吴学亮
姓名 吴学亮
电子邮件 hlw@ntnu.edu.tw
联络电话 (02)77496142
实验室电话 (02)77496155
职称 优聘教授
研究领域 有机化学 不对称合成 天然物合成 药物合成
学术专长 有机合成化学 有机金属化学
指导学生 博士后:李韦贤。
博士班: 曾昊葳,程友毅, 杨玉珠
硕士班:萧萱霈,林羽宣,邱奕文,张景智,陈承威,郭瑀洁,蔡宇轩,黄俊杰 
实验室 不对称合成实验室

学术着作

  1. Wei-Sian Li, Ting-Shen Kuo, Meng-Chi Hsieh, Ming-Kang Tsai, Ping-Yu Yu, Hsyueh-Liang Wu* "Enantioselective Rhodium-Catalyzed Allylation of Aliphatic Imines: Synthesis of Chiral C-Aliphatic Homoallylic Amines" Org. Lett. 2020, 22, 5675-5679.
  2. Hao-Wei Zeng, Ping-Yu Wu, Hsyueh-Liang Wu* "Progress in recent development of stereoselective synthesis of beta2-amino acid derivatives from beta-nitroacrylate derivatives" Org. Biomol. Chem. 2020, 18, 2991-3006.
  3. Jia-Hong Jian, Hao-Wei Zeng, Ting-Shen Kuo, Ping-Yu Wu, Hsyueh-Liang Wu* "Asymmetric Synthesis of Functionalized Phenylalanine Derivatives via Rh-Catalyzed Conjugate Addition and Enantioselective Protonation Cascade" Org. Lett. 2019, 21, 9468-9472.
  4. Jin-Fong Syu, Balraj, Gopula, Jia-Hong Jian, Wei-Sian Li, Ting-Shen Kuo, Ping-Yu Wu, Julian P. Henschke, Meng-Chi Hsieh, Ming-Kang Tsai, Hsyueh-Liang Wu* "Asymmetric Synthesis of beta-Aryl beta-Imido Sulfones Using Rhodium Catalysts with Chiral Diene Ligands: Synthesis of Apremilast" Org. Lett. 2019, 21, 4614-4618.
  5. Jia-Hong Jian, Chih-Lung Hsu, Jin-Fong Syu, Ting-Shen Kuo, Ming-Kang Tsai, Ping-Yu Wu, Hsyuh-Liang Wu* "Access to ß2-Amino Acids via Enantioselective 1,4-Arylation of ß-Nitroacrylates Catalyzed by Chiral Rhodium Catalysts" J. Org. Chem. 201883, 12184–12191.
  6. Chiung-An Chang, Tsung-Ying Uang, Jia-Hong Jian, Meng-Yi Zhou, Ming-Liang Chen, Ting-Shen Kuo, Ping-Yu Wu, and Hsyueh-Liang Wu* "Efficient and Enantioselective Rhodium(I)-Catalyzed Arylation of alpha-Ketoesters: Synthesis of (S)-Flutriafol"  Adv. Syn. Cat. 2018360, 3381-3390.
    参考连结参考连结
  7. Chiang, Pei-Feng; Li, Wei-Sian; Jian, Jia-Hong ; Kuo, Ting-Shen; Wu, Ping-Yu; Wu, Hsyueh-Liang  "Rh-catalyzed Enantioselective Allylation of N-Ts and N-Ns Aldimines: Total Synthesis of (–)-Crispine A" Org. Lett. 201820, 158–161.
    参考连结参考连结
  8. Jin-Fong Syu, Huang-Ying Lin, Yu-Yi Cheng, Yao-Chu Tsai, Yi-Ching Ting, Ting-Shen Kuo, Damodar Janmanchi, Ping-Yu Wu, Julian P. Henschke and Hsyueh-Liang Wu* "Design and Synthesis of Chiral Diene Ligands for Rh(I)-Catalyzed Enantioselective Arylation of N-DPP-protected Aldimines: Synthesis of the Antifungal Agent Bifonazole" Chem. Eur. J. 201723, 14515–14522.
    参考连结参考连结
  9. Hsyueh-Liang Wu,* Chiung-An Chang, Ping-Yu Wu, Biing-Jiun Uang.* "Recent developents in Zn-catalyzed asymmetric addition reaction to ketones: Syntheses of chiral tertiary alcohols" Tetrahedron Lett 201758, 706–710.  参考连结参考连结
  10. Jin-Fong Syu, Yun-Ting Wang, Kung-Cheng Liu, Ping-Yu Wu, Julian P. Henschke,*, and Hsyueh-Liang Wu*, "Rh(I)-Catalyzed 1,4-Conjugate Addition of Alkenylboronic Acids to a Cyclopentenone Useful for the Synthesis of Prostaglandins" J. Org. Chem. 201681, 10832–10844. 参考连结参考连结
  11. Jo-Hsuan Fang, Jia-Hong Jian, Hao-Ching Chang,Ting-Shen Kuo, Way-Zen Lee, Hsyueh-Liang Wu.* "Synthesis of Quaternary Carbon-containing β2,2-Amino Acids via Rh(I)-Catalyzed Enantioselective Arylation of α-Substituted β-Nitroacrylates" Chem. Eur.–J. 2017, 23, 1830–1838. 参考连结参考连结
  12.  Hsyueh-Liang Wu, Ping-Yu Wu, Ying-Ni Cheng, Biing-Jiun Uang,* "Enantioselective addition of organozinc reagents to carbonyl compounds catalyzed by a camphor derived chiral gamma-amino thiol ligand" Tetrahedron 2016, 72, 2656–2665 参考连结参考连结
  13. Jo-Hsuan Fang, Chiung-An Chang, Balraj Gopula,Ting-Shen Kuo, Ping-Yu Wu, Julian P. Henschke, and Hsyueh-Liang Wu* "Rhodium-Catalyzed Enantioselective Arylation of N-Substituted alpha,beta-Unsaturated gamma-Lactams: Preparation of Chiral 4-Aryl-2- Pyrrolidones" Asian J. Org. Chem. 20165, 481 – 485  参考连结参考连结
  14. Balraj Gopula, Shu-Han Yang, Ting-Shen Kuo, Jen-Chieh Hsieh,* Ping-Yu Wu, Julian P. Henschke,* and Hsyueh-Liang Wu* "Direct Synthesis of Chiral 3-Arylsuccinimides by Rhodium- Catalyzed Enantioselective Conjugate Addition of Arylboronic Acids to Maleimides" Chem. Eur. J. 201521, 11050 – 11055. (Hot paper and highlighted on back cover)  参考连结参考连结
  15. Balraj Gopula, Yun-Fan Tsai, Ting-Shen Kuo, Ping-Yu Wu, Julian, P. Henschke, and Hsyueh-Liang Wu " Rhodium/Chiral Diene Complexes in the Catalytic Asymmetric Arylation of beta-Pyrazole-1-yl Acrylates"
    Org. Lett. 2015, 17, 1142–1145. 参考连结参考连结
  16. Balraj Gopula, Chien-Wei Chiang, Way-Zen Lee, Ting-Shen Kuo, Ping-Yu Wu, Julian P. Henschke and Hsyueh-Liang Wu* " Highly Enantioselective Rh-Catalyzed Asymmetric Alkenylation of Imines: Synthesis of Chiral Allylic Amines via Asymmetric Addition of Potassium Alkenyltrifluoroborates fo N-Tosyl Imines " Org. Lett. 201416, 632-635.
  17. Chun-Chih Chen, Balraj Gopula, Jin-Fong Syu, Jhih-Han Pan, Ting-Shen Kuo, Ping-Yu Wu, Julian P. Henschke and Hsyueh-Liang Wu* " Enantioselective and Rapid Rh-Catalyzed Arylation of N-Tosyl and N-Nosylaldimines in Methanol" J. Org. Chem. 201479, 8077-8085.
  18. Yedukondalu Meesala, Hsyueh-Liang Wu, Bommisetti Koteswararao, Ting-Shen Kuo, and Way-Zen Lee* "Aerobic Oxidative Coupling of 2‐Naphthol Derivatives Catalyzed by a Hexanuclear Bis(μ-hydroxo)copper(II) Catalyst" Organometallics, 2014, 33, 4385–4393
    参考连结参考连结
  19. Kung-Chih Huang, Balraj Gopula, Ting-Shen Kuo, Chien-Wei Chiang, Ping-Yu Wu, Julian P. Henschke and Hsyueh-Liang Wu* " Rhodium-Catalyzed Asymmetric Addition of Arylboronic Acids to β-Nitroolefins: Formal Synthesis of (S)-SKF 38393 " Org. Lett. 201315, 5730-5733.
  20. Toshiyuki Moriuchi ,  Lisheng Mao ,  Hsyueh-Liang Wu ,  Satoshi D. Ohmura ,  Masami Watanabe and Toshikazu Hirao*"Synthesis of facial cyclometalated iridium(III) complexes triggered by tripodal ligands" DALTON TRANSACTIONS , 201241, 9519-9525.
  21. Balraj Gopula, Way-Zen Lee, and Hsyueh-Liang Wu* "Preparation of Chiral alpha-Substituted Alaninates through an Efficient Diastereoselective Synthesis of Trisubstituted Allylic Alcohols" Chem. Asian J. 20138, 80-83. -Most Accessed from Jan/2013-Sep/2013
  22.  Ying-Ni Cheng, Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang* “Enantioselective Addition of Dialkylzincs to Aldehydes Catalyzed by (-)-MITH“ Chem. Asian. J. 20127, 2921-2924.
  23. Yu-Chiang, Chung, Damodar Janmanchi and Hsyueh-Liang Wu* " Preparation of Chiral 3-Aryl Pyrrolidines via the Enantioselective 1,4-Addition of Arylboronic Acids to Fumaric Esters Catalyzed by Rh(I)/Chiral Diene Complexes." Org. Lett. 2012, 14, 2766-2769. 
  24. Chia-Chen Liu, Damodar Janmanchi, Chun-Chih Chen, Hsyueh-Liang Wu* “Expanding C1-Symmetric Bicyclo[2.2.1]heptadiene Ligand Family: Highly Enantioselective Synthesis of Cyclic b-Aryl Substituted Carbonyl Compounds.” Eur. J. Org. Chem. 2012, 2503-2507. 
  25. Wei-Ting Wei, Jiann-Yih Yeh, Ting-Shen Kuo, Hsyueh-Liang Wu* "Highly Enantioselective Rhodium-Catalyzed Asymmetric 1,4-Addition Reactions of Arylboronic Acids to Acyclic a,b-Unsaturated Compounds: The Formal Synthesis of (-)-Indatraline" Chem. Eur. J. 2011, 17, 11405-11409. 
  26. Ping-Yu Wu, Hsyueh-Liang Wu, Ying-Ying Shen, Biing-Jiun Uang “Asymmetric Synthesis of Propargylic Alcohols Catalyzed by (-)-MITH” Tetrahedron: Asymmetry 2009, 20, 1837-1841. 
  27. Zhi-Long Wu, Hsyueh-Liang Wu, Ping-Yu Wu, Biing-Jiun Uang “Asymmetric Addition of Diethylzinc to Aldehydes Catalyzed by a Camphor-Derived β-Amino Alcohol” Tetrahedron: Asymmetry 2009, 20, 1556-1560.
  28. Hsyueh-Liang Wu, Ping-Yu Wu, Biing-Jiun Uang “ Asymmetric Addition of Dimethylzinc to α-Ketoesters Catalyzed by (-)-MITH.” J. Org. Chem. 2008, 73, 6445-6447.
  29. Mei-Chi Chang, Hsyueh-Liang Wu, Chiu-Po Chan, Biing-Jiun Uang, Chia-Shan Lee, Bor-Dong Chen, Bor-Ru Lin, Hsiao-Hwa Chang, Chen-Jie Kao, Jiiang-Huei Jeng “Antithrombotic Effect of Hydroxychavicol, a Novel Betel Leaf Component: Role of Cyclooxygenase, Reactive Oxygen Species and Calcium Mobilization” British Journal of Pharmacology 2007, 152, 73-82. 
  30. Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang “ Highly enantioselective synthesis of (E)-allylic alcohols” J. Org. Chem. 2007, 72, 5935-5937 
  31. Toru Amaya, Koichi Mori, Hsyueh-Liang Wu, Satoshi Ishida, Jun-ichi Narkamura, Kazuhiko Murata, Toshikazu Hirao. “Synthesis and Characterization of π-extended Bowl-shaped π-Conjugated Molecules.” Chem. Commun. 2007, 1902-1904. 
  32. Ping-Yu Wu, Hsyueh-Liang Wu, and Biing-Jiun Uang, “Asymmetric Synthesis of Functionalized Diarylmethanols Catalyzed by a New γ-Amino Thiol.” J. Org. Chem. 2006, 71, 833-835.
  33. Post-Conference of 1st International Conference on Cutting Edge Organic Chemistry in Asia, Oct 21-24, 2006, National Tsing Hua University, Hsinchu, Taiwan, Presentation Titles: (a) Asymmetric Synthesis of Functionalized Diarylmethanols Catalyzed by a New γ−Amino Thiol (Best Poster Award) Ping-Yu Wu, Hsyueh-Liang Wu and Biing-Jiun Uang (b) The Effects of Sulfur and Oxygen Atoms of the Ligands in the Addition Reaction of Dialkylzinc to Aldehydes Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang 
  34. J. H. Jeng,Y. J. Wang, W. H. Chang, H. L. Wu, C. H. Li, B. J. Uang, J. J. Kang, J. J. Lee, L. J. Hahn, B. R. Lin, and M. C. Chang "Reactive Oxygen Species are Crucial for Hydroxychavicol Toxicity Toward KB Epithelial Cells" Cellular and Molecular Life Sciences2004, 61, 83-96.
  35. Hsyueh-Liang Wu and Biing-Jiun Uang “Asymmetric Epoxidation of Allylic Alcohols Catalyzed by New Chiral Vanadium (V) Complexes”. Tetrahedron: Asymmetry 2002, 13, 2625.
  36. M. C. Chang, B. J. Uang. H. L. Wu, J. J. Lee, L. J. Hahn, J. H. Jeng. “Inducing the cell cycle arrest and apoptosis of oral KB carcinoma cells by hydroxychavicol : roles of glutathione and reactive oxygen species” British Journal of Pharmacology 2002, 135, 619.
年度 论文名称
2021 Application of Rh(I)/Bicyclo[2.2.1] heptadiene Catalysts to the Enantioselective Synthesis of Chiral Amines, The Chemical Record, vol. 21, Oct. 2021
2021 Cross-Dimerization of 2,5-Dihydrofuran with Conjugated Dienes Catalyzed by (Chiral Diene)ruthenium(0) Complexes and Origins of the Enantioselectivity, Organometallics, vol. 2021, Aug. 2021
2021 Enantioselective Synthesis of 1‑Aryl Tetrahydroisoquinolines by the Rhodium-Catalyzed Reaction of 3,4-Dihydroisoquinolinium Tetraarylborates, Organic Letter, vol. 23, Jan. 2021
2020 Enantioselective Rhodium-Catalyzed Allylation of Aliphatic Imines: Synthesis of Chiral C‐Aliphatic Homoallylic Amines, Organic Letters, vol. 2020, Jul. 2020
2020 Progress in recent development of stereoselective synthesis of β2-amino acid derivatives from β-nitroacrylate derivatives, Organic & Biomolecular Chemistry, vol. 2020, Mar. 2020
2019 Stimulation of MMP-9 of oral epithelial cells by areca nut extract is related to TGF-β/Smad2-dependent and –independent pathways and prevented by betel leaf extract, hydroxychavicol and melatonin, Aging, vol. 11, Dec. 2019
2019 Asymmetric Synthesis of Functionalized Phenylalanine Derivatives via Rh-Catalyzed Conjugate Addition and Enantioselective Protonation Cascade, Organic Letters, vol. 21, Dec. 2019
2019 Asymmetric Synthesis of β-Aryl β-Imido Sulfones Using Rhodium Catalysts with Chiral Diene Ligands: Synthesis of Apremilast, Organic Letters, vol. 21, Jun. 2019
2018 Access to β2‐Amino Acids via Enantioselective 1,4-Arylation of β‐Nitroacrylates Catalyzed by Chiral Rhodium Catalysts, The Journal of Organic Chemistry, vol. 83, Aug. 2018
2018 Efficient and Enantioselective Rhodium(I)-Catalyzed Arylation of a-Ketoesters: Synthesis of (S)-Flutriafol, Advanced Synthesis & Catalysis, vol. 360, Jul. 2018
2018 A Rapid Synthesis of Chiral Allylic Amines via Microwave-assisted Asymmetric Alkenylation of N-Tosyl Aldimines Catalyzed by Rhodium/Chiral Diene Complexes, JOURNAL OF THE CHINESE CHEMICAL SOCIETY, vol. 65, Mar. 2018
2018 Rh-catalyzed Enantioselective Allylation of N-Ts and N-Ns Aldimines: Total Synthesis of (–)-Crispine A, Organic Letters, vol. 20, Jan. 2018
2017 Design and Synthesis of Chiral Diene Ligands for RhI-Catalyzed Enantioselective Arylation of N-DPP-protected Aldimines: Synthesis of the Antifungal Agent Bifonazole, Chemistry-An European Journal, vol. 2017, Sep. 2017
2017 Recent developments in Zn-catalyzed asymmetric addition reaction to ketones: Syntheses of chiral tertiary alcohols, Tetrahedron Letters, vol. 58, Jan. 2017
2017 Synthesis of Quaternary-Carbon-Containing b2,2-Amino Acids by the RhI-Catalyzed Enantioselective Arylation of a-Substituted b-Nitroacrylates, Chemistry-A European Jounal, vol. 23, Jan. 2017
2016 Rh(I)-Catalyzed 1,4-Conjugate Addition of Alkenylboronic Acids to a Cyclopentenone Useful for the Synthesis of Prostaglandins, The Journal of Organic Chemistry, vol. 81, Oct. 2016
2016 Enantioselective addition of organozinc reagents to carbonyl compounds catalyzed by a camphor derived chiral g-amino thiol ligand, Tetrahedron, vol. 72, May. 2016
2016 Rhodium-Catalyzed Enantioselective Arylation of N-Substituted a,b-Unsaturated g-Lactams: Preparation of Chiral 4-Aryl-2- Pyrrolidones, Asian Journal of Organic Chemsitry, vol. 2016, Apr. 2016
2015 Direct Synthesis of Chiral 3-Arylsuccinimides by Rhodium- Catalyzed Enantioselective Conjugate Addition of Arylboronic Acids to Maleimides, Chemistry A European Journal, vol. 21, Jul. 2015
2015 Rhodium/Chiral Diene Complexes in the Catalytic Asymmetric Arylation of β‐Pyrazol-1-yl Acrylates, Organic Letters, vol. 17, Feb. 2015
2014 Aerobic Oxidative Coupling of 2‐Naphthol Derivatives Catalyzed by a Hexanuclear Bis(μ-hydroxo)copper(II) Catalyst, Organometallics, vol. 33, Aug. 2014
2014 Enantioselective and Rapid Rh-Catalyzed Arylation of N‐Tosyl- and N‐Nosylaldimines in Methanol, Journal of Organic Chemistry, vol. 79, Aug. 2014
2014 Highly Enantioselective Rh-Catalyzed Alkenylation of Imines: Synthesis of Chiral Allylic Amines via Asymmetric Addition of Potassium Alkenyltrifluoroborates to N‐Tosyl Imines, Organic Letters, vol. 15, Jan. 2014
2013 Rhodium-Catalyzed Asymmetric Addition of Arylboronic Acids to β‐Nitroolefins: Formal Synthesis of (S)‐SKF 38393, Organic Letters, vol. 15, Dec. 2013
2013 Preparation of Chiral alpha-Substituted Alaninates through an Efficient Diastereoselective Synthesis of Trisubstituted Allylic Alcohols, Chemistry An Asian Journal, vol. 2013, Jan. 2013
2012 Enantioselective Addition of Dialkylzincs to Aldehydes Catalyzed by (-)-MITH, Chemistry An Asian Journal, vol. 2012, Dec. 2012
2012 Synthesis of facial cyclometalated iridium(III) complexes triggered by tripodal ligands, Dalton Transactions, vol. 41, Jun. 2012
2012 Preparation of Chiral 3-Arylpyrrolidines via the Enantioselective 1,4-Addition of Arylboronic Acids to Fumaric Esters Catalyzed by Rh(I)/Chiral Diene Complexes, Organic Letter, vol. 14, Jun. 2012
2012 Expanding the C1-Symmetric Bicyclo[2.2.1]heptadiene Ligand Family: Highly Enantioselective Synthesis of Cyclic β-Aryl-Substituted Carbonyl Compounds, European Journal of Organic Chemistry, vol. 2012, Mar. 2012
2011 Highly Enantioselective Rhodium-Catalyzed Asymmetric 1,4-Addition Reactions of Arylboronic Acids to Acyclic alpha, beta-Unsaturated Compounds: The Formal Synthesis of (-)-Indatraline, Chemistry A European Journal, vol. 17, Oct. 2011
2009 Asymmetric synthesis of propargylic alcohols catalyzed by (-)-MITH, Tetrahedron: Asymmetry, vol. 20, Sep. 2009
2009 Asymmetric addition of diethylzinc to aldehydes catalyzed by a camphor-derived β-amino alcohol, Tetrahedron: Asymmetry, vol. 20, Jul. 2009
2008 Asymmetric Addition of Dimethylzinc to α-Ketoesters Catalyzed by (-)-MITH, J. Org. Chem., vol. 73, Jul. 2008
2007 Antithrombotic Effect of Hydroxychavicol, a Novel Betel Leaf Component: Role of Cyclooxygenase, Reactive Oxygen Species and Calcium Mobilization, British Journal of Pharmacology, vol. 152, Jul. 2007
2007 Highly enantioselective synthesis of (E)-allylic alcohols, J. Org. Chem., vol. 72, Jun. 2007
2007 Synthesis and characterization of π-extended bowl-shaped π-conjugated molecules, Chem. Commun., Apr. 2007
2006 Asymmetric Synthesis of Functionalized Diarylmethanols Catalyzed by a New γ-Amino Thiol, J. Org. Chem., vol. 71, Jan. 2006
  1. Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang. A review article regarding “(-)-2-exo-Morpholinoisobornane-10-thiol” in e-EROS Encyclopedia of Reagents for Organic Synthesis. 
  2. Hsyueh-Liang Wu and Toshikazu Hirao. First update on “Vanadyl Bis(acetyl acetonate)” in e-EROS Encyclopedia of Reagents for Organic Synthesis.
年度 论文名称
2019 A Practical Synthesis of Apremilast, 第21届中国科协年会——海峡两岸暨港澳绿色发展青年论坛, Jun. 28-Jul. 01, 2019, 哈尔滨
2019 Asymmetric Synthesis of b-Imido-b-Aryl Sulfones through Rhodium Catalysts with Chiral Diene Ligands: Synthesis of Apremilast, 2019 Workshop on Organic Chemistry for Junior Chemists (WOCJC-11), Jun. 14-17, 2019, Daejeon, Korea
2019 Rh(I)-catalyzed enantioselective allylation of N -Ts and N -Ns aldimines: Total synthesis of (–)-crispine A, 台师大-九州大学研讨会议, May. 27-28, 2019, 台湾、台北
2019 Enantioselective Rh-Catalyzed Syntheses of Chiral Nitrogen Containing Compounds, 10th OCARINA International Symposium, Mar. 05-06, 2019, Osaka
2018 Rh(I)-catalyzed enantioselective allylation of N -Ts and N -Ns aldimines: Total synthesis of (–)-crispine A, PERCH-CIC Congress X: 2018 International Congress for Innovation in Chemistry, Jul. 04-07, 2018, Jomtien Palm Beach Hotel & Resort, Pattaya, Chonburi, Thailand
2017 Rh(I)-Cataltzed Two-Component Synthesis of Prostaglandins: Gram Scale Synthesis of Dinoprost and Tafluprost, the 5th NRCT-IFS-MU-PERCH-CIC Workshops: NRCT-IFS-MU-PERCH-CIC: Current Trends in Chemical and Pharmaceutical Sciences, and Related Disciplines, Mar. 01-07, 2017, Wangchan Riverview, Phitsanulok Province, Thailand
2016 Preparation of Chiral 4-Aryl-2-Pyrrolidones via Enantioselective Rh- Catalyzed Arylation of N-Substituted α,β-Unsaturated-γ-lactams, The 12th International Symposium on Organic Reactions, Apr. 22-24, 2016, Kyoto
2016 Rhodium/Chiral Diene Complexes in the Catalytic Asymmetric Acylation and alkenylation of β-Pyrazole-1-yl Acrylates, Joint Workshop on Chirality in Chiba University (WCCU) and on Soft-Molecule Activation, Mar. 07, 2016, Chiba
2020 Asymmetric Synthesis of Functional Phenylalanines via Rh-Catalyzed Conjugate Addition and Enantioselective Protonation Cascade, The 14th International Symposium on Organic Reactions, Apr. 24-26, 2020, Yokohama
2020 Asymmetric Synthesis of Functional Phenylalanines via Rh-Catalyzed Conjugate Addition and Enantioselective Protonation Cascade, The 14th International Symposium on Organic Reactions, Apr. 24-26, 2020, Yokohama
2012 必填字段, Taiwan-Japan Symposium of Frontier Research on Design and Application of Fine Chemicals, Jan. 06, 2012, Taipei
2011 Bicyclo[2.2.1] Chiral Dienes in the Rh-Catalyzed 1,4-Addition Reactions, 10th International Symposium Organic Reactions (ISOR-10), Nov. 21-24, 2011, Yokohama
2011 Bicyclo[2.2.1] Chiral Dienes in the Rh-Catalyzed 1,4-Addition Reactions, Workshop on Organic Chemistry for Junior Chemists Special Symposium at Tokyo Tech, Nov. 21, 2011, Yokohama
  1. Chiral diene ligands, a fabrication method thereof and applications thereof (US 8,586,810 B2) 
  2.  METAL-CATALYZED ASYMMETRIC 1,4-CONJUGATE ADDITION OF VINYLBORON COMPOUNDS TO 2-SUBSTITUTED-4-OXY-CYCLOPENT-2-EN-1-ONES YIELDING PROSTAGLANDINS AND PROSTAGLANDIN ANALOGS (U.S. Pat. Appl. 2016/0009740 A1, 2016)
  3. 掌性双烯配体及其制备方法与应用-中华民国专利
I.  ORAL PRESENTATION
1. 2nd Workshop on Organic Chemistry for Junior Chemists (TIT-NTHU) 2002 Hsyueh-Liang Wu and Biing-Jiun Uang “Asymmetric epoxidation of allylic alcohols catalyzed by camphor derived chiral hydroxamic acids.”
2. 1st Workshop on Organic Chemistry for Junior Chemists 2003 (NTHU-Nagaoka Institute of Technology) Hsyueh-Liang Wu and Biing-Jiun Uang “Enantioselective addition of Et2Zn to aldehydes catalyzed by camphor derived chiral ligands.”
3. 4th Workshop on Organic Chemistry for Junior Chemists (2004), Tokyo Institute of Technology, Yokohama, Japan. Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang, Enantioselective Addition of Diethylzinc Reagent to Aldehydes with Camphor-Derived Ligands.
4. NTHU-KAIST 2005 Junior Chemists Workshop (2005), National Tsing Hua University, Hsinchu, Taiwan. Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang, (+)-Nonlinear Effect in Asymmetric Addition of the Diethylzinc to Aldehydes
5. 86th spring meeting. Toru Amaya, Hsyueh-Liang Wu, Koichi Mori, Toshikazu Hirao. Synthesis of p-conjugated Sumanenes.
6. 86th spring meeting. Toru Amaya, Hsyueh-Liang Wu, Satoshi Ishida, Jun-ichi Nakamura, Kazuhiko Murata, Hidehiro Sakurai, Toshikazu Hirao, Study on π- Conjugation of Bowl-shaped π-Conjugated Sumanene.
7.International Symposium on Organic Reaction 2006. Toru Amaya, Hsyueh-Liang Wu, Koichi Mori, Toshikazu Hirao. Synthesis of p-conjugated Sumanenes
8. Invited speaker in COEIEC 8 Symposium. Title: Camphor derived chiral ligands in organozincs addition to aldehydes.
9. Invited speaker in WOCJC-7 Symposium. Title: Chiral [2.2.1] Diene Ligands for Asymmetric Catalysis
II. POSTER:
1. 5th International Conference on Cutting Edge Organic Chemistry in Asia, Nov 7-11, 2010, National Tsing Hua University, Hsinchu, Taiwan, Presentation Titles: Chiral [2.2.1] Diene Ligands for Asymmetric Catalysis
2. 5th Workshop on Organic Chemistry for Junior Chemists. Nov 23-26, 2006, National Tsing Hua University, Hsinchu, Taiwan Presentation Titles: Asymmetric Catalytic Organozinc Addition Reactions Based on Camphor Derived Ligand. Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang.
3. Post-Conference of 1st International Conference on Cutting Edge Organic Chemistry in Asia, Oct 21-24, 2006, National Tsing Hua University, Hsinchu, Taiwan, Presentation Titles: (a) Asymmetric Synthesis of Functionalized Diarylmethanols Catalyzed by a New γ−Amino Thiol (Best Poster Award) Ping-Yu Wu, Hsyueh-Liang Wu and Biing-Jiun Uang
(b) The Effects of Sulfur and Oxygen Atoms of the Ligands in the Addition Reaction of Dialkylzinc to Aldehydes Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang
4. The 8th International 21st Century COE Symposium on Integrated EcoChemistry, Aug 28-29, 2006, Osaka University, Japan Presentation Title: Asymmetric Synthesis of Functionalized Diarylmethanols Catalyzed by a New γ-Amino Thiol
Ping-Yu Wu, Hsyueh-Liang Wu and Biing-Jiun Uang
5. The 8th International Symposium on Organic Reactions, Apr 23-26, 2006, Kobe,Japan. Presentation Titles: Highly Enantioselective Addition of Alkenylzinc to Aldehydes Catalyzed by γ-Amino Thiol Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang
6. The 10th International Chemical Conference, Taipei, Oct 28-30, 2005, National Tsing Hua University, Hsinchu, Taiwan. Presentation Titles: (a) Highly Enantioselective Addition of Alkenylzinc to Aldehydes Catalyzed by (-)- MITH
Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang
(b) Asymmetric Synthesis of Functionalized Diarylmethanols Catalyzed by a New γ- Amino Thiol Ping-Yu Wu, Hsyueh-Liang Wu and Biing-Jiun Uang
7. Tokyo Summer School on Frontier Chemistry 2005, Aug 25-27, 2005, The University of Tokyo, Tokyo, Japan Presentation Title: Asymmetric Synthesis of Functionalized Diarylmethanols Catalyzed by γ-Amino Thiol
Ping-Yu Wu, Hsyueh-Liang Wu and Biing-Jiun Uang
8. NTHU-KAIST 2005 Junior Chemists Workshop, Feb 25-27, 2005, National Tsing Hua University, Hsinchu, Taiwan Presentation Title: (+)-Nonlinear Effect in Asymmetric Addition of the Diethylzinc to Aldehydes Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang
9. Annual Meeting of Chinese Chemical Society, Taipei, Nov 19-20, 2005, National Sun Yat-Sen University, Kaohsiung, Taiwan Presentation Titles:
(a) Camphor-Derived Oxazolines in Asymmetic Addition of Et2Zn to Aldehydes Ming-Shau Yang, Hsyueh-Liang Wu, Ping-Yu Wu, Che-Chia Chen and Biing-Jiun Uang
(b) Asymmetric Synthesis of Functionalized Diarylmethanols Catalyzed by a New γ- Amino Thiol Ping-Yu Wu, Hsyueh-Liang Wu and Biing-Jiun Uang
(c) Highly Enantioselective Addition of Alkenylzinc to Aldehydes Catalyzed by (-)- MITH Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang
10. 4th Workshop on Organic Chemistry for Junior Chemists, Sep 24-27, 2004, Tokyo Institute of Technology, Japan Presentation Title: Enantioselective Addition of Diethylzinc Reagent to Aldehydes with Camphor Derived Ligands
Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang
11. Annual Symposium of Chinese Chemical Society 2004 a) Chih-Lung Wu, Hsyueh-Liang Wu and Biing-Jiun Uang “Enantioselective Addition of Et2Zn to Aldehydes Catalyzed by b-Amino Alcohols”.....ORS-B-089
b) Hsyueh-Liang Wu, Ping-Yu Wu and Biing Jiun Uang “ (+)-Nonlinear Effect in Asymmetric Addition of the Et2Zn to Aldehydes.” ........ ORS-B-090.
12. 3rd Workshop on Organic Chemistry for Junior Chemists (TIT-NTHU) 2004 Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang “Enantioselective addition of Et2Zn to aldehydes with camphor derived chiral ligands.”
13. Annual Symposium of Chinese Chemical Society 2003 Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang “Enantioselective addition of Et2Zn to aldehydes “..............................OR-PA-061.
14.The 7th International Symposium for Chinese Organic Chemists 2002 Hsyueh- Liang Wu and Biing-Jiun Uang “Chiral camphor based hydroxamic acid catalyzed asymmetric epoxidation of allylic alcohols”........P-058.
15. Annual Symposium of Chinese Chemical Society 2002 Hsyueh-Liang Wu and Biing-Jiun Uang “Chiral camphor based hydroxamic acid catalyzed asymmetric epoxidation of allylic alcohols”........P-OR-072.
16. 2nd Workshop on Organic Chemistry for Junior Chemists (TIT-NTHU) 2002 Hsyueh-Liang Wu and Biing-Jiun Uang “Asymmetric epoxidation of allylic alcohols catalyzed by camphor derived chiral hydroxamic acids.”
17. 1st Workshop on Organic Chemistry for Junior Chemists 2002 (NTHU-Shanghai Institute of Organic Chemistry) Hsyueh-Liang Wu and Biing-Jiun Uang “Asymmetric epoxidation of allylic alcohols catalyzed by camphor derived chiral hydroxamic acids.”
18. 3rd International Symposium on Chemistry and Chemical Biology of Vanadium at Osaka Japan 2001 Hsyueh-Liang Wu and Biing-Jiun Uang “Asymmetric epoxidation of allylic alcohols catalyzed by camphor derived chiral hydroxamic acids.
年度 计画名称 职称/担任之工作 计画期间 补助/委讬或合作机构
2023 设计与发展新颖性金属催化不对称反应及其合成应用研究(2/3) 2022.08 ~ 2023.07 科技部(原国科会)
2022 设计与发展新颖性金属催化不对称反应及其合成应用研究(1/3) 主持人 2021.08 ~ 2022.07 科技部(原国科会)
2021 新型过渡金属催化不对称反应之研究发展及其应用于合成天然物与药物分子 主持人 2020.08 ~ 2021.07 科技部(原国科会)
2020 新型过渡金属催化不对称反应之研究发展及其应用于合成天然物与药物分子 主持人 2019.08 ~ 2020.07 科技部(原国科会)
2019 新型过渡金属催化不对称反应之研究发展及其应用于合成天然物与药物分子 主持人 2018.08 ~ 2019.07 科技部(原国科会)
2018 开发新颖金属催化反应:具生物活性之天然物与药物的合成 主持人 2017.08 ~ 2018.07 科技部(原国科会)
2017 开发新颖金属催化反应:具生物活性之天然物与药物的合成 主持人 2016.08 ~ 2017.07 科技部(原国科会)
2016 开发新颖金属催化反应:具生物活性之天然物与药物的合成 (中型仪器补助计画) 主持人 2015.08 ~ 2016.07 科技部(原国科会)
2016 开发新颖金属催化反应:具生物活性之天然物与药物的合成 主持人 2015.08 ~ 2016.07 科技部(原国科会)
2015 发展高效能过渡金属催化不对称反应并应用于合成具生理活性与药性的分子 主持人 2014.08 ~ 2015.07 国科会
2014 发展高效能过渡金属催化不对称反应并应用于合成具生理活性与药性的分子 主持人 2013.08 ~ 2014.07 国科会
2013 掌性双环「2.2.1」双烯配体在一价铑金属催化之不对称合成上的应用 主持人 2012.08 ~ 2013.07 国科会
2012 掌性双环「2.2.1」双烯配体在一价铑金属催化之不对称合成上的应用 主持人 2011.08 ~ 2012.07 国科会
2012 重点二子题1:具掌性四级碳之生理活性分子的合成:Sphingofungin F 的全合成 主持人 2011.08 ~ 2012.07 国科会
2011 重点二子题1:具掌性四级碳之生理活性分子的合成:Sphingofungin F 的全合成 主持人 2010.08 ~ 2011.07 国科会
2011 新型掌性双烯配体的开发及其在不对称合成上的应用 主持人 2010.08 ~ 2011.07 国科会
2010 新型掌性双烯配体的开发及其在不对称合成上的应用 主持人 2009.12 ~ 2010.07 国科会
2010 1.金,银,镍,铑-催化环形双烯分子内双烯与官能基的偶合反应; 2.以环己二烯为共轭连接体的染料敏性太阳能电池材料的合成(创新启动补助方案) 协同/共同主持人 2009.12 ~ 2010.11 国科会
国家 学校名称 系所 学位 期间
台湾 国立清华大学 化学所 博士 1998.09 ~ 2004.06
服务机关名称 单位 职务 期间
国立台湾师范大学 化学系 教授 2017.08 ~ 迄今
大坂大学 visiting professor supported by MEXT 2013.02 ~ 2013.02
国立台湾师范大学 化学系 副教授 2013.02 ~ 迄今
大坂府立大学 化学系 访问教授 2011.07 ~ 2011.07
国立台湾师范大学 化学系 助理教授 2009.08 ~ 2013.01
美国麻省理工学院 博士后研究 2008.07 ~ 2009.06
国立清华大学 博士后研究 2007.04 ~ 2008.06
大坂大学 博士后研究 2005.04 ~ 2007.03
国立清华大学 博士后研究 2004.08 ~ 2005.03
类别 年度 奖项名称 颁奖单位
校内荣誉 2017 优聘教授
校内荣誉 2016 绩优产学合作奖
校内荣誉 2015 优聘教授
校内荣誉 2015 绩优产学合作奖
校外荣誉 2015 年轻学者研究计画 科技部自然司
校外荣誉 2015 Asian Core Program Lectureship Award to China
校外荣誉 2015 Asian Core Program Lectureship Award to Korea
校内荣誉 2014 绩优产学合作奖
校外荣誉 2014 Asian Core Program Lectureship Award to Thailand
校外荣誉 2013 Asian Core Program Lectureship Award to Singapore
校外荣誉 2013 Asian Core Program Lectureship Award to Korea
校外荣誉 2012 Asian Core Program Lectureship Award to Japan