會)
2022 設計與發展新穎性金屬催化不對稱反應及其合成應用研究(1/3) 主持人 2021.08 ~ 2022.07 科技部(原國科會)
2021 新型過渡金屬催化不對稱反應之研究發展及其應用於合成天然物與藥物分子 主持人 2020.08 ~ 2021.07 科技部(原國科會)
2020 新型過渡金屬催化不對稱反應之研究發展及其應用於合成天然物與藥物分子 主持人 2019.08 ~ 2020.07 科技部(原國科會)
2019 新型過渡金屬催化不對稱反應之研究發展及其應用於合成天然物與藥物分子 主持人 2018.08 ~ 2019.07 科技部(原國科會)
2018 開發新穎金屬催化反應:具生物活性之天然物與藥物的合成 主持人 2017.08 ~ 2018.07 科技部(原國科會)
2017 開發新穎金屬催化反應:具生物活性之天然物與藥物的合成 主持人 2016.08 ~ 2017.07 科技部(原國科會)
2016 開發新穎金屬催化反應:具生物活性之天然物與藥物的合成 (中型儀器補助計畫) 主持人 2015.08 ~ 2016.07 科技部(原國科會)
2016 開發新穎金屬催化反應:具生物活性之天然物與藥物的合成 主持人 2015.08 ~ 2016.07 科技部(原國科會)
2015 發展高效能過渡金屬催化不對稱反應並應用於合成具生理活性與藥性的分子 主持人 2014.08 ~ 2015.07 國科會
2014 發展高效能過渡金屬催化不對稱反應並應用於合成具生理活性與藥性的分子 主持人 2013.08 ~ 2014.07 國科會
2013 掌性雙環「2.2.1」雙烯配體在一價銠金屬催化之不對稱合成上的應用 主持人 2012.08 ~ 2013.07 國科會
2012 掌性雙環「2.2.1」雙烯配體在一價銠金屬催化之不對稱合成上的應用 主持人 2011.08 ~ 2012.07 國科會
2012 重點二子題1:具掌性四級碳之生理活性分子的合成:Sphingofungin F 的全合成 主持人 2011.08 ~ 2012.07 國科會
2011 重點二子題1:具掌性四級碳之生理活性分子的合成:Sphingofungin F 的全合成 主持人 2010.08 ~ 2011.07 國科會
2011 新型掌性雙烯配體的開發及其在不對稱合成上的應用 主持人 2010.08 ~ 2011.07 國科會
2010 新型掌性雙烯配體的開發及其在不對稱合成上的應用 主持人 2009.12 ~ 2010.07 國科會
2010 1.金,銀,鎳,銠-催化環形雙烯分子內雙烯與官能基的偶合反應; 2.以環己二烯為共軛連接體的染料敏性太陽能電池材料的合成(創新啟動補助方案) 協同/共同主持人 2009.12 ~ 2010.11 國科會
Country School Name Department Degree Duration
Taiwan National Tsing Hua University department of chemistry Ph.D. 1998.09 ~ 2004.06
Organization Title Department Job Title Duration
2017.08 ~ Up to today
2013.02 ~ 2013.02
2013.02 ~ Up to today
2011.07 ~ 2011.07
National Taiwan Normal University department of chemistry Assistant Professor 2009.08 ~ 2013.01
Massachusetts Institute of Technology Postdoctoral Fellow 2008.07 ~ 2009.06
National Tsing Hua University Postdoctoral Fellow 2007.04 ~ 2008.06
Osaka University Postdoctoral Fellow 2005.04 ~ 2007.03
National Tsing Hua University Postdoctoral Fellow 2004.08 ~ 2005.03
Honor Category Year Award Name Awarding Unit
Congratulations 2017
Congratulations 2016
Congratulations 2015
Congratulations 2015
Off-campus Excellence 2015
Off-campus Excellence 2015
Off-campus Excellence 2015
Congratulations 2014
Off-campus Excellence 2014
Off-campus Excellence 2013
Off-campus Excellence 2013
Off-campus Excellence 2012